Detailed information for compound 554735

Basic information

Technical information
  • TDR Targets ID: 554735
  • Name: sanguinarine
  • MW: 367.782 | Formula: C20H14ClNO4
  • H donors: 0 H acceptors: 0 LogP: 5.25 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[n+]1cc2c3OCOc3ccc2c2c1c1cc3OCOc3cc1cc2.[Cl-]
  • InChi: 1S/C20H14NO4.ClH/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21;/h2-8H,9-10H2,1H3;1H/q+1;/p-1
  • InChiKey: GIZKAXHWLRYMLE-UHFFFAOYSA-M  


Substructure search Similarity search

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Synonyms

  • 5578-73-4
  • D05799
  • Sanguinarium chloride (USAN)
  • Sanguinarine chloride hydrate
  • (1,3)Benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium, 13-methyl-, chloride
  • Sanguinarine hydrochloride
  • Sanguinarine, chloride
  • Sanguinarium Chloride
  • Sanguinarium chloride [USAN:INN]
  • Viadent
  • S5890_SIGMA
  • EU-0101108

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens peripheral myelin protein 22 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Escherichia coli endonuclease IV with intrinsic 3'-5' exonuclease activity Starlite/ChEMBL No references
Homo sapiens transient receptor potential cation channel, subfamily V, member 1 Starlite/ChEMBL No references
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) References
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum endonuclease V, putative Get druggable targets OG5_129467 All targets in OG5_129467
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129467 All targets in OG5_129467
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis rho4, putative Get druggable targets OG5_126995 All targets in OG5_126995
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii endonuclease IV APN Get druggable targets OG5_129467 All targets in OG5_129467
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica Rho family GTPase Get druggable targets OG5_126995 All targets in OG5_126995
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) Get druggable targets OG5_129467 All targets in OG5_129467
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni rac gtpase Get druggable targets OG5_126995 All targets in OG5_126995
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) Get druggable targets OG5_129467 All targets in OG5_129467
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) rac GTPase Get druggable targets OG5_126995 All targets in OG5_126995
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica Rho family GTPase Get druggable targets OG5_126995 All targets in OG5_126995
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis ras C3 botulinum toxin substrate 2 Get druggable targets OG5_126995 All targets in OG5_126995
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Babesia bovis apurinic endonuclease (APN1) family protein Get druggable targets OG5_129467 All targets in OG5_129467
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Chlamydia trachomatis endonuclease IV Get druggable targets OG5_129467 All targets in OG5_129467
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis Ras C3 botulinum toxin substrate 1 Get druggable targets OG5_126995 All targets in OG5_126995
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans one of two genes similar to S. cerevisiae CDC42 (YLR229C) rho family small monomeric GTPase Get druggable targets OG5_126995 All targets in OG5_126995
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans endonuclease IV Get druggable targets OG5_129467 All targets in OG5_129467
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_126995 All targets in OG5_126995
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04392 Ras-related C3 botulinum toxin substrate 1, putative Get druggable targets OG5_126995 All targets in OG5_126995
Loa Loa (eye worm) small GTPase Get druggable targets OG5_126995 All targets in OG5_126995
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica Rho family GTPase Get druggable targets OG5_126995 All targets in OG5_126995
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica Rho family GTPase Get druggable targets OG5_126995 All targets in OG5_126995
Trichomonas vaginalis rho4, putative Get druggable targets OG5_126995 All targets in OG5_126995
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi small GTPase Get druggable targets OG5_126995 All targets in OG5_126995
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans apurinic/apyrimidinic endonuclease/3'-repair diesterase Get druggable targets OG5_129467 All targets in OG5_129467
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi rho-like GTP binding protein, putative Get druggable targets OG5_126995 All targets in OG5_126995
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Transforming protein RhoA precursor, putative Get druggable targets OG5_126995 All targets in OG5_126995
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis apurinic/apyrimidinic endonuclease Apn1 Get druggable targets OG5_129467 All targets in OG5_129467
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Giardia lamblia Rac/Rho-like protein Get druggable targets OG5_126995 All targets in OG5_126995
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase Get druggable targets OG5_129467 All targets in OG5_129467
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis GTPase_rho, putative Get druggable targets OG5_126995 All targets in OG5_126995
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi Ras-related protein Rac1 Get druggable targets OG5_126995 All targets in OG5_126995
Entamoeba histolytica Rho family GTPase Get druggable targets OG5_126995 All targets in OG5_126995
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_129467 All targets in OG5_129467
Plasmodium yoelii AP endonuclease 1 Get druggable targets OG5_129467 All targets in OG5_129467
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ras C3 botulinum toxin substrate 2 Get druggable targets OG5_126995 All targets in OG5_126995
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis rho5 protein, putative Get druggable targets OG5_126995 All targets in OG5_126995
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni gtpase_rho Get druggable targets OG5_126995 All targets in OG5_126995
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi rho-like GTP binding protein, putative Get druggable targets OG5_126995 All targets in OG5_126995
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Candida albicans one of two genes similar to S. cerevisiae CDC42 (YLR229C) rho family small monomeric GTPase Get druggable targets OG5_126995 All targets in OG5_126995
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum AP endonuclease of the TIM barrel fold, possible bacterial horizontal transfer Get druggable targets OG5_129467 All targets in OG5_129467
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica Rho family GTPase Get druggable targets OG5_126995 All targets in OG5_126995
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Plasmodium falciparum ras-related protein Rab-5B ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 192 aa 170 aa 24.1 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide Y receptor 0.000625352 0.000962937 0.000763365
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0455313 0.823641 0.823605
Brugia malayi Protein kinase domain containing protein 0.000926338 0.006477 0.00551938
Brugia malayi small GTPase 0.00204884 0.0270413 0.0261035
Echinococcus granulosus peptide allatostatin:somatostatin 0.000625352 0.000962937 0.000763365
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.00169282 0.0205191 0.019575
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0332506 0.598659 0.598579
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0108739 0.188717 0.187935
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.00169282 0.0205191 0.0249127
Echinococcus granulosus tm gpcr rhodopsin 0.000625352 0.000962937 0.000763365
Echinococcus granulosus neuropeptide receptor 0.000625352 0.000962937 0.000763365
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0295231 0.530371 0.643849
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Trichomonas vaginalis rho5 protein, putative 0.00204884 0.0270413 0.0251655
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Echinococcus granulosus neuropeptide Y receptor 0.000625352 0.000962937 0.000763365
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0160081 0.282775 0.343165
Brugia malayi Peptidase family M1 containing protein 0.0455313 0.823641 0.82347
Onchocerca volvulus 0.0160081 0.282775 0.342555
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.00180373 0.0225509 0.0273796
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.00169282 0.0205191 0.019575
Echinococcus granulosus rhodopsin orphan GPCR 0.000625352 0.000962937 0.000763365
Brugia malayi Matrixin family protein 0.0215872 0.384985 0.384392
Echinococcus granulosus biogenic amine 5HT receptor 0.000625352 0.000962937 0.000763365
Echinococcus multilocularis aminopeptidase N 0.0455313 0.823641 1
Echinococcus granulosus aminopeptidase N 0.0455313 0.823641 0.823605
Loa Loa (eye worm) hypothetical protein 0.0295231 0.530371 0.529919
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Plasmodium vivax cysteine repeat modular protein 1, putative 0.000826661 0.00465092 0.0153332
Entamoeba histolytica Rho family GTPase 0.00204884 0.0270413 0.0324555
Echinococcus granulosus ras C3 botulinum toxin substrate 2 0.00204884 0.0270413 0.0268469
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0332506 0.598659 0.726779
Schistosoma mansoni site-1 peptidase (S08 family) 0.00169282 0.0205191 0.019575
Echinococcus multilocularis neuropeptide receptor 0.000625352 0.000962937 0.000926857
Brugia malayi Matrixin family protein 0.00892805 0.153069 0.152252
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0455313 0.823641 1
Trichomonas vaginalis rotamase, putative 0.00180373 0.0225509 0.0196704
Trypanosoma cruzi aminopeptidase, putative 0.0160081 0.282775 0.343324
Echinococcus multilocularis fmrfamide receptor 0.000625352 0.000962937 0.000926857
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Onchocerca volvulus 0.00892805 0.153069 0.184891
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.000625352 0.000962937 0.000926857
Entamoeba histolytica protein kinase, putative 0.000926338 0.006477 0.00747827
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0160081 0.282775 0.343324
Trypanosoma cruzi rho-like GTP binding protein, putative 0.00204884 0.0270413 0.0328314
Trichomonas vaginalis conserved hypothetical protein 0.00169282 0.0205191 0.0171839
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.000625352 0.000962937 0.000763365
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0160081 0.282775 1
Loa Loa (eye worm) hypothetical protein 0.00892805 0.153069 0.152252
Echinococcus multilocularis fmrfamide receptor 0.000625352 0.000962937 0.000926857
Trichomonas vaginalis conserved hypothetical protein 0.00182302 0.0229043 0.0201028
Schistosoma mansoni rotamase 0.00182302 0.0229043 0.0219625
Onchocerca volvulus Matrix metalloproteinase homolog 0.019802 0.352279 0.42704
Echinococcus multilocularis rhodopsin orphan GPCR 0.000625352 0.000962937 0.000926857
Echinococcus granulosus membrane bound transcription factor site 1 0.00169282 0.0205191 0.0203234
Echinococcus granulosus neuropeptides capa receptor 0.000625352 0.000962937 0.000763365
Giardia lamblia Rac/Rho-like protein 0.00204884 0.0270413 0.0723362
Brugia malayi Protein kinase domain containing protein 0.000826661 0.00465092 0.00369153
Toxoplasma gondii subtilisin SUB2 0.00169282 0.0205191 0.0725631
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0455313 0.823641 1
Schistosoma mansoni serine/threonine-protein kinase 0.000628596 0.00102235 0.000059473
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0160081 0.282775 0.282632
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.000625352 0.000962937 0.000926857
Trypanosoma brucei subtilisin peptidase 0.00169282 0.0205191 0.0249127
Echinococcus granulosus nuclear factor of activated T cells 5 0.0356518 0.642648 0.642577
Brugia malayi Matrixin family protein 0.00892805 0.153069 0.152252
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Echinococcus granulosus netrin receptor unc 5 0.00173611 0.0213121 0.0211166
Brugia malayi Peptidase family M1 containing protein 0.0160081 0.282775 0.282084
Brugia malayi Hemopexin family protein 0.0126592 0.221423 0.220673
Echinococcus multilocularis tachykinin peptides receptor 99D 0.000625352 0.000962937 0.000926857
Echinococcus multilocularis ras C3 botulinum toxin substrate 2 0.00204884 0.0270413 0.0325968
Loa Loa (eye worm) matrixin family protein 0.019802 0.352279 0.351655
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.000625352 0.000962937 0.000926857
Brugia malayi proprotein convertase 2 0.0344036 0.619782 0.619416
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0160081 0.282775 0.343324
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0160081 0.282775 0.343324
Trichomonas vaginalis conserved hypothetical protein 0.00169282 0.0205191 0.0171839
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0160081 0.282775 0.282084
Echinococcus multilocularis g protein coupled receptor 0.000625352 0.000962937 0.000926857
Echinococcus multilocularis alpha 1A adrenergic receptor 0.000625352 0.000962937 0.000926857
Schistosoma mansoni site-1 peptidase (S08 family) 0.00169282 0.0205191 0.019575
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0551579 1 1
Trichomonas vaginalis conserved hypothetical protein 0.00169282 0.0205191 0.0171839
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.000625352 0.000962937 0.000926857
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0324611 0.584195 0.584112
Loa Loa (eye worm) TK/ROR protein kinase 0.000826661 0.00465092 0.00369153
Onchocerca volvulus 0.0455313 0.823641 1
Trichomonas vaginalis hypothetical protein 0.0108036 0.187428 0.221438
Echinococcus granulosus sex peptide receptor 0.000625352 0.000962937 0.000763365
Echinococcus granulosus g protein coupled receptor 0.000625352 0.000962937 0.000763365
Echinococcus multilocularis neuropeptide Y receptor 0.000625352 0.000962937 0.000926857
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.000625352 0.000962937 0.000763365
Entamoeba histolytica protein kinase, putative 0.000926338 0.006477 0.00747827
Trypanosoma brucei aminopeptidase, putative 0.0160081 0.282775 0.343324
Echinococcus granulosus dro:myosuppressin receptor 0.000625352 0.000962937 0.000763365
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Trichomonas vaginalis conserved hypothetical protein 0.00169282 0.0205191 0.0171839
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0124964 0.218441 0.25939
Trichomonas vaginalis conserved hypothetical protein 0.0108036 0.187428 0.221438
Onchocerca volvulus 0.0455313 0.823641 1
Loa Loa (eye worm) aminopeptidase N 0.0455313 0.823641 0.82347
Trichomonas vaginalis conserved hypothetical protein 0.0108036 0.187428 0.221438
Trichomonas vaginalis conserved hypothetical protein 0.0108036 0.187428 0.221438
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0455313 0.823641 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.000628596 0.00102235 0.000853096
Echinococcus granulosus serotonin receptor 0.000625352 0.000962937 0.000763365
Loa Loa (eye worm) hypothetical protein 0.0160081 0.282775 0.282084
Giardia lamblia High cysteine membrane protein Group 2 0.0207542 0.369725 1
Loa Loa (eye worm) peptidase family M1 containing protein 0.0160081 0.282775 0.282084
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.00169282 0.0205191 0.0249127
Toxoplasma gondii AGC kinase 0.000887999 0.00577463 0.0204212
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0108036 0.187428 0.221438
Toxoplasma gondii peptidylprolyl isomerase 0.00180373 0.0225509 0.0797485
Echinococcus granulosus serine threonine protein kinase nrc 0.000590257 0.000319981 0.00012028
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.00180373 0.0225509 0.0273796
Toxoplasma gondii kringle domain-containing protein 0.000826661 0.00465092 0.0164474
Schistosoma mansoni rac gtpase 0.00204884 0.0270413 0.0261035
Echinococcus granulosus Ankyrin 0.00174193 0.0214186 0.0212232
Echinococcus multilocularis expressed protein 0.00182302 0.0229043 0.0275728
Trichomonas vaginalis conserved hypothetical protein 0.0108036 0.187428 0.221438
Echinococcus granulosus furin 0.0551579 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.000625352 0.000962937 0.000926857
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.000625352 0.000962937 0.000926857
Trypanosoma cruzi rho-like GTP binding protein, putative 0.00204884 0.0270413 0.0328314
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0160081 0.282775 0.343324
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.00182302 0.0229043 0.0219625
Mycobacterium ulcerans aminopeptidase N PepN 0.0160081 0.282775 0.326546
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.000572791 0 0.5
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0455313 0.823641 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0455313 0.823641 0.823605
Echinococcus multilocularis netrin receptor unc 5 0.00173611 0.0213121 0.0256392
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0160081 0.282775 0.338119
Entamoeba histolytica Rho family GTPase 0.00204884 0.0270413 0.0324555
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.000590257 0.000319981 0.00012028
Toxoplasma gondii subtilisin SUB10 0.00169282 0.0205191 0.0725631
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0455313 0.823641 1
Loa Loa (eye worm) rac GTPase 0.00204884 0.0270413 0.0261035
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.00173611 0.0213121 0.0256392
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0324611 0.584195 0.709214
Onchocerca volvulus Netrin receptor homolog 0.00173611 0.0213121 0.0247352
Loa Loa (eye worm) hypothetical protein 0.00892805 0.153069 0.152252
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0457476 0.827604 0.827438
Toxoplasma gondii subtilisin SUB12 0.00169282 0.0205191 0.0725631
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0160081 0.282775 0.282632
Echinococcus granulosus neuropeptide receptor 0.000625352 0.000962937 0.000763365
Echinococcus multilocularis rhodopsin orphan GPCR 0.000625352 0.000962937 0.000926857
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.00174193 0.0214186 0.0204754
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.000625352 0.000962937 0.000926857
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0455313 0.823641 1
Plasmodium falciparum cysteine repeat modular protein 1 0.000826661 0.00465092 0.0153332
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.000625352 0.000962937 0.000926857
Loa Loa (eye worm) proprotein convertase 2 0.0124964 0.218441 0.217688
Loa Loa (eye worm) hypothetical protein 0.0160081 0.282775 0.282084
Echinococcus granulosus leukotriene A 4 hydrolase 0.0160081 0.282775 0.282632
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.00169282 0.0205191 0.0203234
Entamoeba histolytica Rho family GTPase 0.00204884 0.0270413 0.0324555
Entamoeba histolytica Rho family GTPase 0.00204884 0.0270413 0.0324555
Brugia malayi Peptidase family M1 containing protein 0.0455313 0.823641 0.82347
Schistosoma mansoni netrin receptor unc5 0.00173611 0.0213121 0.0203687
Echinococcus multilocularis rac serine:threonine kinase 0.000628596 0.00102235 0.000999013
Echinococcus granulosus g-protein coupled receptor 0.000625352 0.000962937 0.000763365
Trichomonas vaginalis conserved hypothetical protein 0.0108036 0.187428 0.221438
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0455313 0.823641 0.82347
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0124964 0.218441 0.25939
Trichomonas vaginalis conserved hypothetical protein 0.0108036 0.187428 0.221438
Echinococcus granulosus tm gpcr rhodopsin 0.000625352 0.000962937 0.000763365
Loa Loa (eye worm) hypothetical protein 0.000826661 0.00465092 0.00369153
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.00169282 0.0205191 0.019575
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Echinococcus granulosus tissue type plasminogen activator 0.000826661 0.00465092 0.00445208
Brugia malayi Matrixin family protein 0.00892805 0.153069 0.152252
Echinococcus multilocularis tissue type plasminogen activator 0.000826661 0.00465092 0.0054056
Schistosoma mansoni hypothetical protein 0.0108036 0.187428 0.186645
Echinococcus multilocularis Ankyrin 0.00174193 0.0214186 0.0257686
Echinococcus multilocularis neuropeptide receptor 0.000625352 0.000962937 0.000926857
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0124964 0.218441 0.25939
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.000625352 0.000962937 0.000926857
Toxoplasma gondii subtilisin SUB8 0.00169282 0.0205191 0.0725631
Mycobacterium ulcerans aminopeptidase N PepN 0.0455313 0.823641 1
Echinococcus multilocularis serotonin receptor 0.000625352 0.000962937 0.000926857
Trypanosoma cruzi subtilisin peptidase 0.00169282 0.0205191 0.0249127
Mycobacterium leprae PROBABLE HYDROLASE 0.0108739 0.188717 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.00173611 0.0213121 0.0203687
Loa Loa (eye worm) hypothetical protein 0.0551579 1 1
Echinococcus multilocularis orexin receptor type 2 0.000625352 0.000962937 0.000926857
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Brugia malayi Protein kinase domain containing protein 0.00174267 0.0214323 0.0204891
Echinococcus multilocularis membrane bound transcription factor site 1 0.00169282 0.0205191 0.0246761
Echinococcus granulosus rhodopsin orphan GPCR 0.000625352 0.000962937 0.000763365
Trypanosoma brucei Aminopeptidase M1, putative 0.0455313 0.823641 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.00180373 0.0225509 0.0270016
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Toxoplasma gondii subtilisin SUB11 0.00169282 0.0205191 0.0725631
Echinococcus multilocularis neuropeptides capa receptor 0.000625352 0.000962937 0.000926857
Echinococcus granulosus expressed protein 0.00182302 0.0229043 0.0227091
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0455313 0.823641 1
Mycobacterium ulcerans hydrolase 0.0108739 0.188717 0.20943
Echinococcus multilocularis neuropeptide s receptor 0.000625352 0.000962937 0.000926857
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.00182302 0.0229043 0.0219625
Plasmodium falciparum subtilisin-like protease 1 0.00169282 0.0205191 0.0715125
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0124964 0.218441 0.25939
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0160081 0.282775 0.282084
Echinococcus granulosus 7tm_1 domain containing protein 0.000625352 0.000962937 0.000763365
Onchocerca volvulus Matrilysin homolog 0.019802 0.352279 0.42704
Echinococcus multilocularis allatostatin A receptor 0.000625352 0.000962937 0.000926857
Trypanosoma cruzi rac serine-threonine kinase, putative 0.000628596 0.00102235 0.00124126
Trichomonas vaginalis conserved hypothetical protein 0.0108036 0.187428 0.221438
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.000590257 0.000319981 0.000146041
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0455313 0.823641 1
Plasmodium vivax subtilisin-like protease 2, putative 0.00169282 0.0205191 0.0715125
Echinococcus granulosus hypothetical protein 0.000625352 0.000962937 0.000763365
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.000625352 0.000962937 0.000763365
Echinococcus granulosus G protein coupled receptor 139 0.000625352 0.000962937 0.000763365
Echinococcus multilocularis rhodopsin orphan GPCR 0.000625352 0.000962937 0.000926857
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Toxoplasma gondii subtilisin SUB9 0.00169282 0.0205191 0.0725631
Echinococcus multilocularis sex peptide receptor 0.000625352 0.000962937 0.000926857
Loa Loa (eye worm) AGC/AKT protein kinase 0.000926338 0.006477 0.00551938
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.00169282 0.0205191 0.0249127
Entamoeba histolytica Rho family GTPase 0.00204884 0.0270413 0.0324555
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.00915379 0.157204 0.156392
Entamoeba histolytica aminopeptidase, putative 0.0455313 0.823641 1
Echinococcus granulosus death domain containing protein 0.00173611 0.0213121 0.0211166
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0124964 0.218441 0.25939
Brugia malayi Kringle domain containing protein 0.000826661 0.00465092 0.00369153
Trichomonas vaginalis conserved hypothetical protein 0.0108036 0.187428 0.221438
Trypanosoma cruzi aminopeptidase, putative 0.0455313 0.823641 1
Echinococcus granulosus serine/threonine protein kinase 0.000628596 0.00102235 0.000822792
Entamoeba histolytica PH domain containing protein kinase, putative 0.000628596 0.00102235 0.000853096
Echinococcus multilocularis neuropeptide receptor A26 0.000625352 0.000962937 0.000926857
Toxoplasma gondii aminopeptidase n, putative 0.0160081 0.282775 1
Echinococcus multilocularis 0.0443543 0.802078 0.973814
Trypanosoma cruzi rac serine-threonine kinase, putative 0.000590257 0.000319981 0.000388496
Echinococcus multilocularis rhodopsin orphan GPCR 0.000625352 0.000962937 0.000926857
Echinococcus granulosus rhodopsin orphan GPCR 0.000625352 0.000962937 0.000763365
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0160081 0.282775 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Schistosoma mansoni furin-1 (S08 family) 0.0236001 0.42186 0.421303
Toxoplasma gondii subtilisin SUB4 0.00169282 0.0205191 0.0725631
Brugia malayi endoprotease bli-4 precursor 0.0551579 1 1
Loa Loa (eye worm) matrix metalloproteinase 0.00892805 0.153069 0.152252
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.00169282 0.0205191 0.0246761
Loa Loa (eye worm) hypothetical protein 0.00174193 0.0214186 0.0204754
Toxoplasma gondii aminopeptidase N, putative 0.0160081 0.282775 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.000625352 0.000962937 0.000926857
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0332506 0.598659 0.72468
Schistosoma mansoni aminopeptidase A (M01 family) 0.0160081 0.282775 0.282084
Echinococcus granulosus thyrotropin releasing hormone receptor 0.000625352 0.000962937 0.000763365
Echinococcus multilocularis g protein coupled receptor 0.000625352 0.000962937 0.000926857
Brugia malayi hypothetical protein 0.0455313 0.823641 0.82347
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.000625352 0.000962937 0.000763365
Brugia malayi Subtilase family protein 0.00169282 0.0205191 0.019575
Onchocerca volvulus 0.0126592 0.221423 0.267979
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Echinococcus multilocularis rhodopsin orphan GPCR 0.000625352 0.000962937 0.000926857
Brugia malayi Matrixin family protein 0.00892805 0.153069 0.152252
Echinococcus multilocularis neuropeptide Y receptor 0.000625352 0.000962937 0.000926857
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0124964 0.218441 0.25939
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.00169282 0.0205191 0.019575
Trichomonas vaginalis conserved hypothetical protein 0.0108036 0.187428 0.221438
Echinococcus granulosus orexin receptor type 2 0.000625352 0.000962937 0.000763365
Brugia malayi hypothetical protein 0.0160081 0.282775 0.282084
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.000887999 0.00577463 0.00481633
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0108739 0.188717 1
Leishmania major hypothetical protein, conserved 0.000826661 0.00465092 0.00564678
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0160081 0.282775 1
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0108036 0.187428 0.221438
Trichomonas vaginalis rotamase, putative 0.00182302 0.0229043 0.0201028
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0295231 0.530371 0.529919
Loa Loa (eye worm) hypothetical protein 0.0295231 0.530371 0.529919
Echinococcus granulosus 7TM GPCR rhodopsin 0.000625352 0.000962937 0.000763365
Toxoplasma gondii subtilisin SUB1 0.00169282 0.0205191 0.0725631
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Echinococcus granulosus rhodopsin orphan GPCR 0.000625352 0.000962937 0.000763365
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.000625352 0.000962937 0.000763365
Toxoplasma gondii aminopeptidase N protein 0.0160081 0.282775 1
Brugia malayi neuroendocrine convertase 1 precursor 0.0344036 0.619782 0.619416
Loa Loa (eye worm) subtilase 0.00169282 0.0205191 0.019575
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0160081 0.282775 1
Loa Loa (eye worm) hypothetical protein 0.0160081 0.282775 0.282084
Echinococcus multilocularis neuroendocrine convertase 2 0.0344036 0.619782 0.752431
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0455313 0.823641 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.000926338 0.006477 0.00786387
Plasmodium falciparum subtilisin-like protease 2 0.00169282 0.0205191 0.0715125
Echinococcus multilocularis g-protein coupled receptor 0.000625352 0.000962937 0.000926857
Schistosoma mansoni ankyrin 23/unc44 0.00173611 0.0213121 0.0203687
Echinococcus multilocularis g protein coupled receptor 0.000625352 0.000962937 0.000926857
Trichomonas vaginalis rho4, putative 0.00204884 0.0270413 0.0251655
Entamoeba histolytica Rho family GTPase 0.00204884 0.0270413 0.0324555
Trypanosoma cruzi Aminopeptidase M1, putative 0.0455313 0.823641 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.000625352 0.000962937 0.000763365
Brugia malayi TATA binding protein associated factor 0.0160081 0.282775 0.282084
Schistosoma mansoni hypothetical protein 0.000826661 0.00465092 0.00369153
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.00173611 0.0213121 0.0203687
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.00892805 0.153069 0.152252
Onchocerca volvulus 0.000826661 0.00465092 0.0044829
Echinococcus multilocularis G protein coupled receptor 139 0.000625352 0.000962937 0.000926857
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.00180373 0.0225509 0.0273796
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Echinococcus granulosus g protein coupled receptor 0.000625352 0.000962937 0.000763365
Echinococcus granulosus fmrfamide receptor 0.000625352 0.000962937 0.000763365
Echinococcus multilocularis rhodopsin orphan GPCR 0.000625352 0.000962937 0.000926857
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Loa Loa (eye worm) small GTPase 0.00204884 0.0270413 0.0261035
Echinococcus granulosus neuroendocrine convertase 2 0.0344036 0.619782 0.619706
Brugia malayi Death domain containing protein 0.00173611 0.0213121 0.0203687
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0455313 0.823641 0.823605
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0455313 0.823641 0.823605
Loa Loa (eye worm) endoprotease bli-4 0.0551579 1 1
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0108036 0.187428 0.221438
Loa Loa (eye worm) hypothetical protein 0.00892805 0.153069 0.152252
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Loa Loa (eye worm) hypothetical protein 0.0219072 0.390848 0.39026
Entamoeba histolytica protein kinase, putative 0.000887999 0.00577463 0.00662518
Schistosoma mansoni gtpase_rho 0.00204884 0.0270413 0.0261035
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0455313 0.823641 1
Brugia malayi p70 ribosomal S6 kinase beta 0.000887999 0.00577463 0.00481633
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0356518 0.642648 0.7802
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0160081 0.282775 0.282084
Schistosoma mansoni serine/threonine-protein kinase 0.000628596 0.00102235 0.000059473
Plasmodium vivax subtilisin-like serine protease, putative 0.00169282 0.0205191 0.0715125
Trichomonas vaginalis rho4, putative 0.00204884 0.0270413 0.0251655
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0295231 0.530371 0.643936
Echinococcus granulosus neuropeptides capa receptor 0.000625352 0.000962937 0.000763365
Echinococcus multilocularis Furin 1 0.0124964 0.218441 0.265036
Echinococcus granulosus allatostatin A receptor 0.000625352 0.000962937 0.000763365
Echinococcus multilocularis neuropeptide FF receptor 2 0.000625352 0.000962937 0.000926857
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0124964 0.218441 0.217688
Plasmodium vivax subtilisin-like protease 1 0.00169282 0.0205191 0.0715125
Trypanosoma brucei Aminopeptidase M1, putative 0.0455313 0.823641 1
Brugia malayi Uncoordinated protein 44 0.00173611 0.0213121 0.0203687
Loa Loa (eye worm) hypothetical protein 0.0295231 0.530371 0.529919
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.00169282 0.0205191 0.0249127
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0160081 0.282775 0.343324
Echinococcus granulosus rhodopsin orphan GPCR 0.000625352 0.000962937 0.000763365
Toxoplasma gondii subtilisin SUB7 0.00169282 0.0205191 0.0725631
Echinococcus multilocularis rhodopsin orphan GPCR 0.000625352 0.000962937 0.000926857
Echinococcus multilocularis Ras C3 botulinum toxin substrate 1 0.00204884 0.0270413 0.0325968
Echinococcus granulosus neuropeptide receptor A26 0.000625352 0.000962937 0.000763365
Onchocerca volvulus 0.00169282 0.0205191 0.0237713
Trichomonas vaginalis conserved hypothetical protein 0.00169282 0.0205191 0.0171839
Brugia malayi Ras-related protein Rac1 0.00204884 0.0270413 0.0261035
Echinococcus granulosus rhodopsin orphan GPCR 0.000625352 0.000962937 0.000763365
Plasmodium falciparum subtilisin-like protease 3 0.00169282 0.0205191 0.0715125
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0455313 0.823641 1
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.00173611 0.0213121 0.0211166
Loa Loa (eye worm) hypothetical protein 0.00173611 0.0213121 0.0203687
Echinococcus granulosus somatostatin receptor 0.000625352 0.000962937 0.000763365
Brugia malayi celfurPC protein 0.0443543 0.802078 0.801888
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.00180373 0.0225509 0.0273796
Trichomonas vaginalis GTPase_rho, putative 0.00204884 0.0270413 0.0251655
Echinococcus multilocularis serotonin receptor 0.000625352 0.000962937 0.000926857
Toxoplasma gondii subtilisin SUB6 0.00169282 0.0205191 0.0725631
Leishmania major subtilisin-like serine peptidase 0.00169282 0.0205191 0.0249127
Echinococcus multilocularis neuropeptides capa receptor 0.000625352 0.000962937 0.000926857
Echinococcus granulosus neuropeptide s receptor 0.000625352 0.000962937 0.000763365
Echinococcus granulosus Furin 1 0.0124964 0.218441 0.218285
Echinococcus multilocularis G-protein coupled receptor, putative 0.000625352 0.000962937 0.000926857
Trichomonas vaginalis conserved hypothetical protein 0.0108036 0.187428 0.221438
Toxoplasma gondii subtilisin SUB5 0.00169282 0.0205191 0.0725631
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0332506 0.598659 0.72468
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0455313 0.823641 1
Echinococcus granulosus tm gpcr rhodopsin 0.000625352 0.000962937 0.000763365
Echinococcus granulosus g protein coupled receptor 0.000625352 0.000962937 0.000763365
Loa Loa (eye worm) hypothetical protein 0.00169282 0.0205191 0.019575
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.000625352 0.000962937 0.000926857
Giardia lamblia Furin precursor putative serine protease 0.0108036 0.187428 0.506513
Trypanosoma cruzi hypothetical protein, conserved 0.000826661 0.00465092 0.00564678
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Schistosoma mansoni hypothetical protein 0.0126592 0.221423 0.220673
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0160081 0.282775 0.343324
Loa Loa (eye worm) TATA binding protein associated factor 0.0160081 0.282775 0.282084
Echinococcus multilocularis biogenic amine (5HT) receptor 0.000625352 0.000962937 0.000926857
Echinococcus granulosus alpha 1A adrenergic receptor 0.000625352 0.000962937 0.000763365
Echinococcus granulosus biogenic amine 5HT receptor 0.000625352 0.000962937 0.000763365
Echinococcus granulosus rhodopsin orphan GPCR 0.000625352 0.000962937 0.000763365
Trypanosoma cruzi Protein kinase B 0.000628596 0.00102235 0.00124126
Onchocerca volvulus 0.00204884 0.0270413 0.0316994
Loa Loa (eye worm) hypothetical protein 0.0108739 0.188717 0.187935
Schistosoma mansoni hypothetical protein 0.00173611 0.0213121 0.0203687
Echinococcus multilocularis dro:myosuppressin receptor 0.000625352 0.000962937 0.000926857
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Echinococcus granulosus neuropeptide FF receptor 2 0.000625352 0.000962937 0.000763365
Echinococcus multilocularis rhodopsin orphan GPCR 0.000625352 0.000962937 0.000926857
Loa Loa (eye worm) matrixin family protein 0.0215872 0.384985 0.384392
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Trichomonas vaginalis conserved hypothetical protein 0.0108036 0.187428 0.221438
Echinococcus multilocularis somatostatin receptor 0.000625352 0.000962937 0.000926857
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00169282 0.0205191 0.0171839
Onchocerca volvulus Matrilysin homolog 0.00892805 0.153069 0.184891

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 44 % Effect on human MRP2-mediated estradiol-17-beta-glucuronide transport in Sf9 cells inverted membrane vesicles relative to control ChEMBL. 18457386
IC50 (functional) = -5.6 Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -5.6 Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -5.5 Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -5.5 Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -5.4 Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -5.4 Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -5.2 Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (binding) = 0.2 mM Inhibition of recombinant human DOPA decarboxylase assessed as inhibition of dopamine production after 30 mins by HPLC method ChEMBL. 24794108
IC50 (functional) = 0.16 ug ml-1 Growth inhibition of human HeLa S3 cells after 72 hrs ChEMBL. 10395504
IC50 (binding) = 4.6 uM Inhibition of Rac1b GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assay ChEMBL. 19716293
IC50 (binding) = 32 uM Inhibition of Cdc42 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assay ChEMBL. 19716293
IC50 (binding) = 58 uM Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assay ChEMBL. 19716293
Inhibition (binding) = 63 % Inhibition of Cdc42 GTPase activity assessed as incorporation of BODIPY-GTP at 50 uM after 40 mins by nucleotide binding competition assay ChEMBL. 19716293
Inhibition (binding) = 63 % Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP at 50 uM after 40 mins by nucleotide binding competition assay ChEMBL. 19716293
MSD (ADMET) = 1.1 day Toxicity against mouse P388 cells xenografted CDF1 mouse assessed as survival time at 50 mg/kg, iv ChEMBL. 10395504
MSD (ADMET) = 2.3 day Toxicity against mouse P388 cells xenografted CDF1 mouse assessed as survival time at 25 mg/kg, iv ChEMBL. 10395504
MSD (ADMET) = 9.5 day Toxicity against mouse P388 cells xenografted CDF1 mouse assessed as survival time at 12.5 mg/kg, iv ChEMBL. 10395504
Potency (functional) = 0.5623 um PUBCHEM_BIOASSAY: Validation of Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 1.9953 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: Validation screen for small molecules that induce DNA re-replication in MCF 10A normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 594 (Rhodamine region spectral profiling screen)] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) = 9.5283 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Human Peripheral Myelin Protein 22 (PMP22) Expression/Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV. (Class of assay: confirmatory) [Related pubchem assays: 1705, 1707 ] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: HTS Assay for Compounds that Act as Enhancers of the Vanilloid Receptor 1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488988] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Validation screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463097, AID463113, AID493165, AID493166, AID504806, AID504809] ChEMBL. No reference
Potency (functional) 20.7865 uM PUBCHEM_BIOASSAY: Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488774] ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Validation Assay for Identification of Novel General Anesthetics. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 30.1313 uM PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488990] ChEMBL. No reference
Potency (functional) 30.1313 uM PUBCHEM_BIOASSAY: Antagonists of the Thyroid Stimulating Hormone Receptor: Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504813] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
T/C (functional) = 12 % Antitumor activity against mouse P388 cells xenografted CDF1 mouse at 50 mg/kg, iv administered on day 1 after 30 days relative to control ChEMBL. 10395504
T/C (functional) = 25 % Antitumor activity against mouse P388 cells xenografted CDF1 mouse at 25 mg/kg, iv administered on day 1 after 30 days relative to control ChEMBL. 10395504
T/C (functional) = 102 % Antitumor activity against mouse P388 cells xenografted CDF1 mouse at 12.5 mg/kg, iv administered on day 1 after 30 days relative to control ChEMBL. 10395504

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 10395504
Plasmodium falciparum ChEMBL23 19734910

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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