Detailed information for compound 554717

Basic information

Technical information
  • TDR Targets ID: 554717
  • Name: 3-allyldisulfanyldisulfanylprop-1-ene
  • MW: 210.404 | Formula: C6H10S4
  • H donors: 0 H acceptors: 0 LogP: 3.08 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCSSSSCC=C
  • InChi: 1S/C6H10S4/c1-3-5-7-9-10-8-6-4-2/h3-4H,1-2,5-6H2
  • InChiKey: RMKCQUWJDRTEHE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-allyldisulfanyldisulfanyl-1-propene
  • 3-prop-2-enyldisulfanyldisulfanylprop-1-ene
  • diallyl tetrasulfide
  • 2444-49-7
  • Diallyl tetrasulphide
  • EINECS 219-485-7
  • AIDS-109732
  • AIDS109732
  • DATS
  • Dially tetrasulfide
  • Tetrasulfide, di-2-propenyl

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni microtubule-associated protein tau 0.0683 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0482 0.0416
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0251 0.0184
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0073 0.0855 0.0791
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.5829 0.58
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0251 0.0184
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0482 0.1116
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0224 0.0156
Schistosoma mansoni ferritin light chain 0.0026 0.0147 0.0079
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0185 0.0272
Schistosoma mansoni hypothetical protein 0.0048 0.0482 0.0416
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.078 0.0716
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0482 0.0416
Schistosoma mansoni bromodomain containing protein 0.0133 0.1746 0.1689
Brugia malayi TAR-binding protein 0.0194 0.2664 0.6166
Onchocerca volvulus 0.0256 0.3603 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0288 0.022
Schistosoma mansoni tar DNA-binding protein 0.0194 0.2664 0.2613
Schistosoma mansoni cpg binding protein 0.0028 0.0185 0.0117
Schistosoma mansoni ferritin 0.0026 0.0147 0.0079
Loa Loa (eye worm) calpain family protein 1 0.007 0.0801 0.1723
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0133 0.3877
Brugia malayi calpain family protein 1 0.007 0.0801 0.1855
Brugia malayi RNA binding protein 0.0194 0.2664 0.6166
Schistosoma mansoni hypothetical protein 0.0168 0.2273 0.222
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.1322 0.3059
Leishmania major hypothetical protein, conserved 0.0025 0.0133 0.1079
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.02 0.2758 0.2708
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0288 0.022
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0482 0.0416
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0147 0.5
Schistosoma mansoni tar DNA-binding protein 0.0194 0.2664 0.2613
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0288 0.022
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0482 0.0416
Loa Loa (eye worm) hypothetical protein 0.007 0.0801 0.1723
Echinococcus multilocularis microtubule associated protein 2 0.0683 1 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0482 0.0416
Echinococcus granulosus ferritin 0.0026 0.0147 0.0079
Loa Loa (eye worm) TAR-binding protein 0.0194 0.2664 0.6104
Echinococcus granulosus zinc finger protein 0.0042 0.039 0.0324
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0147 0.5
Echinococcus granulosus expressed protein 0.0026 0.0147 0.0079
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0133 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0194 0.2664 0.6104
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0657 0.9954
Loa Loa (eye worm) hypothetical protein 0.007 0.0801 0.1723
Brugia malayi Pre-SET motif family protein 0.0033 0.0251 0.0581
Loa Loa (eye worm) calpain family protein 1 0.0049 0.0491 0.0993
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0288 0.022
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.066 1
Schistosoma mansoni hypothetical protein 0.0032 0.0233 0.0166
Loa Loa (eye worm) hypothetical protein 0.0079 0.0949 0.207
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.068 0.0616
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.066 1
Echinococcus multilocularis cpg binding protein 0.0034 0.0268 0.0201
Echinococcus granulosus GPCR family 2 0.0048 0.0482 0.0416
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.2045 0.4733
Schistosoma mansoni tar DNA-binding protein 0.0194 0.2664 0.2613
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.066 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.3137 0.7216
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0251 0.0184
Echinococcus granulosus dnaJ subfamily B 0.0405 0.5829 0.58
Onchocerca volvulus 0.0033 0.0251 0.0194
Plasmodium vivax SET domain protein, putative 0.0033 0.0251 1
Brugia malayi Bromodomain containing protein 0.0079 0.0947 0.2191
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0073 0.0855 0.0791
Echinococcus multilocularis calpain family protein 1, d 0.0049 0.0491 0.0425
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.02 0.2758 0.2708
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.066 1
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0147 0.5
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.007 0.0801 0.0738
Brugia malayi hypothetical protein 0.0149 0.2001 0.4631
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0133 0.3497
Schistosoma mansoni hypothetical protein 0.0048 0.0482 0.0416
Brugia malayi calpain 5 0.0021 0.0069 0.0159
Brugia malayi Bromodomain containing protein 0.0157 0.211 0.4883
Schistosoma mansoni ferritin 0.0026 0.0147 0.0079
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0304 0.4321 1
Echinococcus multilocularis GPCR, family 2 0.0048 0.0482 0.0416
Entamoeba histolytica protein kinase, putative 0.0021 0.0069 0.5
Schistosoma mansoni cpg binding protein 0.0034 0.0268 0.0201
Schistosoma mansoni apoferritin-2 0.0026 0.0147 0.0079
Loa Loa (eye worm) hypothetical protein 0.0104 0.1322 0.2946
Schistosoma mansoni cpg binding protein 0.0034 0.0268 0.0201
Schistosoma mansoni ferritin 0.0026 0.0147 0.0079
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0482 0.1116
Loa Loa (eye worm) hypothetical protein 0.0048 0.0482 0.0972
Loa Loa (eye worm) hypothetical protein 0.009 0.1106 0.2439
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0125 0.1635 0.1577
Schistosoma mansoni zinc finger protein 0.0032 0.0233 0.0166
Brugia malayi PHD-finger family protein 0.0053 0.0556 0.1286
Echinococcus multilocularis calpain A 0.0073 0.0855 0.0791
Schistosoma mansoni apoferritin-2 0.0026 0.0147 0.0079
Onchocerca volvulus 0.0049 0.0491 0.0896
Schistosoma mansoni tar DNA-binding protein 0.0194 0.2664 0.2613
Schistosoma mansoni zinc finger protein 0.0042 0.039 0.0324
Schistosoma mansoni ferritin light chain 0.0026 0.0147 0.0079
Loa Loa (eye worm) hypothetical protein 0.0149 0.2001 0.4544
Loa Loa (eye worm) RNA binding protein 0.0194 0.2664 0.6104
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0251 0.2249
Loa Loa (eye worm) hypothetical protein 0.0304 0.4321 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0185 0.0427
Schistosoma mansoni hypothetical protein 0.0048 0.0482 0.0416
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0125 0.1635 0.1577
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0073 0.0855 0.0791
Echinococcus granulosus geminin 0.0168 0.2273 0.222
Trypanosoma cruzi ISWI complex protein 0.0032 0.0233 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.066 0.0595
Schistosoma mansoni hypothetical protein 0.0168 0.2273 0.222
Loa Loa (eye worm) bromodomain containing protein 0.0037 0.0307 0.0559
Loa Loa (eye worm) hypothetical protein 0.0068 0.078 0.1673
Echinococcus multilocularis tar DNA binding protein 0.0194 0.2664 0.2613
Entamoeba histolytica calpain large subunit domain III containing protein 0.0021 0.0069 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0133 0.3877
Trichomonas vaginalis set domain proteins, putative 0.0256 0.3603 1
Brugia malayi calpain 7 0.0021 0.0069 0.0159
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.066 0.0595
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.066 0.0595
Schistosoma mansoni hypothetical protein 0.0405 0.5829 0.58
Trypanosoma cruzi ISWI complex protein 0.0032 0.0233 1
Echinococcus granulosus tar DNA binding protein 0.0194 0.2664 0.2613
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.2045 0.4648
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.066 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.066 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1953 0.4431
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.078 0.0716
Brugia malayi calpain family protein 1 0.007 0.0801 0.1855
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0133 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.0133 0.015
Brugia malayi Pre-SET motif family protein 0.0225 0.3137 0.726
Onchocerca volvulus 0.0149 0.2001 0.5314
Schistosoma mansoni hypothetical protein 0.0043 0.0399 0.0332
Echinococcus multilocularis expressed protein 0.0026 0.0147 0.0079
Loa Loa (eye worm) hypothetical protein 0.0084 0.1023 0.2243
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.066 0.0595
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0874 0.081
Loa Loa (eye worm) hypothetical protein 0.0049 0.0491 0.0993
Echinococcus granulosus histone lysine methyltransferase setb 0.0068 0.078 0.0716
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0133 0.3877
Echinococcus multilocularis zinc finger protein 0.0042 0.039 0.0324
Trypanosoma brucei ISWI complex protein 0.0032 0.0233 1
Echinococcus multilocularis geminin 0.0168 0.2273 0.222
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0482 0.0972
Schistosoma mansoni ferritin 0.0026 0.0147 0.0079
Loa Loa (eye worm) hypothetical protein 0.0049 0.0491 0.0993
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0874 0.081
Schistosoma mansoni hypothetical protein 0.0104 0.1322 0.1262
Leishmania major hypothetical protein, conserved 0.0032 0.0233 0.2782
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0068 0.078 0.0716
Schistosoma mansoni hypothetical protein 0.0048 0.0482 0.0416
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0073 0.0855 0.0791
Brugia malayi RNA recognition motif domain containing protein 0.0194 0.2664 0.6166
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0399 0.0776
Echinococcus multilocularis ferritin 0.0026 0.0147 0.0079
Brugia malayi hypothetical protein 0.0025 0.0133 0.0307
Echinococcus granulosus calpain A 0.0073 0.0855 0.0791
Echinococcus granulosus cpg binding protein 0.0034 0.0268 0.0201
Schistosoma mansoni tar DNA-binding protein 0.0194 0.2664 0.2613

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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