Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Steroid receptor seven-up type 2 | 0.0217 | 0.0288 | 0.0307 |
Brugia malayi | nuclear receptor RXR | 0.0115 | 0.0031 | 0.0033 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0217 | 0.0288 | 0.0307 |
Trypanosoma brucei | deoxyuridine triphosphatase, putative | 0.0367 | 0.0663 | 0.039 |
Schistosoma mansoni | thyroid hormone receptor | 0.0217 | 0.0288 | 0.0307 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0115 | 0.0031 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.0288 | 0.0307 |
Brugia malayi | thymidylate kinase | 0.0306 | 0.0512 | 0.0545 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0217 | 0.0288 | 0.0307 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0217 | 0.0288 | 0.0307 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0306 | 0.0512 | 0.5 |
Onchocerca volvulus | 0.0217 | 0.0288 | 0.0307 | |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0217 | 0.0288 | 0.0307 |
Loa Loa (eye worm) | thymidylate synthase | 0.3841 | 0.9382 | 1 |
Brugia malayi | hypothetical protein | 0.0115 | 0.0031 | 0.0033 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0217 | 0.0288 | 0.0307 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0217 | 0.0288 | 0.0307 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0217 | 0.0288 | 0.0307 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0217 | 0.0288 | 0.0307 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0217 | 0.0288 | 0.0307 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0217 | 0.0288 | 0.0307 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0217 | 0.0288 | 0.0307 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0217 | 0.0288 | 0.0307 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1827 | 0.4328 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0217 | 0.0288 | 0.0307 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1827 | 0.4328 | 0.4303 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0217 | 0.0288 | 0.0307 |
Echinococcus granulosus | thymidylate kinase | 0.0306 | 0.0512 | 0.0545 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0306 | 0.0512 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0115 | 0.0031 | 0.0033 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4087 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0031 | 0.0033 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0217 | 0.0288 | 0.0307 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0217 | 0.0288 | 0.0307 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0115 | 0.0031 | 0.0033 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0217 | 0.0288 | 0.0307 |
Echinococcus granulosus | dihydrofolate reductase | 0.0463 | 0.0906 | 0.0965 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0217 | 0.0288 | 0.0307 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0306 | 0.0512 | 0.0469 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0217 | 0.0288 | 0.0307 |
Schistosoma mansoni | thymidylate kinase | 0.0306 | 0.0512 | 0.0545 |
Brugia malayi | nuclear hormone receptor | 0.0217 | 0.0288 | 0.0307 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0217 | 0.0288 | 0.0307 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.0288 | 0.0307 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0217 | 0.0288 | 0.0307 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0217 | 0.0288 | 0.0307 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0115 | 0.0031 | 0.0033 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0217 | 0.0288 | 0.0307 |
Onchocerca volvulus | Putative thymidylate kinase | 0.0306 | 0.0512 | 0.0545 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.4087 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0217 | 0.0288 | 0.0307 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0367 | 0.0663 | 0.0621 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0463 | 0.0906 | 0.0965 |
Echinococcus multilocularis | thymidylate kinase | 0.0306 | 0.0512 | 0.0545 |
Brugia malayi | Dihydrofolate reductase | 0.0463 | 0.0906 | 0.0965 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0115 | 0.0031 | 0.0033 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0217 | 0.0288 | 0.0307 |
Brugia malayi | ecdysteroid receptor | 0.0217 | 0.0288 | 0.0307 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0463 | 0.0906 | 1 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0306 | 0.0512 | 0.0234 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0367 | 0.0663 | 0.0621 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0217 | 0.0288 | 0.0307 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.0288 | 0.0307 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0115 | 0.0031 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0031 | 0.0033 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0217 | 0.0288 | 0.0307 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0031 | 0.0033 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0217 | 0.0288 | 0.0307 |
Brugia malayi | hypothetical protein | 0.1827 | 0.4328 | 0.4613 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0217 | 0.0288 | 0.0307 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0217 | 0.0288 | 0.0307 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0217 | 0.0288 | 0.0307 |
Mycobacterium ulcerans | thymidylate synthase | 0.3841 | 0.9382 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0217 | 0.0288 | 0.0307 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.0288 | 0.0307 |
Brugia malayi | nuclear receptor NHR-88 | 0.0217 | 0.0288 | 0.0307 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0217 | 0.0288 | 0.0307 |
Mycobacterium ulcerans | FAD-dependent thymidylate synthase | 0.1577 | 0.3699 | 0.3594 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0115 | 0.0031 | 0.0033 |
Brugia malayi | hypothetical protein | 0.0115 | 0.0031 | 0.0033 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0217 | 0.0288 | 0.0307 |
Echinococcus granulosus | FTZ F1 alpha | 0.0217 | 0.0288 | 0.0307 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0217 | 0.0288 | 0.0307 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3841 | 0.9382 | 1 |
Onchocerca volvulus | 0.3841 | 0.9382 | 1 | |
Brugia malayi | thymidylate synthase | 0.3841 | 0.9382 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.4087 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0031 | 0.0033 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0463 | 0.0906 | 0.0444 |
Schistosoma mansoni | dihydrofolate reductase | 0.0463 | 0.0906 | 0.0965 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0217 | 0.0288 | 0.0307 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0217 | 0.0288 | 0.0307 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0217 | 0.0288 | 0.0307 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0217 | 0.0288 | 0.0307 |
Schistosoma mansoni | nuclear hormone receptor | 0.0217 | 0.0288 | 0.0307 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0463 | 0.0906 | 0.0444 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0217 | 0.0288 | 0.0307 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYX (TS) (TSase) | 0.1577 | 0.3699 | 0.3594 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0306 | 0.0512 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0217 | 0.0288 | 0.0307 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0217 | 0.0288 | 0.0307 |
Schistosoma mansoni | thyroid hormone receptor | 0.0217 | 0.0288 | 0.0307 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.3841 | 0.9382 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.3841 | 0.9382 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.1827 | 0.4328 | 0.4303 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0217 | 0.0288 | 0.0307 |
Schistosoma mansoni | hypothetical protein | 0.0216 | 0.0284 | 0.0303 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0217 | 0.0288 | 0.0307 |
Leishmania major | deoxyuridine triphosphatase, putative,dUTP diphosphatase | 0.0367 | 0.0663 | 0.0621 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0217 | 0.0288 | 0.0307 |
Brugia malayi | steroid hormone receptor | 0.0217 | 0.0288 | 0.0307 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0463 | 0.0906 | 0.0444 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4087 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.3841 | 0.9382 | 1 |
Loa Loa (eye worm) | thymidylate kinase | 0.0306 | 0.0512 | 0.0545 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0306 | 0.0512 | 0.0234 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0217 | 0.0288 | 0.0307 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.4087 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.0288 | 0.0307 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.0288 | 0.0307 |
Schistosoma mansoni | hypothetical protein | 0.0306 | 0.0512 | 0.0545 |
Echinococcus multilocularis | thymidylate synthase | 0.3841 | 0.9382 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0217 | 0.0288 | 0.0307 |
Schistosoma mansoni | thymidylate kinase | 0.0306 | 0.0512 | 0.0545 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0031 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.0288 | 0.0307 |
Leishmania major | thymidylate kinase-like protein | 0.0306 | 0.0512 | 0.0469 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0217 | 0.0288 | 0.0307 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0217 | 0.0288 | 0.0307 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0306 | 0.0512 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.0288 | 0.0307 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0217 | 0.0288 | 0.0307 |
Schistosoma mansoni | coup transcription factor | 0.0217 | 0.0288 | 0.0307 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyX (ts) (TSase) | 0.1577 | 0.3699 | 0.3594 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0217 | 0.0288 | 0.0307 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0463 | 0.0906 | 0.0965 |
Giardia lamblia | CDC8 | 0.0306 | 0.0512 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0463 | 0.0906 | 0.0965 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0217 | 0.0288 | 0.0307 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 3.5 | Calculated partition coefficient (clogP) | ChEMBL. | 7636859 |
logD (ADMET) | = -0.97 | Partition coefficient (logD7.4) | ChEMBL. | 7636859 |
MIC (functional) | = 0.1 ug ml-1 | Compound was tested in vitro for antibiotic activity against the bacteria Klebsiella pneumoniae 8045 | ChEMBL. | 3090265 |
MIC (functional) | = 0.1 ug ml-1 | The compound was tested for its antimicrobial activity against Klebsiella pneumoniae 8045 (Kp) strain. | ChEMBL. | 3020253 |
MIC (functional) | = 0.1 ug ml-1 | Minimum inhibition concentration in vitro determined against Klebsiella pneumoniae 8045 | ChEMBL. | 3934382 |
MIC (functional) | = 0.1 ug ml-1 | Minimum inhibitory concentration against gram-negative Escherichia coli Vogel (EC-1) | ChEMBL. | 7636859 |
MIC (functional) | = 0.1 ug ml-1 | Minimum inhibitory concentration against gram-negative Escherichia coli Vogel (EC-1) | ChEMBL. | 7636859 |
MIC (functional) | = 0.2 ug ml-1 | Compound was tested in vitro for antibiotic activity against the bacteria Escherichia coli juhl | ChEMBL. | 3090265 |
MIC (functional) | = 0.2 ug ml-1 | The compound was tested for its antimicrobial activity against Escherichia coli juhl (Ec) strain. | ChEMBL. | 3020253 |
MIC (functional) | = 0.2 ug ml-1 | Minimum inhibition concentration in vitro determined against Escherichia coli juhl | ChEMBL. | 3934382 |
MIC (functional) | = 0.2 ug ml-1 | Compound was tested in vitro for antibiotic activity against the bacteria Escherichia coli juhl | ChEMBL. | 3090265 |
MIC (functional) | = 0.2 ug ml-1 | The compound was tested for its antimicrobial activity against Escherichia coli juhl (Ec) strain. | ChEMBL. | 3020253 |
MIC (functional) | = 0.2 ug ml-1 | Minimum inhibition concentration in vitro determined against Escherichia coli juhl | ChEMBL. | 3934382 |
MIC (functional) | = 0.39 ug ml-1 | The compound was tested in vitro for antibiotic activity against Staphylococcus aureus ATCC 6538P | ChEMBL. | 3090265 |
MIC (functional) | = 0.39 ug ml-1 | The compound was tested in vitro for antibiotic activity against Staphylococcus aureus 686B | ChEMBL. | 3090265 |
MIC (functional) | = 0.39 ug ml-1 | Compound was tested in vitro for antibiotic activity against bacteria Enterobacter aerogenes ATCC 13048 | ChEMBL. | 3090265 |
MIC (functional) | = 0.39 ug ml-1 | The compound was tested for its antimicrobial activity against Staphylococcus aureus ATCC 6538P (Sa(A)) strain | ChEMBL. | 3020253 |
MIC (functional) | = 0.39 ug ml-1 | The compound was tested for its antimicrobial activity against Staphylococcus aureus CMX 68613 (Sa) strain. | ChEMBL. | 3020253 |
MIC (functional) | = 0.39 ug ml-1 | The compound was tested for its antimicrobial activity against Enterobacter aerogenes ATCC 13048 (Ea) strain. | ChEMBL. | 3020253 |
MIC (functional) | = 0.39 ug ml-1 | Minimum inhibition concentration in vitro determined against Staphylococcus aureus ATCC 6538P | ChEMBL. | 3934382 |
MIC (functional) | = 0.39 ug ml-1 | Minimum inhibition concentration in vitro determined against Staphylococcus aureus CMX 686B | ChEMBL. | 3934382 |
MIC (functional) | = 0.39 ug ml-1 | Minimum inhibition concentration in vitro determined against Enterobacteri aerogenes ATCC 13048 | ChEMBL. | 3934382 |
MIC (functional) | = 0.5 ug ml-1 | Minimum inhibitory concentration against Mycobacterium fortuitum | ChEMBL. | 7636859 |
MIC (functional) | = 0.78 ug ml-1 | The compound was tested in vitro for antibiotic activity against Staphylococcus epidermidis 3519 | ChEMBL. | 3090265 |
MIC (functional) | = 0.78 ug ml-1 | Compound was tested in vitro for antibiotic activity against the bacteria Pseudomonas aeruginosa 5007 | ChEMBL. | 3090265 |
MIC (functional) | = 0.78 ug ml-1 | Compound was tested in vitro for antibiotic activity against the bacteria Acinetobacter sp. CMX669 | ChEMBL. | 3090265 |
MIC (functional) | = 0.78 ug ml-1 | The compound was tested evaluated for its antimicrobial activity against Pseudomonas aeruginosa A5007 (Pa(5)) strain. | ChEMBL. | 3020253 |
MIC (functional) | = 0.78 ug ml-1 | The compound was tested for its antimicrobial activity against Acinetobacter sp. CMX 669 (A) strain. | ChEMBL. | 3020253 |
MIC (functional) | = 0.78 ug ml-1 | Minimum inhibition concentration in vitro determined against Pseudomona aeruginosa 5007 | ChEMBL. | 3934382 |
MIC (functional) | = 0.78 ug ml-1 | Minimum inhibition concentration in vitro determined against Actinetobacter sp CMX669 | ChEMBL. | 3934382 |
MIC (functional) | = 0.8 ug ml-1 | Minimum inhibitory concentration against gram-negative Pseudomonas aeruginosa U1-18 (PA-7) | ChEMBL. | 7636859 |
MIC (functional) | = 0.8 ug ml-1 | Minimum inhibitory concentration against gram-positive Staphylococcus aureus H-228 (SA-13) | ChEMBL. | 7636859 |
MIC (functional) | = 1.56 ug ml-1 | The compound was tested in vitro for antibiotic activity against Staphylococcus pyogenes 930 | ChEMBL. | 3090265 |
MIC (functional) | = 1.56 ug ml-1 | Compound was tested in vitro for antibiotic activity against the bacteria Pseudomonas aeruginosa K799/WT | ChEMBL. | 3090265 |
MIC (functional) | = 1.56 ug ml-1 | The compound was tested for its antimicrobial activity against Staphylococcus epidermidis 3519 (Se) strain. | ChEMBL. | 3020253 |
MIC (functional) | = 1.56 ug ml-1 | The compound was tested for its antimicrobial activity against Streptococcus pyogenes 930 (Sp) strain. | ChEMBL. | 3020253 |
MIC (functional) | = 1.56 ug ml-1 | The compound was tested evaluated for its antimicrobial activity against Pseudomonas aeruginosa ( Pa(K)) strain. | ChEMBL. | 3020253 |
MIC (functional) | = 1.56 ug ml-1 | Minimum inhibition concentration in vitro determined against Staphylococcus epidermidis 3519 | ChEMBL. | 3934382 |
MIC (functional) | = 1.56 ug ml-1 | Minimum inhibition concentration in vitro determined against Streptococcus pyogenes 930 | ChEMBL. | 3934382 |
MIC (functional) | = 1.56 ug ml-1 | Minimum inhibition concentration in vitro determined against Pseudomona aeruginosa K799/WT | ChEMBL. | 3934382 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentration against Mycobacterium smegmatis | ChEMBL. | 7636859 |
MIC (functional) | = 3.1 ug ml-1 | Minimum inhibitory concentration against gram-positive Streptococcus pyogenes C203 (SP1-1) | ChEMBL. | 7636859 |
MIC (functional) | = 12.5 ug ml-1 | The compound was tested in vitro for antibiotic activity against Staphylococcus faecium ATCC 8043 | ChEMBL. | 3090265 |
MIC (functional) | = 12.5 ug ml-1 | The compound was tested for its antimicrobial activity against Streptococcus faecium ATCC 8043 (Sf) strain. | ChEMBL. | 3020253 |
MIC (functional) | = 12.5 ug ml-1 | Minimum inhibition concentration in vitro determined against Streptococcus faecium ATCC 8043 | ChEMBL. | 3934382 |
pKa1 | = 6.06 | Dissociation constant (pKa1) | ChEMBL. | 7636859 |
pKa2 | = 8.72 | Dissociation constant (pKa2) | ChEMBL. | 7636859 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
4 literature references were collected for this gene.