Detailed information for compound 555922

Basic information

Technical information
  • TDR Targets ID: 555922
  • Name: (2S)-2-amino-3-[2,3-dihydroxypropoxy(hydroxy) phosphoryl]oxy-propanoic acid
  • MW: 259.151 | Formula: C6H14NO8P
  • H donors: 5 H acceptors: 6 LogP: -5.91 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(COP(=O)(OC[C@@H](C(=O)O)N)O)O
  • InChi: 1S/C6H14NO8P/c7-5(6(10)11)3-15-16(12,13)14-2-4(9)1-8/h4-5,8-9H,1-3,7H2,(H,10,11)(H,12,13)/t4?,5-/m0/s1
  • InChiKey: ZWZWYGMENQVNFU-AKGZTFGVSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-2-amino-3-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxypropanoic acid
  • (2S)-2-azanyl-3-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-propanoic acid
  • (2S)-2-amino-3-[glyceryloxy(hydroxy)phosphoryl]oxy-propionic acid
  • glycerophosphoserine
  • (2S)-2-amino-3-(2,3-dihydroxypropoxy-hydroxyphosphoryl)oxypropanoic acid
  • (2S)-2-amino-3-(2,3-dihydroxypropoxy-hydroxy-phosphoryl)oxy-propanoic acid
  • 26289-09-8
  • L-Serine, 2,3-dihydroxypropyl hydrogen phosphate (ester)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 1 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0583 1
Brugia malayi chromobox protein homolog 3 0.0043 0.0456 0.1629
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.4265 0.5
Plasmodium falciparum phd finger protein, putative 0.0031 0 0.5
Treponema pallidum fructose-bisphosphate aldolase 0.0286 1 0.5
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0 0.5
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0255 0.0339
Brugia malayi hypothetical protein 0.0103 0.2802 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.1291 0.1717
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0456 0.7826
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 1 0.5
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.4265 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 1 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0866 0.1152
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0223 0.752 1
Trichomonas vaginalis chromobox protein, putative 0.0076 0.1765 0.1371
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0583 0.0133
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.2759 0.3669
Echinococcus multilocularis chromobox protein 1 0.0076 0.1765 0.2347
Brugia malayi jmjC domain containing protein 0.0101 0.2759 0.9847
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0475 0.0632
Schistosoma mansoni chromobox protein 0.0076 0.1765 0.2347
Echinococcus granulosus chromobox protein 1 0.0076 0.1765 0.2347
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 1 1
Echinococcus granulosus leukotriene A 4 hydrolase 0.0223 0.752 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 1 1
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.1765 0.2347
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0223 0.752 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 1 1
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0583 0.0133
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 1 1
Echinococcus multilocularis chromobox protein 1 0.0076 0.1765 0.2347
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0255 0.0339
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0255 0.0339
Onchocerca volvulus 0.0033 0.0096 0.1642
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 1 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0456 0.0607
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0096 0.0127
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0223 0.752 1
Brugia malayi jmjC domain containing protein 0.0038 0.0255 0.0911
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0255 0.0339
Giardia lamblia Fructose-bisphosphate aldolase 0.0286 1 1
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0475 0.0632
Trichomonas vaginalis chromobox protein, putative 0.0076 0.1765 0.1371
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.4265 0.5
Plasmodium vivax hypothetical protein, conserved 0.0031 0 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0255 0.0339
Schistosoma mansoni chromobox protein 0.0076 0.1765 0.2347
Schistosoma mansoni jumonji domain containing protein 0.0081 0.1943 0.2584
Brugia malayi Heterochromatin protein 1 0.0076 0.1765 0.6298
Echinococcus granulosus chromobox protein 1 0.0076 0.1765 0.2347
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.2759 0.3669

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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