Detailed information for compound 555194

Basic information

Technical information
  • TDR Targets ID: 555194
  • Name: [2,2-bis(hydroxymethyl)-3-[(E)-octadec-9-enoy l]oxy-propyl] (E)-octadec-9-enoate
  • MW: 665.039 | Formula: C41H76O6
  • H donors: 2 H acceptors: 4 LogP: 13.71 Rotable bonds: 38
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCCC=CCCCCCCCC(=O)OCC(COC(=O)CCCCCCC/C=C/CCCCCCCC)(CO)CO
  • InChi: 1S/C41H76O6/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-39(44)46-37-41(35-42,36-43)38-47-40(45)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,42-43H,3-16,21-38H2,1-2H3/b19-17+,20-18+
  • InChiKey: BJXXCOMGRRCAGN-XPWSMXQVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-9-octadecenoic acid [2,2-bis(hydroxymethyl)-3-[(E)-1-oxooctadec-9-enoxy]propyl] ester
  • (E)-octadec-9-enoic acid [2,2-dimethylol-3-[(E)-octadec-9-enoyl]oxy-propyl] ester
  • [2,2-bis(hydroxymethyl)-3-[(E)-octadec-9-enoyl]oxypropyl] (E)-octadec-9-enoate
  • pentol
  • (E)-octadec-9-enoic acid [2,2-bis(hydroxymethyl)-3-[(E)-1-oxooctadec-9-enoxy]propyl] ester
  • 25151-96-6
  • 172339-64-9
  • 2307-91-7
  • 2,2-Bis(hydroxymethyl)-1,3-propanediyl dioleate
  • 9-Octadecenoic acid (9Z)-, 2,2-bis(hydroxymethyl)-1,3-propanediyl ester
  • 9-Octadecenoic acid (Z)-, 2,2-bis(hydroxymethyl)-1,3-propanediyl
  • 9-Octadecenoic acid (Z)-, 2,2-bis(hydroxymethyl)-1,3-propanediyl ester
  • 9-Octadecenoic acid, 2,2-bis(hydroxymethyl)-1,3-propanediylester
  • EINECS 246-665-2
  • Pentaerythritol dioleate
  • Pentaerythrityl dioleate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.2592 0.2592
Loa Loa (eye worm) hypothetical protein 0.0016 0.0619 0.0679
Echinococcus granulosus Smad4 0.0008 0.0097 0.0097
Schistosoma mansoni ferritin 0.0008 0.0093 0.0093
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0425 0.3784
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.1169 1
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.1554 1
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.0093 0.0906
Brugia malayi ecdysteroid receptor 0.0031 0.1554 0.1705
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.2387 0.2618
Loa Loa (eye worm) hypothetical protein 0.0016 0.0619 0.0679
Brugia malayi ecdysone receptor 0.0015 0.0507 0.0556
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0231 0.2056
Mycobacterium ulcerans hypothetical protein 0.0023 0.1031 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0759 0.6497
Echinococcus granulosus GPCR family 2 0.0047 0.2592 0.2592
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0602 0.5844
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0231 0.2056
Loa Loa (eye worm) hypothetical protein 0.0031 0.1554 0.1705
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0759 0.6762
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.1123 1
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0507 0.0507
Brugia malayi hypothetical protein 0.0024 0.1123 0.1232
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.1554 0.1705
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.1031 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0759 0.0759
Echinococcus granulosus smad 0.0008 0.0097 0.0097
Brugia malayi hypothetical protein 0.0016 0.0619 0.0679
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0231 0.0253
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0097 0.0097
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0.0093 0.0906
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0425 0.3784
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0507 0.0556
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.1554 0.1554
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0619 0.0619
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.1554 0.1554
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0267 0.0267
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.1554 0.1554
Echinococcus multilocularis smad 0.0008 0.0097 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.1554 0.1705
Loa Loa (eye worm) hypothetical protein 0.0023 0.1031 0.113
Brugia malayi hypothetical protein 0.0015 0.0507 0.0556
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0507 0.0507
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.1554 0.1554
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.1554 0.1554
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0097 0.0097
Loa Loa (eye worm) TAR-binding protein 0.0125 0.7565 0.8298
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0507 0.0507
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0759 0.6762
Onchocerca volvulus 0.0015 0.0507 0.3261
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.2592 0.2843
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.1031 1
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.1123 1
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0507 0.0556
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.1554 0.1554
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0662 0.6421
Trypanosoma brucei unspecified product 0.0013 0.0391 0.3479
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0097 0.0107
Echinococcus granulosus dna polymerase kappa 0.0019 0.0759 0.0759
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.9117 1
Brugia malayi TAR-binding protein 0.0125 0.7565 0.8298
Schistosoma mansoni tar DNA-binding protein 0.0125 0.7565 0.7565
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0759 0.7367
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.1031 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.2387 0.2387
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.2592 0.2592
Schistosoma mansoni DNA polymerase eta 0.0019 0.0759 0.0759
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0759 0.7367
Echinococcus multilocularis Smad4 0.0008 0.0097 0.0097
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0507 0.0507
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0507 0.3261
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0759 0.6762
Schistosoma mansoni smad1 5 8 and 0.0008 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0015 0.0507 0.0556
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0639 0.5688
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.1554 0.1705
Loa Loa (eye worm) hypothetical protein 0.0015 0.0507 0.0556
Echinococcus granulosus expressed protein 0.0008 0.0093 0.0093
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.1554 0.1554
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0425 0.3784
Schistosoma mansoni ferritin light chain 0.0008 0.0093 0.0093
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.1031 1
Echinococcus granulosus ferritin 0.0008 0.0093 0.0093
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.1554 0.1705
Brugia malayi hypothetical protein 0.0016 0.0573 0.0629
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0008 0.0093 0.5
Schistosoma mansoni hypothetical protein 0.0102 0.6097 0.6097
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0759 0.0833
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.1554 0.1705
Trypanosoma brucei unspecified product 0.0019 0.0759 0.6762
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.1554 0.1705
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0507 0.0507
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.1554 0.1554
Loa Loa (eye worm) RecQ helicase 0.0025 0.1169 0.1282
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.1554 0.1705
Brugia malayi MH1 domain containing protein 0.0008 0.0097 0.0107
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0507 0.0556
Loa Loa (eye worm) hypothetical protein 0.0015 0.0507 0.0556
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.1554 0.1705
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0231 0.0253
Brugia malayi nuclear hormone receptor 0.0031 0.1554 0.1705
Loa Loa (eye worm) hypothetical protein 0.0017 0.0662 0.0726
Loa Loa (eye worm) hypothetical protein 0.0023 0.1031 0.113
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0662 0.5894
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.1554 0.1705
Echinococcus multilocularis bloom syndrome protein 0.0025 0.1169 0.1169
Brugia malayi AMP-binding enzyme family protein 0.0023 0.1031 0.113
Loa Loa (eye worm) hypothetical protein 0.0015 0.0507 0.0556
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0759 0.6762
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0507 0.0507
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0391 0.3479
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0759 0.7367
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0019 0.0759 0.0833
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.1031 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.1031 1
Trichomonas vaginalis ferritin, putative 0.0008 0.0093 0.0799
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.1554 0.1705
Schistosoma mansoni smad1 5 8 and 0.0008 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0126 0.7611 0.8348
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.7565 0.8298
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.2387 0.2387
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0507 0.0556
Onchocerca volvulus 0.0015 0.0507 0.3261
Loa Loa (eye worm) hypothetical protein 0.0016 0.0619 0.0679
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0507 0.0507
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.1554 0.1554
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.2387 0.2387
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0619 0.0619
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0097 0.0097
Echinococcus multilocularis ferritin 0.0008 0.0093 0.0093
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.1554 0.1554
Loa Loa (eye worm) hypothetical protein 0.0031 0.1554 0.1705
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0391 0.3479
Loa Loa (eye worm) hypothetical protein 0.0015 0.0507 0.0556
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.1554 0.1705
Schistosoma mansoni DNA helicase recq5 0.001 0.0231 0.0231
Schistosoma mansoni hypothetical protein 0.0047 0.2592 0.2592
Echinococcus granulosus dna polymerase eta 0.0019 0.0759 0.0759
Schistosoma mansoni tar DNA-binding protein 0.0125 0.7565 0.7565
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.1123 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.1554 0.1554
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.7289 0.7995
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.1554 0.1705
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0507 0.0507
Trypanosoma brucei unspecified product 0.0013 0.0391 0.3479
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0662 0.5
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.1031 1
Schistosoma mansoni nuclear receptor 0.0015 0.0507 0.0507
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0507 0.0507
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0097 0.0097
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0602 0.5844
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.7289 0.7995
Schistosoma mansoni apoferritin-2 0.0008 0.0093 0.0093
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0619 0.0619
Schistosoma mansoni ferritin 0.0008 0.0093 0.0093
Schistosoma mansoni smad 0.0008 0.0097 0.0097
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.1554 0.1554
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0425 0.4122
Schistosoma mansoni tar DNA-binding protein 0.0125 0.7565 0.7565
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0.0093 0.0906
Brugia malayi hypothetical protein 0.0016 0.0619 0.0679
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0759 0.7367
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.1031 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0759 0.0833
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.2387 0.2387
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.1554 0.1705
Leishmania major DNA polymerase eta, putative 0.0019 0.0759 0.6762
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.1554 0.1554
Loa Loa (eye worm) hypothetical protein 0.0031 0.1554 0.1705
Loa Loa (eye worm) hypothetical protein 0.0017 0.0662 0.0726
Schistosoma mansoni hypothetical protein 0.0164 1 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0097 0.0097
Brugia malayi MH2 domain containing protein 0.0008 0.0097 0.0107
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0231 0.0231
Brugia malayi nuclear receptor NHR-88 0.0015 0.0507 0.0556
Loa Loa (eye worm) RNA binding protein 0.0125 0.7565 0.8298
Treponema pallidum bacterioferrin (TpF1) 0.0008 0.0093 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0619 0.0679
Schistosoma mansoni hypothetical protein 0.0164 1 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0759 0.6762
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0507 0.0507
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.1554 1
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0507 0.0507
Brugia malayi tailless protein 0.0015 0.0507 0.0556
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.1031 1
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.1123 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0507 0.0556
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0231 0.0231
Brugia malayi nuclear receptor NHR-88 0.0031 0.1554 0.1705
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0759 0.6762
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0507 0.0507
Schistosoma mansoni Smad4 0.0008 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0016 0.0619 0.0679
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0652 0.5802
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0759 0.0759
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.7565 0.8298
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0507 0.0507
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.1123 1
Brugia malayi Latrophilin receptor protein 2 0.0047 0.2592 0.2843
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.1554 0.1705
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.1554 0.1705
Loa Loa (eye worm) hypothetical protein 0.0031 0.1554 0.1705
Loa Loa (eye worm) hypothetical protein 0.0015 0.0507 0.0556
Brugia malayi steroid hormone receptor 0.0031 0.1554 0.1705
Loa Loa (eye worm) hypothetical protein 0.0024 0.1123 0.1232
Giardia lamblia DINP protein human, muc B family 0.0019 0.0759 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0391 0.3479
Loa Loa (eye worm) hypothetical protein 0.0015 0.0507 0.0556
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.1554 0.1705
Loa Loa (eye worm) hypothetical protein 0.0047 0.2592 0.2843
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0759 0.6762
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.1554 0.1705
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.6097 0.6687
Loa Loa (eye worm) hypothetical protein 0.0015 0.0507 0.0556
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0759 0.6762
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0759 0.0833
Loa Loa (eye worm) hypothetical protein 0.0016 0.0619 0.0679
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0507 0.3261
Schistosoma mansoni hypothetical protein 0.0011 0.0267 0.0267
Schistosoma mansoni ferritin 0.0008 0.0093 0.0093
Echinococcus multilocularis geminin 0.0164 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.1123 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0759 0.6762
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0759 0.6762
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.1554 0.1705
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0759 0.6762
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.1554 0.1554
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0759 0.6497
Loa Loa (eye worm) hypothetical protein 0.0015 0.0507 0.0556
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0833 0.0833
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0759 0.6762
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0759 0.6762
Leishmania major hypothetical protein, conserved 0.0024 0.1123 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.1554 0.1554
Schistosoma mansoni apoferritin-2 0.0008 0.0093 0.0093
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0425 0.3635
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.2592 0.2592
Loa Loa (eye worm) hypothetical protein 0.0031 0.1554 0.1705
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.1554 0.1554
Brugia malayi nuclear receptor RXR 0.0015 0.0507 0.0556
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.1554 0.1554
Brugia malayi nuclear hormone receptor 0.0015 0.0507 0.0556
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.1169 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0507 0.0507
Loa Loa (eye worm) Smad1 0.0008 0.0097 0.0107
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0097 0.0097
Schistosoma mansoni thyroid hormone receptor 0.0031 0.1554 0.1554
Loa Loa (eye worm) hypothetical protein 0.0017 0.0662 0.0726
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.1554 0.1705
Brugia malayi nuclear receptor RXR 0.0016 0.0619 0.0679
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.2592 0.2843
Echinococcus multilocularis GPCR, family 2 0.0047 0.2592 0.2592
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.1169 0.1282
Brugia malayi AMP-binding enzyme family protein 0.0023 0.1031 0.113
Loa Loa (eye worm) hypothetical protein 0.0023 0.1031 0.113
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0015 0.0507 0.0556
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0231 0.0231
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.1554 0.1554
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.1554 0.1554
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.1554 0.1554
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.1554 0.1705
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0759 0.6762
Loa Loa (eye worm) hypothetical protein 0.015 0.9117 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0602 0.5844
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.1554 0.1554
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0759 0.0759
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.1031 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0759 0.6762
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0231 0.0253
Schistosoma mansoni tar DNA-binding protein 0.0125 0.7565 0.7565
Schistosoma mansoni DNA helicase recq1 0.001 0.0231 0.0231
Schistosoma mansoni hypothetical protein 0.0047 0.2592 0.2592
Echinococcus granulosus tar DNA binding protein 0.0125 0.7565 0.7565
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.1031 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.1554 0.1554
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0759 0.0759
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0602 0.5844
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.1031 1
Brugia malayi MH2 domain containing protein 0.0121 0.7289 0.7995
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0759 0.6762
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0507 0.0507
Echinococcus multilocularis expressed protein 0.0008 0.0093 0.0093
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.1554 0.1554
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.1554 0.1554
Onchocerca volvulus 0.0023 0.1031 0.6631
Schistosoma mansoni hypothetical protein 0.0047 0.2592 0.2592
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0619 0.0679
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.1554 1
Schistosoma mansoni zinc finger protein 0.0015 0.0507 0.0507
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0507 0.0556
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.2592 0.2592
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.1031 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0759 0.6762
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0231 0.2056
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.1554 0.1705
Schistosoma mansoni nuclear receptor 0.0015 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0015 0.0507 0.0556
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0975 0.8681
Schistosoma mansoni thyroid hormone receptor 0.0031 0.1554 0.1554
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.1031 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0759 0.6762
Brugia malayi hypothetical protein 0.0015 0.0507 0.0556
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.2387 0.2387
Loa Loa (eye worm) hypothetical protein 0.001 0.0231 0.0253
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0507 0.0556
Echinococcus granulosus bloom syndrome protein 0.0025 0.1169 0.1169
Schistosoma mansoni hypothetical protein 0.0047 0.2592 0.2592
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0097 0.0107
Brugia malayi Smad1 0.0008 0.0097 0.0107
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0619 0.0679
Echinococcus granulosus FTZ F1 alpha 0.0031 0.1554 0.1554
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0267 0.0267
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0662 0.6421
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.9117 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.2387 0.2387
Loa Loa (eye worm) hypothetical protein 0.0031 0.1554 0.1705
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.1554 0.1705
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0507 0.0556
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0507 0.0556
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.1554 0.1554
Schistosoma mansoni coup transcription factor 0.0031 0.1554 0.1554
Echinococcus multilocularis tar DNA binding protein 0.0125 0.7565 0.7565
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0759 0.0759
Loa Loa (eye worm) hypothetical protein 0.0017 0.0662 0.0726
Schistosoma mansoni nuclear hormone receptor 0.0031 0.1554 0.1554
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.1031 0.9179
Brugia malayi MH1 domain containing protein 0.0008 0.0097 0.0107
Loa Loa (eye worm) DR-78 0.0015 0.0507 0.0556
Loa Loa (eye worm) hypothetical protein 0.0031 0.1554 0.1705
Echinococcus multilocularis dna polymerase eta 0.0019 0.0759 0.0759
Brugia malayi nuclear receptor NHR-67 0.0015 0.0507 0.0556
Schistosoma mansoni ferritin light chain 0.0008 0.0093 0.0093
Onchocerca volvulus 0.0031 0.1554 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.2387 0.2387
Brugia malayi MH2 domain containing protein 0.0008 0.0097 0.0107
Loa Loa (eye worm) hypothetical protein 0.0031 0.1554 0.1705
Loa Loa (eye worm) hypothetical protein 0.0017 0.0662 0.0726
Loa Loa (eye worm) hypothetical protein 0.0102 0.6097 0.6687
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0507 0.0507
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0.0093 0.0906
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0759 0.7367
Schistosoma mansoni ferritin 0.0008 0.0093 0.0093
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.1554 0.1554
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0507 0.0556
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0759 0.6762
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0662 0.5894
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.1123 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.1554 0.1705
Brugia malayi RNA binding protein 0.0125 0.7565 0.8298
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0759 0.6762
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0619 0.0619
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.1031 0.9179
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.1031 0.9179
Loa Loa (eye worm) hypothetical protein 0.0015 0.0507 0.0556
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.2387 0.2618
Brugia malayi AMP-binding enzyme family protein 0.0023 0.1031 0.113
Leishmania major DNA polymerase kappa, putative 0.0019 0.0759 0.6762
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.0093 0.0906
Schistosoma mansoni tar DNA-binding protein 0.0125 0.7565 0.7565
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.9117 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.1554 0.1705
Brugia malayi conserved hypotetical protein 0.0015 0.0507 0.0556

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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