Detailed information for compound 557243

Basic information

Technical information
  • TDR Targets ID: 557243
  • Name: 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)ben zenesulfonamide
  • MW: 336.368 | Formula: C17H12N4O2S
  • H donors: 2 H acceptors: 4 LogP: 2.37 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cccc(c1)S(=O)(=O)Nc1ccc(c2c1[nH]cc2C#N)C
  • InChi: 1S/C17H12N4O2S/c1-11-5-6-15(17-16(11)13(9-19)10-20-17)21-24(22,23)14-4-2-3-12(7-14)8-18/h2-7,10,20-21H,1H3
  • InChiKey: LWGUASZLXHYWIV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzene-sulfonamide
  • 289483-69-8
  • 3-Cyano-N-(3-cyano-4-methyl-1H-indole-7-yl)benzensulfonamide
  • Benzenesulfonamide, 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-
  • E 7820
  • E7820
  • N-(3-cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzenesulfonamide
  • NSC719239

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0038 0.07 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0137 0.5
Loa Loa (eye worm) hypothetical protein 0.0309 0.903 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.2158 0.239
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0393 0.0436
Echinococcus multilocularis lamin dm0 0.0028 0.0393 0.0344
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0281 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0137 0.0152
Echinococcus multilocularis zinc finger protein 0.0019 0.0126 0.0075
Loa Loa (eye worm) hypothetical protein 0.0039 0.0753 0.0834
Schistosoma mansoni lamin 0.0028 0.0393 0.0344
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.2158 0.239
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0137 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0281 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0281 1
Echinococcus granulosus lamin 0.0028 0.0393 0.0344
Loa Loa (eye worm) hypothetical protein 0.0027 0.0378 0.0419
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.07 0.0652
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0214 0.0163
Brugia malayi hypothetical protein 0.0228 0.6551 0.7255
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.07 0.0652
Echinococcus multilocularis muscleblind protein 0.0309 0.903 0.9025
Loa Loa (eye worm) hypothetical protein 0.0068 0.1641 0.1818
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0214 0.0163
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0137 0.0086
Schistosoma mansoni bromodomain containing protein 0.0061 0.1421 0.1377
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.07 0.0652
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0057
Schistosoma mansoni survival motor neuron protein 0.0047 0.0975 0.0928
Entamoeba histolytica hypothetical protein 0.0024 0.0281 0.2555
Schistosoma mansoni tar DNA-binding protein 0.0131 0.3568 0.3535
Brugia malayi Bromodomain containing protein 0.0037 0.0681 0.0754
Echinococcus multilocularis musashi 0.0028 0.0393 0.0344
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.1315 0.127
Schistosoma mansoni hypothetical protein 0.0341 1 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0281 1
Echinococcus granulosus zinc finger protein 0.0019 0.0126 0.0075
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0281 1
Schistosoma mansoni tar DNA-binding protein 0.0131 0.3568 0.3535
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0137 0.0152
Onchocerca volvulus 0.0085 0.2158 1
Onchocerca volvulus 0.0047 0.0975 0.3295
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0137 0.0086
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0393 0.0436
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0214 0.0163
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0137 0.5
Schistosoma mansoni tar DNA-binding protein 0.0131 0.3568 0.3535
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0137 0.5
Schistosoma mansoni hypothetical protein 0.0038 0.07 0.0652
Schistosoma mansoni zinc finger protein 0.0019 0.0126 0.0075
Brugia malayi intermediate filament protein 0.0028 0.0393 0.0436
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0157 0.0174
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.2158 0.2118
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0281 1
Loa Loa (eye worm) RNA binding protein 0.0131 0.3568 0.3951
Schistosoma mansoni ap endonuclease 0.0019 0.0137 0.0086
Brugia malayi TAR-binding protein 0.0131 0.3568 0.3951
Echinococcus granulosus muscleblind protein 0.0309 0.903 0.9025
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0281 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.2158 0.2118
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.6551 0.6534
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.3568 0.3951
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0611 0.0562
Brugia malayi RNA binding protein 0.0131 0.3568 0.3951
Loa Loa (eye worm) hypothetical protein 0.0309 0.903 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0281 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0281 1
Schistosoma mansoni hypothetical protein 0.002 0.0157 0.0107
Entamoeba histolytica hypothetical protein 0.0038 0.07 1
Entamoeba histolytica hypothetical protein 0.0038 0.07 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0683 0.0756
Loa Loa (eye worm) TAR-binding protein 0.0131 0.3568 0.3951
Schistosoma mansoni hypothetical protein 0.0341 1 1
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0393 0.0436
Loa Loa (eye worm) hypothetical protein 0.0228 0.6551 0.7255
Schistosoma mansoni tar DNA-binding protein 0.0131 0.3568 0.3535
Echinococcus granulosus tar DNA binding protein 0.0131 0.3568 0.3535
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0281 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0975 0.108
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0069 0.0077
Echinococcus granulosus lamin dm0 0.0028 0.0393 0.0344
Echinococcus granulosus intermediate filament protein 0.0028 0.0393 0.0344
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0281 0.5
Echinococcus multilocularis geminin 0.0341 1 1
Brugia malayi Muscleblind-like protein 0.0309 0.903 1
Schistosoma mansoni hypothetical protein 0.0047 0.0975 0.0928
Schistosoma mansoni intermediate filament proteins 0.0028 0.0393 0.0344
Schistosoma mansoni lamin 0.0028 0.0393 0.0344
Schistosoma mansoni ap endonuclease 0.0019 0.0137 0.0086
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0137 0.5
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0611 0.0562
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.3568 0.3951
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0281 1
Echinococcus multilocularis tar DNA binding protein 0.0131 0.3568 0.3535
Echinococcus multilocularis muscleblind protein 1 0.0309 0.903 0.9025
Schistosoma mansoni tar DNA-binding protein 0.0131 0.3568 0.3535
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.1315 0.127
Loa Loa (eye worm) hypothetical protein 0.0041 0.081 0.0896
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.6551 0.6534
Brugia malayi Bromodomain containing protein 0.0072 0.1768 0.1958
Brugia malayi hypothetical protein 0.0038 0.07 0.0775
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.2158 0.2118
Loa Loa (eye worm) hypothetical protein 0.0028 0.0393 0.0436
Entamoeba histolytica hypothetical protein 0.0038 0.07 1
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0281 1
Echinococcus multilocularis lamin 0.0028 0.0393 0.0344
Brugia malayi PHD-finger family protein 0.0024 0.0284 0.0315

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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