Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | jmjC domain containing protein | 0.01 | 0.2019 | 0.898 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.2248 | 0.266 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.001 | 0.0011 |
Onchocerca volvulus | Alhambra homolog | 0.0031 | 0.001 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0108 | 0.2248 | 0.266 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0.001 | 0.001 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0377 | 1 | 0.5 |
Echinococcus granulosus | peregrin | 0.0031 | 0.001 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.126 | 0.1492 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0037 | 0.0195 | 0.0231 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.01 | 0.2019 | 0.2389 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0641 | 0.0758 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0.001 | 0.001 |
Brugia malayi | RNA, U transporter 1 | 0.0086 | 0.161 | 0.7162 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0078 | 0.1379 | 0.1632 |
Plasmodium falciparum | phd finger protein, putative | 0.0031 | 0.001 | 0.001 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0074 | 0.126 | 0.5607 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0108 | 0.2248 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0323 | 0.845 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0377 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0377 | 1 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0377 | 1 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0377 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0114 | 0.0135 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.1379 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0031 | 0.001 | 0.0011 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.001 | 0.0011 |
Echinococcus multilocularis | peregrin | 0.0031 | 0.001 | 0.0011 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.0114 | 0.0508 |
Echinococcus granulosus | snurportin 1 | 0.0323 | 0.845 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0195 | 0.0231 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0108 | 0.2248 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.0114 | 0.0508 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0114 | 0.0135 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.126 | 0.1492 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.003 | 0 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0034 | 0.0114 | 0.0135 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0078 | 0.1379 | 0.1632 |
Schistosoma mansoni | jumonji domain containing protein | 0.008 | 0.1424 | 0.1686 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0.001 | 0.001 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0031 | 0.001 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0114 | 0.0135 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0031 | 0.001 | 0.0011 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.4604 | 0.5449 |
Brugia malayi | hypothetical protein | 0.0078 | 0.1379 | 0.6136 |
Echinococcus granulosus | jumonji domain containing protein | 0.0043 | 0.0356 | 0.0421 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0114 | 0.0135 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0195 | 0.0231 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0114 | 0.0135 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0031 | 0.001 | 0.0011 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0078 | 0.1379 | 0.1632 |
Echinococcus multilocularis | geminin | 0.019 | 0.4604 | 0.5449 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.1379 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.01 | 0.2019 | 0.2389 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.0114 | 0.0135 |
Brugia malayi | Bromodomain containing protein | 0.0031 | 0.001 | 0.0043 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0377 | 1 | 0.5 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0043 | 0.0356 | 0.0421 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0114 | 0.0135 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0114 | 0.0135 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0063 | 0.095 | 0.1124 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0114 | 0.0135 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0037 | 0.0195 | 0.0231 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0114 | 0.0135 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0377 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.4604 | 0.5449 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.003 | 0 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0031 | 0.001 | 0.0043 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.1379 | 0.1632 |
Echinococcus granulosus | geminin | 0.019 | 0.4604 | 0.5449 |
Giardia lamblia | PHD finger protein 15 | 0.0031 | 0.001 | 0.5 |
Echinococcus multilocularis | snurportin 1 | 0.0323 | 0.845 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0377 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.1379 | 0.5 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0323 | 0.845 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.1379 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0037 | 0.0195 | 0.0231 |
Echinococcus multilocularis | GPCR, family 2 | 0.0034 | 0.0114 | 0.0135 |
Brugia malayi | jmjC domain containing protein | 0.0037 | 0.0195 | 0.0869 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.