Detailed information for compound 558143

Basic information

Technical information
  • TDR Targets ID: 558143
  • Name: N-[(1S,2R,3S,4R)-2,3,4,5-tetrahydroxy-1-(hydr oxymethyl)pentyl]acetamide
  • MW: 223.224 | Formula: C8H17NO6
  • H donors: 6 H acceptors: 6 LogP: -3.62 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)NC(=O)C
  • InChi: 1S/C8H17NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h5-8,10-11,13-15H,2-3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1
  • InChiKey: DWAICOVNOFPYLS-LXGUWJNJSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-yl]ethanamide
  • N-[(1S,2R,3S,4R)-2,3,4,5-tetrahydroxy-1-methylol-pentyl]acetamide
  • N-[(2S,3R,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-yl]acetamide
  • N-acetylglucosaminitol
  • 2-Acetamido-2-deoxy-D-glucitol
  • 2-Acetamido-2-deoxyglucitol
  • D-Glucitol, 2-(acetylamino)-2-deoxy-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.055 0.0552
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.055 0.0552
Onchocerca volvulus 0.0052 0.1061 0.169
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.055 0.0859
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.055 0.5
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.9606 1
Schistosoma mansoni tar DNA-binding protein 0.0126 0.4227 0.6836
Echinococcus granulosus tar DNA binding protein 0.0126 0.4227 0.4388
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.6173 0.595
Onchocerca volvulus Huntingtin homolog 0.0123 0.4095 0.6623
Loa Loa (eye worm) hypothetical protein 0.004 0.055 0.055
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0414 0.041
Schistosoma mansoni survival motor neuron protein 0.0052 0.1061 0.169
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.9606 1
Brugia malayi hypothetical protein 0.0253 0.9606 0.9605
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0414 0.0638
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.034 0.0319
Schistosoma mansoni hypothetical protein 0.0172 0.6173 1
Trichomonas vaginalis glucosylceramidase, putative 0.0263 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.034 0.034
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.055 0.0552
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0021 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.6173 0.595
Loa Loa (eye worm) TAR-binding protein 0.0126 0.4227 0.4227
Schistosoma mansoni hypothetical protein 0.0036 0.0414 0.0638
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0414 0.041
Schistosoma mansoni tar DNA-binding protein 0.0126 0.4227 0.6836
Schistosoma mansoni hypothetical protein 0.0035 0.034 0.0518
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0021 0.0021
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.055 0.5
Brugia malayi TAR-binding protein 0.0126 0.4227 0.4215
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.1019 0.1
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.6566 0.6367
Schistosoma mansoni tar DNA-binding protein 0.0126 0.4227 0.6836
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.055 0.5
Echinococcus multilocularis tar DNA binding protein 0.0126 0.4227 0.4388
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0263 1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.1061 0.1042
Onchocerca volvulus Huntingtin homolog 0.0123 0.4095 0.6623
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.055 1
Schistosoma mansoni hypothetical protein 0.0052 0.1061 0.169
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.1019 0.1019
Loa Loa (eye worm) hypothetical protein 0.0051 0.1019 0.1019
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0238 0.8972 0.8972
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.6173 0.595
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.055 0.0552
Loa Loa (eye worm) hypothetical protein 0.0123 0.4095 0.4095
Schistosoma mansoni tar DNA-binding protein 0.0126 0.4227 0.6836
Loa Loa (eye worm) hypothetical protein 0.0253 0.9606 0.9606
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.6566 0.6367
Echinococcus granulosus geminin 0.0172 0.6173 0.6419
Loa Loa (eye worm) hypothetical protein 0.0123 0.4095 0.4095
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.4227 0.4215
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.055 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0263 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0263 1 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.055 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0263 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0263 1 1
Schistosoma mansoni tar DNA-binding protein 0.0126 0.4227 0.6836
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.6173 0.595
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.1019 0.1
Echinococcus multilocularis geminin 0.0172 0.6173 0.6419
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.055 0.0552
Trichomonas vaginalis glucosylceramidase, putative 0.0263 1 1
Brugia malayi hypothetical protein 0.0036 0.0414 0.0393
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.4227 0.4227
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.055 0.0859
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.6173 0.595
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.6173 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0021
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.055 0.053
Schistosoma mansoni hypothetical protein 0.0172 0.6173 1
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.055 0.0552
Loa Loa (eye worm) RNA binding protein 0.0126 0.4227 0.4227
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.6173 0.595
Brugia malayi RNA binding protein 0.0126 0.4227 0.4215
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.6173 0.595
Brugia malayi hypothetical protein 0.0123 0.4095 0.4083
Brugia malayi follicle stimulating hormone receptor 0.0238 0.8972 0.897

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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