Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.2503 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.082 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.2503 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.082 | 0.5 |
Brugia malayi | hypothetical protein | 0.0038 | 0.2503 | 0.2503 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.082 | 0.3278 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.082 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.082 | 0.082 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.082 | 0.082 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.082 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.082 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.082 | 0.3278 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.082 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.2503 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.2503 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.2503 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.082 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.2503 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.2503 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.082 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.082 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.082 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.082 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.082 | 0.3278 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.2503 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.082 | 0.3278 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.082 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.082 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.082 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.