Detailed information for compound 556205

Basic information

Technical information
  • TDR Targets ID: 556205
  • Name: [7-(dimethylamino)-4-nitro-phenothiazin-3-yli dene]-dimethyl-ammonium chloride
  • MW: 364.85 | Formula: C16H17ClN4O2S
  • H donors: 0 H acceptors: 2 LogP: 3.08 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1c2sc3cc(ccc3nc2ccc1=[N+](C)C)N(C)C.[Cl-]
  • InChi: 1S/C16H17N4O2S.ClH/c1-18(2)10-5-6-11-14(9-10)23-16-12(17-11)7-8-13(19(3)4)15(16)20(21)22;/h5-9H,1-4H3;1H/q+1;/p-1
  • InChiKey: YYGBVRCTHASBKD-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • [7-(dimethylamino)-4-nitro-3-phenothiazinylidene]-dimethylammonium chloride
  • [7-(dimethylamino)-4-nitro-phenothiazin-3-ylidene]-dimethyl-azanium chloride
  • [7-(dimethylamino)-4-nitrophenothiazin-3-ylidene]-dimethylazanium chloride
  • methylene green
  • (7-dimethylamino-4-nitrophenothiazin-3-ylidene)-dimethylazanium chloride
  • (7-dimethylamino-4-nitro-phenothiazin-3-ylidene)-dimethyl-ammonium chloride
  • (7-dimethylamino-4-nitro-3-phenothiazinylidene)-dimethylammonium chloride
  • (7-dimethylamino-4-nitro-phenothiazin-3-ylidene)-dimethyl-azanium chloride
  • 2679-01-8
  • 97835-59-1
  • 3,7-Bis(dimethylamino)-4-nitrophenothiazin-5-ium chloride
  • 7-(Dimethylamino)-6-nitro-3H-phenothiazin-3-ylidene)dimethylammonium chloride
  • C.I. Basic Green 5
  • C.I. Basic Green 5 (VAN)
  • EINECS 220-231-2
  • Methylene green (VAN)
  • NSC 367083
  • NSC 9403
  • Phenothiazin-5-ium, 3,7-bis(dimethylamino)-4-nitro-, chloride
  • NSC367083
  • NSC9403
  • WLN: T C666 BN ISJ FN1&1 GNW LN1&1 &Q &G

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0639 0.0816
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0834 0.082
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.125 0.5034
Onchocerca volvulus 0.003 0.2296 0.6276
Schistosoma mansoni jumonji domain containing protein 0.0073 0.7669 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.125 0.1785
Schistosoma mansoni DNA polymerase eta 0.0021 0.125 0.1613
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.125 0.1237
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 1 1
Schistosoma mansoni hypothetical protein 0.0015 0.0534 0.0678
Schistosoma mansoni cpg binding protein 0.0029 0.2265 0.294
Brugia malayi hypothetical protein 0.0018 0.0844 0.083
Brugia malayi TAR-binding protein 0.0061 0.6183 0.6178
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.125 0.5034
Schistosoma mansoni chromobox protein 0.0067 0.6934 0.904
Echinococcus granulosus tar DNA binding protein 0.0061 0.6183 0.6178
Brugia malayi Bromodomain containing protein 0.0028 0.2123 0.2111
Echinococcus granulosus jumonji domain containing protein 0.0039 0.3479 0.3469
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.2042 0.9621
Onchocerca volvulus 0.0028 0.2071 0.5656
Schistosoma mansoni hypothetical protein 0.0012 0.0177 0.0212
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0787 0.1117
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.125 0.5034
Echinococcus multilocularis chromobox protein 1 0.0067 0.6934 0.693
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.3298 0.4746
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0534 0.052
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.5122 1
Echinococcus multilocularis tar DNA binding protein 0.0061 0.6183 0.6178
Echinococcus multilocularis cpg binding protein 0.0029 0.2265 0.2254
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0015 0.0069
Loa Loa (eye worm) hypothetical protein 0.0015 0.0534 0.075
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.125 0.5034
Schistosoma mansoni hypothetical protein 0.0015 0.0534 0.0678
Schistosoma mansoni tar DNA-binding protein 0.0061 0.6183 0.8059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0787 0.1117
Brugia malayi SET domain containing protein 0.0012 0.0089 0.0075
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.125 0.1237
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.1944 0.2789
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.125 0.5034
Onchocerca volvulus Alhambra homolog 0.0028 0.2123 0.5798
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 1 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.6183 0.8059
Brugia malayi PHD-finger family protein 0.0028 0.2123 0.2111
Schistosoma mansoni hypothetical protein 0.0015 0.0534 0.0678
Brugia malayi hypothetical protein 0.0028 0.2042 0.2031
Echinococcus multilocularis dna polymerase eta 0.0021 0.125 0.1237
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.125 0.5
Plasmodium vivax hypothetical protein, conserved 0.0028 0.2123 1
Loa Loa (eye worm) RNA binding protein 0.0061 0.6183 0.8914
Onchocerca volvulus 0.0012 0.0089 0.0205
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.2042 0.9621
Schistosoma mansoni cpg binding protein 0.0029 0.2265 0.294
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0787 0.1117
Schistosoma mansoni hypothetical protein 0.0015 0.0534 0.0678
Echinococcus multilocularis chromobox protein 1 0.0067 0.6934 0.693
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.2042 0.9621
Schistosoma mansoni tar DNA-binding protein 0.0061 0.6183 0.8059
Loa Loa (eye worm) hypothetical protein 0.0048 0.4596 0.6621
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.2071 0.2972
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.125 0.5034
Trypanosoma brucei unspecified product 0.0021 0.125 0.5034
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.3046 0.396
Echinococcus granulosus peregrin 0.0028 0.2123 0.2111
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0209 0.0195
Echinococcus granulosus dna polymerase kappa 0.0021 0.125 0.1237
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.2123 0.4127
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.2707 0.2697
Trichomonas vaginalis chromobox protein, putative 0.0067 0.6934 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.125 0.5034
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.3046 0.396
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.125 0.1613
Trichomonas vaginalis chromobox protein, putative 0.0067 0.6934 1
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0015 0.0069
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.125 0.5
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0209 0.0254
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.4581 0.4573
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.125 0.1785
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0373 0.0518
Loa Loa (eye worm) hypothetical protein 0.0028 0.2123 0.3046
Trichomonas vaginalis chromobox protein, putative 0.0041 0.3651 0.5254
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.2042 1
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0015 0.0069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0787 0.1117
Brugia malayi CHD4 protein 0.0013 0.0209 0.0195
Plasmodium falciparum phd finger protein, putative 0.0028 0.2123 1
Brugia malayi Heterochromatin protein 1 0.0067 0.6934 0.693
Echinococcus multilocularis GPCR, family 2 0.0015 0.0534 0.052
Loa Loa (eye worm) hypothetical protein 0.0038 0.3298 0.4746
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0015 0.0069
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.125 0.1237
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.3479 0.3469
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.125 0.5034
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0534 0.052
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.125 0.5034
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.3298 0.4746
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.125 0.5034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0787 0.1117
Echinococcus multilocularis dna polymerase kappa 0.0021 0.125 0.1237
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.125 0.5
Loa Loa (eye worm) TAR-binding protein 0.0061 0.6183 0.8914
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0534 0.052
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.4581 0.6598
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0089 0.0097
Brugia malayi RNA binding protein 0.0061 0.6183 0.6178
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.125 0.5034
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0015 0.0069
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0534 0.052
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.2123 0.4127
Leishmania major hypothetical protein, conserved 0.0028 0.2042 1
Loa Loa (eye worm) hypothetical protein 0.003 0.2296 0.3297
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.6183 0.8914
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.125 0.5034
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.2123 0.2111
Loa Loa (eye worm) hypothetical protein 0.0048 0.4581 0.6598
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.5895 0.7682
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.2123 0.2111
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0015 0.0069
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.125 0.1613
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0787 0.1117
Schistosoma mansoni cpg binding protein 0.0028 0.2071 0.2686
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.3298 0.9031
Echinococcus granulosus chromobox protein 1 0.0067 0.6934 0.693
Loa Loa (eye worm) hypothetical protein 0.0033 0.2707 0.3891
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.3651 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.2042 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.4581 0.4573
Schistosoma mansoni hypothetical protein 0.0028 0.2123 0.2754
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.125 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.6183 0.8059
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.6934 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0209 0.0281
Brugia malayi CXXC zinc finger family protein 0.0028 0.2071 0.2059
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.2123 0.2754
Echinococcus granulosus chromobox protein 1 0.0067 0.6934 0.693
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0209 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0429 0.0599
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.3046 0.438
Loa Loa (eye worm) hypothetical protein 0.0028 0.2042 0.293
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0177 0.0163
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.3046 0.3035
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0177 0.0163
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0787 0.1117
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.125 0.5034
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0534 0.052
Schistosoma mansoni chromobox protein 0.0067 0.6934 0.904
Trichomonas vaginalis chromobox protein, putative 0.0041 0.3651 0.5254
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0534 0.075
Echinococcus multilocularis peregrin 0.0028 0.2123 0.2111
Echinococcus granulosus cpg binding protein 0.0029 0.2265 0.2254
Loa Loa (eye worm) hypothetical protein 0.0021 0.125 0.1785
Schistosoma mansoni tar DNA-binding protein 0.0061 0.6183 0.8059
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.125 0.5
Schistosoma mansoni hypothetical protein 0.0033 0.2707 0.3518
Giardia lamblia PHD finger protein 15 0.0028 0.2123 1
Brugia malayi chromobox protein homolog 3 0.0038 0.3298 0.3289
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.2042 0.397
Brugia malayi jmjC domain containing protein 0.0036 0.3046 0.3035
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.125 0.1785
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0787 0.1117
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.1944 0.2789
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.2123 0.3046
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.2042 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0429 0.0599
Echinococcus granulosus dna polymerase eta 0.0021 0.125 0.1237
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.125 0.5034
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.5809 0.8374
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.6183 0.6178
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.2851 0.2841
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.125 0.1237
Echinococcus granulosus GPCR family 2 0.0015 0.0534 0.052
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0534 0.052

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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