Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin | 0.0027 | 0.0238 | 0.0196 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0647 | 0.0606 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.0909 | 0.0017 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0647 | 0.0647 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0238 | 0.0196 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.3028 | 0.2998 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0061 | 0.0893 | 0.0893 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0271 | 0.4902 | 0.4879 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0238 | 0.0196 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.0909 | 1 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0061 | 0.0893 | 0.0853 |
Schistosoma mansoni | glutaminase | 0.0288 | 0.5233 | 0.5212 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0647 | 0.0606 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0909 | 0.0869 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0206 | 0.3655 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0206 | 0.3655 | 0.3033 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0061 | 0.0893 | 0.0853 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.0909 | 0.004 |
Schistosoma mansoni | eyes absent homolog | 0.0096 | 0.155 | 0.1513 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0149 | 0.2571 | 0.2539 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0245 | 0.4404 | 0.4404 |
Schistosoma mansoni | cytochrome B5 | 0.0061 | 0.0893 | 0.0853 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0267 | 0.4823 | 1 |
Echinococcus multilocularis | geminin | 0.0173 | 0.3028 | 0.2998 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0538 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0538 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0245 | 0.4404 | 0.4404 |
Loa Loa (eye worm) | diaphorase | 0.0061 | 0.0893 | 0.0893 |
Onchocerca volvulus | 0.0061 | 0.0893 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0538 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0238 | 0.0238 |
Chlamydia trachomatis | sulfite reductase | 0.0332 | 0.607 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0206 | 0.3655 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0477 | 0.8832 | 0.8717 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0477 | 0.8832 | 0.8159 |
Treponema pallidum | flavodoxin | 0.0206 | 0.3655 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0245 | 0.4404 | 0.4404 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0238 | 0.0196 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0538 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0238 | 0.0238 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.0909 | 0.0869 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0647 | 0.0606 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0538 | 1 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0017 | 0.0044 | 0.0044 |
Mycobacterium ulcerans | glutaminase | 0.0288 | 0.5233 | 0.4765 |
Leishmania major | hypothetical protein, conserved | 0.0206 | 0.3655 | 0.3033 |
Brugia malayi | Muscleblind-like protein | 0.0149 | 0.2571 | 0.2571 |
Brugia malayi | hypothetical protein | 0.0096 | 0.155 | 0.155 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0538 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.0206 | 0.3655 | 0.3655 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0538 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0538 | 1 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0206 | 0.3655 | 0.3033 |
Leishmania major | p450 reductase, putative | 0.0538 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0206 | 0.3655 | 1 |
Brugia malayi | diaphorase | 0.0061 | 0.0893 | 0.0893 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0206 | 0.3655 | 0.3655 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.3028 | 0.2998 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0538 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0647 | 0.0647 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0538 | 1 | 1 |
Echinococcus granulosus | NADH cytochrome b5 reductase 3 | 0.0061 | 0.0893 | 0.0853 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.0909 | 0.0869 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0238 | 0.0238 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.045 | 0.0408 |
Brugia malayi | FAD binding domain containing protein | 0.0332 | 0.607 | 0.607 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0017 | 0.0044 | 0.0044 |
Trichomonas vaginalis | glutaminase, putative | 0.0288 | 0.5233 | 0.2486 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0538 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0647 | 0.0606 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0206 | 0.3655 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0238 | 0.0196 |
Brugia malayi | MH2 domain containing protein | 0.0017 | 0.0044 | 0.0044 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.045 | 0.0408 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0238 | 0.0238 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0238 | 0.0196 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0538 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0538 | 1 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0288 | 0.5233 | 0.5233 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2571 | 0.2571 |
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0061 | 0.0893 | 0.0853 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0647 | 0.0606 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0477 | 0.8832 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.0238 | 0.0196 |
Brugia malayi | glutaminase DH11.1 | 0.0288 | 0.5233 | 0.5233 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.045 | 0.0408 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0238 | 0.0196 |
Brugia malayi | MH1 domain containing protein | 0.0017 | 0.0044 | 0.0044 |
Brugia malayi | MH2 domain containing protein | 0.0017 | 0.0044 | 0.0044 |
Echinococcus granulosus | geminin | 0.0173 | 0.3028 | 0.2998 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0206 | 0.3655 | 0.3033 |
Echinococcus granulosus | muscleblind protein | 0.0149 | 0.2571 | 0.2539 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0538 | 1 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0288 | 0.5233 | 0.5233 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0538 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0538 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0332 | 0.607 | 0.6052 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0267 | 0.4823 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0238 | 0.0238 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.045 | 0.0408 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0909 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0229 | 0.0229 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0206 | 0.3655 | 0.3033 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0206 | 0.3655 | 0.3033 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0909 | 0.0017 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0909 | 0.0017 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0332 | 0.607 | 0.6052 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0017 | 0.0044 | 0.0044 |
Brugia malayi | Smad1 | 0.0017 | 0.0044 | 0.0044 |
Schistosoma mansoni | lamin | 0.0027 | 0.0238 | 0.0196 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0267 | 0.4823 | 0.4801 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0538 | 1 | 1 |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0061 | 0.0893 | 0.0853 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0647 | 0.0606 |
Plasmodium vivax | hypothetical protein, conserved | 0.0206 | 0.3655 | 0.3033 |
Echinococcus multilocularis | muscleblind protein | 0.0149 | 0.2571 | 0.2539 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2571 | 0.2571 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0538 | 1 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0017 | 0.0044 | 0.0044 |
Giardia lamblia | Hypothetical protein | 0.0477 | 0.8832 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0477 | 0.8832 | 0.8717 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0647 | 0.0606 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.155 | 0.155 |
Echinococcus granulosus | methionine synthase reductase | 0.0332 | 0.607 | 0.6052 |
Brugia malayi | FAD binding domain containing protein | 0.0538 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0538 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0909 | 0.0869 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.155 | 0.155 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0538 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0206 | 0.3655 | 1 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0206 | 0.3655 | 0.3033 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0061 | 0.0893 | 0.0893 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0061 | 0.0893 | 0.0853 |
Brugia malayi | hypothetical protein | 0.0038 | 0.045 | 0.045 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0332 | 0.607 | 0.607 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.