Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | Curated by TDR Targets | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 492 aa | 548 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0026 | 0.1234 | 0.1009 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.4084 | 0.5 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0026 | 0.1234 | 0.1009 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0026 | 0.1234 | 0.1009 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0026 | 0.1234 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0026 | 0.1234 | 0.1009 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0052 | 0.5811 | 0.5703 |
Plasmodium falciparum | glutathione reductase | 0.0076 | 1 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0026 | 0.1234 | 0.1009 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.4084 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.4084 | 0.3251 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0026 | 0.1234 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.4084 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.4084 | 0.3251 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0026 | 0.1234 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.4084 | 0.3251 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0026 | 0.1234 | 0.1009 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0026 | 0.1234 | 0.1009 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.4084 | 0.3251 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0026 | 0.1234 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0026 | 0.1234 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0076 | 1 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0026 | 0.1234 | 0.1009 |
Brugia malayi | hypothetical protein | 0.0043 | 0.4084 | 0.4084 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0026 | 0.1234 | 0.1009 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0026 | 0.1234 | 0.1009 |
Plasmodium vivax | glutathione reductase, putative | 0.0076 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0026 | 0.1234 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0021 | 0.025 | 0.025 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0026 | 0.1234 | 0.1234 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0076 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0076 | 1 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0026 | 0.1234 | 0.1009 |
Toxoplasma gondii | thioredoxin reductase | 0.0076 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0021 | 0.025 | 0.025 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0076 | 1 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0026 | 0.1234 | 0.1009 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.4084 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0026 | 0.1234 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0026 | 0.1234 | 0.1009 |
Brugia malayi | Thioredoxin reductase | 0.0076 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0026 | 0.1234 | 0.1009 |
Trypanosoma brucei | trypanothione reductase | 0.0076 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.1234 | 0.5 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0026 | 0.1234 | 0.1009 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0026 | 0.1234 | 0.1009 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0026 | 0.1234 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0076 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0026 | 0.1234 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0076 | 1 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0076 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0076 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.1234 | 0.5 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0026 | 0.1234 | 0.1009 |
Brugia malayi | Cytochrome P450 family protein | 0.0052 | 0.5811 | 0.5811 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.7 mM | In vitro inhibitory activity against Selectin E binding to human recombinant AGP (alpha-1 acid glycoprotein) | ChEMBL. | 11206447 |
IC50 (binding) | = 6.7 mM | In vitro inhibitory activity against Selectin E binding to human recombinant AGP (alpha-1 acid glycoprotein) | ChEMBL. | 11206447 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.