Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid stimulating hormone receptor | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | Get druggable targets OG5_130089 | All targets in OG5_130089 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | Get druggable targets OG5_130089 | All targets in OG5_130089 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.1145 | 0.9594 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.119 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0804 | 0.651 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0804 | 0.651 | 0.651 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.028 | 0.1763 | 0.2708 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0804 | 0.651 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0804 | 0.651 | 0.651 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0804 | 0.651 | 0.6785 |
Onchocerca volvulus | 0.0085 | 0 | 0.5 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.0085 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0085 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0085 | 0 | 0.5 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0804 | 0.651 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0804 | 0.651 | 0.5 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0804 | 0.651 | 0.5 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0804 | 0.651 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0465 | 0.3444 | 0.359 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0465 | 0.3444 | 0.3444 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0804 | 0.651 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.028 | 0.1763 | 0.2708 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 0.96 | Calculated partition coefficient (clogP) | ChEMBL. | 9046351 |
EC50 (functional) | > 195 um | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] | ChEMBL. | No reference |
ED50 (functional) | = 5 mg kg-1 | Ability to cause 50% reduction in sorbitol levels of sciatic nerve of streptozotocinized rats was determined | ChEMBL. | 3121857 |
ED50 (functional) | = 10 mg kg-1 | Ability to cause 50% reduction in sorbitol levels of sciatic nerve of streptozotocinized rats was determined; value ranges from 10-25 | ChEMBL. | 3121857 |
IC50 (binding) | = 0.0001 M | Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M | ChEMBL. | 3121857 |
IC50 (binding) | = 0.0001 M | Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M | ChEMBL. | 3121857 |
IC50 (binding) | 0 uM | Inhibition of [3H]-BTX-B binding to Neuronal voltage-dependent sodium channel of rat cerebral cortex synaptoneurosomes (no data) | ChEMBL. | 9046351 |
IC50 (binding) | = 2112 uM | In vitro inhibition of Voltage-gated sodium channel by the displacement of [3H]-batrachotoxin A 20-alpha-benzoate in rat brain cerebral cortex synaptoneurosomes | ChEMBL. | 10229624 |
IC50 (binding) | = 2112 uM | Inhibition of [3H]-BTX-B binding to Neuronal voltage-dependent sodium channel of rat cerebral cortex synaptoneurosomes | ChEMBL. | 9046351 |
IC50 (binding) | = 2112 uM | In vitro inhibition of Voltage-gated sodium channel by the displacement of [3H]-batrachotoxin A 20-alpha-benzoate in rat brain cerebral cortex synaptoneurosomes | ChEMBL. | 10229624 |
IC50 (binding) | = 2112 uM | Inhibition of [3H]-BTX-B binding to Neuronal voltage-dependent sodium channel of rat cerebral cortex synaptoneurosomes | ChEMBL. | 9046351 |
logP (ADMET) | = 0.96 | Partition coefficient (logP) | ChEMBL. | 10229624 |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.