Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0187 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0099 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear hormone receptor | 0.0187 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0187 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0187 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0187 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0187 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1071 | 0.1071 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0187 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0187 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0187 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0187 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0187 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0099 | 0.1071 | 0.1071 |
Brugia malayi | steroid hormone receptor | 0.0187 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0187 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0187 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0187 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0187 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0099 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0187 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0099 | 0.1071 | 0.1071 |
Brugia malayi | nuclear receptor NHR-88 | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0187 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0187 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0187 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0187 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0187 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0187 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0187 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0187 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0187 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0187 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0187 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0187 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0099 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0187 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0099 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0187 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0187 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0187 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0187 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0099 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0099 | 0.1071 | 0.1071 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0187 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0187 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0187 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0187 | 1 | 1 |
Onchocerca volvulus | 0.0187 | 1 | 1 | |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0187 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0187 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0187 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0187 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0187 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0187 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0099 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1071 | 0.1071 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0187 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0187 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0187 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0099 | 0.1071 | 0.1071 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
APTT (functional) | = 9.7 uM | Effectiveness to inhibit coagulation in plasma measured as activated partial thromboplastin time (APTT) | ChEMBL. | 10915052 |
F (ADMET) | ND 0 % | Bioavailability in rat (intraduodenal administration) | ChEMBL. | 10915052 |
F (ADMET) | ND 0 % | Oral bioavailability in rat | ChEMBL. | 10915052 |
Ki (binding) | = 27 nM | Evaluated for the binding affinity against thrombin | ChEMBL. | 10915052 |
Ki (binding) | = 27 nM | Evaluated for the binding affinity against thrombin | ChEMBL. | 10915052 |
S | 0 mg ml-1 | Aqueous solubility of the compound; not determined | ChEMBL. | 10915052 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.