Detailed information for compound 556722

Basic information

Technical information
  • TDR Targets ID: 556722
  • Name: 1-chloro-4,6-dioxo-1,3,5-triazin-2-olate chlo ride
  • MW: 197.964 | Formula: C3HCl2N3O3--
  • H donors: 1 H acceptors: 3 LogP: 1.4 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]c1nc(=O)[nH]c(=O)n1Cl.[Cl-]
  • InChi: 1S/C3H2ClN3O3.ClH/c4-7-2(9)5-1(8)6-3(7)10;/h(H2,5,6,8,9,10);1H/p-2
  • InChiKey: VSQXPKKOXCTXLW-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

  • 1-chloro-4,6-diketo-s-triazin-2-olate chloride
  • troclosene

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0012 0.02 0.1422
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0148 0.042
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0456 0.0441
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0456 0.0369
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0456 0.6325
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0074 0.1545
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0456 0.0441
Schistosoma mansoni DNA helicase recq1 0.001 0.0148 0.0133
Loa Loa (eye worm) hypothetical protein 0.0012 0.02 0.061
Brugia malayi nuclear receptor NHR-88 0.0011 0.017 0.0799
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.017 0.0799
Brugia malayi nuclear receptor NHR-67 0.0011 0.017 0.0799
Onchocerca volvulus 0.0022 0.0456 0.6325
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0456 0.0369
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0456 0.6619
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.02 0.0185
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.017 0.0799
Loa Loa (eye worm) hypothetical protein 0.0011 0.017 0.0498
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0148 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0074 0.1545
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0133 0.0044
Loa Loa (eye worm) hypothetical protein 0.0022 0.0456 0.1544
Loa Loa (eye worm) hypothetical protein 0.0022 0.0456 0.1544
Brugia malayi hypothetical protein 0.0011 0.017 0.0799
Brugia malayi conserved hypotetical protein 0.0011 0.017 0.0799
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.02 0.1422
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0011 0.017 0.0498
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0074 0.1545
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0456 0.0369
Loa Loa (eye worm) hypothetical protein 0.0011 0.017 0.0498
Loa Loa (eye worm) hypothetical protein 0.0011 0.017 0.0498
Echinococcus multilocularis dnaJ subfamily B 0.0419 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0074 0.1545
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0456 0.0369
Echinococcus granulosus bloom syndrome protein 0.0024 0.0481 0.0395
Loa Loa (eye worm) hypothetical protein 0.0011 0.017 0.0498
Brugia malayi Nuclear hormone receptor E75 0.0011 0.017 0.0799
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0074 0.1545
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.02 0.0185
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0456 0.0441
Brugia malayi nuclear receptor RXR 0.0012 0.02 0.1422
Brugia malayi nuclear receptor RXR 0.0011 0.017 0.0799
Trichomonas vaginalis helicase, putative 0.0007 0.0074 0.1545
Loa Loa (eye worm) hypothetical protein 0.0011 0.017 0.0498
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0481 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0074 0.1545
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0456 0.0369
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0456 0.1544
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.017 0.0799
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0074 0.1545
Schistosoma mansoni cpg binding protein 0.0031 0.0662 0.0648
Brugia malayi steroid hormone receptor 0.0022 0.0456 0.6619
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0456 0.6619
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0456 0.0441
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0074 0.1545
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0456 0.1544
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.017 0.008
Onchocerca volvulus 0.0029 0.0622 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0456 0.1544
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0456 0.0369
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0074 0.1545
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.02 0.061
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.017 0.008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.009 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0074 0.1545
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.017 0.008
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.017 0.008
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0456 0.0441
Brugia malayi hypothetical protein 0.0012 0.02 0.1422
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0362 0.0347
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0217 0.5
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0148 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0456 0.6619
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0456 0.6619
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0456 0.6619
Loa Loa (eye worm) hypothetical protein 0.0011 0.017 0.0498
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0456 0.6619
Schistosoma mansoni nuclear receptor 0.0011 0.017 0.0154
Schistosoma mansoni nuclear receptor 0.0011 0.017 0.0154
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.017 0.008
Loa Loa (eye worm) hypothetical protein 0.0011 0.017 0.0498
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0456 0.1544
Treponema pallidum ATP-dependent DNA helicase 0.0005 0.0033 0.5
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.02 0.0111
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0456 0.0441
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0456 0.0369
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0622 0.2152
Loa Loa (eye worm) nuclear hormone receptor 0.0011 0.017 0.0498
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0074 0.1545
Loa Loa (eye worm) hypothetical protein 0.0011 0.017 0.0498
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1256 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0456 0.1544
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0481 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0456 0.1544
Brugia malayi nuclear receptor NHR-88 0.0022 0.0456 0.6619
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0297 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.02 0.061
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0148 0.0059
Loa Loa (eye worm) hypothetical protein 0.0118 0.2769 1
Brugia malayi tailless protein 0.0011 0.017 0.0799
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0456 0.6619
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0148 0.0363
Schistosoma mansoni DNA helicase recq5 0.001 0.0148 0.0133
Loa Loa (eye worm) nuclear receptor NHR-67 0.0011 0.017 0.0498
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0456 0.6325
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0456 0.0441
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0074 0.1545
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0148 0.0059
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0148 0.0363
Loa Loa (eye worm) RecQ helicase 0.0024 0.0481 0.1637
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0148 0.0939
Schistosoma mansoni zinc finger protein 0.0011 0.017 0.0154
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0456 0.0369
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0456 0.0369
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1416 0.1403
Brugia malayi CXXC zinc finger family protein 0.0029 0.0622 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0456 0.0441
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0456 0.6619
Loa Loa (eye worm) hypothetical protein 0.0022 0.0456 0.1544
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0456 0.6619
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0217 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0456 0.0369
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0456 0.1544
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0217 0.5
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0133 0.0365
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0074 0.1545
Brugia malayi Nuclear hormone receptor E75 0.0011 0.017 0.0799
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0456 0.0441
Loa Loa (eye worm) hypothetical protein 0.0011 0.017 0.0498
Loa Loa (eye worm) hypothetical protein 0.0011 0.017 0.0498
Loa Loa (eye worm) hypothetical protein 0.0011 0.017 0.0498
Echinococcus granulosus cpg binding protein 0.0031 0.0662 0.0578
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0293 0.2124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0456 0.1544
Schistosoma mansoni blooms syndrome DNA helicase 0.0005 0.0033 0.0018
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.017 0.008
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.02 0.1422
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0148 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0456 0.0369
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0456 0.6619
Loa Loa (eye worm) hypothetical protein 0.0012 0.02 0.061
Schistosoma mansoni nuclear hormone receptor 0.0011 0.017 0.0154
Loa Loa (eye worm) hypothetical protein 0.001 0.0148 0.042
Loa Loa (eye worm) hypothetical protein 0.0012 0.02 0.061
Loa Loa (eye worm) hypothetical protein 0.0022 0.0456 0.1544
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.017 0.008
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.017 0.0799
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0456 0.0369
Loa Loa (eye worm) hypothetical protein 0.0012 0.02 0.061
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0011 0.017 0.0154
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0148 0.0939
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0456 0.6619
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0456 0.0369
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0074 0.1545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0456 0.1544
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0456 0.0369
Schistosoma mansoni nuclear receptor nhr-48 0.0011 0.017 0.0154
Brugia malayi nuclear hormone receptor 0.0011 0.017 0.0799
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0456 0.0441
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0217 1
Schistosoma mansoni hypothetical protein 0.0419 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0456 0.6619
Loa Loa (eye worm) hypothetical protein 0.0011 0.017 0.0498
Loa Loa (eye worm) DR-78 0.0011 0.017 0.0498
Loa Loa (eye worm) hypothetical protein 0.0022 0.0456 0.1544
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0456 0.6619
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0004 0.000000000096553 0.0000000020067
Brugia malayi nuclear hormone receptor 0.0022 0.0456 0.6619
Schistosoma mansoni cpg binding protein 0.0031 0.0662 0.0648
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0456 0.0441
Schistosoma mansoni nuclear hormone receptor 0.0011 0.017 0.0154
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0481 1
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0456 0.6619
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0412 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.017 0.008
Entamoeba histolytica recQ family DNA helicase 0.0005 0.0033 0.0241
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0074 0.1545
Brugia malayi ecdysteroid receptor 0.0022 0.0456 0.6619
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.017 0.008
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0456 0.0441
Brugia malayi ecdysone receptor 0.0011 0.017 0.0799
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0133 0.0044
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0217 0.4509
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0481 0.7135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0456 0.1544
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.017 0.008
Loa Loa (eye worm) hypothetical protein 0.0011 0.017 0.0498
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0456 0.0369
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0011 0.017 0.0154
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0456 0.0369
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0456 0.0369
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0456 0.6325
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0456 0.0369
Schistosoma mansoni coup transcription factor 0.0022 0.0456 0.0441
Echinococcus multilocularis cpg binding protein 0.0031 0.0662 0.0578
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0456 0.6619
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0074 0.1545
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.02 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0456 0.6619
Brugia malayi hypothetical protein 0.0011 0.017 0.0799
Loa Loa (eye worm) hypothetical protein 0.0022 0.0456 0.1544
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.017 0.008
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.017 0.008
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0074 0.1545
Schistosoma mansoni cpg binding protein 0.0029 0.0622 0.0608

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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