Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Serotonin receptor | Get druggable targets OG5_135430 | All targets in OG5_135430 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0286 | 0.416 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0286 | 0.416 | 0.5 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0286 | 0.416 | 0.5 |
Mycobacterium tuberculosis | Inorganic polyphosphate/ATP-NAD kinase PpnK (poly(P)/ATP NAD kinase) | 0.0329 | 0.5081 | 1 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0286 | 0.416 | 0.5 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0286 | 0.416 | 0.5 |
Mycobacterium ulcerans | inorganic polyphosphate/ATP-NAD kinase | 0.0359 | 0.5704 | 1 |
Trichomonas vaginalis | poly(p)/ATP NAD kinase, putative | 0.0359 | 0.5704 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0286 | 0.416 | 0.7294 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0286 | 0.416 | 0.5 |
Mycobacterium leprae | Inorganic polyphosphate/ATP-NAD kinase PpnK (Poly(P)/ATP NAD kinase) | 0.0329 | 0.5081 | 1 |
Treponema pallidum | hypothetical protein | 0.0359 | 0.5704 | 0.5 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0286 | 0.416 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0286 | 0.416 | 0.5996 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0286 | 0.416 | 0.7294 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0286 | 0.416 | 0.5 |
Giardia lamblia | Inorganic polyphosphate/ATP-NAD kinase, putative | 0.0359 | 0.5704 | 0.5 |
Echinococcus multilocularis | NAD kinase | 0.0359 | 0.5704 | 1 |
Schistosoma mansoni | poly(p)/ATP NAD kinase | 0.0359 | 0.5704 | 1 |
Trichomonas vaginalis | poly(p)/ATP NAD kinase, putative | 0.0359 | 0.5704 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0286 | 0.416 | 0.5 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0286 | 0.416 | 0.5 |
Echinococcus granulosus | NAD kinase | 0.0359 | 0.5704 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 300 nM | Displacement of [3H]-DOB from human 5-hydroxytryptamine 2A receptor | ChEMBL. | 11755343 |
Ki (binding) | = 300 nM | Displacement of [3H]-DOB from human 5-hydroxytryptamine 2A receptor | ChEMBL. | 11755343 |
Ki (binding) | = 1000 nM | Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor | ChEMBL. | 11755343 |
Ki (binding) | = 1000 nM | Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor | ChEMBL. | 11755343 |
Ki (binding) | = 1990 nM | Binding affinity towards human 5-hydroxytryptamine 2C receptor. | ChEMBL. | 11755343 |
Ki (binding) | = 1990 nM | Binding affinity towards human 5-hydroxytryptamine 2C receptor. | ChEMBL. | 11755343 |
Selectivity (binding) | = 6.6 | Relative affinity for human 5-HT2C and 5-HT2A receptors | ChEMBL. | 11755343 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.