Detailed information for compound 558535

Basic information

Technical information
  • TDR Targets ID: 558535
  • Name: N4-(2-chloro-7-methoxy-acridin-9-yl)-N1,N1-di ethyl-pentane-1,4-diamine; methanesulfonic ac id
  • MW: 592.168 | Formula: C25H38ClN3O7S2
  • H donors: 3 H acceptors: 7 LogP: 1.97 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CS(=O)(=O)O.CS(=O)(=O)O.CCN(CCCC(Nc1c2cc(Cl)ccc2nc2c1cc(OC)cc2)C)CC
  • InChi: 1S/C23H30ClN3O.2CH4O3S/c1-5-27(6-2)13-7-8-16(3)25-23-19-14-17(24)9-11-21(19)26-22-12-10-18(28-4)15-20(22)23;2*1-5(2,3)4/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H3,(H,2,3,4)
  • InChiKey: WWVNAZRWEIACFQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N4-(2-chloro-7-methoxy-9-acridinyl)-N1,N1-diethylpentane-1,4-diamine; methanesulfonic acid
  • 4-[(2-chloro-7-methoxy-acridin-9-yl)amino]pentyl-diethyl-amine; mesylic acid
  • 4-N-(2-chloro-7-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine; methanesulfonic acid
  • Quinacrine
  • N'-(2-chloro-7-methoxyacridin-9-yl)-N,N-diethylpentane-1,4-diamine; methanesulfonic acid
  • N'-(2-chloro-7-methoxy-acridin-9-yl)-N,N-diethyl-pentane-1,4-diamine; methanesulfonic acid
  • N'-(2-chloro-7-methoxy-9-acridinyl)-N,N-diethylpentane-1,4-diamine; methanesulfonic acid
  • 4-[(2-chloro-7-methoxy-acridin-9-yl)amino]pentyl-diethyl-amine; methanesulfonic acid
  • 316-05-2
  • 1,4-Pentanediamine, N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-, dimethanesulfonate
  • ACRIDINE, 6-CHLORO-9-((4-(DIETHYLAMINO)-1-METHYLBUTYL)AMINO)-2-METHOXY-, DIMETHA
  • Acridine, 6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-, dimethanesulfonate
  • EINECS 206-256-1
  • Mepacrine dimethanesulfonate salt
  • Mepacrine mesilate
  • Mepacrine methanesulfonate
  • Musonal
  • Quinacrine methanesulfonate
  • Quinacrine, dimethanesulfonate (6CI)

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum lysophospholipase, putative Curated by TDR Targets References
Leishmania major DNA topoisomerase ii Curated by TDR Targets References
Trypanosoma cruzi trypanothione reductase, putative Curated by TDR Targets No references
Trypanosoma cruzi trypanothione reductase, putative Curated by TDR Targets No references
Leishmania major mitochondrial DNA topoisomerase II Curated by TDR Targets References
Plasmodium falciparum esterase, putative Curated by TDR Targets References
Plasmodium falciparum lysophospholipase, putative Curated by TDR Targets References
Leishmania major trypanothione reductase Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium knowlesi DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma brucei gambiense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium vivax DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Trichomonas vaginalis DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Theileria parva hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Plasmodium vivax DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei gambiense DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Giardia lamblia DNA topoisomerase II Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium vivax PST-A protein Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum esterase, putative Get druggable targets OG5_144587 All targets in OG5_144587
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Echinococcus multilocularis DNA topoisomerase 2 alpha Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium vivax lysophospholipase, putative Get druggable targets OG5_144587 All targets in OG5_144587
Plasmodium knowlesi DNA topoisomerase 2, putative Get druggable targets OG5_127113 All targets in OG5_127113
Neospora caninum hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Schistosoma japonicum expressed protein Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Cryptosporidium hominis DNA topoisomerase II Get druggable targets OG5_127113 All targets in OG5_127113
Leishmania major monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium berghei DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Chlamydia trachomatis DNA gyrase subunit B Get druggable targets OG5_127113 All targets in OG5_127113
Leishmania donovani DNA topoisomerase ii Get druggable targets OG5_127113 All targets in OG5_127113
Mycobacterium tuberculosis Possible lysophospholipase Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei gambiense DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma brucei DNA topoisomerase II beta, putative Get druggable targets OG5_127113 All targets in OG5_127113
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_144587 All targets in OG5_144587
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania major mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Entamoeba histolytica DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Leishmania donovani monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Treponema pallidum DNA gyrase, subunit B (gyrB) Get druggable targets OG5_128755 All targets in OG5_128755
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans lysophospholipase Get druggable targets OG5_127037 All targets in OG5_127037
Theileria parva DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) Get druggable targets OG5_128755 All targets in OG5_128755
Candida albicans similar to YJU3 Get druggable targets OG5_127037 All targets in OG5_127037
Onchocerca volvulus DNA topoisomerase 2 homolog Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei gambiense DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Chlamydia trachomatis DNA gyrase subunit B Get druggable targets OG5_128755 All targets in OG5_128755
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma congolense DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Trichomonas vaginalis valacyclovir hydrolase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania infantum monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei DNA topoisomerase 2, putative Get druggable targets OG5_127113 All targets in OG5_127113
Cryptosporidium parvum DNA topoisomerase II Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium yoelii DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein Get druggable targets OG5_144587 All targets in OG5_144587
Candida albicans DNA topoisomerase II similar to S. cerevisiae TOP2 (YNL088W) Get druggable targets OG5_127113 All targets in OG5_127113
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE Get druggable targets OG5_127037 All targets in OG5_127037
Loa Loa (eye worm) TOPoisomerase family member Get druggable targets OG5_127113 All targets in OG5_127113
Candida albicans DNA topoisomerase II similar to S. cerevisiae TOP2 (YNL088W) Get druggable targets OG5_127113 All targets in OG5_127113
Theileria parva hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein Get druggable targets OG5_127037 All targets in OG5_127037
Theileria parva DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania mexicana monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania braziliensis DNA topoisomerase ii Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum esterase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein Get druggable targets OG5_127113 All targets in OG5_127113
Leishmania mexicana DNA topoisomerase ii Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma cruzi monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei DNA topoisomerase II alpha, putative Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium vivax unspecified product Get druggable targets OG5_144587 All targets in OG5_144587
Toxoplasma gondii DNA topoisomerase 2, putative Get druggable targets OG5_127113 All targets in OG5_127113
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium falciparum DNA topoisomerase 2 Get druggable targets OG5_127113 All targets in OG5_127113
Babesia bovis DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Neospora caninum hypothetical protein Get druggable targets OG5_128755 All targets in OG5_128755
Neospora caninum hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Leishmania donovani mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania mexicana mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma cruzi DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Brugia malayi DNA topoisomerase II, alpha isozyme Get druggable targets OG5_127113 All targets in OG5_127113
Mycobacterium ulcerans DNA gyrase subunit B Get druggable targets OG5_128755 All targets in OG5_128755
Brugia malayi Probable DNA topoisomerase II Get druggable targets OG5_127113 All targets in OG5_127113
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K03164 DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum DNA gyrase subunit B Get druggable targets OG5_128755 All targets in OG5_128755
Theileria parva hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Schistosoma mansoni DNA topoisomerase II Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium yoelii DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma congolense DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Babesia bovis DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma brucei DNA topoisomerase ii Get druggable targets OG5_128755 All targets in OG5_128755
Onchocerca volvulus DNA topoisomerase 2 homolog Get druggable targets OG5_127113 All targets in OG5_127113
Leishmania infantum mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum esterase, putative Get druggable targets OG5_144587 All targets in OG5_144587
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to YJU3 Get druggable targets OG5_127037 All targets in OG5_127037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus DNA topoisomerase 2 alpha Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma brucei gambiense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania major DNA topoisomerase ii Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum DNA topoisomerase ii Get druggable targets OG5_127113 All targets in OG5_127113
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum lysophospholipase, putative lysophospholipase, putative 371 aa 380 aa 41.0 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast trypanothione reductase, putative 189 aa 197 aa 20.8 %
Trypanosoma brucei DNA topoisomerase II beta, putative mitochondrial DNA topoisomerase II 1236 aa 1047 aa 35.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast trypanothione reductase, putative 492 aa 548 aa 21.5 %
Plasmodium falciparum lysophospholipase, putative esterase, putative 373 aa 405 aa 51.6 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast trypanothione reductase 491 aa 551 aa 23.4 %
Plasmodium falciparum lysophospholipase, putative lysophospholipase, putative 353 aa 379 aa 44.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0092 0.4278 0.4278
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0169 0.8675 0.8623
Mycobacterium ulcerans monoxygenase 0.0025 0.0377 0.0422
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.1873 0.1579
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0092 0.4278 0.4278
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0025 0.0377 0.0422
Schistosoma mansoni DNA topoisomerase II 0.0169 0.8675 0.8623
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0025 0.0377 0.0031
Brugia malayi hypothetical protein 0.0036 0.1065 0.0741
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0098 0.4628 0.4417
Mycobacterium ulcerans hypothetical protein 0.0173 0.8941 1
Entamoeba histolytica hypothetical protein 0.0036 0.1065 0.0809
Loa Loa (eye worm) hypothetical protein 0.0051 0.1873 0.1873
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0092 0.4278 0.4278
Leishmania major hypothetical protein, conserved 0.0025 0.0377 0.0029
Leishmania major NADH dehydrogenase, putative 0.0025 0.0377 0.0029
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0349 0.0349
Mycobacterium ulcerans glutamate synthase subunit beta 0.0025 0.0377 0.0422
Onchocerca volvulus 0.0027 0.0539 0.0367
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0098 0.4628 1
Plasmodium falciparum thioredoxin reductase 0.0092 0.4278 0.4278
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0092 0.4278 0.9176
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0092 0.4278 0.4278
Plasmodium falciparum glutathione reductase 0.0092 0.4278 0.4278
Entamoeba histolytica hypothetical protein 0.0036 0.1065 0.0809
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0173 0.8941 0.9723
Plasmodium vivax DNA topoisomerase II, putative 0.0169 0.8675 0.8675
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0092 0.4278 0.4054
Loa Loa (eye worm) hypothetical protein 0.0023 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0024 0.0349 0.0349
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0173 0.8941 0.9722
Leishmania major mitochondrial DNA topoisomerase II 0.0189 0.9863 0.9858
Loa Loa (eye worm) hypothetical protein 0.0114 0.5536 0.5536
Mycobacterium tuberculosis Possible lysophospholipase 0.0173 0.8941 0.8941
Plasmodium vivax ferrodoxin reductase, putative 0.0025 0.0377 0.0377
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0025 0.0377 0.0032
Chlamydia trachomatis DNA gyrase subunit B 0.0078 0.3439 0.7432
Schistosoma mansoni lamin 0.0027 0.0539 0.0169
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0173 0.8941 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0954 0.0954
Trypanosoma cruzi trypanothione reductase, putative 0.0092 0.4278 0.4054
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0025 0.0377 0.0377
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0025 0.0377 0.0032
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0169 0.8675 0.8623
Entamoeba histolytica hypothetical protein 0.0036 0.1065 0.0809
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0349 0.0349
Trichomonas vaginalis DNA topoisomerase II, putative 0.0169 0.8675 0.9419
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0092 0.4278 0.4054
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0092 0.4278 0.4054
Leishmania major DNA topoisomerase ii 0.016 0.8151 0.8084
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0189 0.9863 0.9857
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0092 0.4278 0.4071
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0025 0.0377 0.0377
Plasmodium vivax lysophospholipase, putative 0.0178 0.9186 0.9186
Chlamydia trachomatis DNA gyrase subunit A 0.0036 0.1055 0.228
Loa Loa (eye worm) hypothetical protein 0.0069 0.2916 0.2916
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0349 0.0391
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0437 0.0437
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0092 0.4278 0.4071
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0025 0.0377 0.0377
Leishmania major hypothetical protein, conserved 0.0026 0.0437 0.009
Loa Loa (eye worm) hypothetical protein 0.0114 0.5536 0.5536
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0437 0.0062
Loa Loa (eye worm) hypothetical protein 0.0025 0.0377 0.0377
Plasmodium falciparum lysophospholipase, putative 0.0173 0.8941 0.8941
Echinococcus granulosus lamin dm0 0.0027 0.0539 0.0169
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.1065 0.0715
Plasmodium falciparum ferrodoxin reductase-like protein 0.0025 0.0377 0.0377
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0954 0.0626
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0025 0.0377 0.0032
Leishmania major hypothetical protein, conserved 0.0025 0.0377 0.0029
Mycobacterium tuberculosis Probable oxidoreductase 0.0092 0.4278 0.4278
Echinococcus multilocularis thioredoxin glutathione reductase 0.0192 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0437 0.0437
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0036 0.1055 0.1055
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0092 0.4278 0.9244
Loa Loa (eye worm) hypothetical protein 0.0069 0.2916 0.2916
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0092 0.4278 0.4054
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.1065 0.0715
Mycobacterium ulcerans DNA gyrase subunit B 0.0098 0.4628 0.5176
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0437 0.0062
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0173 0.8941 0.9723
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0349 0.0391
Echinococcus multilocularis muscleblind protein 0.0151 0.7675 0.7584
Toxoplasma gondii thioredoxin reductase 0.0192 1 1
Plasmodium vivax DNA gyrase subunit B, putative 0.0098 0.4628 0.4628
Trichomonas vaginalis glutathione reductase, putative 0.0092 0.4278 0.4428
Plasmodium falciparum DNA gyrase subunit A 0.0036 0.1055 0.1055
Leishmania major hypothetical protein, conserved 0.0025 0.0377 0.0029
Onchocerca volvulus 0.0025 0.0377 0.0053
Plasmodium falciparum lysophospholipase, putative 0.0173 0.8941 0.8941
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0025 0.0377 0.0029
Loa Loa (eye worm) hypothetical protein 0.0151 0.7675 0.7675
Entamoeba histolytica hypothetical protein 0.0036 0.1065 0.0809
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0092 0.4278 0.4784
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0169 0.8675 0.8627
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0025 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0027 0.0539 0.0539
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0192 1 1
Trypanosoma brucei trypanothione reductase 0.0192 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0349 0.0349
Plasmodium vivax PST-A protein 0.0173 0.8941 0.8941
Plasmodium falciparum lysophospholipase, putative 0.0173 0.8941 0.8941
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0068 0.2868 0.261
Loa Loa (eye worm) hypothetical protein 0.0026 0.0437 0.0437
Brugia malayi Muscleblind-like protein 0.0151 0.7675 0.7591
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0025 0.0377 0.0029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0092 0.4278 0.4054
Brugia malayi hypothetical protein 0.0026 0.0437 0.009
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0025 0.0377 0.0377
Plasmodium vivax DNA gyrase subunit A, putative 0.0036 0.1055 0.1055
Loa Loa (eye worm) hypothetical protein 0.0027 0.0511 0.0511
Brugia malayi intermediate filament protein 0.0027 0.0539 0.0197
Chlamydia trachomatis DNA gyrase subunit A 0.0036 0.1055 0.228
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0025 0.0377 0.0422
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0025 0.0377 0.0422
Schistosoma mansoni lamin 0.0027 0.0539 0.0169
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0539 0.0539
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0349 0.0391
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0173 0.8941 0.9722
Loa Loa (eye worm) hypothetical protein 0.0023 0.0301 0.0301
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0092 0.4278 0.4054
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0349 0.0391
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0173 0.8941 0.9722
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0092 0.4278 0.4278
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0025 0.0377 0.0029
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0092 0.4278 0.4278
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0437 0.0062
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0025 0.0377 0.0377
Mycobacterium ulcerans dehydrogenase 0.0025 0.0377 0.0422
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0539 0.0197
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0437 0.0437
Plasmodium falciparum thioredoxin reductase 0.0192 1 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0092 0.4278 0.4784
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0025 0.0377 0.0377
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0092 0.4278 0.4054
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0092 0.4278 0.4054
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0092 0.4278 0.4054
Mycobacterium ulcerans DNA gyrase subunit A 0.0036 0.1055 0.118
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0092 0.4278 0.4054
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0025 0.0377 0.0377
Trypanosoma brucei DNA topoisomerase ii 0.0189 0.9863 0.9857
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0025 0.0377 0.0377
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0092 0.4278 0.4054
Echinococcus granulosus muscleblind protein 0.0151 0.7675 0.7584
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0092 0.4278 0.4054
Toxoplasma gondii hypothetical protein 0.0178 0.9186 0.9154
Trypanosoma brucei monoglyceride lipase, putative 0.0173 0.8941 0.89
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0068 0.2868 0.261
Loa Loa (eye worm) hypothetical protein 0.0024 0.0349 0.0349
Plasmodium falciparum esterase, putative 0.0178 0.9186 0.9186
Mycobacterium ulcerans ferredoxin reductase 0.0025 0.0377 0.0422
Loa Loa (eye worm) programmed cell death 8 0.0025 0.0377 0.0377
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0044 0.149 0.1327
Trypanosoma cruzi DNA topoisomerase II, putative 0.016 0.8151 0.8078
Mycobacterium ulcerans NADH dehydrogenase 0.0025 0.0377 0.0422
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0025 0.0377 0.0377
Chlamydia trachomatis thioredoxin reductase 0.0025 0.0377 0.0814
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0025 0.0377 0.0031
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0098 0.4628 1
Plasmodium falciparum lysophospholipase, putative 0.0178 0.9186 0.9186
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0025 0.0377 0.0377
Echinococcus multilocularis lamin dm0 0.0027 0.0539 0.0169
Schistosoma mansoni intermediate filament proteins 0.0027 0.0539 0.0169
Brugia malayi glutamate synthase 0.0025 0.0377 0.0029
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0025 0.0377 0.0031
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.016 0.8151 0.8078
Entamoeba histolytica disulphide oxidoreductase, putative 0.0025 0.0377 0.0031
Leishmania major monoglyceride lipase, putative 0.0173 0.8941 0.8903
Mycobacterium tuberculosis Probable reductase 0.0025 0.0377 0.0377
Echinococcus granulosus intermediate filament protein 0.0027 0.0539 0.0169
Plasmodium falciparum DNA topoisomerase 2 0.0169 0.8675 0.8675
Schistosoma mansoni hypothetical protein 0.0035 0.0954 0.06
Loa Loa (eye worm) TOPoisomerase family member 0.0169 0.8675 0.8675
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0189 0.9863 0.9857
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0025 0.0377 0.0031
Leishmania major trypanothione reductase 0.0192 1 1
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0025 0.0377 0.0029
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.1873 0.1873
Treponema pallidum NADH oxidase 0.0092 0.4278 0.9176
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0114 0.5527 1
Brugia malayi Thioredoxin reductase 0.0192 1 1
Giardia lamblia DNA topoisomerase II 0.016 0.8169 1
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.8941 0.9722
Trichomonas vaginalis conserved hypothetical protein 0.0178 0.9186 1
Onchocerca volvulus 0.0027 0.0539 0.0367
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0092 0.4278 0.9176
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0092 0.4278 0.4054
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0092 0.4278 0.4071
Plasmodium vivax glutathione reductase, putative 0.0192 1 1
Plasmodium falciparum esterase, putative 0.0173 0.8941 0.8941
Entamoeba histolytica thioredoxin reductase, putative 0.0025 0.0377 0.0031
Echinococcus granulosus lamin 0.0027 0.0539 0.0169
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0092 0.4278 0.4071
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0025 0.0377 0.0377
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0178 0.9186 1
Toxoplasma gondii DNA topoisomerase 2, putative 0.0169 0.8675 0.8623
Entamoeba histolytica DNA topoisomerase II, putative 0.0169 0.8675 0.9421
Plasmodium falciparum esterase, putative 0.0178 0.9186 0.9186
Toxoplasma gondii NADPH-glutathione reductase 0.0092 0.4278 0.4054
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0437 0.0062
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0098 0.4628 0.4628
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0025 0.0377 0.0032
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0036 0.1055 0.0705
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0025 0.0377 0.0032
Chlamydia trachomatis DNA gyrase subunit B 0.0098 0.4628 1
Mycobacterium ulcerans hypothetical protein 0.0025 0.0377 0.0422
Trypanosoma cruzi monoglyceride lipase, putative 0.0173 0.8941 0.89
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0173 0.8941 0.9722
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0092 0.4278 0.4572
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.8941 0.9722
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0349 0.0391
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0173 0.8941 0.9722
Schistosoma mansoni hypothetical protein 0.0036 0.1065 0.0715
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0025 0.0377 0.0377
Trypanosoma cruzi DNA topoisomerase II, putative 0.016 0.8151 0.8078
Loa Loa (eye worm) hypothetical protein 0.0151 0.7675 0.7675
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0025 0.0377 0.0422
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0169 0.8675 0.8627
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0092 0.4278 0.4278
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0025 0.0377 0.0422
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.1873 0.1579
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0025 0.0377 0.0377
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0025 0.0377 0.0031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0301 0.0301
Loa Loa (eye worm) thioredoxin reductase 0.0192 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0349 0.0391
Echinococcus multilocularis musashi 0.0027 0.0539 0.0169
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0092 0.4278 0.4071
Plasmodium falciparum glutathione reductase 0.0192 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0092 0.4278 0.4054
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0025 0.0377 0.0422
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0092 0.4278 0.4784
Giardia lamblia NADH oxidase lateral transfer candidate 0.0092 0.4278 0.5006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.1065 0.0715
Trypanosoma brucei DNA topoisomerase II beta, putative 0.016 0.8151 0.8078
Mycobacterium ulcerans hypothetical protein 0.0024 0.0349 0.0391
Plasmodium vivax thioredoxin reductase, putative 0.0192 1 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0114 0.5527 1
Echinococcus multilocularis muscleblind protein 1 0.0151 0.7675 0.7584
Trichomonas vaginalis mercuric reductase, putative 0.0092 0.4278 0.4428
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0092 0.4278 0.4054
Echinococcus granulosus thioredoxin glutathione reductase 0.0192 1 1
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0036 0.1055 0.1596
Echinococcus multilocularis lamin 0.0027 0.0539 0.0169
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0092 0.4278 0.4054
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0036 0.1055 0.1596
Mycobacterium tuberculosis Probable dehydrogenase 0.0025 0.0377 0.0377
Mycobacterium ulcerans lysophospholipase 0.0173 0.8941 1
Loa Loa (eye worm) glutathione reductase 0.0192 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0349 0.0391
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0025 0.0377 0.0422
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0025 0.0377 0.0377
Plasmodium vivax unspecified product 0.0178 0.9186 0.9186
Trypanosoma brucei monoglyceride lipase, putative 0.0173 0.8941 0.89
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0114 0.5527 1
Trypanosoma cruzi trypanothione reductase, putative 0.0192 1 1
Brugia malayi Probable DNA topoisomerase II 0.0169 0.8675 0.8627
Plasmodium falciparum DNA gyrase subunit B 0.0098 0.4628 0.4628
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0539 0.0539
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0025 0.0377 0.0029
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0173 0.8941 0.9722

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from bioassay (ECO:0000094) Leishmania donovani 22664  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with various inhibitors leads to slow growth of Leishmania sp. in cell assay; quinacrine analogues References: 11551771
cytolysis (GO:0019835) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania chagasi 22297  
Annotator: aaronjr@u.washington.edu Comment: Drug: 13365-36-1; Drug: 61421-82-7; Drug: 61421-83-8; Drug: 139501-99-8. chemical inhibition with topoisomerase inhibitors leads to lysis and reduced motility; unclear as to which topoisomerase II gene/enzyme was studied References: 1318684
cytolysis (GO:0019835) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania chagasi 22658  
Annotator: aaronjr@u.washington.edu Comment: Drug: 13365-36-1; Drug: 61421-82-7; Drug: 61421-83-8; Drug: 139501-99-8. chemical inhibition with topoisomerase inhibitors leads to lysis and reduced motility; unclear as to which topoisomerase II gene/enzyme was studied References: 1318684
cytolysis (GO:0019835) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 22297  
Annotator: aaronjr@u.washington.edu Comment: Drug: 13365-36-1; Drug: 61421-82-7; Drug: 61421-83-8; Drug: 139501-99-8. chemical inhibition with topoisomerase inhibitors leads to lysis and reduced motility; unclear as to which topoisomerase II gene/enzyme was studied References: 1318684
cytolysis (GO:0019835) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 22658  
Annotator: aaronjr@u.washington.edu Comment: Drug: 13365-36-1; Drug: 61421-82-7; Drug: 61421-83-8; Drug: 139501-99-8. chemical inhibition with topoisomerase inhibitors leads to lysis and reduced motility; unclear as to which topoisomerase II gene/enzyme was studied References: 1318684
cell motility (GO:0006928) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania chagasi 22297  
Annotator: aaronjr@u.washington.edu Comment: Drug: 13365-36-1; Drug: 61421-82-7; Drug: 61421-83-8; Drug: 139501-99-8. chemical inhibition with topoisomerase inhibitors leads to lysis and reduced motility; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 1318684
cell motility (GO:0006928) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania chagasi 22658  
Annotator: aaronjr@u.washington.edu Comment: Drug: 13365-36-1; Drug: 61421-82-7; Drug: 61421-83-8; Drug: 139501-99-8. chemical inhibition with topoisomerase inhibitors leads to lysis and reduced motility; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 1318684
cell motility (GO:0006928) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 22297  
Annotator: aaronjr@u.washington.edu Comment: Drug: 13365-36-1; Drug: 61421-82-7; Drug: 61421-83-8; Drug: 139501-99-8. chemical inhibition with topoisomerase inhibitors leads to lysis and reduced motility; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 1318684
cell motility (GO:0006928) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 22658  
Annotator: aaronjr@u.washington.edu Comment: Drug: 13365-36-1; Drug: 61421-82-7; Drug: 61421-83-8; Drug: 139501-99-8. chemical inhibition with topoisomerase inhibitors leads to lysis and reduced motility; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 1318684
chromosomal_structural_element (SO:0000628) biosynthetic process (GO:0009058) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania chagasi 22297  
Annotator: crowther@u.washington.edu Comment: Drug: 13365-36-1; Drug: 13365-38-3; Drug: 61421-82-7; Drug: 61462-75-7; Drug: 62382-99-4; Drug: 75775-90-5; Drug: 136633-55-1. chemical inhibition with topoisomerase inhibitors leads to generation of cleavable complex and growth inhibition; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 7935616
chromosomal_structural_element (SO:0000628) biosynthetic process (GO:0009058) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania chagasi 22658  
Annotator: crowther@u.washington.edu Comment: Drug: 13365-36-1; Drug: 13365-38-3; Drug: 61421-82-7; Drug: 61462-75-7; Drug: 62382-99-4; Drug: 75775-90-5; Drug: 136633-55-1. chemical inhibition with topoisomerase inhibitors leads to generation of cleavable complex and growth inhibition; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 7935616
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania chagasi 22297  
Annotator: crowther@u.washington.edu Comment: Drug: 13365-36-1; Drug: 13365-38-3; Drug: 61421-82-7; Drug: 61462-75-7; Drug: 62382-99-4; Drug: 75775-90-5; Drug: 136633-55-1. chemical inhibition with topoisomerase inhibitors leads to generation of cleavable complex and growth inhibition; unclear as to which topoisomerase II gene/enzyme was studied References: 7935616
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania chagasi 22658  
Annotator: crowther@u.washington.edu Comment: Drug: 13365-36-1; Drug: 13365-38-3; Drug: 61421-82-7; Drug: 61462-75-7; Drug: 62382-99-4; Drug: 75775-90-5; Drug: 136633-55-1. chemical inhibition with topoisomerase inhibitors leads to generation of cleavable complex and growth inhibition; unclear as to which topoisomerase II gene/enzyme was studied References: 7935616
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium falciparum 2350  
Annotator: saralph@unimelb.edu.au Comment: 012/Mar/09 References: 8022653
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium falciparum 3067  
Annotator: saralph@unimelb.edu.au Comment: 012/Mar/09 References: 8022653
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium falciparum 3068  
Annotator: saralph@unimelb.edu.au Comment: 012/Mar/09 References: 8022653
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from enzyme inhibition (ECO:0000184) Trypanosoma cruzi 35349  
Annotator: millerja@u.washington.edu Comment: References: 11328673 17439174 19296695 19747949
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from enzyme inhibition (ECO:0000184) Trypanosoma cruzi 50541  
Annotator: millerja@u.washington.edu Comment: References: 11328673 17439174 19296695 19747949

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

150 literature references were collected for this gene.

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