Detailed information for compound 557433

Basic information

Technical information
  • TDR Targets ID: 557433
  • Name: (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(2-hydrox ybenzoyl)oxy-tetrahydropyran-2-carboxylic aci d
  • MW: 314.245 | Formula: C13H14O9
  • H donors: 5 H acceptors: 7 LogP: 0.09 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)[C@H]1O[C@@H](OC(=O)c2ccccc2O)[C@@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C13H14O9/c14-6-4-2-1-3-5(6)12(20)22-13-9(17)7(15)8(16)10(21-13)11(18)19/h1-4,7-10,13-17H,(H,18,19)/t7-,8-,9+,10-,13-/m0/s1
  • InChiKey: IXVVXKRKCLJCKA-UNLLLRGISA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[(2-hydroxyphenyl)-oxomethoxy]-2-tetrahydropyrancarboxylic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(2-hydroxyphenyl)carbonyloxy-oxane-2-carboxylic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-salicyloyloxy-tetrahydropyran-2-carboxylic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(2-hydroxybenzoyl)oxyoxane-2-carboxylic acid
  • salicylacyl glucuronide
  • 29315-53-5
  • Acyl SA glucuronide
  • Salicyl acyl glucuronide
  • beta-D-Glucopyranuronic acid, 1-(2-hydroxybenzoate)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) transcription factor SMAD2 0.0378 0.0494 0.0982
Onchocerca volvulus 0.0195 0.0235 0.0736
Trypanosoma cruzi polo-like protein kinase, putative 0.0196 0.0236 0.2032
Loa Loa (eye worm) RGC/RGC protein kinase 0.0836 0.1144 0.2283
Plasmodium vivax heterochromatin protein 1, putative 0.0038 0.0012 0.0228
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.0236 0.1357
Onchocerca volvulus Serine\/threonine kinase homolog 0.0196 0.0236 0.074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0149 0.354
Echinococcus granulosus regulator of G protein signaling 7 0.0064 0.0049 0.0045
Schistosoma mansoni glutamate receptor kainate 0.6244 0.8814 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0008 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.0008 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0008 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0157 0.0181 0.02
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0065 0.005 0.0093
Echinococcus multilocularis beta adrenergic receptor kinase 0.0065 0.005 0.0046
Treponema pallidum glutamate racemase 0.1175 0.1624 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.003 0.006
Onchocerca volvulus 0.0035 0.0008 0.001
Echinococcus granulosus neutral amino acid transporter A 0.2235 0.3127 0.3124
Schistosoma mansoni glutamate receptor NMDA 0.3195 0.4489 0.5091
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.007 0.0066
Trypanosoma brucei hypothetical protein, conserved 0.0052 0.0032 0.0671
Brugia malayi Associated with TFs and helicases family protein 0.0038 0.0012 0.0024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0008 0.0022
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.007 0.0057 0.0152
Brugia malayi Ets-domain containing protein 0.0079 0.007 0.0141
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0008 0.0016
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.2235 0.3127 1
Toxoplasma gondii hypothetical protein 0.0052 0.0031 0.1057
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0075 0.0405
Echinococcus multilocularis excitatory amino acid transporter 2 0.2235 0.3127 0.3124
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.0149 0.1266
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0022 0.0105
Schistosoma mansoni glutamate receptor AMPA 0.3195 0.4489 0.5091
Trichomonas vaginalis set domain proteins, putative 0.1237 0.1712 1
Brugia malayi MH2 domain containing protein 0.0378 0.0494 0.0989
Brugia malayi Protein cec-1. 0.0038 0.0012 0.0024
Brugia malayi Cathepsin L-like precursor 0.0035 0.0008 0.0016
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0052 0.0032 0.1369
Echinococcus multilocularis glutamate receptor 2 0.439 0.6183 0.6182
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.0008 0.0008
Onchocerca volvulus Poor gastrulation protein homolog 0.0342 0.0443 0.1402
Schistosoma mansoni tyrosine kinase 0.0836 0.1144 0.1294
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0052 0.0031 0.0157
Leishmania major cysteine peptidase A (CPA) 0.0035 0.0008 0.0033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0008 0.0022
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0065 0.005 0.0093
Brugia malayi Glutamate receptor 1 precursor 0.3553 0.4997 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0075 0.3044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0052 0.0031 0.0157
Brugia malayi hypothetical protein 0.0076 0.0066 0.0132
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0041 0.0037
Brugia malayi jmjC domain containing protein 0.0059 0.0041 0.0082
Onchocerca volvulus 0.006 0.0042 0.0121
Echinococcus granulosus metabotropic glutamate receptor 2 0.2382 0.3336 0.3333
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.0075 0.0271
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0043 0.002 0.0017
Echinococcus multilocularis Chromobox protein 3 0.0038 0.0012 0.0008
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0394 0.0517 0.3051
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.007 0.0133
Loa Loa (eye worm) glutamate receptor 2 0.3195 0.4489 0.8982
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.7081 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0041 0.0214
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.0145 0.016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0008 0.0022
Loa Loa (eye worm) helicase 0.0038 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.321 0.4511 0.9025
Echinococcus multilocularis NMDA receptor 0.4295 0.6049 0.6047
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.1178 0.1629 0.3254
Echinococcus granulosus Chromo domain 0.0038 0.0012 0.0008
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0038 0.0012 0.0589
Echinococcus multilocularis glutamate receptor subunit protein glur 0.1604 0.2232 0.2229
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0008 0.0022
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0064 0.0049 0.0045
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.007 0.0066
Schistosoma mansoni hypothetical protein 0.0076 0.0066 0.007
Schistosoma mansoni hypothetical protein 0.0342 0.0443 0.0498
Loa Loa (eye worm) fibroinase 0.0035 0.0008 0.0008
Trypanosoma brucei hypothetical protein, conserved 0.013 0.0143 0.3403
Entamoeba histolytica hypothetical protein 0.0038 0.0012 0.0067
Onchocerca volvulus 0.0035 0.0008 0.001
Trichomonas vaginalis chromobox protein, putative 0.0103 0.0104 0.0582
Brugia malayi CHD4 protein 0.0043 0.002 0.0039
Echinococcus multilocularis glutamate receptor 4 0.0358 0.0466 0.0462
Echinococcus granulosus atrial natriuretic peptide receptor 0.0836 0.1144 0.114
Leishmania major extracellular receptor, putative 0.0836 0.1144 1
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.0236 0.1357
Loa Loa (eye worm) RGS-3 protein 0.0064 0.0049 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0008 0.0022
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.4295 0.6049 0.6047
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.0035 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0095 0.053
Mycobacterium ulcerans hydantoin racemase 0.0461 0.0612 0.3735
Brugia malayi Regulator of G protein signaling domain containing protein 0.0064 0.0049 0.0099
Brugia malayi Dihydrofolate reductase 0.007 0.0057 0.0114
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0012 0.0045
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0038 0.0012 0.0009
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0035 0.003
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.015 0.0171 0.0166
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.4689 0.6608 0.6607
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0064 0.0049 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0148 0.0168 0.0328
Loa Loa (eye worm) hypothetical protein 0.0033 0.0005 0.0002
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.0075 0.008
Brugia malayi Heterochromatin protein 1 0.0161 0.0186 0.0373
Echinococcus granulosus neuropeptide receptor A26 0.049 0.0653 0.0649
Echinococcus multilocularis Excitatory amino acid transporter 0.2235 0.3127 0.3124
Schistosoma mansoni lamin 0.0033 0.0005 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.019 0.0227 0.135
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0052 0.0032 0.0138
Schistosoma mansoni glutamate receptor NMDA 0.4031 0.5675 0.6437
Schistosoma mansoni aldehyde dehydrogenase 0.019 0.0227 0.0253
Mycobacterium ulcerans aldehyde dehydrogenase 0.019 0.0227 0.135
Brugia malayi PXA domain containing protein 0.0064 0.0049 0.0099
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0041 0.0037
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0052 0.0031 0.0157
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.003 0.006
Echinococcus granulosus nmda type glutamate receptor 0.164 0.2283 0.228
Echinococcus granulosus metabotropic glutamate receptor 5 0.321 0.4511 0.4508
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0149 0.354
Schistosoma mansoni glutamate receptor kainate 0.3195 0.4489 0.5091
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0075 0.0139
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.0008 0.0004
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.019 0.0227 0.1957
Loa Loa (eye worm) dihydrofolate reductase 0.007 0.0057 0.0106
Echinococcus granulosus cpg binding protein 0.0065 0.005 0.0046
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.439 0.6183 0.6182
Trichomonas vaginalis Heterochromatin protein, putative 0.0038 0.0012 0.0045
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0196 0.0236 0.2032
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0008 0.001
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0991 0.1363 0.1542
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0129 0.0141 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0049 0.0263
Echinococcus multilocularis nmda type glutamate receptor 0.0836 0.1144 0.114
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0038 0.0012 0.0024
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.0035 0.0018
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0103 0.0104 0.0317
Loa Loa (eye worm) hypothetical protein 0.0048 0.0026 0.0045
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0991 0.1363 0.1542
Brugia malayi Cathepsin L-like precursor 0.0035 0.0008 0.0016
Leishmania major cathepsin L-like protease 0.0035 0.0008 0.0033
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0066 0.0062
Schistosoma mansoni regulator of G protein signaling 0.0064 0.0049 0.0051
Loa Loa (eye worm) hypothetical protein 0.0082 0.0075 0.0142
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0008 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.005 0.0052
Echinococcus multilocularis excitatory amino acid transporter 2 0.2235 0.3127 0.3124
Echinococcus multilocularis metabotropic glutamate receptor 2 0.2382 0.3336 0.3333
Leishmania major cathepsin L-like protease 0.0035 0.0008 0.0033
Loa Loa (eye worm) glutamate receptor 1 0.3553 0.4997 1
Brugia malayi Cathepsin L-like precursor 0.0035 0.0008 0.0016
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.0149 0.1266
Echinococcus granulosus cathepsin l cysteine peptidase 0.0035 0.0008 0.0004
Trypanosoma brucei mitochondrial DNA polymerase beta 0.032 0.0412 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0012 0.0045
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.0008 0.0004
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0836 0.1144 0.2283
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0012 0.0045
Brugia malayi Cathepsin L-like precursor 0.0035 0.0008 0.0016
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.2235 0.3127 0.3124
Leishmania major cathepsin L-like protease 0.0035 0.0008 0.0033
Echinococcus granulosus glutamate receptor subunit protein glur 0.1604 0.2232 0.2229
Echinococcus granulosus glutamate receptor 2 0.439 0.6183 0.6182
Entamoeba histolytica cysteine protease, putative 0.0035 0.0008 0.0033
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0052 0.0032 0.1077
Brugia malayi chromobox protein homolog 3 0.0096 0.0095 0.019
Schistosoma mansoni hypothetical protein 0.0174 0.0205 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0041 0.0214
Brugia malayi Probable ClpP-like protease 0.0082 0.0075 0.015
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.032 0.0412 0.3575
Brugia malayi Excitatory amino acid transporter 0.2235 0.3127 0.6258
Echinococcus granulosus beta-adrenergic receptor kinase 0.0065 0.005 0.0046
Schistosoma mansoni chromobox protein 0.0161 0.0186 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0095 0.053
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.003 0.0053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0175 0.0206 0.0229
Trypanosoma brucei hypothetical protein, conserved 0.013 0.0143 0.3403
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.1178 0.1629 0.3254
Trypanosoma cruzi polo-like protein kinase, putative 0.0196 0.0236 0.2032
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0052 0.0032 0.0138
Echinococcus granulosus regulator of G protein signaling 3 0.0064 0.0049 0.0045
Brugia malayi PXA domain containing protein 0.0064 0.0049 0.0099
Brugia malayi Fli-1 protein 0.024 0.0299 0.0598
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.7081 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0008 0.0022
Entamoeba histolytica hypothetical protein 0.0064 0.0049 0.0395
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0041 0.0037
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.0149 0.1266
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0075 0.3044
Loa Loa (eye worm) hypothetical protein 0.0381 0.0499 0.0991
Trypanosoma cruzi cysteine peptidase, putative 0.0035 0.0008 0.0033
Loa Loa (eye worm) hypothetical protein 0.016 0.0185 0.0363
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0012 0.0045
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.019 0.0227 0.0223
Onchocerca volvulus Excitatory amino acid transporter homolog 0.2235 0.3127 1
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.013 0.0143 0.1217
Loa Loa (eye worm) hypothetical protein 0.0064 0.0049 0.0091
Echinococcus granulosus axis inhibition protein axin 0.0064 0.0049 0.0045
Loa Loa (eye worm) hypothetical protein 0.0064 0.0049 0.0091
Schistosoma mansoni chromobox protein 0.0038 0.0012 0.0009
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0012 0.0045
Leishmania major cathepsin L-like protease 0.0134 0.0149 0.1266
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.0008 0.0022
Onchocerca volvulus 0.0836 0.1144 0.3649
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0149 0.354
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0012 0.0045
Loa Loa (eye worm) RGC/RGC protein kinase 0.0836 0.1144 0.2283
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0005 0.0002
Echinococcus granulosus cathepsin l1 0.0035 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.004 0.0015 0.0023
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0078 0.0068 0.0137
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.011 0.0114 0.011
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0043 0.002 0.0015
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0052 0.0032 0.0071
Brugia malayi Pre-SET motif family protein 0.0157 0.0181 0.0361
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0129 0.0141 0.0155
Onchocerca volvulus 0.0185 0.022 0.0689
Echinococcus multilocularis cysteine protease 0.0035 0.0008 0.0004
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0008 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0008 0.0022
Schistosoma mansoni gabp alpha 0.0079 0.007 0.0075
Brugia malayi Metabotropic glutamate receptor precursor. 0.2723 0.382 0.7645
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0022 0.0154
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0022 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0012 0.0045
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0042 0.0077
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.013 0.0143 0.1217
Entamoeba histolytica hypothetical protein 0.0076 0.0066 0.054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0052 0.0031 0.0157
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.019 0.0227 0.0223
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0049 0.0263
Brugia malayi Angiotensin-converting enzyme family protein 0.033 0.0426 0.0853
Brugia malayi hypothetical protein 0.0064 0.0049 0.0099
Schistosoma mansoni metabotropic glutamate receptor 0.2382 0.3336 0.3782
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0261 0.0328 0.0368
Loa Loa (eye worm) hypothetical protein 0.0175 0.0206 0.0405
Schistosoma mansoni tyrosine kinase 0.0836 0.1144 0.1294
Schistosoma mansoni lamin 0.0033 0.0005 0.0001
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0271 0.0342 0.0677
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0052 0.0032 0.1077
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.0236 0.1357
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0342 0.0443 0.0886
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0123 0.0132 0.112
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0008 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0008 0.0022
Brugia malayi CXXC zinc finger family protein 0.006 0.0042 0.0085
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0049 0.0051
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0012 0.0067
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.1887 0.2634 0.5271
Echinococcus multilocularis Chromo domain 0.0038 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0068 0.0054 0.01
Echinococcus granulosus cathepsin L cysteine proteinase 0.0035 0.0008 0.0004
Echinococcus multilocularis dihydrofolate reductase 0.007 0.0057 0.0053
Onchocerca volvulus 0.0148 0.0168 0.0522
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0041 0.0042
Schistosoma mansoni survival motor neuron protein 0.0078 0.0068 0.0073
Loa Loa (eye worm) hypothetical protein 0.0064 0.0049 0.0091
Echinococcus multilocularis neutral amino acid transporter A 0.2235 0.3127 0.3124
Echinococcus granulosus excitatory amino acid transporter 3 0.2235 0.3127 0.3124
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0129 0.0141 0.0137
Schistosoma mansoni hypothetical protein 0.0078 0.0068 0.0073
Plasmodium falciparum heterochromatin protein 1 0.0038 0.0012 0.0589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0149 0.354
Brugia malayi SET domain containing protein 0.0045 0.0022 0.0044
Brugia malayi Guanylyl cyclase protein 23 0.0836 0.1144 0.2289
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0075 0.3868
Echinococcus granulosus glutamate receptor 2 0.3144 0.4417 0.4415
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0157 0.0181 0.787
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.4295 0.6049 0.6047
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0096 0.0535
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.1245 0.1724 0.172
Echinococcus multilocularis Excitatory amino acid transporter 0.2235 0.3127 0.3124
Schistosoma mansoni chromobox protein 0.0161 0.0186 0.0207
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.0008 0.0004
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0129 0.0141 0.0422
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0008 0.0033
Brugia malayi Regulator of G protein signaling domain containing protein 0.0064 0.0049 0.0099
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0075 0.0405
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0408 0.0537 0.1067
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0008
Schistosoma mansoni axis inhibition protein axin 0.0064 0.0049 0.0051
Plasmodium vivax SET domain protein, putative 0.0157 0.0181 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0064 0.0049 0.0051
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0016
Chlamydia trachomatis glutamate symporter 0.2235 0.3127 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.0236 0.1357
Echinococcus multilocularis dnaJ subfamily B 0.0849 0.1162 0.1158
Schistosoma mansoni regulator of G protein signaling 0.0064 0.0049 0.0051
Trypanosoma brucei polo-like protein kinase 0.0196 0.0236 0.5685
Echinococcus granulosus Excitatory amino acid transporter 0.2235 0.3127 0.3124
Echinococcus granulosus chromobox protein 1 0.0161 0.0186 0.0182
Brugia malayi Receptor family ligand binding region containing protein 0.1178 0.1629 0.3259
Brugia malayi hypothetical protein 0.0381 0.0499 0.0998
Loa Loa (eye worm) hypothetical protein 0.0043 0.0019 0.003
Echinococcus multilocularis glutamate receptor 2 0.3144 0.4417 0.4415
Echinococcus granulosus expressed protein 0.1253 0.1735 0.1732
Brugia malayi Cathepsin L-like precursor 0.0035 0.0008 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.0236 0.1357
Trichomonas vaginalis chromobox protein, putative 0.0161 0.0186 0.1067
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0005 0.0002
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.032 0.0412 0.3575
Loa Loa (eye worm) hypothetical protein 0.0064 0.0049 0.0091
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0394 0.0517 0.3146
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0096 0.0095 0.0288
Loa Loa (eye worm) hypothetical protein 0.0065 0.005 0.0092
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.0236 0.1357
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0038 0.0012 0.0179
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0008 0.0033
Loa Loa (eye worm) fli-1 protein 0.024 0.0299 0.0591
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0185 0.022 0.044
Onchocerca volvulus Cathepsin F homolog 0.0035 0.0008 0.001
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0065 0.005 0.01
Echinococcus granulosus survival motor neuron protein 1 0.0381 0.0499 0.0495
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0049 0.009
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0157 0.0181 0.0176
Loa Loa (eye worm) cysteine protease 0.0035 0.0008 0.0008
Schistosoma mansoni lipoxygenase 0.0068 0.0054 0.0056
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0052 0.0048
Loa Loa (eye worm) excitatory amino acid transporter 0.2235 0.3127 0.6255
Loa Loa (eye worm) hypothetical protein 0.0836 0.1144 0.2283
Echinococcus granulosus receptor type guanylyl cyclase 0.0836 0.1144 0.114
Loa Loa (eye worm) hypothetical protein 0.0836 0.1144 0.2283
Echinococcus granulosus dihydrofolate reductase 0.007 0.0057 0.0053
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0066 0.0062
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0008 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0008 0.0022
Schistosoma mansoni ATP-binding cassette transporter 0.3195 0.4489 0.5091
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.013 0.0143 0.1217
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0044 0.0021 0.0097
Brugia malayi Ets-domain containing protein 0.0079 0.007 0.0141
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.005 0.0052
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.033 0.0426 0.0846
Loa Loa (eye worm) hypothetical protein 0.0372 0.0485 0.0964
Onchocerca volvulus 0.0035 0.0008 0.001
Trichomonas vaginalis chromobox protein, putative 0.0103 0.0104 0.0582
Entamoeba histolytica hypothetical protein 0.0836 0.1144 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0016
Schistosoma mansoni dihydrofolate reductase 0.007 0.0057 0.006
Schistosoma mansoni aldehyde dehydrogenase 0.019 0.0227 0.0253
Echinococcus granulosus Excitatory amino acid transporter 0.2235 0.3127 0.3124
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.0075 0.0071
Echinococcus multilocularis sodium:dicarboxylate symporter 0.2235 0.3127 0.3124
Chlamydia trachomatis dihydrofolate reductase 0.007 0.0057 0.0082
Echinococcus multilocularis nmda type glutamate receptor 0.164 0.2283 0.228
Echinococcus granulosus excitatory amino acid transporter 2 0.2235 0.3127 0.3124
Schistosoma mansoni microtubule-associated protein tau 0.0727 0.0988 0.1117
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0022 0.043
Mycobacterium ulcerans hypothetical protein 0.0169 0.0197 0.1162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0008 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0052 0.0031 0.0157
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.013 0.0143 0.1217
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0196 0.0236 0.0465
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0038 0.0012 0.0008
Onchocerca volvulus 0.0836 0.1144 0.3649
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0035 0.003
Brugia malayi regulator of G-protein signaling rgs-7 0.0064 0.0049 0.0099
Echinococcus granulosus glutamate NMDA receptor subunit 0.3195 0.4489 0.4487
Echinococcus granulosus regulator of G protein signaling 7 0.0064 0.0049 0.0045
Loa Loa (eye worm) hypothetical protein 0.0148 0.0168 0.0328
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0149 0.354
Brugia malayi Bromodomain containing protein 0.0082 0.0075 0.015
Echinococcus multilocularis axis inhibition protein axin 0.0064 0.0049 0.0045
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0038 0.0012 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0012 0.0045
Echinococcus granulosus Chromobox protein 3 0.0038 0.0012 0.0008
Schistosoma mansoni intermediate filament proteins 0.0033 0.0005 0.0001
Treponema pallidum glutamate/aspartate transporter 0.0991 0.1363 0.836
Brugia malayi Valyl-tRNA synthetase 0.0038 0.0012 0.0024
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.013 0.0143 0.1217
Schistosoma mansoni ets-related 0.024 0.0299 0.0334
Echinococcus granulosus geminin 0.0174 0.0205 0.0201
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.3195 0.4489 0.4487
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0049 0.0263
Echinococcus multilocularis chromobox protein 1 0.0161 0.0186 0.0182
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.011 0.0114 0.0124
Echinococcus granulosus Regulator of G protein signaling 20 0.0064 0.0049 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0195 0.0235 0.0261
Loa Loa (eye worm) heterochromatin protein 1 0.0161 0.0186 0.0366
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0052 0.0031 0.0157
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0038 0.0012 0.0009
Onchocerca volvulus 0.0078 0.0068 0.0203
Echinococcus multilocularis regulator of G protein signaling 7 0.0064 0.0049 0.0045
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0113 0.0118 0.0228
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0049 0.0045
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0129 0.0141 0.0814
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.0075 0.0139
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0008 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0008 0.0022
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.019 0.0227 0.0699
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0038 0.0012 0.0589
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.007 0.0057 0.0159
Loa Loa (eye worm) hypothetical protein 0.0185 0.022 0.0432
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0151 0.0173 0.4134
Entamoeba histolytica hypothetical protein 0.0052 0.0032 0.024
Echinococcus multilocularis chromobox protein 1 0.0161 0.0186 0.0182
Schistosoma mansoni glutamate receptor AMPA 0.3195 0.4489 0.5091
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.2235 0.3127 1
Schistosoma mansoni hypothetical protein 0.1245 0.1724 0.1952
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0096 0.0535
Brugia malayi hypothetical protein 0.0064 0.0049 0.0099
Echinococcus granulosus glutamate receptor 1 0.0358 0.0466 0.0462
Echinococcus multilocularis expressed protein 0.1253 0.1735 0.1732
Brugia malayi Pre-SET motif family protein 0.1087 0.1499 0.3
Onchocerca volvulus 0.0035 0.0008 0.001
Mycobacterium tuberculosis Probable glutamate racemase MurI 0.1175 0.1624 0.5178
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.7081 1 1
Brugia malayi jmjC domain containing protein 0.0064 0.0049 0.0098
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0394 0.0517 0.1569
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0836 0.1144 0.2289
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0149 0.354
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.007 0.0057 0.0294
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.0173 0.1478
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0012 0.0045
Loa Loa (eye worm) hypothetical protein 0.0096 0.0095 0.0182
Loa Loa (eye worm) hypothetical protein 0.0836 0.1144 0.2283
Mycobacterium ulcerans glutamate racemase 0.1175 0.1624 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0012 0.0067
Schistosoma mansoni regulator of G protein signaling 0.0064 0.0049 0.0051
Echinococcus multilocularis neutral amino acid transporter A 0.2235 0.3127 0.3124
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0012 0.0007
Loa Loa (eye worm) glutamate receptor 0.0828 0.1133 0.2261
Echinococcus multilocularis glutamate receptor 2 0.3553 0.4997 0.4995
Schistosoma mansoni kinase 0.01 0.0099 0.0108
Mycobacterium ulcerans aldehyde dehydrogenase 0.019 0.0227 0.135
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0035 0.0008 0.0008
Schistosoma mansoni chromobox protein 0.0038 0.0012 0.0009
Schistosoma mansoni regulator of G protein signaling 0.0064 0.0049 0.0051
Schistosoma mansoni axis inhibition protein axin 0.0064 0.0049 0.0051
Schistosoma mansoni bromodomain containing protein 0.007 0.0057 0.006
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.0075 0.0071
Echinococcus multilocularis cysteine protease 0.0035 0.0008 0.0004
Schistosoma mansoni cpg binding protein 0.0065 0.005 0.0052
Brugia malayi hypothetical protein 0.0129 0.0141 0.0282
Schistosoma mansoni protein kinase 0.0836 0.1144 0.1294
Echinococcus multilocularis regulator of G protein signaling 3 0.0064 0.0049 0.0045
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0991 0.1363 0.1359
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0064 0.0049 0.0091
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0129 0.0141 0.0814
Echinococcus granulosus GPCR family 3 C terminal 0.0342 0.0443 0.0439
Schistosoma mansoni hypothetical protein 0.0035 0.0007 0.0004
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0196 0.0236 0.0232
Echinococcus multilocularis regulator of G protein signaling 7 0.0064 0.0049 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0008 0.0022
Trypanosoma cruzi extracellular receptor, putative 0.0836 0.1144 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0043 0.002 0.0031
Loa Loa (eye worm) hypothetical protein 0.0836 0.1144 0.2283
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0064 0.0049 0.0051
Echinococcus granulosus nmda type glutamate receptor 0.0836 0.1144 0.114
Chlamydia trachomatis glutamine binding protein 0.0394 0.0517 0.1569
Loa Loa (eye worm) hypothetical protein 0.0064 0.0049 0.0091
Brugia malayi hypothetical protein 0.0836 0.1144 0.2289
Leishmania major cathepsin L-like protease 0.0035 0.0008 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0175 0.0206 0.0229
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0129 0.0141 0.0282
Trichomonas vaginalis CAMK family protein kinase 0.0196 0.0236 0.1357
Schistosoma mansoni cpg binding protein 0.0065 0.005 0.0052
Toxoplasma gondii aldehyde dehydrogenase 0.019 0.0227 1
Echinococcus multilocularis axis inhibition protein axin 0.0064 0.0049 0.0045
Loa Loa (eye worm) hypothetical protein 0.0836 0.1144 0.2283
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0075 0.0271
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0836 0.1144 0.3649
Loa Loa (eye worm) hypothetical protein 0.0051 0.003 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0052 0.0031 0.0157
Echinococcus granulosus glutamate receptor ionotropic kainate 0.4295 0.6049 0.6047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0149 0.354
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0052 0.0048
Echinococcus granulosus L aminoadipate semialdehyde 0.0185 0.022 0.0216
Schistosoma mansoni glutamate receptor kainate 0.6244 0.8814 1
Trichomonas vaginalis chromobox protein, putative 0.0161 0.0186 0.1067
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0012 0.0067
Echinococcus multilocularis neuropeptide s receptor 0.049 0.0653 0.0649
Mycobacterium leprae PROBABLE GLUTAMATE RACEMASE MURI 0.1175 0.1624 1
Trypanosoma brucei Enriched in surface-labeled proteome protein 12 0.013 0.0143 0.3403
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0012 0.0045
Brugia malayi intermediate filament protein 0.0033 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0342 0.0443 0.0879
Leishmania major mitochondrial DNA polymerase beta 0.032 0.0412 0.3575
Entamoeba histolytica hypothetical protein 0.0076 0.0066 0.054
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0175 0.0206 0.0202
Entamoeba histolytica hypothetical protein 0.0076 0.0066 0.054
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.2235 0.3127 0.3545
Schistosoma mansoni hypothetical protein 0.0174 0.0205 0.0228
Leishmania major cathepsin L-like protease 0.0035 0.0008 0.0033
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2536 0.3555 0.3552
Giardia lamblia Kinase, PLK 0.0196 0.0236 1
Onchocerca volvulus 0.0035 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.0358 0.0466 0.0926
Echinococcus multilocularis Regulator of G protein signaling 20 0.0064 0.0049 0.0045
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.0197 0.0602
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0066 0.007
Echinococcus multilocularis metabotropic glutamate receptor 5 0.321 0.4511 0.4508
Trichomonas vaginalis hypothetical protein 0.0038 0.0012 0.0045
Entamoeba histolytica hypothetical protein 0.0076 0.0066 0.054
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0049 0.0263
Loa Loa (eye worm) hypothetical protein 0.0129 0.0141 0.0274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0008 0.0022
Loa Loa (eye worm) glutamate receptor 0.2723 0.382 0.7643
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.0173 0.1478
Brugia malayi metabotropic glutamate receptor type 2 0.1665 0.2319 0.464
Trypanosoma cruzi major cysteine proteinase, putative 0.0106 0.0108 0.0908
Onchocerca volvulus 0.1237 0.1712 0.5467
Echinococcus granulosus dnaJ subfamily B 0.0849 0.1162 0.1158
Echinococcus multilocularis cpg binding protein 0.0065 0.005 0.0046
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.1245 0.1724 0.172
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0012 0.0228
Echinococcus granulosus regulator of G protein signaling 3 0.0064 0.0049 0.0045
Onchocerca volvulus 0.0065 0.005 0.0144
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.013 0.5551
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0016
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0064 0.0049 0.0263
Leishmania major cathepsin L-like protease 0.0134 0.0149 0.1266
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.439 0.6183 0.6182
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0196 0.0236 0.0232
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0012 0.0228
Loa Loa (eye worm) hypothetical protein 0.0388 0.0508 0.101
Loa Loa (eye worm) hypothetical protein 0.0836 0.1144 0.2283
Loa Loa (eye worm) hypothetical protein 0.0836 0.1144 0.2283
Loa Loa (eye worm) MH2 domain-containing protein 0.0378 0.0494 0.0982
Loa Loa (eye worm) hypothetical protein 0.0358 0.0466 0.0926
Echinococcus multilocularis regulator of G protein signaling 0.0064 0.0049 0.0045
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0064 0.0049 0.0051
Echinococcus granulosus chromobox protein 1 0.0161 0.0186 0.0182
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.011 0.0114 0.0124
Entamoeba histolytica hypothetical protein 0.0038 0.0012 0.0067
Schistosoma mansoni z-protein (S1r protein) 0.0064 0.0049 0.0051
Echinococcus granulosus glutamate receptor 4 0.0358 0.0466 0.0462
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0052 0.0032 0.3538
Brugia malayi M-phase phosphoprotein, mpp8 0.0148 0.0168 0.0336
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.0035 0.0081
Brugia malayi hypothetical protein 0.0148 0.0168 0.0336
Schistosoma mansoni hypothetical protein 0.0849 0.1162 0.1314
Onchocerca volvulus 0.0148 0.0168 0.0522
Echinococcus granulosus sodium:dicarboxylate symporter 0.2235 0.3127 0.3124
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0342 0.0443 0.1402
Echinococcus multilocularis neuropeptide receptor A26 0.049 0.0653 0.0649
Echinococcus granulosus Ankyrin repeat domain containing protein 0.011 0.0114 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0012 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.0236 0.0263
Brugia malayi Cathepsin L-like precursor 0.0035 0.0008 0.0016
Echinococcus granulosus neutral amino acid transporter A 0.2235 0.3127 0.3124
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0038 0.0012 0.0008
Echinococcus multilocularis microtubule associated protein 2 0.0727 0.0988 0.0985
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0045 0.0022 0.0105
Onchocerca volvulus 0.0035 0.0008 0.001
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0005 0.001
Loa Loa (eye worm) ctsf protein 0.0035 0.0008 0.0008
Schistosoma mansoni metabotropic glutamate receptor 0.1665 0.2319 0.2627
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0012 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.005 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0012 0.0045
Loa Loa (eye worm) hypothetical protein 0.0074 0.0064 0.012
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0068 0.0054 0.0049
Loa Loa (eye worm) hypothetical protein 0.0064 0.0049 0.0091
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0394 0.0517 0.3051
Schistosoma mansoni cpg binding protein 0.006 0.0042 0.0043
Echinococcus granulosus histone lysine methyltransferase setb 0.0175 0.0206 0.0202
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0394 0.0517 0.1629
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0836 0.1144 0.114
Echinococcus granulosus neutral amino acid transporter 0.2235 0.3127 0.3124
Echinococcus multilocularis geminin 0.0174 0.0205 0.0201
Loa Loa (eye worm) hypothetical protein 0.0358 0.0466 0.0926
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.7081 1 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.7081 1 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0068 0.0054 0.0049
Onchocerca volvulus 0.0035 0.0008 0.001
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0075 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0052 0.0031 0.0157
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0022 0.0154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0149 0.354
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0149 0.354
Entamoeba histolytica hypothetical protein 0.0064 0.0049 0.0395
Echinococcus multilocularis chromobox protein 2 0.0038 0.0012 0.0008
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0185 0.022 0.0245
Brugia malayi serine/threonine-protein kinase plk-2 0.0196 0.0236 0.0472
Echinococcus multilocularis GPCR, family 3, C terminal 0.0342 0.0443 0.0439
Loa Loa (eye worm) hypothetical protein 0.1178 0.1629 0.3254
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0007 0.0015
Treponema pallidum glutamate transporter 0.0991 0.1363 0.836
Echinococcus multilocularis tyrosine kinase 0.0836 0.1144 0.114
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1087 0.1499 0.2994
Loa Loa (eye worm) PXA domain-containing protein 0.0064 0.0049 0.0091
Chlamydia trachomatis neutral amino acid transporter 0.0991 0.1363 0.43
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0049 0.0263
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0036 0.0276
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0398 0.0523 0.0519
Echinococcus granulosus microtubule associated protein 2 0.0727 0.0988 0.0985
Echinococcus multilocularis regulator of G protein signaling 3 0.0064 0.0049 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0008 0.0022
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0991 0.1363 0.1359
Onchocerca volvulus 0.016 0.0185 0.0577
Brugia malayi hypothetical protein 0.016 0.0185 0.037
Onchocerca volvulus Huntingtin homolog 0.0129 0.0141 0.0436
Loa Loa (eye worm) hypothetical protein 0.0129 0.0141 0.0274
Trypanosoma cruzi cruzipain precursor, putative 0.0134 0.0149 0.1266
Loa Loa (eye worm) hypothetical protein 0.0035 0.0007 0.0007
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0038 0.0012 0.0179
Brugia malayi regulator of G-protein signaling egl-10 0.0064 0.0049 0.0099
Loa Loa (eye worm) RGC/RGC protein kinase 0.0836 0.1144 0.2283
Echinococcus granulosus neuropeptide s receptor 0.049 0.0653 0.0649
Onchocerca volvulus Huntingtin homolog 0.0129 0.0141 0.0436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0008 0.0022
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0075 0.0139
Schistosoma mansoni regulator of G protein signaling 0.0064 0.0049 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0149 0.354
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.2374 0.3324 0.3769
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.0149 0.354
Leishmania major phosphopantetheinyl transferase-like protein 0.0052 0.0032 0.024
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0012 0.0007
Echinococcus multilocularis survival motor neuron protein 1 0.0381 0.0499 0.0495
Brugia malayi Receptor family ligand binding region containing protein 0.0836 0.1144 0.2289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0008 0.0022
Brugia malayi hypothetical protein 0.0149 0.0169 0.0338
Leishmania major cathepsin L-like protease 0.0134 0.0149 0.1266
Echinococcus multilocularis receptor type guanylyl cyclase 0.0836 0.1144 0.114
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0049 0.0051
Echinococcus granulosus excitatory amino acid transporter 2 0.2235 0.3127 0.3124
Echinococcus multilocularis L aminoadipate semialdehyde 0.0185 0.022 0.0216
Entamoeba histolytica hypothetical protein 0.0064 0.0049 0.0395
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0008 0.0022
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0043 0.002 0.0015
Brugia malayi Glutamate receptor 2 precursor 0.3553 0.4997 1
Echinococcus multilocularis neutral amino acid transporter A 0.2235 0.3127 0.3124
Brugia malayi A-kinase anchor protein 10, precursor 0.0064 0.0049 0.0099
Entamoeba histolytica serine/threonine protein kinase, putative 0.0196 0.0236 0.2032
Entamoeba histolytica hypothetical protein 0.0038 0.0012 0.0067
Echinococcus granulosus tyrosine kinase 0.0836 0.1144 0.114
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0129 0.0141 0.1198
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0049 0.0263
Echinococcus multilocularis excitatory amino acid transporter 3 0.2235 0.3127 0.3124
Brugia malayi Bromodomain containing protein 0.004 0.0015 0.003
Schistosoma mansoni hypothetical protein 0.0038 0.0012 0.0009
Echinococcus granulosus chromobox protein 2 0.0038 0.0012 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0012 0.0045
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0038 0.0012 0.0179
Echinococcus granulosus axis inhibition protein axin 0.0064 0.0049 0.0045
Brugia malayi dihydrofolate reductase family protein 0.007 0.0057 0.0114

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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