Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.105 | 0.1507 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0157 | 0.0088 |
Brugia malayi | RNA binding protein | 0.0132 | 0.3561 | 0.5107 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0048 | 0.1034 | 1 |
Leishmania major | importin beta-1 subunit, putative | 0.0026 | 0.0384 | 0.1857 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0039 | 0.0771 | 0.0698 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0039 | 0.0771 | 0.7036 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0088 | 0.2242 | 0.218 |
Onchocerca volvulus | 0.0088 | 0.2242 | 1 | |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0053 | 0.1192 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0048 | 0.1034 | 0.0963 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0018 | 0.0147 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0771 | 0.0698 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.0157 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0157 | 0.008 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.0348 | 0.0051 |
Plasmodium falciparum | glutathione reductase | 0.0053 | 0.1192 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0061 | 0.1421 | 0.1353 |
Plasmodium vivax | importin-beta 2, putative | 0.0032 | 0.0568 | 0.4029 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0039 | 0.0771 | 0.7036 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0039 | 0.0771 | 0.5975 |
Echinococcus multilocularis | snurportin 1 | 0.0345 | 1 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0018 | 0.0147 | 0.0069 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0061 | 0.1421 | 0.1353 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.0348 | 0.0051 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0121 | 0.324 | 0.877 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0025 | 0.0338 | 0.1828 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0121 | 0.324 | 0.8844 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0025 | 0.0338 | 0.15 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0025 | 0.0338 | 0.1828 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0568 | 0.0493 |
Echinococcus granulosus | tar DNA binding protein | 0.0132 | 0.3561 | 0.351 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0348 | 0.1581 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0061 | 0.1421 | 0.2038 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.2385 | 0.2325 |
Trypanosoma brucei | trypanothione reductase | 0.0053 | 0.1192 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0039 | 0.0771 | 0.5975 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3561 | 0.351 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0642 | 0.0568 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3561 | 0.351 |
Plasmodium vivax | glutathione reductase, putative | 0.0053 | 0.1192 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0384 | 0.2666 |
Brugia malayi | hypothetical protein | 0.0037 | 0.07 | 0.1004 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0026 | 0.0384 | 0.2264 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0348 | 0.1581 |
Echinococcus granulosus | importin subunit beta 1 | 0.0032 | 0.0568 | 0.0493 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0044 | 0.0914 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0121 | 0.324 | 0.8844 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.0348 | 0.1581 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.07 | 0.1769 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0044 | 0.0914 | 0.2814 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.0348 | 0.1581 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0348 | 0.0272 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0039 | 0.0771 | 0.0698 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.105 | 0.098 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0039 | 0.0771 | 0.49 |
Leishmania major | trypanothione reductase | 0.0053 | 0.1192 | 0.8202 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0025 | 0.0338 | 0.15 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0061 | 0.1421 | 0.3676 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0018 | 0.0147 | 0.0069 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.0348 | 0.0031 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0348 | 0.1581 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0018 | 0.0147 | 0.0211 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0093 | 0.2385 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0032 | 0.0568 | 0.4029 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0163 | 0.4493 | 0.6445 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0348 | 0.05 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.07 | 0.1769 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0053 | 0.1192 | 0.1122 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0348 | 0.1581 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.0348 | 0.063 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0039 | 0.0771 | 0.0698 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0348 | 0.1581 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0771 | 0.7036 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.0157 | 0.0099 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0039 | 0.0771 | 0.5975 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0039 | 0.0771 | 0.2116 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0044 | 0.0914 | 0.7342 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.07 | 0.1769 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0039 | 0.0771 | 0.1106 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.07 | 0.0627 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0132 | 0.3561 | 0.351 |
Brugia malayi | glutathione reductase | 0.0053 | 0.1192 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0157 | 0.008 |
Brugia malayi | TAR-binding protein | 0.0132 | 0.3561 | 0.5107 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.1127 | 0.1617 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.0348 | 0.0031 |
Schistosoma mansoni | hypothetical protein | 0.0345 | 1 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0048 | 0.1034 | 0.8491 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0078 | 0.0113 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0568 | 0.4029 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.105 | 0.098 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0093 | 0.2385 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0348 | 0.1581 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0384 | 0.2666 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0061 | 0.1421 | 1 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0025 | 0.0338 | 0.15 |
Loa Loa (eye worm) | TAR-binding protein | 0.0132 | 0.3561 | 0.351 |
Brugia malayi | Thioredoxin reductase | 0.0053 | 0.1192 | 0.1709 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0032 | 0.0568 | 0.0493 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0134 | 0.3647 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0568 | 0.4029 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.07 | 0.0627 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0134 | 0.3647 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0345 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0025 | 0.0338 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.105 | 0.098 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0121 | 0.324 | 0.8844 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0158 | 0.4356 | 0.4311 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0121 | 0.324 | 0.8844 |
Loa Loa (eye worm) | glutathione reductase | 0.0053 | 0.1192 | 0.1122 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.105 | 0.098 |
Brugia malayi | follicle stimulating hormone receptor | 0.0245 | 0.6972 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0088 | 0.2242 | 0.218 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0642 | 0.0921 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0061 | 0.1421 | 0.1353 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0053 | 0.1192 | 0.3026 |
Brugia malayi | RNA, U transporter 1 | 0.0092 | 0.2365 | 0.3393 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0057 | 0.1298 | 0.1229 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0025 | 0.0348 | 0.0051 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0088 | 0.2242 | 0.3216 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0025 | 0.0338 | 0.1828 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0025 | 0.0338 | 1 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0039 | 0.0771 | 0.0698 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0348 | 0.05 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0048 | 0.1034 | 1 |
Plasmodium falciparum | importin beta, putative | 0.0032 | 0.0568 | 0.4029 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0134 | 0.3647 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0348 | 0.0272 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0061 | 0.1421 | 1 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0025 | 0.0338 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0078 | 0.0113 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0053 | 0.1192 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0132 | 0.3561 | 0.351 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0019 | 0.0157 | 0.0082 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.07 | 0.0627 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.105 | 0.098 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0121 | 0.324 | 0.8844 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.105 | 0.098 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0157 | 0.008 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.1127 | 0.1617 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.1127 | 0.1057 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0061 | 0.1421 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0348 | 0.05 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0053 | 0.1192 | 0.1122 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0025 | 0.0338 | 0.0601 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3561 | 0.351 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.2242 | 0.218 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0039 | 0.0771 | 0.0698 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0025 | 0.0338 | 0.1828 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0157 | 0.0544 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0048 | 0.1034 | 0.8491 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1127 | 0.1057 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.105 | 0.098 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0039 | 0.0771 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0157 | 0.008 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0053 | 0.1192 | 0.1122 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.0348 | 0.063 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0134 | 0.3647 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.07 | 0.0627 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.105 | 0.098 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0039 | 0.0771 | 0.8137 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0157 | 0.008 |
Schistosoma mansoni | importin beta-1 | 0.0032 | 0.0568 | 0.0493 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0384 | 0.0222 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0039 | 0.0771 | 0.0698 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0132 | 0.3561 | 0.5107 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0163 | 0.4493 | 0.445 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0245 | 0.6972 | 0.6948 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0163 | 0.4493 | 0.445 |
Loa Loa (eye worm) | acetyltransferase | 0.0163 | 0.4493 | 0.445 |
Toxoplasma gondii | thioredoxin reductase | 0.0053 | 0.1192 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0348 | 0.0272 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0025 | 0.0338 | 0.1828 |
Trichomonas vaginalis | importin beta-1, putative | 0.0026 | 0.0384 | 0.2666 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3561 | 0.351 |
Mycobacterium tuberculosis | Probable reductase | 0.0121 | 0.324 | 0.8844 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0048 | 0.1034 | 0.8491 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0018 | 0.0147 | 0.0069 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.0348 | 0.1581 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0039 | 0.0771 | 0.0698 |
Echinococcus multilocularis | tar DNA binding protein | 0.0132 | 0.3561 | 0.351 |
Plasmodium falciparum | thioredoxin reductase | 0.0053 | 0.1192 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.07 | 0.1769 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.0348 | 0.1581 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0348 | 0.1581 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0642 | 0.0568 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3561 | 0.351 |
Brugia malayi | Importin beta-1 subunit | 0.0032 | 0.0568 | 0.0815 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0088 | 0.2242 | 0.218 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.