Detailed information for compound 55824

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 435.468 | Formula: C22H29NO8
  • H donors: 5 H acceptors: 5 LogP: 0.58 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1[C@@H](NC(=O)/C(=C/c2ccc(c(c2)O)OC2CCCC2)/C)[C@@H](O)[C@H]2[C@@H]([C@@H]1O)OCO2
  • InChi: 1S/C22H29NO8/c1-11(8-12-6-7-15(14(24)9-12)31-13-4-2-3-5-13)22(28)23-16-17(25)19(27)21-20(18(16)26)29-10-30-21/h6-9,13,16-21,24-27H,2-5,10H2,1H3,(H,23,28)/b11-8+/t16-,17+,18-,19-,20+,21-/m1/s1
  • InChiKey: NILTWNUWKVVYTK-ZWAWJJHXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi protein kinase C3,putative 0.0049 0.0247 0.0247
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0128 0.1008 0.1977
Brugia malayi RhoGAP domain containing protein 0.0048 0.0233 0.0233
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0128 0.1008 0.1008
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0423 0.0964
Loa Loa (eye worm) hypothetical protein 0.0615 0.5689 0.5689
Plasmodium falciparum lysophospholipase, putative 0.045 0.4105 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0195 0.1651 0.1651
Echinococcus granulosus protein kinase c eta type 0.0048 0.0233 0.0233
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0027 0.003 0.5
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0335 0.0748
Echinococcus granulosus fatty acid amide hydrolase 1 0.1063 1 1
Echinococcus granulosus regulator of G protein signaling 7 0.0042 0.0182 0.0182
Echinococcus granulosus jun protein 0.0089 0.0635 0.0635
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0574 0.0574
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0004 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0004 0.0004
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0128 0.1008 0.24
Loa Loa (eye worm) hypothetical protein 0.0294 0.2601 0.2601
Echinococcus multilocularis N chimaerin 0.0048 0.0233 0.0233
Trypanosoma cruzi monoglyceride lipase, putative 0.045 0.4105 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0574 0.0574
Brugia malayi Protein kinase domain containing protein 0.0067 0.0423 0.0423
Brugia malayi diacylglycerol kinase 0.0048 0.0233 0.0233
Plasmodium falciparum lysophospholipase, putative 0.045 0.4105 1
Mycobacterium ulcerans amidase 0.0128 0.1008 0.1977
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0388 0.0879
Loa Loa (eye worm) RGS-3 protein 0.0042 0.0182 0.0182
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0027 0.003 0.003
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0049 0.0247 0.0247
Echinococcus multilocularis regulator of G protein signaling 0.0042 0.0182 0.0182
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0004 0.0004
Echinococcus multilocularis regulator of G protein signaling 3 0.0042 0.0182 0.0182
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0257 0.0557
Echinococcus multilocularis unc 13 (munc13) 0.0054 0.0296 0.0296
Brugia malayi hypothetical protein 0.0042 0.0182 0.0182
Echinococcus granulosus unc 13 munc13 0.0054 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0361 0.3249 0.3249
Echinococcus multilocularis RNA directed DNA polymerase 0.0164 0.1351 0.1351
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0066 0.0409 0.093
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0388 0.0879
Loa Loa (eye worm) AGC/NDR protein kinase 0.0067 0.0423 0.0423
Echinococcus granulosus NDR protein kinase 0.0067 0.0423 0.0423
Schistosoma mansoni lipoxygenase 0.0054 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0042 0.0182 0.0182
Brugia malayi Hr1 repeat family protein 0.0067 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0042 0.0182 0.0182
Loa Loa (eye worm) amidase 0.0128 0.1008 0.1008
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0054 0.0296 0.0296
Schistosoma mansoni axis inhibition protein axin 0.0042 0.0182 0.0182
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0004 0.0004
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0128 0.1008 0.1977
Brugia malayi putative amidase 0.0128 0.1008 0.1008
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0004 0.0004
Mycobacterium ulcerans lysophospholipase 0.045 0.4105 0.8236
Echinococcus multilocularis myotubularin protein 13 0.0048 0.0233 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0182 0.0374
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0044 0.0196 0.0196
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.045 0.4105 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0342 0.0342
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.045 0.4105 1
Leishmania major cathepsin L-like protease 0.0064 0.0388 0.0879
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0196 0.0196
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0004 0.0004
Onchocerca volvulus 0.0104 0.0773 0.297
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0004 0.0004
Echinococcus multilocularis serine:threonine protein kinase N2 0.0141 0.1129 0.1129
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0027 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0004 0.0004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0342 0.063
Brugia malayi regulator of G-protein signaling egl-10 0.0042 0.0182 0.0182
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0004 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0423 0.0423
Echinococcus granulosus axis inhibition protein axin 0.0042 0.0182 0.0182
Leishmania major monoglyceride lipase, putative 0.045 0.4105 1
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0233 0.0233
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0042 0.0182 0.0182
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0342 0.063
Schistosoma mansoni protein kinase C mu 0.0049 0.0247 0.0247
Echinococcus multilocularis serine:threonine protein kinase N2 0.0067 0.0423 0.0423
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0128 0.1008 0.1008
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0182 0.0374
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0004 0.0004
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0342 0.7934
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0391 0.0391
Echinococcus multilocularis protein kinase c eta type 0.0048 0.0233 0.0233
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0004 0.0004
Echinococcus granulosus Regulator of G protein signaling 20 0.0042 0.0182 0.0182
Echinococcus granulosus regulator of G protein signaling 3 0.0042 0.0182 0.0182
Loa Loa (eye worm) ShTK domain-containing protein 0.0104 0.0773 0.0773
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0054 0.0296 0.0296
Echinococcus multilocularis jun protein 0.0089 0.0635 0.0635
Mycobacterium ulcerans amidase 0.0128 0.1008 0.1977
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0048 0.0233 0.0233
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0104 0.0773 0.0773
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0004 0.0004
Brugia malayi Common central domain of tyrosinase family protein 0.0104 0.0773 0.0773
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0423 0.0964
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0004 0.0004
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0004 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0423 0.0423
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0132 0.0132
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0342 0.063
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0388 0.0879
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0004 0.0004
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0104 0.0773 0.0773
Mycobacterium ulcerans short chain dehydrogenase 0.0541 0.4978 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0388 0.0879
Plasmodium falciparum esterase, putative 0.045 0.4105 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0541 0.4978 1
Echinococcus multilocularis protein kinase c epsilon type 0.0195 0.1651 0.1651
Mycobacterium ulcerans amidase 0.0128 0.1008 0.1977
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0182 0.0374
Brugia malayi Protein kinase domain containing protein 0.0049 0.0247 0.0247
Mycobacterium ulcerans hypothetical protein 0.045 0.4105 0.8236
Mycobacterium ulcerans amidase 0.0128 0.1008 0.1977
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0067 0.0423 0.0423
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.045 0.4105 1
Entamoeba histolytica hypothetical protein 0.0042 0.0182 0.0374
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0388 0.0879
Entamoeba histolytica protein kinase, putative 0.0067 0.0423 0.0964
Schistosoma mansoni fatty-acid amide hydrolase 0.1063 1 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0342 0.0765
Loa Loa (eye worm) hypothetical protein 0.0048 0.0233 0.0233
Echinococcus granulosus abhydrolase domain containing 3 0.0027 0.003 0.003
Echinococcus granulosus raf serine:threonine protein kinase 0.0048 0.0233 0.0233
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0044 0.0196 0.0196
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0294 0.2601 0.2601
Schistosoma mansoni z-protein (S1r protein) 0.0042 0.0182 0.0182
Entamoeba histolytica hypothetical protein 0.0042 0.0182 0.0374
Echinococcus multilocularis axis inhibition protein axin 0.0042 0.0182 0.0182
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0247 0.0247
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0182 0.0182
Echinococcus granulosus regulator of G protein signaling 3 0.0042 0.0182 0.0182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0004 0.0004
Echinococcus granulosus axis inhibition protein axin 0.0042 0.0182 0.0182
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0067 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0004
Echinococcus multilocularis Regulator of G protein signaling 20 0.0042 0.0182 0.0182
Echinococcus granulosus abhydrolase domain containing protein 13 0.0027 0.003 0.003
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0128 0.1008 0.1977
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0004
Echinococcus multilocularis expressed protein 0.0825 0.7713 0.7713
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0048 0.0233 0.0233
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0048 0.0233 0.0233
Brugia malayi ShTK domain containing protein 0.0104 0.0773 0.0773
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0067 0.0423 0.0423
Loa Loa (eye worm) tyrosinase 1 0.0104 0.0773 0.0773
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0388 0.0879
Echinococcus granulosus serine:threonine protein kinase N2 0.0075 0.0495 0.0495
Brugia malayi PXA domain containing protein 0.0042 0.0182 0.0182
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.045 0.4105 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0004 0.0004
Loa Loa (eye worm) amidase 0.0128 0.1008 0.1008
Entamoeba histolytica diacylglycerol kinase, putative 0.0048 0.0233 0.0498
Brugia malayi Protein kinase domain containing protein 0.0067 0.0423 0.0423
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0067 0.0423 0.0423
Schistosoma mansoni tyrosinase precursor 0.0104 0.0773 0.0773
Schistosoma mansoni protein kinase C mu 0.0048 0.0233 0.0233
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0182 0.0182
Echinococcus multilocularis Phospholipase carboxylesterase 0.0027 0.003 0.003
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0128 0.1008 0.1977
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0128 0.1008 0.1977
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0128 0.1008 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0004 0.0016
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0128 0.1008 0.1008
Loa Loa (eye worm) hypothetical protein 0.0042 0.0182 0.0182
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1063 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0004 0.0004
Loa Loa (eye worm) PXA domain-containing protein 0.0042 0.0182 0.0182
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0042 0.0182 0.0182
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0089 0.0635 0.0635
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0004 0.0004
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0004 0.0004
Trypanosoma brucei monoglyceride lipase, putative 0.045 0.4105 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0042 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0048 0.0233 0.0233
Echinococcus multilocularis Diacylglycerol kinase theta 0.0048 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0048 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0027 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0027 0.003 0.003
Brugia malayi Amidase family protein 0.0128 0.1008 0.1008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0388 0.0879
Echinococcus granulosus Diacylglycerol kinase theta 0.0048 0.0233 0.0233
Schistosoma mansoni serine/threonine protein kinase 0.0285 0.252 0.252
Trypanosoma brucei monoglyceride lipase, putative 0.045 0.4105 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0067 0.0423 0.0423
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0388 0.0879
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0049 0.0247 0.0247
Brugia malayi diacylglycerol kinase 0.0048 0.0233 0.0233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0388 0.0879
Schistosoma mansoni amidase 0.1063 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0004 0.0004
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0164 0.1351 0.1351
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0042 0.0182 0.0182
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0423 0.0964
Brugia malayi follicle stimulating hormone receptor 0.0247 0.2148 0.2148
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0391 0.0391
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0128 0.1008 1
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0027 0.003 0.003
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0089 0.0635 0.0635
Brugia malayi Protein kinase c protein 2 0.0219 0.1886 0.1886
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0388 0.0879
Trypanosoma brucei rac serine-threonine kinase, putative 0.0067 0.0423 0.0964
Leishmania major cathepsin L-like protease 0.0064 0.0388 0.0879
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0004 0.0004
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0104 0.0773 0.0773
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.045 0.4105 1
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0004 0.0004
Echinococcus granulosus expressed protein 0.0825 0.7713 0.7713
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.045 0.4105 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0004
Echinococcus granulosus regulator of G protein signaling 7 0.0042 0.0182 0.0182
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0049 0.0247 0.0247
Echinococcus granulosus myotubularin protein 13 0.0048 0.0233 0.0233
Echinococcus granulosus protein kinase c iota type 0.0115 0.0881 0.0881
Plasmodium falciparum lysophospholipase, putative 0.045 0.4105 1
Mycobacterium ulcerans peptide amidase, GatA 0.0128 0.1008 0.1977
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0391 0.0391
Onchocerca volvulus 0.0054 0.0296 0.1138
Brugia malayi RhoGEF domain containing protein 0.0048 0.0233 0.0233
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0423 0.0964
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0004 0.0004
Brugia malayi MGC83647 protein 0.0027 0.003 0.003
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0042 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0211 0.1809 0.1809
Echinococcus multilocularis regulator of G protein signaling 7 0.0042 0.0182 0.0182
Echinococcus granulosus RNA directed DNA polymerase 0.0164 0.1351 0.1351
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0391 0.0886
Loa Loa (eye worm) ShTK domain-containing protein 0.0104 0.0773 0.0773
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0391 0.0391
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0342 0.063
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0027 0.003 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0423 0.0423
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0182 0.0182
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0004 0.0004
Onchocerca volvulus 0.007 0.045 0.173
Echinococcus multilocularis raf serine:threonine protein kinase 0.0048 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0048 0.0233 0.0233
Echinococcus multilocularis Rac GTPase activating protein 1 0.0048 0.0233 0.0233
Schistosoma mansoni serine/threonine kinase 0.0067 0.0423 0.0423
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0423 0.0964
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0004 0.0004
Echinococcus granulosus fatty acid amide hydrolase 1 0.0128 0.1008 0.1008
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0004 0.0004
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0049 0.0247 0.0247
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0233 0.0233
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0388 0.0879
Loa Loa (eye worm) hypothetical protein 0.0294 0.2601 0.2601
Echinococcus granulosus Phospholipase carboxylesterase 0.0027 0.003 0.003
Echinococcus multilocularis abhydrolase domain containing 3 0.0027 0.003 0.003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0004 0.0004
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0342 0.0342
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0004 0.0016
Schistosoma mansoni hypothetical protein 0.0073 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.0042 0.0182 0.0182
Loa Loa (eye worm) raf kinase 0.0048 0.0233 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0004 0.0004
Brugia malayi Protein kinase domain containing protein 0.0067 0.0423 0.0423
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0042 0.0182 0.0374
Onchocerca volvulus 0.0083 0.0574 0.2207
Schistosoma mansoni serine/threonine protein kinase 0.0285 0.252 0.252
Echinococcus multilocularis serine:threonine protein kinase 38 0.0067 0.0423 0.0423
Schistosoma mansoni peptidase 0.0027 0.003 0.003
Mycobacterium ulcerans amidase 0.0128 0.1008 0.1977
Entamoeba histolytica PH domain containing protein kinase, putative 0.0075 0.0495 0.1142
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.045 0.4105 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0611 0.0611
Brugia malayi PXA domain containing protein 0.0042 0.0182 0.0182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0388 0.0879
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0004 0.0004
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0048 0.0233 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.045 0.4105 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.1351 0.1351
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.029 0.029
Brugia malayi MGC79044 protein 0.0027 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0004 0.0004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0004 0.0004
Toxoplasma gondii diacylglycerol kinase, putative 0.0048 0.0233 0.5166
Entamoeba histolytica protein kinase, putative 0.0067 0.0423 0.0964
Onchocerca volvulus 0.0104 0.0773 0.297
Brugia malayi protein kinase C II. 0.0195 0.1651 0.1651
Loa Loa (eye worm) hypothetical protein 0.0027 0.003 0.003
Trypanosoma cruzi amidase, putative 0.0128 0.1008 0.24
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0004 0.0004
Entamoeba histolytica hypothetical protein 0.0042 0.0182 0.0374
Leishmania major hypothetical protein, conserved 0.0128 0.1008 0.24
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0004 0.0004
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0574 0.0574
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0423 0.0964
Echinococcus multilocularis protein kinase c iota type 0.0115 0.0881 0.0881
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0388 0.0879
Brugia malayi p70 ribosomal S6 kinase beta 0.0067 0.0423 0.0423
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0044 0.0196 0.0196
Schistosoma mansoni fatty-acid amide hydrolase 0.0128 0.1008 0.1008
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0182 0.0182
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.045 0.4105 1
Schistosoma mansoni axis inhibition protein axin 0.0042 0.0182 0.0182
Onchocerca volvulus 0.0048 0.0233 0.0896
Mycobacterium tuberculosis Possible lysophospholipase 0.045 0.4105 0.8236
Loa Loa (eye worm) hypothetical protein 0.0048 0.0233 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0004 0.0004
Trypanosoma cruzi amidase, putative 0.0128 0.1008 0.24
Onchocerca volvulus 0.0294 0.2601 1
Schistosoma mansoni unc-13 (munc13) 0.0054 0.0296 0.0296
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0247 0.0247
Echinococcus granulosus beta-adrenergic receptor kinase 0.0044 0.0196 0.0196
Echinococcus granulosus protein kinase c epsilon type 0.0195 0.1651 0.1651
Echinococcus multilocularis serine threonine protein kinase 0.0238 0.2062 0.2062
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0004 0.0004
Echinococcus multilocularis regulator of G protein signaling 7 0.0042 0.0182 0.0182
Brugia malayi regulator of G-protein signaling rgs-7 0.0042 0.0182 0.0182
Schistosoma mansoni diacylglycerol kinase theta 0.0048 0.0233 0.0233
Echinococcus granulosus Rac GTPase activating protein 1 0.0048 0.0233 0.0233
Schistosoma mansoni jun-related protein 0.0073 0.0474 0.0474
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0196 0.0196
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0049 0.0247 0.0247
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0172 0.1428 0.1428
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0042 0.0182 0.0182
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0128 0.1008 0.5
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0067 0.0423 0.0423
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.045 0.4105 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0574 0.0574
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0004 0.0004
Echinococcus granulosus protein kinase C gamma type 0.0238 0.2062 0.2062
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0388 0.0879
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0391 0.0391
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0423 0.0964
Schistosoma mansoni tyrosinase precursor 0.0104 0.0773 0.0773
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0004
Schistosoma mansoni rac gtpase activating protein 0.0048 0.0233 0.0233
Echinococcus multilocularis beta adrenergic receptor kinase 0.0044 0.0196 0.0196
Brugia malayi Pleckstrin Homology Domain 0.0048 0.0233 0.0233
Brugia malayi ecdysteroid receptor 0.0024 0.0004 0.0004
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0067 0.0423 0.0423
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0004 0.0004
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0067 0.0423 0.0423
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0004 0.0004
Schistosoma mansoni atypical protein kinase C 0.0115 0.0881 0.0881
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0196 0.0196
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0048 0.0233 0.0233
Loa Loa (eye worm) RasGEF domain-containing protein 0.0048 0.0233 0.0233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0388 0.0879
Brugia malayi Regulator of G protein signaling domain containing protein 0.0042 0.0182 0.0182
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0342 0.0342
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0423 0.0423
Brugia malayi nuclear receptor NHR-88 0.0024 0.0004 0.0004
Entamoeba histolytica protein kinase, putative 0.0067 0.0423 0.0964
Toxoplasma gondii AGC kinase 0.0067 0.0423 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0182 0.0374
Schistosoma mansoni diacylglycerol kinase theta 0.0048 0.0233 0.0233
Plasmodium vivax PST-A protein 0.045 0.4105 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0048 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0048 0.0233 0.0233
Onchocerca volvulus 0.0104 0.0773 0.297
Loa Loa (eye worm) hypothetical protein 0.0048 0.0233 0.0233
Echinococcus granulosus Protein kinase C brain isozyme 0.0285 0.252 0.252
Loa Loa (eye worm) hypothetical protein 0.0042 0.0182 0.0182
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0004 0.0004
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0423 0.0964
Schistosoma mansoni unc-13 (munc13) 0.0054 0.0296 0.0296
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.1651 0.1651
Loa Loa (eye worm) hypothetical protein 0.0104 0.0773 0.0773
Echinococcus granulosus fatty acid amide hydrolase 1 0.1063 1 1
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0027 0.003 0.003
Entamoeba histolytica protein kinase, putative 0.0067 0.0423 0.0964
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.1063 1 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0042 0.0182 0.0182
Brugia malayi RhoGAP domain containing protein 0.0048 0.0233 0.0233
Brugia malayi Protein C20orf22 0.0027 0.003 0.003
Schistosoma mansoni protein kinase C 0.0054 0.0296 0.0296
Loa Loa (eye worm) AGC/AKT protein kinase 0.0067 0.0423 0.0423
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0128 0.1008 0.1977
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0004 0.0004
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0104 0.0773 0.0773
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0391 0.0886
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0027 0.003 0.003
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0004 0.0004
Leishmania major cathepsin L-like protease 0.0064 0.0388 0.0879
Brugia malayi A-kinase anchor protein 10, precursor 0.0042 0.0182 0.0182
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0423 0.0964
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0423 0.0964
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0067 0.0423 0.0423
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0391 0.0886
Loa Loa (eye worm) hypothetical protein 0.0341 0.306 0.306
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0285 0.252 0.252
Brugia malayi steroid hormone receptor 0.0024 0.0004 0.0004
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0054 0.0296 0.0296
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0128 0.1008 0.24
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0004 0.0004
Echinococcus multilocularis regulator of G protein signaling 3 0.0042 0.0182 0.0182
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0048 0.0233 0.0233
Brugia malayi nuclear hormone receptor 0.0024 0.0004 0.0004
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0004
Onchocerca volvulus 0.0024 0.0004 0.0016
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0128 0.1008 0.1008
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0104 0.0773 0.0773
Loa Loa (eye worm) AGC/PKN protein kinase 0.0067 0.0423 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0182 0.0374
Schistosoma mansoni vav2 0.0048 0.0233 0.0233
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0247 0.2148 0.2148
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0342 0.0342
Entamoeba histolytica diacylglycerol kinase, putative 0.0048 0.0233 0.0498
Schistosoma mansoni coup transcription factor 0.0024 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0004 0.0004
Brugia malayi Ras association domain family 1 isoform A 0.0048 0.0233 0.0233
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0004 0.0004
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0391 0.0886
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0048 0.0233 0.0233
Trichomonas vaginalis valacyclovir hydrolase, putative 0.045 0.4105 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0182 0.0182
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1063 1 1
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0128 0.1008 0.24
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0004
Echinococcus granulosus N chimaerin 0.0048 0.0233 0.0233
Brugia malayi Amidase family protein 0.0128 0.1008 0.1008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0004
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0004 0.0004
Brugia malayi C1-like domain containing protein 0.0049 0.0247 0.0247
Echinococcus multilocularis axis inhibition protein axin 0.0042 0.0182 0.0182
Entamoeba histolytica hypothetical protein 0.0048 0.0233 0.0498
Schistosoma mansoni hypothetical protein 0.0048 0.0233 0.0233
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0067 0.0423 0.0423
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.029 0.029
Brugia malayi hypothetical protein 0.007 0.045 0.045
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0574 0.0574
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0067 0.0423 0.0423
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0423 0.0964
Brugia malayi hypothetical protein 0.0042 0.0182 0.0182
Brugia malayi bZIP transcription factor family protein 0.0089 0.0635 0.0635
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0182 0.0374
Onchocerca volvulus 0.0104 0.0773 0.297
Brugia malayi small heat shock protein 0.0615 0.5689 0.5689
Onchocerca volvulus 0.0048 0.0233 0.0896
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0048 0.0233 0.0233
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0391 0.0886

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 6.25 ug ml-1 In vitro antibacterial activity against Serpulina (Treponema) hyodysenteriae ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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