Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0128 | 0.3175 | 1 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0149 | 0.3787 | 0.3743 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0018 | 0.007 | 0.007 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0247 | 0.0247 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.007 | 0.007 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0369 | 1 | 1 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0122 | 0.3012 | 0.296 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0149 | 0.3787 | 0.3743 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0018 | 0.007 | 0.007 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0369 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0075 | 0.0005 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0369 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0075 | 0.0005 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0369 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0247 | 0.0174 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0247 | 0.0178 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3373 | 0.3326 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0018 | 0.007 | 0.5 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0241 | 0.6375 | 0.6348 |
Brugia malayi | nuclear hormone receptor | 0.0018 | 0.007 | 0.007 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0018 | 0.007 | 0.007 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0075 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0075 | 0.0005 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0241 | 0.6375 | 0.6348 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0369 | 1 | 1 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0369 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0247 | 0.0174 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0075 | 0.0005 |
Brugia malayi | ecdysteroid receptor | 0.0018 | 0.007 | 0.007 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0369 | 1 | 1 |
Onchocerca volvulus | 0.0018 | 0.007 | 0.5 | |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0369 | 1 | 1 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0369 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0247 | 0.0174 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0369 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.007 | 0.007 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0247 | 0.0174 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0018 | 0.007 | 0.007 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0369 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.3787 | 0.3743 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.007 | 0.007 |
Brugia malayi | nuclear receptor NHR-88 | 0.0018 | 0.007 | 0.007 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0075 | 0.0005 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.007 | 0.007 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0018 | 0.007 | 0.007 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0075 | 0.5 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0369 | 1 | 1 |
Trypanosoma cruzi | Glucose-6-phosphate dehydrogenase, putative | 0.0119 | 0.2912 | 0.2859 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0018 | 0.007 | 0.007 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0369 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.007 | 0.007 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0018 | 0.007 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.007 | 0.007 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0075 | 0.0075 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0369 | 1 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0247 | 0.0174 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0247 | 0.0174 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0018 | 0.007 | 0.007 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0369 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0018 | 0.007 | 0.007 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0018 | 0.007 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0018 | 0.007 | 0.007 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0018 | 0.007 | 0.007 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0247 | 0.0174 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0247 | 0.0174 |
Echinococcus granulosus | sterol O acyltransferase 1 | 0.0149 | 0.3787 | 0.3743 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0018 | 0.007 | 0.007 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0351 | 0.9488 | 0.9484 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0369 | 1 | 1 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0369 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.