Detailed information for compound 554977

Basic information

Technical information
  • TDR Targets ID: 554977
  • Name: (4S)-4-amino-5-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[( 1S)-2-[[2-[[(1S)-5-amino-1-[(2S)-2-[[(1S)-1-( carboxymethylcarbamoyl)-2-methyl-propyl]carba moyl]pyrrolidine-1-carbonyl]pentyl]amino]-2-o xo-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo -ethyl]carbamoyl]-4-guanidino-butyl]amino]-1- benzyl-2-oxo-ethyl]amino]-1-(4H-imidazol-4-yl methyl)-2-oxo-ethyl]amino]-5-oxo-pentanoic ac id
  • MW: 1212.36 | Formula: C57H81N17O13
  • H donors: 15 H acceptors: 13 LogP: -6.46 Rotable bonds: 45
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)C(C)C)NC(=O)CNC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)N)CC1C=NC=N1)Cc1ccccc1)CCCN=C(N)N
  • InChi: 1S/C57H81N17O13/c1-32(2)48(55(86)66-30-47(78)79)73-54(85)44-18-11-23-74(44)56(87)40(16-8-9-21-58)68-45(75)29-65-50(81)42(25-34-27-64-38-15-7-6-14-36(34)38)72-51(82)39(17-10-22-63-57(60)61)69-52(83)41(24-33-12-4-3-5-13-33)71-53(84)43(26-35-28-62-31-67-35)70-49(80)37(59)19-20-46(76)77/h3-7,12-15,27-28,31-32,35,37,39-44,48,64H,8-11,16-26,29-30,58-59H2,1-2H3,(H,65,81)(H,66,86)(H,68,75)(H,69,83)(H,70,80)(H,71,84)(H,72,82)(H,73,85)(H,76,77)(H,78,79)(H4,60,61,63)/t35?,37-,39-,40-,41-,42-,43-,44-,48-/m0/s1
  • InChiKey: BLDNUQHZLJUOQZ-WETCCYADSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4S)-4-amino-5-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[[(1S)-2-[[2-[[(1S)-5-amino-1-[[(2S)-2-[[[(1S)-1-[(carboxymethylamino)-oxomethyl]-2-methylpropyl]amino]-oxomethyl]-1-pyrrolidinyl]-oxomethyl]pentyl]amino]-2-oxoethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino]-oxomethyl]-4-guanidinobutyl]amino]-1-benzyl-2-oxoethyl]amino]-1-(4H-imidazol-4-ylmethyl)-2-oxoethyl]amino]-5-oxopentanoic acid
  • (4S)-4-azanyl-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-6-azanyl-1-[(2S)-2-[[(2S)-1-(carboxymethylamino)-3-methyl-1-oxo-butan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-hexan-2-yl]amino]-2-oxo-ethyl]amino]-3-(1H-indol-3-yl)-1-oxo-propan-2-yl]amino]-5-[bis(azanyl)methylideneamino]-1-oxo-pentan-2-yl]amino]-1-oxo-3-phenyl-propan-2-yl]amino]-3-(4H-imidazol-4-yl)-1-oxo-propan-2-yl]amino]-5-oxo-pentanoic acid
  • (4S)-4-amino-5-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[2-[[(1S)-5-amino-1-[(2S)-2-[[(1S)-1-(carboxymethylcarbamoyl)-2-methyl-propyl]carbamoyl]pyrrolidine-1-carbonyl]pentyl]amino]-2-keto-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-keto-ethyl]carbamoyl]-4-guanidino-butyl]amino]-1-benzyl-2-keto-ethyl]amino]-1-(4H-imidazol-4-ylmethyl)-2-keto-ethyl]amino]-5-keto-valeric acid
  • (4S)-4-amino-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-(carboxymethylamino)-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(4H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
  • ACTH (5-14)
  • (4S)-4-amino-5-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[2-[[(1S)-5-amino-1-[(2S)-2-[[(1S)-1-(carboxymethylcarbamoyl)-2-methyl-propyl]carbamoyl]pyrrolidine-1-carbonyl]pentyl]amino]-2-oxo-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]amino]-2-oxo-1-(phenylmethyl)ethyl]amino]-1-(4H-imidazol-4-ylmethyl)-2-oxo-ethyl]amino]-5-oxo-pentanoic acid
  • (4S)-4-amino-5-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[[(1S)-2-[[2-[[(1S)-5-amino-1-[[(2S)-2-[[[(1S)-1-[(carboxymethylamino)-oxomethyl]-2-methylpropyl]amino]-oxomethyl]-1-pyrrolidinyl]-oxomethyl]pentyl]amino]-2-oxoethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino]-oxomethyl]-4-guanidinobutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]amino]-1-(4H-imidazol-4-ylmethyl)-2-oxoethyl]amino]-5-oxopentanoic acid
  • (4S)-4-amino-5-[[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[2-[[(1S)-5-amino-1-[(2S)-2-[[(1S)-1-(carboxymethylcarbamoyl)-2-methyl-propyl]carbamoyl]pyrrolidine-1-carbonyl]pentyl]amino]-2-keto-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-keto-ethyl]carbamoyl]-4-guanidino-butyl]amino]-1-(benzyl)-2-keto-ethyl]amino]-1-(4H-imidazol-4-ylmethyl)-2-keto-ethyl]amino]-5-keto-valeric acid
  • (4S)-4-amino-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-(carboxymethylamino)-3-methyl-1-oxo-butan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-hexan-2-yl]amino]-2-oxo-ethyl]amino]-3-(1H-indol-3-yl)-1-oxo-propan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxo-pentan-2-yl]amino]-1-oxo-3-phenyl-propan-2-yl]amino]-3-(4H-imidazol-4-yl)-1-oxo-propan-2-yl]amino]-5-oxo-pentanoic acid
  • 24828-93-1
  • Acth(5-14)
  • Glycine, N-(N-(1-(N2-(N-(N-(N2-(N-(N-L-alpha-glutamyl-L-histidyl)-L-phenylalanyl)-L-arginyl)-L-tryptophyl)glycyl)-L-lysyl)-L-prolyl)-L-valyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni BC026374 protein (S09 family) 0.0034 0.0277 0.0297
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0091 0.0091
Echinococcus granulosus FTZ F1 alpha 0.002 0.0091 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0091 0.0073
Loa Loa (eye worm) hypothetical protein 0.0199 0.2503 0.2503
Brugia malayi Carboxylesterase family protein 0.0034 0.0277 0.0259
Onchocerca volvulus 0.0034 0.0277 0.0865
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0427 0.0532
Onchocerca volvulus 0.002 0.0091 0.0242
Brugia malayi Pre-SET motif family protein 0.003 0.0226 0.0208
Echinococcus multilocularis acetylcholinesterase 0.0199 0.2503 0.3121
Loa Loa (eye worm) hypothetical protein 0.0057 0.0593 0.0593
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0091 0.0113
Schistosoma mansoni alpha-glucosidase 0.015 0.1841 0.2257
Echinococcus granulosus lamin dm0 0.0027 0.0188 0.0234
Entamoeba histolytica hypothetical protein 0.0037 0.0316 0.6937
Brugia malayi MH1 domain containing protein 0.0016 0.004 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0034 0.0277 0.0277
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0091 0.0064
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.2986 0.2986
Echinococcus granulosus lysosomal alpha glucosidase 0.0174 0.2168 0.2703
Brugia malayi ecdysteroid receptor 0.002 0.0091 0.0073
Echinococcus multilocularis smad 0.0016 0.004 0.005
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0034 0.0277 0.0865
Echinococcus multilocularis GPCR, family 2 0.0096 0.1109 0.1383
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.1109 0.1383
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0427 0.0484
Brugia malayi MH2 domain containing protein 0.0016 0.004 0.0022
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0034 0.0277 0.0277
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.2168 0.2703
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0302 0.3884 0.3884
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0226 0.0233
Brugia malayi MH2 domain containing protein 0.0235 0.2986 0.2972
Echinococcus granulosus snurportin 1 0.061 0.8019 1
Brugia malayi intermediate filament protein 0.0027 0.0188 0.0169
Schistosoma mansoni alpha glucosidase 0.0039 0.0345 0.0382
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0345 0.043
Schistosoma mansoni hypothetical protein 0.0096 0.1109 0.134
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0091 0.0113
Onchocerca volvulus 0.003 0.0226 0.0695
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0316 0.0394
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.039 0.4463
Brugia malayi steroid hormone receptor 0.002 0.0091 0.0073
Echinococcus multilocularis lamin dm0 0.0027 0.0188 0.0234
Schistosoma mansoni hypothetical protein 0.0096 0.1109 0.134
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0345 0.0327
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0091 0.0073
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0345 0.109
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0091 0.0073
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0447 0.1433
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0091 0.0064
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0593 0.7763
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0019 0.0019
Schistosoma mansoni mucolipin 0.0066 0.0715 0.0846
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.004 0.005
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.039 0.0372
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0091 0.0242
Echinococcus multilocularis geminin 0.0166 0.2056 0.2564
Trichomonas vaginalis ran, putative 0.0042 0.039 0.1241
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0091 0.0113
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0193 0.2421 0.8026
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.039 0.0486
Echinococcus multilocularis Smad4 0.0016 0.004 0.005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0091 0.0113
Loa Loa (eye worm) hypothetical protein 0.0034 0.0277 0.0277
Brugia malayi N-terminal motif family protein 0.0193 0.2421 0.2407
Loa Loa (eye worm) carboxylesterase 0.0034 0.0277 0.0277
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0091 0.0091
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.1109 0.1383
Schistosoma mansoni hypothetical protein 0.0166 0.2056 0.2527
Echinococcus multilocularis musashi 0.0027 0.0188 0.0234
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0345 0.109
Onchocerca volvulus 0.0034 0.0277 0.0865
Echinococcus granulosus Smad4 0.0016 0.004 0.005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0698 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0091 0.0073
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.2986 0.2986
Echinococcus multilocularis lamin 0.0027 0.0188 0.0234
Plasmodium vivax importin-beta 2, putative 0.0057 0.0593 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0091 0.0113
Schistosoma mansoni hypothetical protein 0.0096 0.1109 0.134
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0757 1 1
Trypanosoma brucei glucosidase, putative 0.0039 0.0345 0.0327
Loa Loa (eye worm) hypothetical protein 0.0302 0.3884 0.3884
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0226 0.0233
Leishmania major GTP-binding protein, putative 0.0042 0.039 0.0372
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0091 0.0064
Brugia malayi latrophilin 2 splice variant baaae 0.0207 0.26 0.2586
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0427 0.0409
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.004 0.005
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0193 0.2421 0.2421
Brugia malayi Coelomocyte uptake defective protein 5 0.0066 0.0715 0.0698
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0091 0.0073
Brugia malayi Carboxylesterase family protein 0.0199 0.2503 0.2489
Echinococcus granulosus lamin 0.0027 0.0188 0.0234
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.004 0.005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0091 0.0073
Brugia malayi hypothetical protein 0.0037 0.0316 0.0298
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0091
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0212 0.0264
Schistosoma mansoni hypothetical protein 0.061 0.8019 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0593 0.0575
Entamoeba histolytica hypothetical protein 0.0037 0.0316 0.6937
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0316 0.0394
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0091
Onchocerca volvulus 0.0034 0.0277 0.0865
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0345 0.109
Onchocerca volvulus 0.0034 0.0277 0.0865
Brugia malayi MH2 domain containing protein 0.0016 0.004 0.0022
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0091 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0091 0.0073
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0698 0.0824
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0447 0.1433
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.2168 0.2703
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0091 0.0073
Brugia malayi Latrophilin receptor protein 2 0.0096 0.1109 0.1093
Echinococcus granulosus geminin 0.0166 0.2056 0.2564
Brugia malayi Calcitonin receptor-like protein seb-1 0.0302 0.3884 0.3873
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0091 0.0091
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0091 0.0091
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0345 0.0327
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0698 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0091 0.0113
Schistosoma mansoni alpha-glucosidase 0.015 0.1841 0.2257
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0034 0.0277 0.0346
Echinococcus granulosus GPCR family 2 0.0096 0.1109 0.1383
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0345 0.109
Schistosoma mansoni lamin 0.0027 0.0188 0.0185
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0447 0.1433
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.039 0.0372
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0027 0.0188 0.0188
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0091 0.0064
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0593 0.0575
Entamoeba histolytica Ran family GTPase 0.0042 0.039 0.8659
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0091 0.0113
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0091 0.0064
Schistosoma mansoni importin beta-1 0.0057 0.0593 0.0692
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.039 0.039
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0447 0.043
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0091
Schistosoma mansoni hypothetical protein 0.0037 0.0316 0.0346
Loa Loa (eye worm) hypothetical protein 0.0034 0.0277 0.0277
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0698 0.087
Loa Loa (eye worm) hypothetical protein 0.003 0.0226 0.0226
Echinococcus granulosus para nitrobenzyl esterase 0.0034 0.0277 0.0346
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0302 0.3884 0.3873
Echinococcus granulosus acetylcholinesterase 0.0199 0.2503 0.3121
Trichomonas vaginalis spcc417.12 protein, putative 0.0034 0.0277 0.0865
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0091 0.0073
Schistosoma mansoni hypothetical protein 0.0207 0.26 0.3208
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0226 0.0282
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0345 0.2508
Echinococcus multilocularis snurportin 1 0.061 0.8019 1
Echinococcus multilocularis mucolipin 3 0.0066 0.0715 0.0892
Schistosoma mansoni nuclear hormone receptor 0.002 0.0091 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0226 0.0233
Brugia malayi hypothetical protein 0.0151 0.1858 0.1843
Onchocerca volvulus 0.0237 0.3011 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0277 0.0277
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0034 0.0277 0.0297
Echinococcus multilocularis para nitrobenzyl esterase 0.0034 0.0277 0.0346
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0091 0.0064
Loa Loa (eye worm) carboxylesterase 0.0034 0.0277 0.0277
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0034 0.0277 0.0346
Brugia malayi hypothetical protein 0.0034 0.0277 0.0259
Echinococcus multilocularis BC026374 protein (S09 family) 0.0034 0.0277 0.0346
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.1109 0.1093
Schistosoma mansoni neuroligin 3 (S09 family) 0.0034 0.0277 0.0297
Trypanosoma brucei C-8 sterol isomerase, putative 0.0757 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0345 0.109
Echinococcus granulosus importin subunit beta 1 0.0057 0.0593 0.0739
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0698 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0091 0.0113
Loa Loa (eye worm) carboxylesterase 0.0199 0.2503 0.2503
Schistosoma mansoni ran 0.0042 0.039 0.0438
Loa Loa (eye worm) acetylcholinesterase 1 0.0199 0.2503 0.2503
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0091 0.0073
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0188 0.0169
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0427 0.0532
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.004 0.005
Echinococcus multilocularis carboxylesterase 5A 0.0199 0.2503 0.3121
Schistosoma mansoni ran 0.0042 0.039 0.0438
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0345 0.0327
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0345 0.043
Schistosoma mansoni thyroid hormone receptor 0.002 0.0091 0.0064
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0698 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0091 0.0113
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0698 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.1109 0.1383
Loa Loa (eye worm) Smad1 0.0016 0.004 0.004
Echinococcus multilocularis neuroligin 0.0034 0.0277 0.0346
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0427 0.0532
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0091 0.0073
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.1109 0.1109
Brugia malayi MH1 domain containing protein 0.0016 0.004 0.0022
Loa Loa (eye worm) mucolipin 1 0.0066 0.0715 0.0715
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0345 0.109
Echinococcus granulosus BC026374 protein S09 family 0.0034 0.0277 0.0346
Brugia malayi Carboxylesterase family protein 0.0199 0.2503 0.2489
Onchocerca volvulus 0.0034 0.0277 0.0865
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0091 0.0091
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0019 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0091 0.0091
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0091 0.0073
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0034 0.0277 0.0297
Echinococcus granulosus carboxylesterase 5A 0.0199 0.2503 0.3121
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.039 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0345 0.109
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0091 0.0113
Brugia malayi Smad1 0.0016 0.004 0.0022
Loa Loa (eye worm) hypothetical protein 0.0034 0.0277 0.0277
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0427 0.0484
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0345 0.0345
Schistosoma mansoni coup transcription factor 0.002 0.0091 0.0064
Brugia malayi Pre-SET motif family protein 0.0208 0.2625 0.2611
Brugia malayi nuclear receptor NHR-88 0.002 0.0091 0.0073
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0226 0.0282
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0091 0.0073
Loa Loa (eye worm) hypothetical protein 0.0757 1 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.039 0.0372
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0091 0.0242
Echinococcus granulosus smad 0.0016 0.004 0.005
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0226 0.0282
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.2625 0.2625
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0427 0.0532
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.039 0.3465
Echinococcus granulosus acetylcholinesterase 0.0199 0.2503 0.3121
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0345 0.0327
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0091
Schistosoma mansoni lamin 0.0027 0.0188 0.0185
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0091 0.0242
Entamoeba histolytica hypothetical protein 0.0046 0.0447 1
Trichomonas vaginalis set domain proteins, putative 0.0237 0.3011 1
Echinococcus granulosus neuroligin 0.0034 0.0277 0.0346
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0345 0.109
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0345 0.109
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0091 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0091 0.0091
Plasmodium falciparum importin beta, putative 0.0057 0.0593 1
Brugia malayi Carboxylesterase family protein 0.0034 0.0277 0.0259
Echinococcus granulosus intermediate filament protein 0.0027 0.0188 0.0234
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.061 0.8019 0.8019
Loa Loa (eye worm) hypothetical protein 0.0207 0.26 0.26
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0091
Onchocerca volvulus 0.0101 0.118 0.388
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0316 0.0346
Brugia malayi RNA, U transporter 1 0.0162 0.2008 0.1993
Schistosoma mansoni thyroid hormone receptor 0.002 0.0091 0.0064
Loa Loa (eye worm) hypothetical protein 0.0034 0.0277 0.0277
Schistosoma mansoni intermediate filament proteins 0.0027 0.0188 0.0185
Entamoeba histolytica hypothetical protein 0.0037 0.0316 0.6937
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0698 0.0681
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0091 0.0073
Brugia malayi Carboxylesterase family protein 0.0034 0.0277 0.0259
Loa Loa (eye worm) hypothetical protein 0.0387 0.5026 0.5026
Echinococcus granulosus mucolipin 3 0.0066 0.0715 0.0892
Loa Loa (eye worm) hypothetical protein 0.0096 0.1109 0.1109
Loa Loa (eye worm) hypothetical protein 0.0027 0.0181 0.0181
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0091 0.0113
Echinococcus multilocularis acetylcholinesterase 0.0199 0.2503 0.3121
Schistosoma mansoni acetylcholinesterase 0.0034 0.0277 0.0297
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.039 0.0486
Schistosoma mansoni hypothetical protein 0.0166 0.2056 0.2527
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0091 0.0113
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0188 0.0188
Onchocerca volvulus 0.0151 0.1858 0.6145
Onchocerca volvulus 0.0027 0.0188 0.0565
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0091 0.0064
Loa Loa (eye worm) hypothetical protein 0.0151 0.1858 0.1858
Loa Loa (eye worm) hypothetical protein 0.0199 0.2503 0.2503
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.039 0.0372
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0091
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0091 0.0113
Leishmania major importin beta-1 subunit, putative 0.0046 0.0447 0.043
Schistosoma mansoni hypothetical protein 0.0096 0.1109 0.134
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0174 0.2168 0.2168
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0698 0.0824
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0091 0.0113
Leishmania major C-8 sterol isomerase-like protein 0.0757 1 1
Onchocerca volvulus 0.0027 0.0188 0.0565
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0019
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0593 0.0739
Brugia malayi nuclear hormone receptor 0.002 0.0091 0.0073
Brugia malayi Importin beta-1 subunit 0.0057 0.0593 0.0575
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.004 0.004
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0091 0.0113
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0199 0.2503 0.3086
Brugia malayi Glycosyl hydrolases family 31 protein 0.0174 0.2168 0.2153
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0091 0.0113
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0345 0.7607
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0091 0.0113
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0226 0.0233
Entamoeba histolytica hypothetical protein 0.0037 0.0316 0.6937
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0427 0.0484
Schistosoma mansoni mucolipin 0.0061 0.0641 0.0752
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0345 0.7607
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0698 0.087
Brugia malayi Carboxylesterase family protein 0.0034 0.0277 0.0259
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.1109 0.1383
Schistosoma mansoni gliotactin 0.0034 0.0277 0.0297
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0034 0.0277 0.0297
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0091 0.0064
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0091 0.0064

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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