Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | Curated by TDR Targets | References |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | Curated by TDR Targets | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 165 aa | 143 aa | 34.3 % |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 159 aa | 140 aa | 37.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0002 | 0.0001 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0115 | 0.0446 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0006 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0024 | 0.0091 | 0.095 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0062 | 0.0243 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0053 | 0.0274 | 0.2895 |
Plasmodium falciparum | phd finger protein, putative | 0.0029 | 0.0123 | 0.1287 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | nuclear hormone receptor | 0.002 | 0.0069 | 0.027 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.002 | 0.0069 | 0.027 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0017 | 0.005 | 0.0512 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0201 | 0.1209 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0274 | 0.1068 |
Mycobacterium ulcerans | hypothetical protein | 0.0071 | 0.0387 | 0.1506 |
Schistosoma mansoni | topbp1 | 0.001 | 0.0002 | 0.001 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0062 | 0.0639 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0099 | 0.0563 | 0.0562 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0072 | 0.0393 | 0.1348 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.001 | 0.0002 | 0.0001 |
Brugia malayi | DKFZp564C0469 protein | 0.001 | 0.0002 | 0.001 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0123 | 0.0478 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0253 | 0.0986 |
Echinococcus granulosus | serine:threonine protein kinase SMG1 | 0.001 | 0.0002 | 0.0004 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0042 | 0.0207 | 0.0808 |
Brugia malayi | AMP-binding enzyme family protein | 0.0071 | 0.0387 | 0.1514 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.005 | 0.0256 | 0.081 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0024 | 0.0091 | 0.0358 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.001 | 0.0002 | 0.0001 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0017 | 0.005 | 0.0512 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0472 | 0.2913 | 0.2912 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0064 | 0.0342 | 0.117 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0021 | 0.0071 | 0.027 |
Echinococcus multilocularis | protein patched | 0.0042 | 0.0207 | 0.0206 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0055 | 0.0557 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.002 | 0.0069 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0274 | 0.1068 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0071 | 0.0387 | 0.1334 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0006 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0021 | 0.0071 | 0.0759 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.001 | 0.0001 | 0.0004 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0029 | 0.0123 | 0.0482 |
Brugia malayi | Frizzled/Smoothened family membrane region containing protein | 0.0015 | 0.0034 | 0.0132 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0011 | 0.0009 | 0.0028 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0024 | 0.0259 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0071 | 0.0275 |
Onchocerca volvulus | 0.0028 | 0.0115 | 0.2954 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0008 | 0.0032 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0064 | 0.0342 | 0.0341 |
Echinococcus multilocularis | expressed conserved protein | 0.0093 | 0.0525 | 0.0524 |
Echinococcus multilocularis | frizzled | 0.0015 | 0.0034 | 0.0033 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0021 | 0.0071 | 0.0073 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.002 | 0.0069 | 0.027 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0141 | 0.083 | 0.2846 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.0021 | 0.0071 | 0.1232 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0021 | 0.0071 | 0.0073 |
Loa Loa (eye worm) | glutaminase | 0.0272 | 0.1655 | 0.6478 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0001 | 0.0004 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0095 | 0.0539 | 0.1849 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0229 | 0.0898 |
Brugia malayi | AMP-binding enzyme family protein | 0.0071 | 0.0387 | 0.1514 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.005 | 0.0256 | 0.081 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0024 | 0.0091 | 0.0358 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0395 | 0.2429 | 0.2428 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0055 | 0.0559 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0021 | 0.0071 | 0.027 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0069 | 0.0068 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0017 | 0.005 | 0.0535 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0071 | 0.0275 |
Schistosoma mansoni | zinc finger protein | 0.001 | 0.0001 | 0.0004 |
Schistosoma mansoni | patched 1 | 0.0042 | 0.0207 | 0.0811 |
Onchocerca volvulus | Alhambra homolog | 0.0029 | 0.0123 | 0.3166 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0062 | 0.0662 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0042 | 0.0207 | 0.0708 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.002 | 0.0069 | 0.027 |
Mycobacterium ulcerans | glutaminase | 0.0272 | 0.1655 | 0.6476 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.0062 | 0.0243 |
Mycobacterium ulcerans | peptide synthetase Nrp (peptide synthase) | 0.0021 | 0.0071 | 0.027 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0062 | 0.024 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0062 | 0.0662 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0064 | 0.0342 | 0.117 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Onchocerca volvulus | 0.0071 | 0.0387 | 1 | |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0017 | 0.005 | 0.0197 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.002 | 0.0069 | 0.1765 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0062 | 0.0061 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtE | 0.0021 | 0.0071 | 0.027 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Trypanosoma brucei | unspecified product | 0.0013 | 0.0024 | 0.0259 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Plasmodium vivax | hypothetical protein, conserved | 0.0011 | 0.0011 | 0.0088 |
Brugia malayi | jmjC domain containing protein | 0.0037 | 0.0172 | 0.0672 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0125 | 0.0489 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.0062 | 0.0061 |
Mycobacterium leprae | POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) | 0.0021 | 0.0071 | 0.027 |
Schistosoma mansoni | jumonji domain containing protein | 0.0076 | 0.0416 | 0.1629 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.002 | 0.0069 | 0.027 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.0062 | 0.0639 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.002 | 0.0069 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0069 | 0.0267 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0021 | 0.0071 | 0.0279 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0207 | 0.124 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.197 | 0.7711 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.002 | 0.0069 | 0.027 |
Onchocerca volvulus | Bile acid receptor homolog | 0.002 | 0.0069 | 0.1765 |
Mycobacterium ulcerans | long-chain-acyl-CoA synthetase | 0.0021 | 0.0071 | 0.027 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtF | 0.0021 | 0.0071 | 0.027 |
Schistosoma mansoni | nuclear hormone receptor | 0.002 | 0.0069 | 0.027 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0123 | 0.0482 |
Schistosoma mansoni | frizzled-like receptor | 0.0015 | 0.0034 | 0.0132 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0115 | 0.045 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0055 | 0.0935 |
Brugia malayi | PHD-finger family protein | 0.0011 | 0.001 | 0.0039 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0017 | 0.005 | 0.0169 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0172 | 0.0672 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0099 | 0.0563 | 0.2202 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.094 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0069 | 0.027 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0099 | 0.0563 | 0.1929 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0274 | 0.1068 |
Mycobacterium ulcerans | acetyl-CoA synthetase | 0.0021 | 0.0071 | 0.027 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0072 | 0.0393 | 0.0392 |
Schistosoma mansoni | DNA ligase IV | 0.001 | 0.0002 | 0.001 |
Echinococcus granulosus | tumor protein p63 | 0.0339 | 0.2076 | 0.7127 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.0123 | 0.131 |
Schistosoma mansoni | nuclear receptor | 0.001 | 0.0001 | 0.0004 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.001 | 0.0001 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0006 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0021 | 0.0071 | 0.0759 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0198 | 0.0774 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.0195 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0254 | 0.099 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0071 | 0.0387 | 0.1334 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0125 | 0.0489 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0062 | 0.0036 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0021 | 0.0071 | 0.0073 |
Echinococcus granulosus | serine protein kinase ATM | 0.0024 | 0.0091 | 0.031 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0069 | 0.0267 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0069 | 0.0234 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.0123 | 0.131 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.002 | 0.0069 | 0.027 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0229 | 0.0228 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0342 | 0.1337 |
Echinococcus granulosus | peregrin | 0.0029 | 0.0123 | 0.0419 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0229 | 0.0784 |
Brugia malayi | tailless protein | 0.001 | 0.0001 | 0.0004 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0021 | 0.0071 | 0.027 |
Mycobacterium leprae | Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) | 0.0021 | 0.0071 | 0.027 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0229 | 0.0228 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0071 | 0.0387 | 0.1506 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Echinococcus granulosus | frizzled | 0.0015 | 0.0034 | 0.0112 |
Echinococcus granulosus | frizzled 4 | 0.0015 | 0.0034 | 0.0112 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.002 | 0.0069 | 0.0068 |
Loa Loa (eye worm) | frizzled/Smoothened family membrane region containing protein | 0.0015 | 0.0034 | 0.0128 |
Onchocerca volvulus | 0.0021 | 0.0071 | 0.1823 | |
Echinococcus multilocularis | tumor protein p63 | 0.0339 | 0.2076 | 0.2075 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0021 | 0.0071 | 0.0279 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0062 | 0.0662 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0071 | 0.0387 | 0.1506 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.001 | 0.0001 | 0.0004 |
Schistosoma mansoni | nuclear receptor | 0.001 | 0.0001 | 0.0004 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.002 | 0.0069 | 0.027 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0071 | 0.0387 | 0.6862 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0002 | 0.0001 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0062 | 0.0662 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.002 | 0.0069 | 0.0068 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0064 | 0.0342 | 0.0341 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0001 | 0.0004 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0062 | 0.4951 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.001 | 0.0002 | 0.0003 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0115 | 0.045 |
Echinococcus granulosus | neuropeptide s receptor | 0.0472 | 0.2913 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0021 | 0.0071 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0808 | 0.3158 |
Brugia malayi | Bromodomain containing protein | 0.0029 | 0.0123 | 0.0482 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0069 | 0.027 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0002 | 0.0001 |
Giardia lamblia | PHD finger protein 15 | 0.0029 | 0.0123 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.002 | 0.0069 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0387 | 0.151 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0071 | 0.0387 | 0.1506 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0029 | 0.0123 | 0.0478 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0141 | 0.083 | 0.0829 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0064 | 0.0342 | 0.1337 |
Leishmania major | phosphatidylinositol kinase related protein, putative | 0.0018 | 0.005 | 0.0002 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0011 | 0.0009 | 0.0008 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0053 | 0.0274 | 0.2895 |
Echinococcus granulosus | nibrin | 0.001 | 0.0002 | 0.0005 |
Echinococcus granulosus | geminin | 0.0169 | 0.1003 | 0.3443 |
Brugia malayi | nuclear receptor NHR-88 | 0.002 | 0.0069 | 0.027 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0229 | 0.0898 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.002 | 0.0069 | 0.027 |
Loa Loa (eye worm) | steroid hormone receptor | 0.002 | 0.0069 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0069 | 0.0267 |
Onchocerca volvulus | 0.002 | 0.0069 | 0.1765 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.001 | 0.0001 | 0.0004 |
Echinococcus multilocularis | cpg binding protein | 0.0029 | 0.0125 | 0.0124 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0069 | 0.0234 |
Echinococcus granulosus | smoothened | 0.0329 | 0.2013 | 0.691 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | Nuclear hormone receptor E75 | 0.001 | 0.0001 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0006 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0021 | 0.0071 | 0.0418 |
Toxoplasma gondii | FATC domain-containing protein | 0.0024 | 0.0091 | 0.0972 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0062 | 0.0234 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.0021 | 0.0071 | 0.0735 |
Onchocerca volvulus | 0.0021 | 0.0071 | 0.1823 | |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0415 | 0.2555 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0415 | 0.2555 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0071 | 0.0387 | 0.1506 |
Echinococcus multilocularis | frizzled 10 | 0.0015 | 0.0034 | 0.0033 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0071 | 0.0387 | 0.3782 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0415 | 0.2555 | 1 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0017 | 0.005 | 0.0856 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.0123 | 0.0482 |
Brugia malayi | CHE-14 protein | 0.0042 | 0.0207 | 0.0811 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.002 | 0.0069 | 0.027 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0342 | 0.1337 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0062 | 0.021 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.001 | 0.0002 | 0.001 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0071 | 0.0387 | 0.6862 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0055 | 1 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.0017 | 0.005 | 0.0197 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0069 | 0.0234 |
Echinococcus multilocularis | smoothened | 0.0329 | 0.2013 | 0.2012 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.094 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0062 | 0.0662 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.002 | 0.0069 | 0.0267 |
Brugia malayi | AMP-binding enzyme family protein | 0.0021 | 0.0071 | 0.0279 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0201 | 0.1209 | 0.4733 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0011 | 0.0009 | 0.01 |
Schistosoma mansoni | glutaminase | 0.0272 | 0.1655 | 0.648 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.001 | 0.0001 | 0.0004 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.001 | 0.0002 | 0.0026 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0002 | 0.0001 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0021 | 0.0071 | 0.0279 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0198 | 0.0774 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0055 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0387 | 0.151 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0062 | 0.0363 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0008 | 0.0032 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0062 | 0.0243 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Echinococcus multilocularis | FTZ F1 alpha | 0.002 | 0.0069 | 0.0068 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0021 | 0.0071 | 0.0073 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0055 | 0.0317 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0069 | 0.027 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0017 | 0.005 | 0.0512 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0021 | 0.0071 | 0.0073 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0071 | 0.0387 | 0.1506 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0415 | 0.2555 | 1 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0018 | 0.005 | 0.0514 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0472 | 0.2913 | 0.2912 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0008 | 0.0029 |
Brugia malayi | glutaminase DH11.1 | 0.0272 | 0.1655 | 0.648 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0071 | 0.0387 | 0.1506 |
Onchocerca volvulus | 0.001 | 0.0002 | 0.0038 | |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0053 | 0.0274 | 0.0882 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0011 | 0.0008 | 0.0029 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.094 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.002 | 0.0069 | 0.027 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0069 | 0.0068 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0393 | 0.698 |
Brugia malayi | ecdysteroid receptor | 0.002 | 0.0069 | 0.027 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0011 | 0.0008 | 0.0007 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0037 | 0.0172 | 0.0668 |
Echinococcus granulosus | cpg binding protein | 0.0029 | 0.0125 | 0.0426 |
Loa Loa (eye worm) | oxidoreductase | 0.0021 | 0.0071 | 0.0275 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.002 | 0.0069 | 0.027 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.002 | 0.0069 | 0.027 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0062 | 0.0036 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.001 | 0.0002 | 0.0001 |
Mycobacterium ulcerans | phenyloxazoline synthase MbtB | 0.0021 | 0.0071 | 0.027 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0029 | 0.0123 | 0.0122 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.002 | 0.0069 | 0.027 |
Echinococcus multilocularis | frizzled 4 | 0.0015 | 0.0034 | 0.0033 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.001 | 0.0002 | 0.0009 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0017 | 0.005 | 0.0535 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0021 | 0.0071 | 0.0073 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0055 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0008 | 0.0029 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.001 | 0.0002 | 0.0002 |
Leishmania major | long-chain-fatty-acid-CoA ligase, putative | 0.0021 | 0.0071 | 0.0237 |
Schistosoma mansoni | fkbp-rapamycin associated protein | 0.001 | 0.0002 | 0.0009 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0069 | 0.027 |
Schistosoma mansoni | coup transcription factor | 0.002 | 0.0069 | 0.027 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0021 | 0.0071 | 0.0073 |
Toxoplasma gondii | propionate-CoA ligase | 0.0021 | 0.0071 | 0.0759 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0064 | 0.0342 | 0.1334 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.002 | 0.0069 | 0.027 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.001 | 0.0002 | 0.0001 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0393 | 0.698 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0055 | 0.0214 |
Echinococcus granulosus | frizzled | 0.0015 | 0.0034 | 0.0112 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0021 | 0.0071 | 0.0736 |
Schistosoma mansoni | hypothetical protein | 0.0138 | 0.0808 | 0.3161 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.1003 | 0.3928 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Echinococcus multilocularis | frizzled 5 | 0.0015 | 0.0034 | 0.0033 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0011 | 0.0009 | 0.0043 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0011 | 0.0008 | 0.0025 |
Brugia malayi | ecdysone receptor | 0.001 | 0.0001 | 0.0004 |
Brugia malayi | AMP-binding enzyme family protein | 0.0021 | 0.0071 | 0.0279 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.0017 | 0.005 | 0.0169 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0001 | 0.0004 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0024 | 0.0259 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0055 | 0.0559 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0069 | 0.0267 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.002 | 0.0069 | 0.0267 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.0069 | 0.027 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0062 | 0.0662 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0055 | 0.4324 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0342 | 0.1334 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0018 | 0.0053 | 0.0209 |
Echinococcus multilocularis | peregrin | 0.0029 | 0.0123 | 0.0122 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0021 | 0.0071 | 0.0073 |
Plasmodium falciparum | conserved Plasmodium membrane protein, unknown function | 0.0011 | 0.0011 | 0.0088 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.001 | 0.0002 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0069 | 0.0267 |
Brugia malayi | AMP-binding enzyme family protein | 0.0021 | 0.0071 | 0.0279 |
Loa Loa (eye worm) | glutaminase 2 | 0.0272 | 0.1655 | 0.6478 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.002 | 0.0069 | 0.0234 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0229 | 0.0898 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0006 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0001 | 0.0004 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0062 | 0.0363 |
Echinococcus multilocularis | nibrin | 0.001 | 0.0002 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0342 | 0.1337 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0017 | 0.005 | 0.0193 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0071 | 0.0387 | 0.3782 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0017 | 0.005 | 0.0197 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0062 | 0.0662 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.01 | 0.0572 | 0.224 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.002 | 0.0069 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0274 | 0.1068 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.0024 | 0.0091 | 0.0972 |
Brugia malayi | jmjC domain containing protein | 0.0095 | 0.0539 | 0.2111 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0055 | 0.0581 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.001 | 0.0035 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0021 | 0.0071 | 0.0736 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0062 | 0.0662 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0011 | 0.0009 | 0.0043 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.1003 | 0.3928 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0021 | 0.0071 | 0.0418 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.0695 | 0.272 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.007 | 0.0271 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.001 | 0.0002 | 0.0001 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0062 | 0.0639 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.002 | 0.0069 | 0.0267 |
Toxoplasma gondii | non-specific serine/threonine protein kinase | 0.0011 | 0.0009 | 0.01 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.005 | 0.0256 | 0.081 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0021 | 0.0071 | 0.0237 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0021 | 0.0071 | 0.027 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0062 | 0.0662 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0472 | 0.2913 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0415 | 0.2555 | 1 |
Brugia malayi | hypothetical protein | 0.001 | 0.0001 | 0.0004 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.001 | 0.0002 | 0.0026 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0062 | 0.0662 |
Onchocerca volvulus | 0.0021 | 0.0071 | 0.1823 | |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0011 | 0.0008 | 0.0032 |
Brugia malayi | AMP-binding enzyme family protein | 0.0071 | 0.0387 | 0.1514 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0021 | 0.0071 | 0.0759 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0229 | 0.0898 |
Brugia malayi | hypothetical protein | 0.0072 | 0.0393 | 0.154 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0059 | 0.0311 | 0.1217 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.002 | 0.0069 | 0.0267 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0053 | 0.0274 | 0.1063 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0274 | 0.1068 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0055 | 0.0317 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0021 | 0.0071 | 0.0275 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.0062 | 0.0134 |
Brugia malayi | hypothetical protein | 0.001 | 0.0002 | 0.001 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.0021 | 0.0071 | 0.0735 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.002 | 0.0069 | 0.0234 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0008 | 0.0032 |
Echinococcus granulosus | FTZ F1 alpha | 0.002 | 0.0069 | 0.0234 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0021 | 0.0071 | 0.0073 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0062 | 0.0243 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0062 | 0.0061 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0021 | 0.0071 | 0.027 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.001 | 0.0001 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0069 | 0.0267 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0069 | 0.0068 |
Trypanosoma brucei | unspecified product | 0.0013 | 0.0024 | 0.0259 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.002 | 0.0069 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0062 | 0.024 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0021 | 0.0071 | 0.027 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0055 | 0.0006 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.001 | 0.0002 | 0.001 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0053 | 0.0274 | 0.1063 |
Brugia malayi | Nuclear hormone receptor E75 | 0.001 | 0.0001 | 0.0004 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0042 | 0.0207 | 0.0708 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0017 | 0.005 | 0.0197 |
Brugia malayi | AMP-binding enzyme family protein | 0.0021 | 0.0071 | 0.0279 |
Echinococcus multilocularis | geminin | 0.0169 | 0.1003 | 0.1003 |
Echinococcus granulosus | expressed conserved protein | 0.0093 | 0.0525 | 0.1799 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0207 | 0.0808 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0017 | 0.005 | 0.0512 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0029 | 0.0123 | 0.0419 |
Brugia malayi | hypothetical protein | 0.001 | 0.0001 | 0.0004 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0071 | 0.0387 | 0.1506 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0095 | 0.0539 | 0.0538 |
Trichomonas vaginalis | glutaminase, putative | 0.0272 | 0.1655 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0017 | 0.005 | 0.0193 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.0123 | 0.1287 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.0062 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0006 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0021 | 0.0071 | 0.0237 |
Brugia malayi | nuclear receptor NHR-67 | 0.001 | 0.0001 | 0.0004 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0042 | 0.0207 | 0.0206 |
Echinococcus multilocularis | frizzled | 0.0015 | 0.0034 | 0.0033 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0091 | 0.0539 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.0695 | 0.2717 |
Toxoplasma gondii | ATPase, AAA family protein | 0.001 | 0.0002 | 0.0026 |
Echinococcus granulosus | frizzled | 0.0015 | 0.0034 | 0.0112 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0021 | 0.0071 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0008 | 0.0029 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.094 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0017 | 0.005 | 0.0512 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0198 | 0.0774 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0021 | 0.0071 | 0.0275 |
Brugia malayi | steroid hormone receptor | 0.002 | 0.0069 | 0.027 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0099 | 0.0563 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.005 | 0.0256 | 0.081 |
Echinococcus granulosus | dihydrofolate reductase | 0.0415 | 0.2555 | 0.877 |
Loa Loa (eye worm) | frizzled/Smoothened family membrane region containing protein | 0.0015 | 0.0034 | 0.0128 |
Onchocerca volvulus | 0.0021 | 0.0071 | 0.1823 | |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0069 | 0.0234 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.002 | 0.0069 | 0.0267 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0055 | 0.0581 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0062 | 0.0243 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0138 | 0.0808 | 0.3161 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0069 | 0.0068 |
Brugia malayi | nuclear receptor RXR | 0.001 | 0.0001 | 0.0004 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.0162 | 0.0161 |
Schistosoma mansoni | hypothetical protein | 0.0395 | 0.2429 | 0.9507 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0062 | 0.0662 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0069 | 0.027 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0017 | 0.005 | 0.0856 |
Brugia malayi | nuclear receptor RXR | 0.0011 | 0.0008 | 0.0032 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0198 | 0.0774 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0069 | 0.0068 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0071 | 0.0387 | 0.3782 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.006 | 0.0318 | 0.1241 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0064 | 0.0342 | 0.1337 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0062 | 0.0662 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Echinococcus granulosus | GPCR family 2 | 0.0064 | 0.0342 | 0.117 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0393 | 0.698 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0071 | 0.0387 | 0.1506 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0062 | 0.0639 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0069 | 0.0267 |
Onchocerca volvulus | 0.005 | 0.0253 | 0.6529 | |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0016 | 0.0043 | 0.017 |
Giardia lamblia | GTOR | 0.0017 | 0.005 | 0.396 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.002 | 0.0069 | 0.0267 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0055 | 0.0214 |
Brugia malayi | conserved hypotetical protein | 0.001 | 0.0001 | 0.0004 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0062 | 0.0234 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.002 | 0.0069 | 0.0234 |
Schistosoma mansoni | frizzled | 0.0015 | 0.0034 | 0.0132 |
Echinococcus granulosus | frizzled 5 | 0.0015 | 0.0034 | 0.0112 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0062 | 0.021 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0062 | 0.0662 |
Entamoeba histolytica | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Brugia malayi | topoisomerase | 0.001 | 0.0002 | 0.001 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0069 | 0.0234 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.0195 | 0.0665 |
Echinococcus granulosus | replication factor c subunit 1 | 0.001 | 0.0002 | 0.0005 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0017 | 0.005 | 0.0535 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0021 | 0.0071 | 0.0759 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0229 | 0.0894 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0201 | 0.1209 | 0.4731 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0091 | 0.159 |
Brugia malayi | Frizzled/Smoothened family membrane region containing protein | 0.0015 | 0.0034 | 0.0132 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0008 | 0.0032 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.002 | 0.0069 | 0.027 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.002 | 0.0069 | 0.1765 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0172 | 0.0672 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0055 | 0.0049 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.005 | 0.0253 | 0.099 |
Echinococcus multilocularis | protein dispatched 1 | 0.0048 | 0.0245 | 0.0244 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0055 | 0.0054 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0055 | 0.0214 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.0017 | 0.005 | 0.0535 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.001 | 0.0001 | 0.0004 |
Echinococcus multilocularis | GPCR, family 2 | 0.0064 | 0.0342 | 0.0341 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0387 | 0.151 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0008 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0069 | 0.0267 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0002 | 0.0001 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0021 | 0.0071 | 0.0736 |
Echinococcus multilocularis | serine:threonine protein kinase SMG1 | 0.001 | 0.0002 | 0.0001 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0017 | 0.005 | 0.0049 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0021 | 0.0071 | 0.0073 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0055 | 0.0204 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0021 | 0.0071 | 0.0736 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0062 | 0.0662 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0062 | 0.0639 |
Mycobacterium ulcerans | O-succinylbenzoic acid--CoA ligase | 0.0021 | 0.0071 | 0.027 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.0062 | 0.0134 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0062 | 0.107 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0055 | 0.0184 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0037 | 0.0172 | 0.0586 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0229 | 0.0784 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0021 | 0.0071 | 0.0073 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0055 | 0.0557 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0393 | 0.154 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0342 | 0.1337 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0024 | 0.0259 |
Brugia malayi | hypothetical protein | 0.001 | 0.0002 | 0.001 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.0017 | 0.005 | 0.0049 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0021 | 0.0071 | 0.027 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.0271 | 0.2886 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0563 | 0.2199 |
Schistosoma mansoni | topbp1 | 0.001 | 0.0002 | 0.001 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.094 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Brugia malayi | dihydrofolate reductase family protein | 0.0415 | 0.2555 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0062 | 0.0662 |
Schistosoma mansoni | frizzled-like receptor | 0.0015 | 0.0034 | 0.0132 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.0069 | 0.027 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0017 | 0.005 | 0.0535 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0415 | 0.2555 | 0.2554 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0415 | 0.2555 | 1 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0008 | 0.0032 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0393 | 0.698 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0267 | 0.1043 |
Echinococcus granulosus | dnaJ subfamily B | 0.0395 | 0.2429 | 0.8338 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0017 | 0.005 | 0.029 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.0695 | 0.2717 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0021 | 0.007 | 0.0724 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0071 | 0.0387 | 0.6862 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0008 | 0.0029 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0072 | 0.0393 | 0.154 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.1209 | 0.4731 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.001 | 0.0002 | 0.0001 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0021 | 0.0071 | 0.027 |
Echinococcus multilocularis | serine protein kinase ATM | 0.0024 | 0.0091 | 0.009 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.002 | 0.0069 | 0.027 |
Mycobacterium leprae | POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0021 | 0.0071 | 0.027 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.0021 | 0.0071 | 0.027 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0021 | 0.0071 | 0.0241 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0415 | 0.2555 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0071 | 0.0387 | 0.1506 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0017 | 0.005 | 0.0535 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0009 | 0.0033 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0.094 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.0062 | 0.0134 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0069 | 0.027 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
17 literature references were collected for this gene.