Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | DNA topoisomerase II beta, putative | mitochondrial DNA topoisomerase II, putative | 1231 aa | 1042 aa | 35.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.0063 | 0.1969 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0093 | 0.0148 | 0.3811 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0078 | 0.012 | 0.7498 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0104 | 0.0168 | 0.016 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0016 | 0.0009 | 0.0144 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0169 | 0.0285 | 0.4739 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0098 | 0.0158 | 0.54 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.0063 | 0.111 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0169 | 0.0285 | 0.4739 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0169 | 0.0285 | 0.7338 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0116 | 0.0189 | 0.0131 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0093 | 0.0148 | 0.3457 |
Brugia malayi | follicle stimulating hormone receptor | 0.0226 | 0.0387 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0114 | 0.0186 | 0.5 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0036 | 0.0046 | 0.1338 |
Brugia malayi | glutathione reductase | 0.0046 | 0.0063 | 0.159 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0016 | 0.0009 | 0.0194 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0104 | 0.0168 | 0.016 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0116 | 0.0189 | 0.0181 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0016 | 0.0009 | 0.0194 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0104 | 0.0168 | 0.016 |
Mycobacterium ulcerans | integral membrane indolylacetylinositol arabinosyltransferase EmbA | 0.5556 | 1 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0104 | 0.0168 | 0.016 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0098 | 0.0158 | 0.541 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0116 | 0.0189 | 0.0181 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0226 | 0.0387 | 1 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0016 | 0.0009 | 0.0022 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0016 | 0.0009 | 0.0194 |
Echinococcus multilocularis | geminin | 0.0344 | 0.06 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0189 | 0.0322 | 1 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0016 | 0.0009 | 0.0022 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.0148 | 0.247 |
Leishmania major | DNA topoisomerase ii | 0.016 | 0.0268 | 0.8319 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0098 | 0.0158 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.0063 | 0.0054 |
Mycobacterium ulcerans | integral membrane indolylacetylinositol arabinosyltransferase EmbB | 0.5556 | 1 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0169 | 0.0285 | 0.4739 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.0063 | 0.1959 |
Schistosoma mansoni | hypothetical protein | 0.0344 | 0.06 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.0148 | 0.247 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0023 | 0.0022 | 0.0691 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0016 | 0.0009 | 0.0194 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0169 | 0.0285 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0016 | 0.0009 | 0.022 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0116 | 0.0189 | 0.0181 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0016 | 0.0009 | 0.001 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0169 | 0.0285 | 0.7186 |
Brugia malayi | Probable DNA topoisomerase II | 0.0169 | 0.0285 | 0.7338 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0016 | 0.0009 | 0.0194 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0169 | 0.0285 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.0148 | 0.247 |
Echinococcus granulosus | bloom syndrome protein | 0.0023 | 0.0022 | 0.0366 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.0063 | 0.1041 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0016 | 0.0009 | 0.0194 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0009 | 0.0198 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0169 | 0.0285 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0023 | 0.0022 | 0.054 |
Echinococcus multilocularis | bloom syndrome protein | 0.0023 | 0.0022 | 0.0366 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0104 | 0.2244 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0036 | 0.0046 | 0.2479 |
Schistosoma mansoni | hypothetical protein | 0.0344 | 0.06 | 1 |
Mycobacterium tuberculosis | Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) | 0.5556 | 1 | 1 |
Mycobacterium leprae | Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) | 0.5556 | 1 | 1 |
Mycobacterium ulcerans | integral membrane indolylacetylinositol arabinosyltransferase EmbC | 0.5556 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.0063 | 0.111 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0036 | 0.0046 | 0.2479 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.0148 | 0.247 |
Echinococcus granulosus | geminin | 0.0344 | 0.06 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0104 | 0.2244 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.0063 | 0.1951 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0024 | 0.0688 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0036 | 0.0046 | 0.2479 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0016 | 0.0009 | 0.0194 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0169 | 0.0285 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.016 | 0.0268 | 0.8319 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0104 | 0.0168 | 0.0109 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0098 | 0.0158 | 0.0149 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0016 | 0.0009 | 0.0194 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0098 | 0.0158 | 0.0149 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0016 | 0.0009 | 0.0194 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0016 | 0.0009 | 0.0194 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0016 | 0.0009 | 0.0194 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0036 | 0.0046 | 0.1347 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0189 | 0.0322 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.016 | 0.0269 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0016 | 0.0009 | 0.001 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.016 | 0.0268 | 0.8319 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0104 | 0.0168 | 0.016 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0169 | 0.0285 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0016 | 0.0009 | 0.0144 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0024 | 0.0572 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.0063 | 0.1951 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.0148 | 0.247 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0098 | 0.0158 | 0.5404 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0186 | 0.4493 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0016 | 0.0009 | 0.022 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0024 | 0.0581 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0036 | 0.0046 | 0.1357 |
Mycobacterium tuberculosis | Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) | 0.5556 | 1 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0169 | 0.0285 | 0.7338 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0016 | 0.0009 | 0.0194 |
Leishmania major | trypanothione reductase | 0.0046 | 0.0063 | 0.188 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.0063 | 0.1041 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0024 | 0.0572 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0186 | 0.4493 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0114 | 0.0186 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0024 | 0.0068 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0189 | 0.0322 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.0148 | 0.247 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0189 | 0.0322 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.0148 | 0.247 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.016 | 0.0268 | 0.8319 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0016 | 0.0009 | 0.0144 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0114 | 0.0186 | 0.5 |
Mycobacterium tuberculosis | Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) | 0.5556 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.0063 | 0.188 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.0063 | 0.159 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0016 | 0.0009 | 0.0194 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0024 | 0.0604 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0036 | 0.0046 | 0.0037 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0023 | 0.0022 | 0.0691 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0036 | 0.0046 | 0.0037 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.0063 | 0.188 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0018 | 0.0013 | 0.0219 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0024 | 0.0688 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0024 | 0.0688 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0191 | 0.4617 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0098 | 0.0158 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0016 | 0.0009 | 0.0194 |
Mycobacterium leprae | Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) | 0.5556 | 1 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0016 | 0.0009 | 0.0196 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.016 | 0.0268 | 0.8319 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0036 | 0.0046 | 0.2479 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.002 | 0.0017 | 0.0297 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0016 | 0.0009 | 0.0194 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0016 | 0.0009 | 0.0194 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0024 | 0.0592 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0098 | 0.0158 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0016 | 0.0009 | 0.0194 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0104 | 0.0168 | 0.016 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.0063 | 0.1959 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0024 | 0.0688 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
24 literature references were collected for this gene.