Detailed information for compound 558853

Basic information

Technical information
  • TDR Targets ID: 558853
  • Name: N-butyl-N-(2-diethylaminoethyl)naphthalene-1- carboxamide
  • MW: 326.476 | Formula: C21H30N2O
  • H donors: 0 H acceptors: 1 LogP: 4.65 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(C(=O)c1cccc2c1cccc2)CCN(CC)CC
  • InChi: 1S/C21H30N2O/c1-4-7-15-23(17-16-22(5-2)6-3)21(24)20-14-10-12-18-11-8-9-13-19(18)20/h8-14H,4-7,15-17H2,1-3H3
  • InChiKey: WWGZXRYELYWJBD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-butyl-N-(2-diethylaminoethyl)-1-naphthalenecarboxamide
  • N-butyl-N-(2-diethylaminoethyl)-1-naphthamide
  • Bunaftine
  • 32421-46-8
  • 1-NAPHTHALENECARBOXAMIDE, N-BUTYL-N-(2-(DIETHYLAMINO)ETHYL)-
  • BRN 2468082
  • Bunaftina [INN-Spanish]
  • Bunaftine [INN]
  • Bunaftinum [INN-Latin]
  • Bunaphtide
  • Bunaphtine
  • EINECS 251-027-1
  • N-Butyl-N-(2-(diethylamino)ethyl)-1-naphthalenecarboxamide
  • N-Butyl-N-(2-(diethylamino)ethyl)-1-naphthamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis methyl CpG binding domain protein 2 0.004 0.0133 0.0152
Brugia malayi DnaJ domain containing protein 0.0071 0.0873 0.237
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0096 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.004 0.0133 0.0152
Schistosoma mansoni zinc finger protein 0.0046 0.0274 0.0891
Loa Loa (eye worm) hypothetical protein 0.01 0.1564 0.1482
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.1603 0.6222
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0096 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.004 0.0133 0.0366
Loa Loa (eye worm) hypothetical protein 0.0456 1 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0 0.5
Loa Loa (eye worm) bromodomain containing protein 0.0042 0.0167 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.1603 0.5844
Loa Loa (eye worm) hypothetical protein 0.0167 0.3134 0.3068
Loa Loa (eye worm) hypothetical protein 0.009 0.1325 0.1241
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0096 0.5
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0053 0.044 0.151
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.004 0.0133 0.0152
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0141 0.2518 1
Brugia malayi Bromodomain containing protein 0.009 0.1321 0.3737
Echinococcus granulosus zinc finger protein 0.0046 0.0274 0.0734
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.1603 0.4598
Schistosoma mansoni hypothetical protein 0.0049 0.0333 0.1112
Loa Loa (eye worm) hypothetical protein 0.004 0.0133 0.0037
Loa Loa (eye worm) DnaJ domain-containing protein 0.0071 0.0873 0.0784
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0085 0.1189 0.4511
Trichomonas vaginalis protein kinase inhibitor, putative 0.0071 0.0873 1
Schistosoma mansoni inositol monophosphatase 0.0039 0.0096 0.0229
Echinococcus granulosus fetal alzheimer antigen falz 0.0053 0.044 0.1419
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.004 0.0133 0.0366
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0053 0.044 0.1419
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0096 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.1603 0.5844
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0096 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.1603 0.6222
Loa Loa (eye worm) hypothetical protein 0.0096 0.1457 0.1374
Loa Loa (eye worm) PHD-finger family protein 0.0049 0.0333 0.0239
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0096 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.004 0.0133 0.0366
Schistosoma mansoni hypothetical protein 0.0071 0.0873 0.3124
Echinococcus multilocularis dnaJ subfamily C 6 0.0071 0.0873 0.3208
Schistosoma mansoni methyl-cpg binding protein mbd 0.004 0.0133 0.0366
Brugia malayi PHD-finger family protein 0.0059 0.0572 0.1453
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.1603 0.1521
Echinococcus granulosus dnaJ subfamily C 6 0.0071 0.0873 0.3208
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0085 0.1189 0.4511
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.1603 0.6222
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.1603 0.6222
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0 0.5
Brugia malayi Bromodomain containing protein 0.0177 0.3373 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0096 0.5
Echinococcus multilocularis zinc finger protein 0.0046 0.0274 0.0734
Schistosoma mansoni inositol monophosphatase 0.0039 0.0096 0.0229
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0096 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0141 0.2518 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.1603 0.5844
Schistosoma mansoni bromodomain containing protein 0.0149 0.2718 1
Echinococcus granulosus histone lysine methyltransferase setb 0.004 0.0133 0.0152

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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