Detailed information for compound 556717

Basic information

Technical information
  • TDR Targets ID: 556717
  • Name: N-(4-butoxyphenyl)propanamide
  • MW: 221.295 | Formula: C13H19NO2
  • H donors: 1 H acceptors: 1 LogP: 2.79 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOc1ccc(cc1)NC(=O)CC
  • InChi: 1S/C13H19NO2/c1-3-5-10-16-12-8-6-11(7-9-12)14-13(15)4-2/h6-9H,3-5,10H2,1-2H3,(H,14,15)
  • InChiKey: JJPRZFHZWKTLJB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-butoxyphenyl)propionamide
  • 3(4-butoxyphenyl)propionamide
  • 27817-15-8
  • ZINC01787819
  • 3-(4-Butoxyphenyl)propionamide
  • BOPPA
  • Propanamide, N-(4-butoxyphenyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni thyroid hormone receptor 0.002 0.0152 0.0161
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0349 0.4139
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.0039 0.0021
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0019 0.002
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0364 0.0364
Plasmodium falciparum importin beta, putative 0.0058 0.0633 1
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0349 0.113
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0141
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0152 0.0161
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0788 0.5414
Echinococcus granulosus importin subunit beta 1 0.0058 0.0633 0.067
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0152 0.0161
Loa Loa (eye worm) hypothetical protein 0.0067 0.0745 0.0771
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0788 0.2731
Mycobacterium tuberculosis Conserved protein 0.0071 0.0788 0.0776
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0043 0.0439 0.5349
Schistosoma mansoni cpg binding protein 0.0029 0.0268 0.0284
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.027 0.027
Brugia malayi Excitatory amino acid transporter 0.076 0.9442 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0788 0.0816
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0019 0.002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0141
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0059 0.0059
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0019 0.0019
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.1126 1
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0059 0.015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0015
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0019 0.002
Brugia malayi Pre-SET motif family protein 0.0029 0.027 0.0268
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0033 0.0017
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0364 0.4346
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2432 0.2561
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0349 0.0369
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0152 0.0143
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0083 0.0947 0.5767
Plasmodium vivax importin-beta 2, putative 0.0058 0.0633 0.7932
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1136 0.1185
Echinococcus multilocularis translational activator gcn1 0.0011 0.0039 0.0039
Echinococcus multilocularis GPCR, family 2 0.0031 0.0291 0.0291
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.1404 0.1434
Schistosoma mansoni nuclear hormone receptor 0.002 0.0152 0.0161
Onchocerca volvulus Excitatory amino acid transporter homolog 0.076 0.9442 1
Echinococcus granulosus dnaJ subfamily B 0.0395 0.4861 0.5148
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0349 0.7616
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0019 0.002
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0019 0.002
Schistosoma mansoni ran 0.0043 0.0439 0.0465
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0019 0.002
Brugia malayi CXXC zinc finger family protein 0.0028 0.0248 0.0246
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0291 0.0291
Plasmodium falciparum glutathione reductase 0.0013 0.0059 0.0344
Echinococcus granulosus FTZ F1 alpha 0.002 0.0152 0.0161
Echinococcus multilocularis excitatory amino acid transporter 2 0.076 0.9442 0.9442
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0152 0.0161
Schistosoma mansoni importin beta-1 0.0058 0.0633 0.067
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0059 0.0075
Echinococcus granulosus neutral amino acid transporter 0.076 0.9442 1
Mycobacterium ulcerans beta-lactamase 0.0071 0.0788 0.5414
Brugia malayi RNA, U transporter 1 0.0166 0.1983 0.2086
Toxoplasma gondii thioredoxin reductase 0.0037 0.0359 0.2345
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0019 0.0002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0788 0.0818
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.1404 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0364 0.0366
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0494 0.5972
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0152 0.0161
Schistosoma mansoni hypothetical protein 0.0067 0.0745 0.0789
Loa Loa (eye worm) hypothetical protein 0.0042 0.0426 0.0432
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0015
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0043 0.0439 0.0448
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0141
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0059 0.015
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0083 0.0947 0.0946
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0364 0.4187
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.1404 1
Echinococcus granulosus translational activator gcn1 0.0011 0.0039 0.0041
Treponema pallidum glutamate/aspartate transporter 0.0337 0.4129 1
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0337 0.4129 0.4373
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0019 0.0002
Onchocerca volvulus 0.0071 0.0788 0.0816
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0043 0.0439 0.0446
Brugia malayi glutathione reductase 0.0037 0.0359 0.0363
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0019 0.002
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0043 0.0439 0.5349
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0152 0.0141
Schistosoma mansoni hypothetical protein 0.004 0.0407 0.0431
Plasmodium vivax SET domain protein, putative 0.0029 0.027 0.3086
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0152 0.0161
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0494 0.1661
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0788 0.0776
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0337 0.4129 0.4129
Schistosoma mansoni hypothetical protein 0.0031 0.0291 0.0308
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0083 0.0947 0.0946
Schistosoma mansoni hypothetical protein 0.0031 0.0291 0.0308
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0291 0.0289
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.4861 0.4861
Loa Loa (eye worm) hypothetical protein 0.0051 0.0545 0.0558
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0019 0.002
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0152 0.0161
Echinococcus multilocularis snurportin 1 0.0623 0.772 0.772
Brugia malayi Importin beta-1 subunit 0.0058 0.0633 0.0653
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.1063 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0158 0.1883 0.1978
Schistosoma mansoni ap endonuclease 0.0037 0.0364 0.0386
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0152 0.0152
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0788 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0083 0.0947 0.0946
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0426 0.0452
Brugia malayi conserved hypotetical protein 0.0009 0.0019 0.0002
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0426 0.0432
Echinococcus granulosus geminin 0.0167 0.2001 0.2119
Schistosoma mansoni importin-beta 2 0.0011 0.0039 0.0041
Loa Loa (eye worm) hypothetical protein 0.0071 0.0788 0.0816
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0019 0.0019
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0349 0.0369
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0152 0.0143
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.027 0.027
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0019 0.002
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0349 0.113
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.104 0.1101
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0033 0.0035
Brugia malayi beta-lactamase family protein 0.0071 0.0788 0.0818
Brugia malayi nuclear receptor NHR-88 0.0009 0.0019 0.0002
Onchocerca volvulus 0.0071 0.0788 0.0816
Mycobacterium tuberculosis Probable reductase 0.0083 0.0947 0.0946
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0788 0.0788
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0788 0.2731
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.104 0.1083
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0033 0.0015
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0152 0.0141
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0019 0.002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.104 0.1101
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.1063 0.107
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0152 0.0143
Entamoeba histolytica hypothetical protein 0.0047 0.0494 0.4187
Schistosoma mansoni hypothetical protein 0.004 0.0407 0.0431
Plasmodium falciparum glutathione reductase 0.0037 0.0359 0.5391
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0364 0.2992
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.1126 0.1193
Treponema pallidum glutamate transporter 0.0337 0.4129 1
Loa Loa (eye worm) histone methyltransferase 0.001 0.0021 0.0002
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0452 0.5569 0.5873
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0349 0.3974
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0291 0.0308
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0152 0.0143
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.076 0.9442 1
Brugia malayi nuclear receptor NHR-88 0.002 0.0152 0.0143
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.027 0.1692
Mycobacterium tuberculosis Conserved protein 0.0071 0.0788 0.0776
Schistosoma mansoni hypothetical protein 0.0031 0.0291 0.0308
Schistosoma mansoni thyroid hormone receptor 0.002 0.0152 0.0161
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0152 0.0141
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0015
Schistosoma mansoni hypothetical protein 0.0167 0.2001 0.2119
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0152 0.0143
Brugia malayi Muscleblind-like protein 0.0158 0.1883 0.198
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0365 0.0387
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0059 0.0344
Schistosoma mansoni nuclear receptor 0.0009 0.0019 0.002
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0152 0.0141
Trichomonas vaginalis set domain proteins, putative 0.0229 0.278 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0633 0.0651
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0152 0.0143
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0788 0.0834
Schistosoma mansoni ran 0.0043 0.0439 0.0465
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0033 0.0017
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0248 0.0244
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0152 0.0161
Echinococcus granulosus importin 5 0.0011 0.0039 0.0041
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0788 0.0776
Echinococcus multilocularis sodium:dicarboxylate symporter 0.076 0.9442 0.9442
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.027 0.0286
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0021 0.0022
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0426 0.0426
Schistosoma mansoni coup transcription factor 0.002 0.0152 0.0161
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0788 1
Trichomonas vaginalis esterase, putative 0.0071 0.0788 0.2731
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.1404 1
Echinococcus multilocularis Excitatory amino acid transporter 0.076 0.9442 0.9442
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0152 0.0161
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0059 0.0045
Echinococcus multilocularis muscleblind protein 0.0158 0.1883 0.1883
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0788 0.0834
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0015
Loa Loa (eye worm) hypothetical protein 0.0036 0.0349 0.035
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0745 0.0772
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0021 0.0021
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0059 0.015
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.1653 0.1653
Plasmodium falciparum thioredoxin reductase 0.0037 0.0359 0.5391
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0059 0.015
Brugia malayi hypothetical protein 0.0009 0.0019 0.0002
Leishmania major GTP-binding protein, putative 0.0043 0.0439 0.2933
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0364 0.2267
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0083 0.0947 0.0946
Trichomonas vaginalis ran, putative 0.0043 0.0439 0.1461
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0349 0.0369
Onchocerca volvulus 0.0029 0.027 0.0266
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0788 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0059 0.0344
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0152 0.0143
Mycobacterium tuberculosis Conserved protein 0.0071 0.0788 0.0776
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0652 0.0691
Brugia malayi hypothetical protein 0.0011 0.0033 0.0017
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0043 0.0439 0.6744
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.0266
Chlamydia trachomatis neutral amino acid transporter 0.0337 0.4129 0.4338
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0043 0.0439 0.0439
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0349 0.113
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0291 0.0291
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0019 0.0002
Loa Loa (eye worm) hypothetical protein 0.0098 0.1136 0.1185
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0059 0.0273
Echinococcus granulosus Excitatory amino acid transporter 0.076 0.9442 1
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0019 0.0002
Loa Loa (eye worm) beta-lactamase 0.0071 0.0788 0.0816
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0365 0.0365
Leishmania major importin beta-1 subunit, putative 0.0047 0.0494 0.3335
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0364 0.8024
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0152 0.0161
Echinococcus granulosus neutral amino acid transporter A 0.076 0.9442 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0019 0.0019
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.8454 0.8454
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0633 0.7932
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.027 0.0286
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0359 0.0361
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.1126 0.1126
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0043 0.0439 0.2933
Echinococcus multilocularis excitatory amino acid transporter 3 0.076 0.9442 0.9442
Mycobacterium tuberculosis Probable dehydrogenase 0.0083 0.0947 0.0946
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0291 0.0308
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.1653 0.175
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0152 0.0143
Schistosoma mansoni hypothetical protein 0.0167 0.2001 0.2119
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0152 0.0161
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0152 0.0141
Echinococcus granulosus transportin 1 0.0011 0.0039 0.0041
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0349 0.0369
Schistosoma mansoni hypothetical protein 0.0031 0.0291 0.0308
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0152 0.0152
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.8454 0.8954
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0019 0.0002
Schistosoma mansoni nuclear receptor 0.0009 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.0071 0.0788 0.0816
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0152 0.0141
Onchocerca volvulus 0.0229 0.278 0.2931
Schistosoma mansoni hypothetical protein 0.0623 0.772 0.8176
Schistosoma mansoni cpg binding protein 0.0028 0.0248 0.0263
Echinococcus multilocularis protein patched 0.0042 0.0426 0.0426
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0059 0.0273
Echinococcus granulosus expressed conserved protein 0.0092 0.1052 0.1114
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0059 0.0273
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0349 0.3974
Brugia malayi nuclear receptor NHR-67 0.0009 0.0019 0.0002
Echinococcus multilocularis neutral amino acid transporter A 0.076 0.9442 0.9442
Schistosoma mansoni hypothetical protein 0.004 0.0407 0.0431
Echinococcus granulosus GPCR family 2 0.0031 0.0291 0.0308
Plasmodium vivax glutathione reductase, putative 0.0037 0.0359 0.4276
Schistosoma mansoni patched 1 0.0042 0.0426 0.0452
Brugia malayi beta-lactamase 0.0071 0.0788 0.0818
Brugia malayi CHE-14 protein 0.0042 0.0426 0.0434
Loa Loa (eye worm) hypothetical protein 0.0071 0.0788 0.0816
Echinococcus multilocularis geminin 0.0167 0.2001 0.2001
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0141
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.1145 0.1213
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0364 0.0325
Toxoplasma gondii HEAT repeat-containing protein 0.0058 0.0633 0.4349
Brugia malayi Pre-SET motif family protein 0.0202 0.2432 0.2562
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0152 0.0152
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.1404 1
Chlamydia trachomatis glutamate symporter 0.076 0.9442 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0349 0.0349
Brugia malayi nuclear hormone receptor 0.0009 0.0019 0.0002
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.002 0.0003
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.1404 0.1404
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0059 0.0273
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0152 0.0152
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0019 0.002
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0788 0.0776
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.104 0.1085
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0788 0.0776
Echinococcus granulosus excitatory amino acid transporter 3 0.076 0.9442 1
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0426 0.0452
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.0039 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0152 0.0143
Loa Loa (eye worm) hypothetical protein 0.0071 0.0788 0.0816
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0573 0.3915
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0788 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0349 0.0352
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0059 0.0063
Brugia malayi nuclear hormone receptor 0.002 0.0152 0.0143
Loa Loa (eye worm) hypothetical protein 0.0031 0.0291 0.0289
Mycobacterium ulcerans lipase LipD 0.0071 0.0788 0.5414
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0788 0.0776
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0494 0.1661
Echinococcus granulosus cpg binding protein 0.0029 0.0268 0.0284
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0152 0.0141
Echinococcus multilocularis neutral amino acid transporter A 0.076 0.9442 0.9442
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0019 0.0019
Brugia malayi nuclear receptor RXR 0.0011 0.0033 0.0017
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0152 0.0161
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.104 0.104
Echinococcus multilocularis expressed conserved protein 0.0092 0.1052 0.1052
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1136 0.1187
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.1126 0.1177
Brugia malayi tailless protein 0.0009 0.0019 0.0002
Echinococcus multilocularis importin subunit beta 1 0.0058 0.0633 0.0633
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.1063 0.107
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0364 0.0386
Echinococcus multilocularis Excitatory amino acid transporter 0.076 0.9442 0.9442
Echinococcus multilocularis excitatory amino acid transporter 2 0.076 0.9442 0.9442
Loa Loa (eye worm) hypothetical protein 0.0098 0.1126 0.1175
Echinococcus granulosus snurportin 1 0.0623 0.772 0.8176
Echinococcus granulosus muscleblind protein 0.0158 0.1883 0.1995
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0152 0.0143
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.027 0.0286
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0059 0.0273
Trypanosoma brucei trypanothione reductase 0.0037 0.0359 0.4276
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0349 0.0369
Echinococcus granulosus excitatory amino acid transporter 2 0.076 0.9442 1
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0359 0.4276
Onchocerca volvulus 0.0071 0.0788 0.0816
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0152 0.0141
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0623 0.772 0.8172
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0152 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0152 0.0143
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0337 0.4129 0.4373
Brugia malayi ecdysone receptor 0.0009 0.0019 0.0002
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0152 0.0152
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0152 0.0161
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0152 0.0141
Brugia malayi kap beta 3 protein 0.0011 0.0039 0.0023
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0152 0.0161
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0349 0.2849
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0152 0.0152
Brugia malayi ecdysteroid receptor 0.002 0.0152 0.0143
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0019 0.0019
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0152 0.0161
Echinococcus granulosus GTP binding nuclear protein Ran 0.0043 0.0439 0.0465
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0249 0.0264
Brugia malayi hypothetical protein 0.0011 0.0033 0.0017
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0364 0.1187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.104 0.1101
Brugia malayi steroid hormone receptor 0.002 0.0152 0.0143
Toxoplasma gondii exonuclease III APE 0.0037 0.0364 0.2383
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0788 0.2731
Brugia malayi nuclear receptor RXR 0.0009 0.0019 0.0002
Brugia malayi beta-lactamase family protein 0.0071 0.0788 0.0818
Echinococcus multilocularis importin 5 0.0011 0.0039 0.0039
Toxoplasma gondii ABC1 family protein 0.0071 0.0788 0.5483
Schistosoma mansoni zinc finger protein 0.0009 0.0019 0.002
Onchocerca volvulus 0.0028 0.0248 0.0244
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0788 0.2731
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.104 0.1101
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0788 0.0834
Schistosoma mansoni hypothetical protein 0.004 0.0407 0.0431
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0033 0.0035
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.076 0.9442 0.9442
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0788 0.0816
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0059 0.015
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0439 0.5219
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0359 0.032
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0141
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0494 0.1661
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0152 0.0143
Echinococcus granulosus microtubule associated protein 2 0.0681 0.8454 0.8954
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0152 0.0152
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0291 0.0291
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.076 0.9442 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.1404 0.1487
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0033 0.0033
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.104 0.104
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0033 0.0035
Mycobacterium ulcerans hypothetical protein 0.0071 0.0788 0.5414
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0364 0.4346
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0019 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0152 0.0141
Leishmania major trypanothione reductase 0.0037 0.0359 0.2345
Echinococcus granulosus excitatory amino acid transporter 2 0.076 0.9442 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0059 0.0273
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0152 0.0141
Schistosoma mansoni ap endonuclease 0.0037 0.0364 0.0386
Brugia malayi hypothetical protein 0.0009 0.0019 0.0002
Plasmodium falciparum thioredoxin reductase 0.0013 0.0059 0.0344
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.1404 0.1487
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0019 0.0019
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0788 0.0776
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0349 0.0349
Brugia malayi Thioredoxin reductase 0.0037 0.0359 0.0363
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0152 0.0143
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0349 0.2269
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0152 0.0152
Echinococcus granulosus Excitatory amino acid transporter 0.076 0.9442 1
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0788 0.0776
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0364 0.1187
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0141
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.1063 0.107
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.076 0.9442 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.027 0.0286
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0364 0.0325
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0364 0.0749
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0152 0.0161
Onchocerca volvulus 0.002 0.0152 0.0141
Echinococcus multilocularis transportin 1 0.0011 0.0039 0.0039
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0364 0.5479
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0059 0.015
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0633 0.7932
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0426 0.1414
Echinococcus multilocularis muscleblind protein 1 0.0158 0.1883 0.1883
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0439 0.5219
Schistosoma mansoni hypothetical protein 0.0395 0.4861 0.5148
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0364 0.0368
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0152 0.0143
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0152 0.0143
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.1404 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0152 0.0161
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0364 0.4187
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0141
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0043 0.0439 1
Loa Loa (eye worm) glutathione reductase 0.0037 0.0359 0.0361
Echinococcus multilocularis protein dispatched 1 0.0048 0.0501 0.0501
Loa Loa (eye worm) excitatory amino acid transporter 0.076 0.9442 1
Schistosoma mansoni cpg binding protein 0.0029 0.0268 0.0284
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.104 0.1101
Leishmania major hypothetical protein, conserved 0.0071 0.0788 0.5483
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1136 0.1187
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0359 0.4116
Echinococcus granulosus neutral amino acid transporter A 0.076 0.9442 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0364 0.2383
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.027 0.0286
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0059 0.0075
Loa Loa (eye worm) hypothetical protein 0.0158 0.1883 0.1978
Echinococcus multilocularis neutral amino acid transporter A 0.076 0.9442 0.9442
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0788 0.5414
Loa Loa (eye worm) hypothetical protein 0.0071 0.0788 0.0816
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0152 0.0161
Entamoeba histolytica Ran family GTPase 0.0043 0.0439 0.3683
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0788 0.2731
Echinococcus multilocularis cpg binding protein 0.0029 0.0268 0.0268
Echinococcus granulosus sodium:dicarboxylate symporter 0.076 0.9442 1
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.1404 0.1487
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0337 0.4129 0.4129
Loa Loa (eye worm) hypothetical protein 0.0011 0.0033 0.0015
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0059 0.0063

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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