Detailed information for compound 556117

Basic information

Technical information
  • TDR Targets ID: 556117
  • Name: p-tolylmethanediamine
  • MW: 136.194 | Formula: C8H12N2
  • H donors: 2 H acceptors: 0 LogP: 0.34 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(c1ccc(cc1)C)N
  • InChi: 1S/C8H12N2/c1-6-2-4-7(5-3-6)8(9)10/h2-5,8H,9-10H2,1H3
  • InChiKey: XBTRYWRVOBZSGM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4-methylphenyl)methanediamine
  • [amino(p-tolyl)methyl]amine
  • xylenediamine
  • [amino-(4-methylphenyl)methyl]amine
  • 26603-36-1
  • 94841-15-3
  • Benzenedimethanamine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0043 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0043 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0043 0.0121
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0944 0.0905
Loa Loa (eye worm) hypothetical protein 0.0249 0.3541 1
Schistosoma mansoni thyroid hormone receptor 0.0265 0.3785 0.3759
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0043 0.0121
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0043 0.0121
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0043 0.0121
Schistosoma mansoni hypothetical protein 0.0079 0.0944 0.0905
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1517 0.4214
Brugia malayi Stress-activated protein kinase jnk-1 0.021 0.2953 0.8338
Echinococcus multilocularis c Jun NH2 terminal kinase 0.021 0.2953 0.2923
Brugia malayi ecdysteroid receptor 0.002 0.0043 0.0121
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0043 0.0121
Loa Loa (eye worm) hypothetical protein 0.0026 0.0141 0.0282
Echinococcus multilocularis mitogen activated protein kinase 14 0.0115 0.1499 0.1463
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0944 0.2667
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0944 0.2667
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0115 0.1499 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0245 0.3485 0.3457
Schistosoma mansoni hypothetical protein 0.0079 0.0944 0.0905
Loa Loa (eye worm) hypothetical protein 0.017 0.2339 0.6564
Echinococcus multilocularis thyroid hormone receptor alpha 0.0265 0.3785 0.3759
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0115 0.1499 0.4163
Echinococcus multilocularis mitogen activated protein kinase 11 0.0115 0.1499 0.1463
Echinococcus granulosus c-Jun N-terminal kinases 0.021 0.2953 0.2923
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0115 0.1499 1
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0043 0.5
Brugia malayi nuclear hormone receptor 0.002 0.0043 0.0121
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0944 0.0905
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.021 0.2953 0.8318
Echinococcus multilocularis microtubule associated protein 2 0.0671 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0043 0.0121
Schistosoma mansoni serine/threonine protein kinase 0.021 0.2953 0.2923
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0141 0.5
Brugia malayi hypothetical protein 0.0026 0.0141 0.0399
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0249 0.3541 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0043 0.0121
Schistosoma mansoni hypothetical protein 0.0079 0.0944 0.0905
Echinococcus granulosus mitogen activated protein kinase 11 0.0115 0.1499 0.1463
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0141 0.5
Brugia malayi MH2 domain containing protein 0.0116 0.1517 0.4284
Schistosoma mansoni hypothetical protein 0.0245 0.3485 0.3457
Brugia malayi P38 map kinase family protein 2 0.0115 0.1499 0.4234
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0043 0.0121
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0249 0.3541 1
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1517 0.4214
Schistosoma mansoni microtubule-associated protein tau 0.0671 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0043 0.0121
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0944 0.0905
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0141 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.017 0.2339 0.6606
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0043 0.0121
Echinococcus granulosus GPCR family 2 0.0079 0.0944 0.0905
Echinococcus multilocularis GPCR, family 2 0.0079 0.0944 0.0905
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0115 0.1499 1
Onchocerca volvulus 0.002 0.0043 0.5
Schistosoma mansoni hypothetical protein 0.0079 0.0944 0.0905
Echinococcus multilocularis mitogen activated protein kinase 11 0.0115 0.1499 0.1463
Schistosoma mansoni hypothetical protein 0.017 0.2339 0.2306
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0043 0.0121
Brugia malayi steroid hormone receptor 0.002 0.0043 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0043 0.0121
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0043 0.5
Echinococcus multilocularis mitogen activated protein kinase 14 0.0115 0.1499 0.1463
Brugia malayi Calcitonin receptor-like protein seb-1 0.0249 0.3541 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0141 0.5
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0115 0.1499 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0944 0.0905
Schistosoma mansoni thyroid hormone receptor 0.0265 0.3785 0.3759
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0245 0.3485 0.3457
Brugia malayi nuclear receptor NHR-88 0.002 0.0043 0.0121
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0043 0.0121
Loa Loa (eye worm) hypothetical protein 0.0079 0.0944 0.2577
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0043 0.0121
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0043 0.5
Echinococcus granulosus mitogen activated protein kinase 14 0.0115 0.1499 0.1463
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0944 0.2577

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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