Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0046 | 0.6591 | 1 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0046 | 0.6591 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0046 | 0.6591 | 0.6591 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0046 | 0.6591 | 0.6342 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.6162 | 0.5881 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0046 | 0.6591 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0046 | 0.6591 | 0.6342 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0046 | 0.6591 | 1 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0046 | 0.6591 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0057 | 0.9041 | 0.8971 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0681 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0046 | 0.6591 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0046 | 0.6591 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0046 | 0.6591 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0046 | 0.6591 | 0.6591 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0046 | 0.6591 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0046 | 0.6591 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0046 | 0.6591 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0046 | 0.6591 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0057 | 0.9041 | 0.8971 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0046 | 0.6591 | 1 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0046 | 0.6591 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0057 | 0.9041 | 0.9041 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0046 | 0.6591 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0046 | 0.6591 | 1 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0046 | 0.6591 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.6162 | 0.5881 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0046 | 0.6591 | 0.6342 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0046 | 0.6591 | 1 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0046 | 0.6591 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1868 | 0.1274 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0046 | 0.6591 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0046 | 0.6591 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0046 | 0.6591 | 0.6591 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.6162 | 0.5881 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 1 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0046 | 0.6591 | 1 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0046 | 0.6591 | 1 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0046 | 0.6591 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.1868 | 0.2009 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0046 | 0.6591 | 1 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0046 | 0.6591 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0057 | 0.9041 | 0.9041 |
Loa Loa (eye worm) | cytochrome P450 | 0.0046 | 0.6591 | 0.6342 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0046 | 0.6591 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0046 | 0.6591 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0046 | 0.6591 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0057 | 0.9041 | 0.8971 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0046 | 0.6591 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.6591 | 0.6342 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.1868 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0046 | 0.6591 | 1 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0046 | 0.6591 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0046 | 0.6591 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.6162 | 0.5881 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 1 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0046 | 0.6591 | 0.6342 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0046 | 0.6591 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0046 | 0.6591 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0046 | 0.6591 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0057 | 0.9041 | 0.8971 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0681 | 0.0681 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0046 | 0.6591 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0057 | 0.9041 | 0.8971 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0057 | 0.9041 | 0.8971 |
Echinococcus multilocularis | 0.0046 | 0.6591 | 0.6342 | |
Schistosoma mansoni | jumonji domain containing protein | 0.0057 | 0.9041 | 0.8971 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0046 | 0.6591 | 1 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0046 | 0.6591 | 1 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0046 | 0.6591 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0046 | 0.6591 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0046 | 0.6591 | 0.6342 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0046 | 0.6591 | 0.6342 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.1868 | 0.2009 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0046 | 0.6591 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.1868 | 0.2009 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0681 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.6162 | 0.6162 |
Brugia malayi | Cytochrome P450 family protein | 0.0046 | 0.6591 | 0.6591 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.6162 | 0.5881 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0681 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.6162 | 0.5881 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.1868 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0046 | 0.6591 | 1 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0046 | 0.6591 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0057 | 0.9041 | 0.8971 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.1868 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.6162 | 0.5881 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0681 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0046 | 0.6591 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0046 | 0.6591 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0046 | 0.6591 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.1868 | 0.2009 |
Leishmania major | cytochrome p450-like protein | 0.0046 | 0.6591 | 1 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0046 | 0.6591 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0681 | 0.0681 |
Brugia malayi | cytochrome P450 | 0.0046 | 0.6591 | 0.6591 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0046 | 0.6591 | 1 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0046 | 0.6591 | 1 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0046 | 0.6591 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.1868 | 0.1868 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.6162 | 0.5881 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0046 | 0.6591 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0046 | 0.6591 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0046 | 0.6591 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.