Detailed information for compound 557813

Basic information

Technical information
  • TDR Targets ID: 557813
  • Name: 2,3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidine
  • MW: 124.184 | Formula: C7H12N2
  • H donors: 0 H acceptors: 0 LogP: -0.17 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CN=C2N(C1)CCC2
  • InChi: 1S/C7H12N2/c1-3-7-8-4-2-6-9(7)5-1/h1-6H2
  • InChiKey: SGUVLZREKBPKCE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,5-diazabicyclo(4.3.0)non-5-ene
  • 3001-72-7
  • EINECS 221-087-3
  • 1,5-Diazobicyclo(4.3.0)non-5-ene
  • NSC118106
  • 136581_ALDRICH
  • 33471_FLUKA
  • 1,5-Diazabicyclo[4.3.0]non-5-ene
  • Pyrrolo[1,2-a]pyrimidine, 2,3,4,6,7,8-hexahydro-
  • NSC 118106
  • InChI=1/C7H12N2/c1-3-7-8-4-2-6-9(7)5-1/h1-6H

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0003 0.0028
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0168 0.0282
Loa Loa (eye worm) MH2 domain-containing protein 0.0382 0.6677 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0038 0.0447 0.3799
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0447 0.0447
Trypanosoma brucei glucosidase, putative 0.0037 0.0424 0.3604
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0038 0.0447 0.0447
Mycobacterium ulcerans lipase LipD 0.0078 0.1177 0.1177
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0447 0.0447
Trichomonas vaginalis set domain proteins, putative 0.0233 0.3983 0.3983
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0113 0.019
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.1116 0.1871
Schistosoma mansoni hypothetical protein 0.0048 0.0621 0.1042
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.091 0.1363
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0038 0.0447 0.0447
Entamoeba histolytica hypothetical protein 0.0075 0.1116 1
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0113 0.019
Loa Loa (eye worm) RNA binding protein 0.0064 0.091 0.1358
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.063 0.1057
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.1177 0.1974
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0297 0.0499
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.063 0.1057
Schistosoma mansoni smad1 5 8 and 0.0026 0.0225 0.0377
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0136 0.0136
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0038 0.0447 0.0447
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.1177 0.1974
Loa Loa (eye worm) hypothetical protein 0.0155 0.2565 0.3838
Schistosoma mansoni hypothetical protein 0.0048 0.0621 0.1042
Brugia malayi Pre-SET motif family protein 0.003 0.0297 0.0446
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0447 0.0447
Schistosoma mansoni alpha glucosidase 0.0037 0.0424 0.0712
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0621 0.1042
Echinococcus multilocularis smad 0.0026 0.0225 0.0377
Loa Loa (eye worm) retinol dehydrogenase 12 0.0038 0.0447 0.0665
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0424 0.0424
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0038 0.0447 0.067
Onchocerca volvulus 0.002 0.0113 0.0277
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0136 0.1192
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0136 0.0199
Trypanosoma brucei oxidoreductase-like protein 0.0038 0.0447 0.3799
Echinococcus granulosus smad 0.0026 0.0225 0.0377
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.1177 0.1177
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0038 0.0447 0.067
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0099 0.1558 0.1558
Echinococcus multilocularis cpg binding protein 0.0034 0.0371 0.0622
Plasmodium vivax glutathione reductase, putative 0.0039 0.0465 0.0465
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0565 1 1
Plasmodium falciparum glutathione reductase 0.0039 0.0465 0.0465
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.1012 0.1697
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0447 0.0447
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.1177 0.1759
Brugia malayi Smad1 0.0026 0.0225 0.0337
Schistosoma mansoni ap endonuclease 0.0021 0.0136 0.0228
Entamoeba histolytica hypothetical protein 0.0075 0.1116 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0424 0.3604
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0136 0.0204
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0501 0.8851 0.8851
Echinococcus multilocularis geminin 0.0342 0.5964 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.1177 0.1759
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0136 0.0136
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.1177 0.1177
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0678 0.5761
Schistosoma mansoni tar DNA-binding protein 0.0064 0.091 0.1526
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0447 0.0447
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.1177 0.1177
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0565 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.091 0.1358
Leishmania major hypothetical protein, conserved 0.0078 0.1177 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0465 0.0465
Brugia malayi MH1 domain containing protein 0.0014 0.0014 0.0021
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0038 0.0447 0.0447
Schistosoma mansoni hypothetical protein 0.0048 0.0621 0.1042
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0447 0.0447
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0678 0.0678
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0447 0.0447
Brugia malayi beta-lactamase 0.0078 0.1177 0.1763
Schistosoma mansoni hypothetical protein 0.002 0.0113 0.019
Onchocerca volvulus 0.0078 0.1177 0.295
Brugia malayi hypothetical protein 0.0075 0.1116 0.1671
Trichomonas vaginalis hypothetical protein 0.0565 1 1
Plasmodium falciparum thioredoxin reductase 0.0039 0.0465 0.0465
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.2777 0.4657
Echinococcus granulosus cpg binding protein 0.0034 0.0371 0.0622
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0447 0.0447
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0003 0.0028
Loa Loa (eye worm) transcription factor SMAD2 0.0382 0.6677 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.2777 0.4657
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0003 0.0003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0621 0.0926
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0038 0.0447 0.0447
Loa Loa (eye worm) oxidoreductase 0.0038 0.0447 0.0665
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0038 0.0447 0.0447
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.009 0.1377 0.0973
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0475 0.0796
Brugia malayi CXXC zinc finger family protein 0.0032 0.0338 0.0506
Mycobacterium leprae Probable lipase LipE 0.0078 0.1177 0.0764
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0447 0.0447
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0678 0.0678
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0447 0.0447
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.063 0.1057
Brugia malayi MH2 domain containing protein 0.0382 0.6677 1
Schistosoma mansoni alpha-glucosidase 0.0143 0.2356 0.3951
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0621 0.093
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0136 0.0136
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.1177 0.1763
Schistosoma mansoni loxhd1 0.002 0.0113 0.019
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0225 0.0377
Schistosoma mansoni alpha-glucosidase 0.0143 0.2356 0.3951
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0225 0.0377
Brugia malayi TAR-binding protein 0.0064 0.091 0.1363
Schistosoma mansoni smad1 5 8 and 0.0026 0.0225 0.0377
Plasmodium falciparum enoyl-acyl carrier reductase 0.0565 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0621 0.1042
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.1177 0.1974
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0447 0.0447
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0038 0.0447 0.0447
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0038 0.0447 0.0447
Echinococcus granulosus GPCR family 2 0.0048 0.0621 0.1042
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0424 0.0424
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0113 0.019
Brugia malayi hypothetical protein 0.0033 0.035 0.0525
Leishmania major oxidoreductase-like protein 0.0038 0.0447 0.3799
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0003 0.0003
Brugia malayi MH1 domain containing protein 0.0026 0.0225 0.0337
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0297 0.0499
Schistosoma mansoni hypothetical protein 0.0048 0.0621 0.1042
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0447 0.0447
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0113 0.019
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.2777 0.4657
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0136 0.0136
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.009 0.1377 0.1377
Onchocerca volvulus 0.0096 0.1502 0.3767
Loa Loa (eye worm) hypothetical protein 0.0078 0.1177 0.1759
Schistosoma mansoni tar DNA-binding protein 0.0064 0.091 0.1526
Loa Loa (eye worm) hypothetical protein 0.0103 0.1628 0.2435
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0136 0.0136
Mycobacterium tuberculosis Conserved protein 0.0078 0.1177 0.1177
Brugia malayi RNA binding protein 0.0064 0.091 0.1363
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0447 0.0447
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0099 0.1558 0.1163
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0038 0.0447 0.075
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0465 0.0692
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.1177 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0038 0.0447 0.0447
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0447 0.0447
Schistosoma mansoni hypothetical protein 0.0075 0.1116 0.1871
Brugia malayi hypothetical protein 0.0051 0.0678 0.1016
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0003 0.0003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.1116 0.1871
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0136 0.1154
Loa Loa (eye worm) hypothetical protein 0.0078 0.1177 0.1759
Toxoplasma gondii exonuclease III APE 0.0021 0.0136 0.0136
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0038 0.0447 0.3799
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0038 0.0447 0.075
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0424 0.0712
Echinococcus multilocularis muscleblind protein 1 0.0155 0.2565 0.43
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0424 0.0636
Brugia malayi Muscleblind-like protein 0.0155 0.2565 0.3841
Echinococcus multilocularis tar DNA binding protein 0.0064 0.091 0.1526
Toxoplasma gondii ABC1 family protein 0.0078 0.1177 0.1177
Loa Loa (eye worm) glutathione reductase 0.0039 0.0465 0.0692
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.1907 0.3197
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0678 0.5761
Mycobacterium tuberculosis Putative ferredoxin reductase 0.009 0.1377 0.1377
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0038 0.0447 0.3799
Loa Loa (eye worm) TAR-binding protein 0.0064 0.091 0.1358
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0003 0.0003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.063 0.0944
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0424 0.3785
Leishmania major trypanothione reductase 0.0039 0.0465 0.3951
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.1177 0.1177
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.3471 0.5196
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0678 0.5761
Mycobacterium tuberculosis Conserved protein 0.0078 0.1177 0.1177
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0136 1
Schistosoma mansoni cpg binding protein 0.0034 0.0371 0.0622
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0424 0.0424
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0225 0.0332
Echinococcus granulosus RUN 0.002 0.0113 0.019
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.2496 0.3739
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.1177 1
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0113 0.019
Onchocerca volvulus 0.0078 0.1177 0.295
Mycobacterium tuberculosis Probable oxidoreductase 0.0099 0.1558 0.1558
Mycobacterium leprae conserved hypothetical protein 0.0078 0.1177 0.0764
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0424 0.0424
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.1177 0.1177
Brugia malayi Doublecortin family protein 0.002 0.0113 0.017
Loa Loa (eye worm) beta-lactamase 0.0078 0.1177 0.1759
Onchocerca volvulus 0.0233 0.3983 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0038 0.0447 0.0665
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.1177 0.1177
Loa Loa (eye worm) hypothetical protein 0.0051 0.0678 0.1012
Loa Loa (eye worm) hypothetical protein 0.002 0.0113 0.0165
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0297 0.0499
Mycobacterium ulcerans oxidoreductase 0.0038 0.0447 0.0447
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0003 0.0003
Brugia malayi MH2 domain containing protein 0.0026 0.0225 0.0337
Chlamydia trachomatis oxoacy-ACP reductase 0.0038 0.0447 0.0447
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0136 0.0228
Mycobacterium tuberculosis Possible oxidoreductase 0.0038 0.0447 0.0447
Echinococcus granulosus Smad4 0.0026 0.0225 0.0377
Plasmodium vivax hypothetical protein, conserved 0.0078 0.1177 0.1177
Brugia malayi MH1 domain containing protein 0.0026 0.0225 0.0337
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.2496 0.3739
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0465 0.0465
Trichomonas vaginalis esterase, putative 0.0078 0.1177 0.1177
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0678 0.0678
Brugia malayi MH1 domain containing protein 0.0014 0.0014 0.0021
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0113 0.0113
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.009 0.1377 0.1377
Schistosoma mansoni hypothetical protein 0.0342 0.5964 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.091 0.1526
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0016
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0038 0.0447 0.3799
Schistosoma mansoni tar DNA-binding protein 0.0064 0.091 0.1526
Loa Loa (eye worm) hypothetical protein 0.002 0.0113 0.0165
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0038 0.0447 0.0447
Echinococcus multilocularis RUN 0.002 0.0113 0.019
Loa Loa (eye worm) Smad1 0.0026 0.0225 0.0332
Mycobacterium tuberculosis Possible oxidoreductase 0.0038 0.0447 0.0447
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0424 0.3785
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0003 0.0028
Schistosoma mansoni Smad4 0.0026 0.0225 0.0377
Mycobacterium tuberculosis Probable oxidoreductase 0.0038 0.0447 0.0447
Echinococcus multilocularis GPCR, family 2 0.0048 0.0621 0.1042
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0038 0.0447 0.0447
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.088 0.088
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0038 0.0447 0.0447
Schistosoma mansoni hypothetical protein 0.0023 0.0168 0.0282
Brugia malayi hypothetical protein 0.002 0.0113 0.017
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0136 1
Brugia malayi Pre-SET motif family protein 0.0205 0.3471 0.5198
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0297 0.0499
Onchocerca volvulus 0.003 0.0297 0.0739
Schistosoma mansoni lipoxygenase 0.0119 0.1907 0.3197
Loa Loa (eye worm) hypothetical protein 0.0078 0.1177 0.1759
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0621 0.1042
Schistosoma mansoni dihydropteridine reductase 0.0038 0.0447 0.075
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0447 0.0447
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0003 0.0003
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0225 0.0377
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0678 0.0678
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0136 0.1154
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0038 0.0447 0.0447
Schistosoma mansoni smad 0.0026 0.0225 0.0377
Mycobacterium tuberculosis Probable reductase 0.009 0.1377 0.1377
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0113 0.019
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0038 0.0447 0.3799
Schistosoma mansoni tar DNA-binding protein 0.0064 0.091 0.1526
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0424 0.0424
Echinococcus multilocularis Smad4 0.0026 0.0225 0.0377
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0565 1 1
Schistosoma mansoni cpg binding protein 0.0034 0.0371 0.0622
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.1177 0.1177
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0136 0.0136
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.2777 0.416
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0475 0.0796
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0038 0.0447 0.3799
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0038 0.0447 0.0447
Trypanosoma brucei pteridine reductase 1 0.0038 0.0447 0.3799
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0447 0.0447
Mycobacterium ulcerans hypothetical protein 0.0078 0.1177 0.1177
Schistosoma mansoni cpg binding protein 0.0032 0.0338 0.0566
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.063 0.1057
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.1177 0.1974
Entamoeba histolytica hypothetical protein 0.0075 0.1116 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0225 0.0332
Loa Loa (eye worm) hypothetical protein 0.0038 0.0447 0.0665
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0038 0.0447 0.0447
Schistosoma mansoni hypothetical protein 0.0103 0.1628 0.2731
Loa Loa (eye worm) hypothetical protein 0.0048 0.0621 0.0926
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0265 0.0445
Loa Loa (eye worm) hypothetical protein 0.0155 0.2565 0.3838
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0136 0.0136
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0447 0.0447
Schistosoma mansoni lipoxygenase 0.0083 0.1259 0.211
Brugia malayi Thioredoxin reductase 0.0039 0.0465 0.0697
Schistosoma mansoni rab6-interacting 0.002 0.0113 0.019
Leishmania major pteridine reductase 1 0.0038 0.0447 0.3799
Schistosoma mansoni ap endonuclease 0.0021 0.0136 0.0228
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0225 0.0377
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0003 0.0005
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0038 0.0447 0.3799
Plasmodium vivax SET domain protein, putative 0.003 0.0297 0.0297
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0099 0.1558 0.1558
Brugia malayi glutathione reductase 0.0039 0.0465 0.0697
Brugia malayi beta-lactamase family protein 0.0078 0.1177 0.1763
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0297 0.0499
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0038 0.0447 0.0447
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.1177 0.1177
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0168 0.0282
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0447 0.0447
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.1177 0.1177
Schistosoma mansoni rab6-interacting 0.002 0.0113 0.019
Toxoplasma gondii thioredoxin reductase 0.0039 0.0465 0.0465
Loa Loa (eye worm) hypothetical protein 0.0151 0.2496 0.3736
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.1177 0.1177
Brugia malayi hypothetical protein 0.002 0.0113 0.017
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.2777 0.4157
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.1177 0.1177
Loa Loa (eye worm) nuclear factor I 0.0014 0.0014 0.0016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0136 0.1154
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0565 1 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0038 0.0447 0.0447
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.063 0.1057
Echinococcus granulosus geminin 0.0342 0.5964 1
Loa Loa (eye worm) doublecortin family protein 0.002 0.0113 0.0165
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.009 0.1377 0.1377
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.1116 0.1871
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0424 0.0424
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.063 0.1057
Schistosoma mansoni smad1 5 8 and 0.0026 0.0225 0.0377
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0424 0.0424
Mycobacterium ulcerans short chain dehydrogenase 0.0038 0.0447 0.0447
Onchocerca volvulus 0.0078 0.1177 0.295
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0424 0.3604
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0338 0.0501
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0038 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.0078 0.1177 0.1759
Onchocerca volvulus 0.0038 0.0447 0.1116
Mycobacterium ulcerans beta-lactamase 0.0078 0.1177 0.1177
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0003 0.0028
Onchocerca volvulus 0.0038 0.0447 0.1116
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0003 0.0003
Leishmania major hypothetical protein, conserved 0.0051 0.0678 0.5761
Loa Loa (eye worm) hypothetical protein 0.003 0.0297 0.0441
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.1177 0.1177
Brugia malayi beta-lactamase family protein 0.0078 0.1177 0.1763
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0621 0.093
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.1177 0.1177
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0424 0.3604
Echinococcus multilocularis muscleblind protein 0.0155 0.2565 0.43
Brugia malayi MH2 domain containing protein 0.0026 0.0225 0.0337
Echinococcus granulosus tar DNA binding protein 0.0064 0.091 0.1526
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.1907 0.3197
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0038 0.0447 0.075
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.063 0.0939
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.1177 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0297 0.0297
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.1628 0.2439
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0424 0.0424
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0297 0.0499
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0424 0.0631
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0038 0.0447 0.3991
Onchocerca volvulus 0.002 0.0113 0.0277
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.063 0.1057
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0565 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0424 0.0424
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0424 0.0424
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0621 0.1042
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0038 0.0447 0.0447
Schistosoma mansoni polycystin 1-related 0.002 0.0113 0.019
Entamoeba histolytica hypothetical protein 0.0075 0.1116 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.1177 0.1177
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0136 0.0228
Echinococcus granulosus muscleblind protein 0.0155 0.2565 0.43
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0038 0.0447 0.0447
Mycobacterium tuberculosis Conserved protein 0.0078 0.1177 0.1177
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0565 1 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0038 0.0447 0.0447
Schistosoma mansoni hypothetical protein 0.0342 0.5964 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.2496 0.3736
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0038 0.0447 0.0447
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0465 0.3951
Loa Loa (eye worm) hypothetical protein 0.0078 0.1177 0.1759
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0136 0.1154
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0297 0.0499
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0424 0.0712
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0225 0.0377
Onchocerca volvulus 0.0032 0.0338 0.084
Mycobacterium tuberculosis Probable dehydrogenase 0.009 0.1377 0.1377
Trypanosoma brucei trypanothione reductase 0.0039 0.0465 0.3951
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0113 0.0113

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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