Detailed information for compound 558814

Basic information

Technical information
  • TDR Targets ID: 558814
  • Name: [(8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7, 8,9,11,12,14,15,16,17-decahydrocyclopenta[a]p henanthren-17-yl] hydrogen sulfate
  • MW: 352.445 | Formula: C18H24O5S
  • H donors: 2 H acceptors: 4 LogP: 3.52 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2OS(=O)(=O)O)C
  • InChi: 1S/C18H24O5S/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)23-24(20,21)22/h3,5,10,14-17,19H,2,4,6-9H2,1H3,(H,20,21,22)/t14-,15-,16+,17+,18+/m1/s1
  • InChiKey: JSUDNGPWAXYETN-ZBRFXRBCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • sulfuric acid [(8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] ester
  • estradiol 17-sulfate
  • 3233-69-0
  • Estradiol-17-sulfate
  • Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 17-(hydrogen sulfate)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ras GTP exchange factor 0.0007 0.0081 0.0093
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0118 0.4512 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.3843 0.6193
Brugia malayi RasGEF domain containing protein 0.0007 0.0081 0.0058
Loa Loa (eye worm) oxidoreductase 0.0008 0.0141 0.0117
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0634 0.3177
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0256 1 1
Brugia malayi hypothetical protein 0.0017 0.0489 0.0467
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0267 0.1277
Loa Loa (eye worm) hypothetical protein 0.002 0.0634 0.0612
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.1538 0.2136
Loa Loa (eye worm) RecQ helicase 0.0023 0.0731 0.0709
Brugia malayi RasGEF domain containing protein 0.0007 0.0081 0.0058
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0141 0.0773
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0634 0.4032
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0285 0.0424
Echinococcus multilocularis Protein son of sevenless 0.0007 0.0081 0.0093
Brugia malayi N-terminal motif family protein 0.0007 0.0081 0.0058
Brugia malayi MAP kinase sur-1 0.0118 0.4512 0.4499
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0141 0.019
Echinococcus granulosus ras GTP exchange factor 0.0007 0.0081 0.0096
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.059 0.6071
Loa Loa (eye worm) hypothetical protein 0.0023 0.0731 0.0709
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.3843 0.6377
Loa Loa (eye worm) hypothetical protein 0.0012 0.0285 0.0262
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0186 0.0163
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0141 0.019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.3843 0.6377
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0141 0.0117
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0909 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0909 0.5683
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0909 0.0888
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0267 0.0543
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0285 0.1398
Echinococcus granulosus son of sevenless 1 0.0007 0.0081 0.0096
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0285 0.046
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0141 0.0134
Loa Loa (eye worm) hypothetical protein 0.002 0.0634 0.0612
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0141 0.0261
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0186 0.0163
Loa Loa (eye worm) hypothetical protein 0.002 0.0634 0.0612
Brugia malayi N-terminal motif family protein 0.0007 0.0081 0.0058
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.3843 0.6193
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0141 0.0134
Loa Loa (eye worm) hypothetical protein 0.002 0.0634 0.0612
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0731 0.4669
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0141 0.0261
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0081 0.0093
Onchocerca volvulus 0.0008 0.0141 0.0083
Giardia lamblia Kinase, CMGC MAPK 0.0118 0.4512 1
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0081 0.018
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0909 0.5683
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0731 0.0709
Brugia malayi DIX domain containing protein 0.0009 0.0186 0.0163
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0909 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0141 0.0546
Schistosoma mansoni dep domain containing protein 0.0009 0.0186 0.0263
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0069 0.0073
Loa Loa (eye worm) hypothetical protein 0.0027 0.0909 0.0888
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0187 0.723 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0141 0.0546
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0285 0.0928
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0731 0.162
Schistosoma mansoni DNA helicase recq5 0.0023 0.0731 0.1147
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0909 0.1973
Schistosoma mansoni dishevelled 0.0009 0.0186 0.0263
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0141 0.0261
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0118 0.4512 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0141 0.0134
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0186 0.0263
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0141 0.0196
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.1695 0.3756
Echinococcus granulosus mitogen activated protein kinase 3 0.0118 0.4512 0.7494
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0285 0.046
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.059 0.6071
Treponema pallidum ATP-dependent DNA helicase 0.0012 0.0285 0.5
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0186 0.0163
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0285 0.0437
Mycobacterium ulcerans hypothetical protein 0.0027 0.0909 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0856 0.5493
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0909 0.5683
Leishmania major hypothetical protein, conserved 0.0026 0.0856 0.1854
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0856 0.1748
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0007 0.0081 0.0096
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.3843 0.6193
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.6191 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0118 0.4512 1
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.4512 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.1695 0.3756
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0186 0.0271
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0285 0.0424
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.3843 0.6193
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0141 0.0117
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0081 0.0093
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0634 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0141 0.0117
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0081 0.0093
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0101 0.3843 0.3828
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0186 0.0263
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0186 0.0271
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0141 0.0546
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0141 0.0546
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0186 0.0271
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0731 0.162
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0731 0.1147
Loa Loa (eye worm) hypothetical protein 0.002 0.0634 0.0612
Schistosoma mansoni DNA helicase recq1 0.0023 0.0731 0.1147
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.6191 1
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0007 0.0081 0.018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0909 0.0888
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0141 0.0546
Toxoplasma gondii hypothetical protein 0.0009 0.0186 0.0362
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0007 0.0081 0.0093
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0909 0.0888
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0909 0.1973
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0141 0.0546
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0186 0.0263
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.4512 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0141 0.0546
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0081 0.018
Schistosoma mansoni dishevelled 0.0009 0.0186 0.0263
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0731 0.1576
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0141 0.0546
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0856 0.1854
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0118 0.4512 1
Echinococcus granulosus mitogen activated protein kinase 0.0118 0.4512 0.7494
Onchocerca volvulus 0.0009 0.0186 0.0146
Echinococcus multilocularis mitogen activated protein kinase 3 0.0118 0.4512 0.7277
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0081 0.0093
Echinococcus multilocularis mitogen activated protein kinase 0.0118 0.4512 0.7277
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0141 0.0117
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0141 0.0261
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0909 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0909 0.1973
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0141 0.0546
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0186 0.0263
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0731 0.4669
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0731 0.162
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0731 0.135
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.3843 0.6193
Brugia malayi RasGEF domain containing protein 0.0007 0.0081 0.0058
Loa Loa (eye worm) hypothetical protein 0.0009 0.0186 0.0163
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.1695 0.279
Loa Loa (eye worm) hypothetical protein 0.0012 0.0285 0.0262
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0856 0.1748
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0909 1
Echinococcus granulosus bloom syndrome protein 0.0023 0.0731 0.1181
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0141 0.0134
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0634 0.6421
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0186 0.0271
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0267 0.0395
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0186 0.0163
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0856 0.1636
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0081 0.0058
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0731 0.0709
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.059 0.6071
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0141 0.0546
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0141 0.0312
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0731 0.1147
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0186 0.0163
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0141 0.0117
Onchocerca volvulus 0.0008 0.0141 0.0083
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0141 0.0312
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0909 0.0888
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0731 0.1466
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.6191 0.6182
Schistosoma mansoni hypothetical protein 0.0012 0.0285 0.0424
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0186 0.0263
Brugia malayi hypothetical protein 0.0009 0.0186 0.0163
Trypanosoma brucei protein kinase, putative 0.0118 0.4512 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0081 0.0058
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0118 0.4512 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.1695 0.3723
Loa Loa (eye worm) hypothetical protein 0.0187 0.723 0.7224
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0081 0.0093
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0731 0.4458
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0731 0.1576
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.1695 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0081 0.0058
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0909 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0731 0.0709
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0731 0.1181
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0856 0.4602
Loa Loa (eye worm) hypothetical protein 0.0027 0.0909 0.0888
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0081 0.0058
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.1695 0.3723
Onchocerca volvulus 0.0008 0.0141 0.0083
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0856 0.5493
Echinococcus granulosus histone acetyltransferase KAT2B 0.0156 0.6012 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0101 0.3843 0.3828
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0909 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0909 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0141 0.0261
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0141 0.0261
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0118 0.4512 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0285 0.0582
Brugia malayi hypothetical protein 0.0009 0.0186 0.0163
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.4512 1
Brugia malayi hypothetical protein 0.0026 0.0856 0.0834
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.059 0.6071
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0731 0.1576
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0141 0.0117
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.1538 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0634 0.6617
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0141 0.0117
Loa Loa (eye worm) hypothetical protein 0.0009 0.0186 0.0163
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0007 0.0081 0.0096
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0909 1
Echinococcus granulosus Protein son of sevenless 0.0007 0.0081 0.0096
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0118 0.4512 1
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0007 0.0081 0.0093
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.4512 0.7277
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0186 0.0263
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0731 0.1147
Loa Loa (eye worm) hypothetical protein 0.0026 0.0856 0.0834
Loa Loa (eye worm) hypothetical protein 0.0007 0.0081 0.0058
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0141 0.0117
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.4512 1
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0186 0.0263
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0731 0.0709
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0118 0.4512 0.4499
Onchocerca volvulus 0.0008 0.0141 0.0083
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0011 0.0267 0.0814
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.1538 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0909 1
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0186 0.0146
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0141 0.0546
Echinococcus multilocularis son of sevenless 1 0.0007 0.0081 0.0093
Loa Loa (eye worm) hypothetical protein 0.0009 0.0186 0.0163
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0141 0.0409
Loa Loa (eye worm) hypothetical protein 0.0008 0.0141 0.0117
Onchocerca volvulus 0.0027 0.0909 0.1158
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0731 0.1181
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0186 0.0263
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0186 0.0271
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0909 1
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0007 0.0081 0.018
Brugia malayi N-terminal motif family protein 0.0187 0.723 0.7224
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0141 0.0117
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0118 0.4512 1
Loa Loa (eye worm) acetyltransferase 0.016 0.6191 0.6182
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0909 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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