Detailed information for compound 556295

Basic information

Technical information
  • TDR Targets ID: 556295
  • Name: (3aR,4S,6Z,10E,11aR)-4-hydroxy-10-(hydroxymet hyl)-6-methyl-3-methylene-3a,4,5,8,9,11a-hexa hydrocyclodeca[b]furan-2-one
  • MW: 264.317 | Formula: C15H20O4
  • H donors: 2 H acceptors: 3 LogP: 0.61 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1=C[C@H]2OC(=O)C(=C)[C@@H]2[C@H](CC(=CCC1)C)O
  • InChi: 1S/C15H20O4/c1-9-4-3-5-11(8-16)7-13-14(12(17)6-9)10(2)15(18)19-13/h4,7,12-14,16-17H,2-3,5-6,8H2,1H3/b9-4-,11-7+/t12-,13+,14+/m0/s1
  • InChiKey: BLDTUWFMPJJRPR-SBPCBFMRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3aR,4S,6Z,10E,11aR)-4-hydroxy-10-(hydroxymethyl)-6-methyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one
  • (3aR,4S,6Z,10E,11aR)-4-hydroxy-6-methyl-3-methylene-10-methylol-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one
  • salonitenolide
  • (3aR,4S,6Z,10E,11aR)-4-hydroxy-10-(hydroxymethyl)-6-methyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[d]furan-2-one
  • (3aR,4S,6Z,10E,11aR)-4-hydroxy-10-(hydroxymethyl)-6-methyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[d]furan-2-one
  • (3aR,4S,6Z,10E,11aR)-4-hydroxy-6-methyl-3-methylene-10-methylol-3a,4,5,8,9,11a-hexahydrocyclodeca[d]furan-2-one
  • (3aR-(3aR*,4S*,6E,10Z,11aR*))-3a,4,5,8,9,11a-Hexahydro-4-hydroxy-10-(hydroxymethyl)-6-methyl-3-methylenecyclodeca(b)furan-2(3H)-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glucose transport protein 0.0111 0.1132 0.1894
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0137 0.0888
Echinococcus multilocularis snurportin 1 0.0303 0.3456 0.3444
Echinococcus granulosus tar DNA binding protein 0.0251 0.2824 0.477
Toxoplasma gondii ABC1 family protein 0.0035 0.0216 0.1614
Schistosoma mansoni ran 0.0021 0.004 0.0038
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0082 0.1588
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.022 0.0202
Onchocerca volvulus 0.004 0.0269 0.3269
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.1132 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0204 0.1503
Trypanosoma brucei Metacaspase-4 0.0043 0.0305 1
Trypanosoma brucei metacaspase 0.0043 0.0305 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0216 0.0626
Schistosoma mansoni tar DNA-binding protein 0.0251 0.2824 0.477
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0362 0.0345
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0216 0.1912
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.022 0.6792
Echinococcus granulosus importin subunit beta 1 0.0028 0.0131 0.0192
Schistosoma mansoni lipoxygenase 0.0053 0.0433 0.0706
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.022 0.0343
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0137 0.0888
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.1986 0.3345
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0216 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1132 0.1894
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0216 0.6944
Plasmodium vivax hexose transporter 0.0111 0.1132 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0305 0.2424
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0137 0.0119
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0204 0.1503
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0018 0.016
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.064 0.0623
Brugia malayi hypothetical protein 0.004 0.0269 0.0896
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0216 0.0337
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.1132 0.1116
Loa Loa (eye worm) TAR-binding protein 0.0251 0.2824 0.8172
Onchocerca volvulus Cell death protein 3 homolog 0.0083 0.0787 1
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0216 0.0856
Entamoeba histolytica hypothetical protein 0.007 0.064 1
Brugia malayi PHD-finger family protein 0.0029 0.0137 0.0425
Schistosoma mansoni hypothetical protein 0.0103 0.1029 0.1719
Schistosoma mansoni caspase-7 (C14 family) 0.0113 0.1156 0.1934
Brugia malayi Bromodomain containing protein 0.0029 0.0137 0.0425
Schistosoma mansoni hypothetical protein 0.0047 0.0362 0.0585
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.064 0.1057
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0072 0.1194
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0204 0.6528
Schistosoma mansoni hypothetical protein 0.0505 0.5901 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0216 0.0337
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.1986 0.3345
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0883
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.004 0.0862
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.1132 0.1116
Mycobacterium ulcerans hypothetical protein 0.0023 0.0072 0.3322
Loa Loa (eye worm) hypothetical protein 0.0028 0.0131 0.0379
Loa Loa (eye worm) hypothetical protein 0.0029 0.0137 0.0397
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0216 0.0199
Brugia malayi RNA, U transporter 1 0.0081 0.0765 0.266
Plasmodium vivax metacaspase 1, putative 0.0043 0.0305 0.2694
Trypanosoma brucei glucose transporter, putative 0.0034 0.0204 0.62
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.022 0.7069
Plasmodium falciparum importin beta, putative 0.0028 0.0131 0.1158
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.022 0.0202
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.1029 0.3604
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0072 0.3322
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0305 0.2694
Trypanosoma brucei glucose transporter, putative 0.0034 0.0204 0.62
Echinococcus granulosus caspase 0.0113 0.1156 0.1934
Brugia malayi beta-lactamase family protein 0.0035 0.0216 0.0707
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.1604 0.5652
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0072 0.1194
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0362 0.1048
Entamoeba histolytica hypothetical protein 0.007 0.064 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0362 0.1048
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.004 0.0079
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.0269 0.0252
Trypanosoma brucei glucose transporter 1E 0.0034 0.0204 0.62
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0216 0.1614
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.022 0.1647
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.1986 0.3345
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0216 0.0856
Loa Loa (eye worm) RNA binding protein 0.0251 0.2824 0.8172
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.1986 0.1971
Schistosoma mansoni caspase-7 (C14 family) 0.0083 0.0787 0.1307
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0216 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.022 0.0343
Loa Loa (eye worm) hypothetical protein 0.0023 0.0072 0.0208
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0216 0.0626
Loa Loa (eye worm) hypothetical protein 0.0023 0.0072 0.0208
Schistosoma mansoni tar DNA-binding protein 0.0251 0.2824 0.477
Loa Loa (eye worm) hypothetical protein 0.0035 0.0216 0.0626
Brugia malayi Sugar transporter family protein 0.0111 0.1132 0.397
Mycobacterium ulcerans hypothetical protein 0.0035 0.0216 1
Plasmodium falciparum metacaspase-like protein 0.0043 0.0305 0.2694
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0216 0.0856
Echinococcus granulosus snurportin 1 0.0303 0.3456 0.5844
Loa Loa (eye worm) hypothetical protein 0.0083 0.0787 0.2277
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0072 0.3322
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0305 0.2424
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.0433 0.0416
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0362 0.0585
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0082 0.2313
Onchocerca volvulus Alhambra homolog 0.0029 0.0137 0.155
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.022 0.1647
Schistosoma mansoni hypothetical protein 0.004 0.0269 0.0427
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0204 0.62
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0305 0.2424
Brugia malayi jmjC domain containing protein 0.0035 0.0211 0.0687
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.1604 0.5652
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0305 0.2424
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.1265 0.366
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0131 0.0831
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0052
Schistosoma mansoni transcription factor LCR-F1 0.007 0.064 0.1057
Echinococcus multilocularis caspase 3 0.007 0.0638 0.0621
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0137 0.0203
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1132 0.1894
Echinococcus granulosus caspase 3 0.007 0.0638 0.1054
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0305 0.2424
Plasmodium vivax importin-beta 2, putative 0.0028 0.0131 0.1158
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0305 0.2424
Leishmania major metacaspase, putative 0.0043 0.0305 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.1986 0.3345
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0066 0.0236
Mycobacterium ulcerans lipase LipD 0.0035 0.0216 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0216 0.0626
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.022 0.0202
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0082 0.0385
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0216 0.0856
Loa Loa (eye worm) hypothetical protein 0.005 0.0387 0.1121
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0305 0.2424
Echinococcus multilocularis geminin 0.0505 0.5901 0.5893
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.022 0.6792
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.004 0.0862
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.022 0.0343
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0933 0.0917
Loa Loa (eye worm) hypothetical protein 0.0035 0.0216 0.0626
Echinococcus multilocularis peregrin 0.0029 0.0137 0.0119
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0211 0.0328
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0072 0.3322
Onchocerca volvulus 0.0035 0.0216 0.258
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0182 0.1986 0.7012
Trypanosoma brucei glucose transporter, putative 0.0034 0.0204 0.62
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0211 0.061
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0305 0.2424
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.022 0.7069
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.1604 0.4642
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0204 0.62
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0305 0.2424
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0072 0.0284
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.022 0.2997
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0305 1
Echinococcus multilocularis caspase 2 0.0083 0.0787 0.077
Loa Loa (eye worm) hypothetical protein 0.0103 0.1029 0.2978
Brugia malayi hypothetical protein 0.0024 0.0082 0.0229
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0182 0.1986 0.5746
Trypanosoma cruzi metacaspase, putative 0.0043 0.0305 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0362 0.0585
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0305 0.2424
Onchocerca volvulus 0.0035 0.0216 0.258
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0251 0.2824 0.8172
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0072 0.1194
Leishmania major hypothetical protein, conserved 0.0035 0.0216 0.6656
Trypanosoma brucei glucose transporter, putative 0.0034 0.0204 0.62
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0 0.5
Schistosoma mansoni importin beta-1 0.0028 0.0131 0.0192
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0082 0.0727
Trypanosoma cruzi metacaspase, putative 0.0043 0.0305 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0216 0.0856
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0072 0.3322
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0362 0.0345
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0204 0.6528
Leishmania major hypothetical protein, conserved 0.0024 0.0082 0.1588
Plasmodium falciparum metacaspase 1 0.0043 0.0305 0.2694
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0204 0.62
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0305 0.2424
Schistosoma mansoni hypothetical protein 0.0505 0.5901 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0216 0.0626
Trypanosoma brucei glucose transporter 2A 0.0034 0.0204 0.62
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.004 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0072 0.3322
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0204 0.1503
Brugia malayi RNA recognition motif domain containing protein 0.0251 0.2824 1
Echinococcus granulosus geminin 0.0505 0.5901 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.1132 0.1116
Mycobacterium leprae Probable lipase LipE 0.0035 0.0216 1
Onchocerca volvulus 0.0035 0.0216 0.258
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.051 0.1475
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0216 0.0337
Trypanosoma brucei metacaspase MCA3 0.0043 0.0305 1
Trichomonas vaginalis esterase, putative 0.0035 0.0216 0.1614
Echinococcus multilocularis General substrate transporter 0.0095 0.0943 0.0927
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0111 0.1132 0.1116
Brugia malayi TAR-binding protein 0.0251 0.2824 1
Trypanosoma brucei glucose transporter, putative 0.0034 0.0204 0.62
Schistosoma mansoni hypothetical protein 0.007 0.064 0.1057
Entamoeba histolytica hypothetical protein 0.0023 0.0066 0.0429
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0018 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.1986 0.3345
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.0204 0.62
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0216 0.0856
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.004 0.0117
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0137 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0204 0.1503
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.0269 0.0427
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0066 0.175
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0211 0.0328
Schistosoma mansoni hypothetical protein 0.0047 0.0362 0.0585
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0082 0.0727
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0305 0.2424
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2529 1
Trypanosoma cruzi metacaspase, putative 0.0043 0.0305 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0211 0.0193
Brugia malayi RNA binding protein 0.0251 0.2824 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.004 0.0356
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0933 0.1556
Brugia malayi MH2 domain containing protein 0.0122 0.1265 0.4443
Onchocerca volvulus 0.0023 0.0072 0.07
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0066 0.0236
Brugia malayi jmjC domain containing protein 0.0095 0.0933 0.3262
Echinococcus multilocularis caspase 0.0113 0.1156 0.114
Mycobacterium tuberculosis Conserved protein 0.0035 0.0216 0.0856
Echinococcus granulosus caspase 2 0.0083 0.0787 0.1307
Echinococcus granulosus GPCR family 2 0.0047 0.0362 0.0585
Mycobacterium tuberculosis Conserved protein 0.0035 0.0216 0.0856
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0204 0.1503
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0137 0.1213
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0137 0.0397
Loa Loa (eye worm) sugar transporter 0.0111 0.1132 0.3276
Schistosoma mansoni tar DNA-binding protein 0.0251 0.2824 0.477
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.004 0.0269 0.078
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0274 0.0257
Schistosoma mansoni hypothetical protein 0.0303 0.3456 0.5844
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.0433 0.0706
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0072 0.0192
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0216 0.1614
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0238
Loa Loa (eye worm) hypothetical protein 0.0035 0.0216 0.0626
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0072 0.0527
Brugia malayi Importin beta-1 subunit 0.0028 0.0131 0.0402
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0216 1
Trypanosoma brucei metacaspase 5, putative 0.0043 0.0305 1
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0362 0.1226
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0216 0.6656
Echinococcus granulosus caspase 8 0.0043 0.0305 0.0488
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0362 0.1226
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0216 0.0707
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0072 0.3322
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0305 1
Trypanosoma brucei glucose transporter, putative 0.0034 0.0204 0.62
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0305 0.2424
Brugia malayi hypothetical protein 0.007 0.064 0.2217
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0131 0.0113
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0698 0.1155
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0082 0.2313
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0305 0.2424
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0637
Schistosoma mansoni glucose transport protein 0.0111 0.1132 0.1894
Schistosoma mansoni glucose transport protein 0.0111 0.1132 0.1894
Loa Loa (eye worm) hypothetical protein 0.0035 0.0216 0.0626
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.1986 0.1971
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.004 0.0356
Echinococcus multilocularis GPCR, family 2 0.0047 0.0362 0.0345
Leishmania major glucose transporter, lmgt1 0.0034 0.0204 0.62
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0072 0.0527
Echinococcus granulosus jumonji domain containing protein 0.004 0.0274 0.0436
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1132 0.1894
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0216 0.0856
Entamoeba histolytica hypothetical protein 0.007 0.064 1
Trypanosoma brucei glucose transporter, putative 0.0034 0.0204 0.62
Trypanosoma brucei glucose transporter, putative 0.0034 0.0204 0.62
Giardia lamblia PHD finger protein 15 0.0029 0.0137 0.5393
Echinococcus granulosus peregrin 0.0029 0.0137 0.0203
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.022 0.0343
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0216 0.1614
Mycobacterium ulcerans beta-lactamase 0.0035 0.0216 1
Loa Loa (eye worm) hypothetical protein 0.015 0.1604 0.4642
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0216 0.6944
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.022 0.1647
Schistosoma mansoni caspase-3 (C14 family) 0.0113 0.1156 0.1934
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0216 0.1614
Echinococcus multilocularis tar DNA binding protein 0.0251 0.2824 0.2811
Schistosoma mansoni tar DNA-binding protein 0.0251 0.2824 0.477
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.3456 1
Brugia malayi beta-lactamase 0.0035 0.0216 0.0707
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0072 0.0284
Plasmodium falciparum phd finger protein, putative 0.0029 0.0137 0.1213
Toxoplasma gondii facilitative glucose transporter GT1 0.0111 0.1132 1
Trypanosoma cruzi metacaspase, putative 0.0043 0.0305 1
Echinococcus multilocularis caspase 8 0.0043 0.0305 0.0287
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0113 0.1156 0.1934
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.022 0.072
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0131 0.3428
Schistosoma mansoni tar DNA-binding protein 0.0251 0.2824 0.477
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0131 0.3428
Plasmodium falciparum hexose transporter 0.0111 0.1132 1
Schistosoma mansoni hypothetical protein 0.0047 0.0362 0.0585
Echinococcus granulosus General substrate transporter 0.0095 0.0943 0.1572
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0204 0.1503
Leishmania major importin beta-1 subunit, putative 0.0023 0.0066 0.0972
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.022 0.0343
Entamoeba histolytica hypothetical protein 0.007 0.064 1
Brugia malayi Cell death protein 3 precursor 0.0083 0.0787 0.274
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0072 0.3322
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0018 0.016
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0082 0.0727
Trypanosoma cruzi hexose transporter 0.0034 0.0204 0.6528
Schistosoma mansoni hypothetical protein 0.0047 0.0362 0.0585
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0052
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0072 0.0527
Leishmania major glucose transporter, lmgt2 0.0034 0.0204 0.62
Loa Loa (eye worm) hypothetical protein 0.0023 0.0072 0.0208
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0305 0.2424
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0043 0.0305 0.0488
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0216 0.1614
Leishmania major glucose transporter, lmgt3 0.0034 0.0204 0.62
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0043 0.0305 0.1022
Trypanosoma brucei metacaspase MCA2 0.0043 0.0305 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1132 0.1894
Brugia malayi beta-lactamase family protein 0.0035 0.0216 0.0707
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0113 0.1156 0.114
Mycobacterium tuberculosis Conserved protein 0.0035 0.0216 0.0856
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.022 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0072 0.0192
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0211 0.0328
Schistosoma mansoni hypothetical protein 0.0029 0.0137 0.0203
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0072 0.0192
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0305 0.2424
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0204 0.6528
Schistosoma mansoni hypothetical protein 0.0111 0.1132 0.1894
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0305 0.2424
Schistosoma mansoni ran 0.0021 0.004 0.0038
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0066 0.0236
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0305 0.2424
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.1265 0.366
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0204 0.1503

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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