Detailed information for compound 559122

Basic information

Technical information
  • TDR Targets ID: 559122
  • Name: 3-(3,4-dichlorophenyl)-1-methoxy-1-methyl-ure a
  • MW: 249.094 | Formula: C9H10Cl2N2O2
  • H donors: 1 H acceptors: 1 LogP: 2.41 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CON(C(=O)Nc1ccc(c(c1)Cl)Cl)C
  • InChi: 1S/C9H10Cl2N2O2/c1-13(15-2)9(14)12-6-3-4-7(10)8(11)5-6/h3-5H,1-2H3,(H,12,14)
  • InChiKey: XKJMBINCVNINCA-UHFFFAOYSA-N  

Network

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Synonyms

  • 3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea
  • Linuron
  • 56645-87-5
  • 330-55-2
  • Profalon
  • Rotalin
  • Sarclex
  • Sinuron
  • Soilcid
  • Urea, 3-(3,4-dichlorophenyl)-1-methoxy-1-methyl-
  • Urea, N'-(3,4-dichlorophenyl)-N-methoxy-N-methyl-
  • du Pont Herbicide 326
  • NCGC00160429-01
  • A3964/0168931
  • ZINC00900693
  • NCGC00160429-02
  • 3-(3,4-Dicloro-fenil)-1-metossi-1-metil-urea [Italian]
  • Cephalon
  • 1-(3,4-Dichlorophenyl)3-methoxy-3-methyluree [French]
  • 1-Methoxy-1-methyl-3-(3,4-dichlorophenyl)urea
  • 3-(3,4-Dichloor-fenyl)-1-methoxy-1-methylureum [Dutch]
  • 3-(3,4-Dichlor-phenyl)-1-methoxy-1-methyl-harnstoff [German]
  • 3-(3,4-Dichloro-fenil)-1-metossi-1-metil-urea [Italian]
  • Caswell No. 528
  • 3-(4,5-Dichlorphenyl)-1-methoxy-1-methylharnstoff [German]
  • Afalon
  • Afalon inuron
  • Aphalon
  • BRN 2128725
  • C11007
  • Certroli-Lin
  • Du Pont 326
  • Dupont herbicide 326
  • EINECS 206-356-5
  • EPA Pesticide Chemical Code 035506
  • Garnitan
  • HOE 2810
  • HSDB 1733
  • Herbicide 326
  • Hoe 002810
  • Hoe 02 810
  • Laroks [Polish]
  • Linex
  • Linex 4L
  • Linorox
  • Linurex
  • Linuron (herbicide)
  • Linuron [ANSI:BSI:ISO]
  • Lorox Weed Killer
  • Lorox linuron weed killer
  • Malurane
  • Methoxydiuron
  • N'-(3,4-Dichlorophenyl)-N-methoxy-N-methylurea
  • N-(3,4-Dichlorophenyl)-N'-methyl-N'-methoxyurea
  • N-(3,4-Dwuchlorofenylo)N'-metoksy-N'-metylomocznik [Polish]

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium leprae Probable lipase LipE 0.0035 0.0208 0.0192
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0235
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0093 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0093 0.0235
Echinococcus granulosus Proteasome subunit alpha type 7 0.009 0.0696 0.1754
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0354 0.3061 0.7701
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.009 0.0696 0.172
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.009 0.0696 0.172
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.009 0.0696 0.172
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0354 0.3061 0.7701
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0208 0.0192
Schistosoma mansoni hypothetical protein 0.0165 0.1367 0.3443
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1949 0.4909
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0305 0.0768
Giardia lamblia 20S proteasome alpha subunit 7 0.009 0.0696 0.172
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.009 0.0696 0.1754
Echinococcus multilocularis cpg binding protein 0.0032 0.0178 0.0255
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0093 0.0133
Echinococcus multilocularis nicotinamide mononucleotide adenylyltransferase 0.0013 0.0016 0.0023
Echinococcus granulosus proteasome prosome macropain 0.0456 0.397 1
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.009 0.0696 0.0681
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.009 0.0696 0.1754
Brugia malayi Proteasome subunit alpha type 7-1 0.009 0.0696 0.1754
Echinococcus multilocularis proteasome subunit alpha type 6 0.009 0.0696 0.0996
Trypanosoma cruzi ISWI complex protein 0.0015 0.0032 0.0041
Treponema pallidum fructose-bisphosphate aldolase 0.0292 0.251 0.2498
Echinococcus multilocularis proteasome (prosome, macropain) 0.0456 0.397 0.568
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0208 0.0525
Trichomonas vaginalis esterase, putative 0.0035 0.0208 0.0486
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.009 0.0696 0.172
Giardia lamblia Proteasome subunit beta type 3 0.009 0.0696 0.172
Toxoplasma gondii proteasome subunit beta type, putative 0.0456 0.397 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0093 0.0235
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.009 0.0696 0.0681
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0219 0.1857 0.4678
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0093 0.0235
Echinococcus multilocularis proteasome subunit beta type 7 0.009 0.0696 0.0996
Leishmania major proteasome alpha 1 subunit, putative 0.009 0.0696 0.172
Schistosoma mansoni ethanolamine-phosphate cytidylyltransferase 0.0013 0.0016 0.0041
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0093 0.073 0.1044
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0456 0.397 0.3961
Brugia malayi proteasome subunit alpha type 6 0.009 0.0696 0.1754
Loa Loa (eye worm) proteasome subunit beta type 2 0.0219 0.1857 0.4678
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.009 0.0696 0.0996
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0532 0.1339
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.009 0.0696 0.172
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0093 0.0235
Brugia malayi Proteasome subunit alpha type 1 0.009 0.0696 0.1754
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0456 0.397 1
Plasmodium falciparum proteasome subunit beta type-5 0.0456 0.397 0.3961
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.009 0.0696 0.172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0093 0.0235
Brugia malayi hypothetical protein 0.0017 0.0044 0.0111
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.1173 0.1159
Loa Loa (eye worm) cytidylyltransferase 0.0013 0.0016 0.0041
Schistosoma mansoni thyroid hormone receptor 0.0174 0.1453 0.366
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0305 0.0768
Loa Loa (eye worm) hypothetical protein 0.0041 0.0259 0.0653
Echinococcus granulosus proteasome subunit alpha type 2 0.009 0.0696 0.1754
Brugia malayi dephospho-CoA kinase family protein 0.0013 0.0016 0.0041
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0093 0.073 0.0715
Toxoplasma gondii proteasome subunit alpha type, putative 0.009 0.0696 0.172
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0208 0.0525
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.009 0.0696 0.172
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0216 0.0545
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.009 0.0696 0.172
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0208 0.0486
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0093 0.0235
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0093 0.0235
Brugia malayi Chain A, Crystal Structure Of NmnNAMN ADENYLYLTRANSFERASE COMPLEXED With Nad. 0.0013 0.0016 0.0041
Schistosoma mansoni thyroid hormone receptor 0.0174 0.1453 0.366
Giardia lamblia Proteasome subunit beta type 9 precursor 0.009 0.0696 0.172
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.003 0.0164 0.0374
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0208 0.0525
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.009 0.0696 0.172
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.009 0.0696 0.1754
Giardia lamblia 20S proteasome alpha subunit 2 0.009 0.0696 0.172
Leishmania major proteasome alpha 1 subunit, putative 0.009 0.0696 0.172
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.009 0.0696 0.172
Loa Loa (eye worm) proteasome subunit beta type 3 0.009 0.0696 0.1754
Brugia malayi ethanolamine-phosphate cytidylyltransferase 0.0013 0.0016 0.0041
Loa Loa (eye worm) proteasome subunit alpha type 3 0.009 0.0696 0.1754
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.009 0.0696 0.172
Toxoplasma gondii heat shock protein hslv, putative 0.009 0.0696 0.172
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0219 0.1857 0.2657
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0443 0.1116
Plasmodium vivax proteasome subunit beta type-1, putative 0.0354 0.3061 0.305
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.009 0.0696 0.172
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0061 0.044 0.0425
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0093 0.073 0.1838
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.009 0.0696 0.172
Schistosoma mansoni dephospho-CoA related kinases 0.0013 0.0016 0.0041
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0525
Brugia malayi Proteasome A-type and B-type family protein 0.009 0.0696 0.1754
Loa Loa (eye worm) hypothetical protein 0.0071 0.0527 0.1327
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0208 0.0486
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.009 0.0696 0.172
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0456 0.397 1
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.008 0.0201
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0093 0.073 0.1838
Giardia lamblia 20S proteasome alpha subunit 3 0.009 0.0696 0.172
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0111 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0093 0.0235
Brugia malayi beta-lactamase family protein 0.0035 0.0208 0.0525
Trypanosoma brucei proteasome beta 2 subunit, putative 0.009 0.0696 0.172
Brugia malayi proteasome subunit beta type 3 0.009 0.0696 0.1754
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.009 0.0696 0.172
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.009 0.0696 0.172
Echinococcus granulosus geminin 0.0165 0.1367 0.3443
Brugia malayi Putative choline-phosphate cytidylyltransferase, putative 0.0013 0.0016 0.0041
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.009 0.0696 0.172
Loa Loa (eye worm) PAS-3 protein 0.009 0.0696 0.1754
Brugia malayi glucose-6-phosphate dehydrogenase 0.0093 0.073 0.1838
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.009 0.0696 0.172
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.009 0.0696 0.172
Treponema pallidum hypothetical protein 0.113 1 1
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.009 0.0696 0.172
Leishmania major proteasome alpha 3 subunit, putative 0.009 0.0696 0.172
Loa Loa (eye worm) hypothetical protein 0.0038 0.0238 0.06
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.009 0.0696 0.0681
Plasmodium vivax proteasome subunit alpha type-6, putative 0.009 0.0696 0.0681
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0208 0.0298
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0093 0.0133
Echinococcus multilocularis Proteasome, subunit alpha beta 0.009 0.0696 0.0996
Plasmodium vivax proteasome subunit beta type-2, putative 0.0219 0.1857 0.1844
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0093 0.0133
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0208 0.0486
Leishmania major proteasome beta 2 subunit, putative 0.0219 0.1857 0.4656
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0354 0.3061 0.7701
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0093 0.0235
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0125 0.0276
Loa Loa (eye worm) proteasome subunit alpha type 2 0.009 0.0696 0.1754
Mycobacterium ulcerans hypothetical protein 0.0035 0.0208 0.0192
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0219 0.1857 0.4678
Plasmodium vivax proteasome subunit beta type-5, putative 0.0456 0.397 0.3961
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0093 0.0133
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0093 0.0235
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.251 0.6308
Mycobacterium ulcerans beta-lactamase 0.0035 0.0208 0.0192
Echinococcus multilocularis proteasome subunit beta type 6 0.009 0.0696 0.0996
Onchocerca volvulus 0.0035 0.0208 0.2825
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0093 0.0235
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.009 0.0696 0.0996
Trypanosoma brucei proteasome beta 6 subunit 0.0354 0.3061 0.7701
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0456 0.397 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0291 0.0732
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0208 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0093 0.0235
Plasmodium falciparum proteasome subunit beta type-6, putative 0.009 0.0696 0.0681
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0235
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.009 0.0696 0.1754
Brugia malayi Bromodomain containing protein 0.0076 0.058 0.146
Onchocerca volvulus 0.0022 0.0093 0.1133
Onchocerca volvulus 0.0035 0.0208 0.2825
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0102 0.0804 0.1993
Brugia malayi proteasome subunit alpha type 4 0.009 0.0696 0.1754
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.009 0.0696 0.172
Echinococcus granulosus proteasome subunit alpha type 6 0.009 0.0696 0.1754
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0235
Plasmodium vivax proteasome subunit alpha type-2, putative 0.009 0.0696 0.0681
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0093 0.0235
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.009 0.0696 0.172
Echinococcus granulosus cpg binding protein 0.0032 0.0178 0.0449
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0208 0.0192
Brugia malayi nuclear hormone receptor 0.0022 0.0093 0.0235
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0208 0.0192
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.009 0.0696 0.172
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0093 0.0235
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0219 0.1857 0.4678
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0093 0.0235
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0208 0.0192
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0305 0.0768
Schistosoma mansoni nicotinamide mononucleotide adenylyltransferase 0.0013 0.0016 0.0041
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.009 0.0696 0.172
Echinococcus multilocularis Rossmann alpha beta alpha sandwich fold 0.0013 0.0016 0.0023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.251 0.6308
Trypanosoma brucei ATP-dependent protease subunit HslV 0.009 0.0696 0.172
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0443 0.0634
Echinococcus multilocularis choline phosphate cytidylyltransferase B 0.0013 0.0016 0.0023
Brugia malayi PHD-finger family protein 0.0026 0.0132 0.0333
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0093 0.0235
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.009 0.0696 0.172
Schistosoma mansoni choline-phosphate cytidylyltransferase 0.0013 0.0016 0.0041
Brugia malayi proteasome subunit alpha type 3 0.009 0.0696 0.1754
Brugia malayi beta-lactamase 0.0035 0.0208 0.0525
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0208 0.0486
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0053 0.0134
Brugia malayi proteasome subunit alpha type 2 0.009 0.0696 0.1754
Plasmodium vivax proteasome subunit alpha type-3, putative 0.009 0.0696 0.0681
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.009 0.0696 0.172
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0393 0.0953
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0354 0.3061 0.7711
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0305 0.0768
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0093 0.0235
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.009 0.0696 0.172
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0093 0.0235
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0093 0.0235
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0093 0.0133
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0208 0.0525
Leishmania major proteasome alpha 7 subunit, putative 0.009 0.0696 0.172
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.251 0.6308
Entamoeba histolytica hypothetical protein 0.0071 0.0532 0.1304
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0208 0.0486
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.009 0.0696 0.172
Brugia malayi ecdysteroid receptor 0.0022 0.0093 0.0235
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0235
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.009 0.0696 0.1754
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0053 0.0134
Loa Loa (eye worm) hypothetical protein 0.023 0.1949 0.4909
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0102 0.0804 0.1993
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0102 0.0804 0.0789
Echinococcus granulosus proteasome subunit beta type 6 0.009 0.0696 0.1754
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.009 0.0696 0.172
Echinococcus multilocularis bifunctional coenzyme A synthase 0.0013 0.0016 0.0023
Brugia malayi hypothetical protein 0.0026 0.0125 0.0316
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.009 0.0696 0.0681
Echinococcus granulosus proteasome subunit beta t family 0.009 0.0696 0.1754
Mycobacterium tuberculosis Conserved protein 0.0035 0.0208 0.0192
Schistosoma mansoni coup transcription factor 0.0022 0.0093 0.0235
Trypanosoma brucei ISWI complex protein 0.0015 0.0032 0.0041
Giardia lamblia Fructose-bisphosphate aldolase 0.0292 0.251 0.6308
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.1255 0.3162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0093 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0093 0.0235
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.009 0.0696 0.172
Brugia malayi Bromodomain containing protein 0.0038 0.0238 0.0598
Schistosoma mansoni cpg binding protein 0.0032 0.0178 0.0449
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.009 0.0696 0.1754
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.009 0.0696 0.172
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0354 0.3061 0.7701
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.009 0.0696 0.172
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0235
Schistosoma mansoni survival motor neuron protein 0.0047 0.0314 0.0792
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0093 0.0235
Plasmodium vivax proteasome subunit alpha type-1, putative 0.009 0.0696 0.0681
Trypanosoma brucei proteasome beta 7 subunit 0.009 0.0696 0.172
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0093 0.0235
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.113 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0093 0.0235
Brugia malayi proteasome subunit beta type 1 0.0354 0.3061 0.7711
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.009 0.0696 0.172
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0532 0.1339
Brugia malayi nuclear receptor NHR-88 0.0022 0.0093 0.0235
Schistosoma mansoni bromodomain containing protein 0.0065 0.0475 0.1196
Echinococcus granulosus Rossmann alpha beta alpha sandwich fold 0.0013 0.0016 0.0041
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0093 0.073 0.1805
Loa Loa (eye worm) cholinephosphate cytidylyl transferase B2 0.0013 0.0016 0.0041
Toxoplasma gondii proteasome beta subunit 0.009 0.0696 0.172
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.251 0.6308
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0048 0.0121
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.009 0.0696 0.172
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1949 0.2788
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.009 0.0696 0.1754
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0093 0.0235
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0093 0.0133
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.009 0.0696 0.172
Echinococcus multilocularis Proteasome subunit alpha type 7 0.009 0.0696 0.0996
Brugia malayi Cytidylyltransferase family protein 0.0013 0.0016 0.0041
Plasmodium vivax proteasome subunit beta type-4, putative 0.009 0.0696 0.0681
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.009 0.0696 0.172
Plasmodium vivax proteasome subunit beta type-3, putative 0.009 0.0696 0.0681
Mycobacterium ulcerans lipase LipD 0.0035 0.0208 0.0192
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0456 0.397 0.3961
Leishmania major proteasome beta 2 subunit, putative 0.009 0.0696 0.172
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.009 0.0696 0.1754
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0208 0.0486
Echinococcus granulosus proteasome subunit beta type 7 0.009 0.0696 0.1754
Mycobacterium ulcerans proteasome PrcA 0.009 0.0696 0.0681
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0093 0.0235
Echinococcus granulosus zinc finger protein 0.0021 0.0085 0.0213
Loa Loa (eye worm) hypothetical protein 0.0026 0.0125 0.0316
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0305 0.0768
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0125 0.0276
Echinococcus multilocularis Proteasome subunit alpha type 7 0.009 0.0696 0.0996
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0102 0.0804 0.1993
Leishmania major proteasome beta 5 subunit, putative 0.0456 0.397 1
Giardia lamblia Proteasome subunit beta type 2 0.0219 0.1857 0.4656
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0456 0.397 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0429 0.1079
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0093 0.0235
Echinococcus multilocularis subfamily T1A non peptidase ue 0.009 0.0696 0.0996
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0208 0.0192
Entamoeba histolytica hypothetical protein 0.0071 0.0532 0.1304
Schistosoma mansoni hypothetical protein 0.0165 0.1367 0.3443
Leishmania major proteasome alpha 7 subunit, putative 0.009 0.0696 0.172
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0147 0.037
Loa Loa (eye worm) ethanolamine-phosphate cytidylyltransferase 0.0013 0.0016 0.0041
Schistosoma mansoni hypothetical protein 0.0152 0.1255 0.3162
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0093 0.0235
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.009 0.0696 0.172
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.251 0.6308
Loa Loa (eye worm) proteasome subunit alpha type 6 0.009 0.0696 0.1754
Trypanosoma cruzi ISWI complex protein 0.0015 0.0032 0.0041
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.009 0.0696 0.172
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0093 0.1133
Mycobacterium tuberculosis Conserved protein 0.0035 0.0208 0.0192
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.113 1 1
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.009 0.0696 0.172
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0208 0.0486
Echinococcus granulosus 20S proteasome subunit alpha 6 0.009 0.0696 0.1754
Giardia lamblia 20S proteasome alpha subunit 1 0.009 0.0696 0.172
Trypanosoma brucei proteasome beta-1 subunit, putative 0.009 0.0696 0.172
Schistosoma mansoni zinc finger protein 0.0015 0.0032 0.0081
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0093 0.0235
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.009 0.0696 0.1754
Plasmodium falciparum proteasome subunit beta type-4 0.009 0.0696 0.0681
Schistosoma mansoni cpg binding protein 0.0032 0.0178 0.0449
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0793 0.699 1
Brugia malayi Proteasome A-type and B-type family protein 0.009 0.0696 0.1754
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0048 0.0068
Brugia malayi steroid hormone receptor 0.0022 0.0093 0.0235
Echinococcus granulosus subfamily T1A non peptidase ue 0.009 0.0696 0.1754
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.009 0.0696 0.0996
Mycobacterium tuberculosis Conserved protein 0.0035 0.0208 0.0192
Giardia lamblia 20S proteasome alpha subunit 6 0.009 0.0696 0.172
Plasmodium falciparum proteasome subunit beta type-3, putative 0.009 0.0696 0.0681
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.009 0.0696 0.1754
Schistosoma mansoni cpg binding protein 0.0028 0.0147 0.037
Schistosoma mansoni hypothetical protein 0.0021 0.008 0.0201
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0208 0.0192
Echinococcus multilocularis geminin 0.0165 0.1367 0.1956
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0525
Echinococcus multilocularis thyroid hormone receptor alpha 0.0174 0.1453 0.2079
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.009 0.0696 0.172
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.009 0.0696 0.1754
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0111 0.028
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.009 0.0696 1
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0061 0.044 0.1073
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.1173 0.1159
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.009 0.0696 0.1754
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0093 0.0235
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.009 0.0696 0.172
Brugia malayi Proteasome A-type and B-type family protein 0.009 0.0696 0.1754
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0305 0.0768
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.009 0.0696 0.172
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.1893 0.188
Leishmania major hypothetical protein, conserved 0.0015 0.0032 0.0041
Leishmania major proteasome beta-1 subunit, putative 0.009 0.0696 0.172
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.009 0.0696 0.172
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0093 0.0235
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.009 0.0696 0.0996
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0354 0.3061 0.7701
Echinococcus multilocularis Proteasome subunit alpha type 7 0.009 0.0696 0.0996
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0102 0.0804 0.1993
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0525
Plasmodium vivax proteasome subunit alpha type-5, putative 0.009 0.0696 0.0681
Trypanosoma brucei proteasome alpha 7 subunit 0.009 0.0696 0.172
Brugia malayi hypothetical protein 0.023 0.1949 0.4909
Giardia lamblia 20S proteasome alpha subunit 4 0.009 0.0696 0.172
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.009 0.0696 0.1754
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.009 0.0696 0.0681
Plasmodium vivax proteasome subunit alpha type-7, putative 0.009 0.0696 0.0681
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.251 0.6308
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0525
Onchocerca volvulus Notchless protein homolog 0.009 0.0696 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0093 0.0235
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0093 0.0235
Echinococcus granulosus bifunctional coenzyme A synthase 0.0013 0.0016 0.0041
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.009 0.0696 0.1754
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.009 0.0696 0.172
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.251 0.6308
Toxoplasma gondii proteasome subunit 0.009 0.0696 0.172
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0093 0.1133
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.009 0.0696 0.172
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.009 0.0696 0.1754
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0456 0.397 1
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0031 0.0172 0.0394
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0525
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0354 0.3061 0.7711
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0208 0.0192
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0093 0.0133
Trypanosoma brucei proteasome beta 3 subunit, putative 0.009 0.0696 0.172
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0053 0.0076
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.009 0.0696 0.172
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0219 0.1857 0.1844
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0093 0.073 0.1838
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0354 0.3061 0.7701
Echinococcus multilocularis zinc finger protein 0.0021 0.0085 0.0121
Leishmania major proteasome beta 3 subunit, putative 0.009 0.0696 0.172
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0208 0.0486
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0219 0.1857 0.4656
Toxoplasma gondii ABC1 family protein 0.0035 0.0208 0.0486
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0032 0.0185 0.0169
Giardia lamblia Proteasome subunit beta type 1 0.0354 0.3061 0.7701
Giardia lamblia Proteasome subunit beta type 7 precursor 0.009 0.0696 0.172
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0125 0.0109
Onchocerca volvulus 0.0035 0.0208 0.2825
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.251 0.6308
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.009 0.0696 0.172
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0125 0.0276
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0456 0.397 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.009 0.0696 0.172
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0053 0.0134
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.009 0.0696 0.172
Entamoeba histolytica hypothetical protein 0.0071 0.0532 0.1304
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0093 0.0235
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0093 0.073 0.1805
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0048 0.0121
Schistosoma mansoni zinc finger protein 0.0021 0.0085 0.0213
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.009 0.0696 0.172
Schistosoma mansoni hypothetical protein 0.0071 0.0532 0.1339
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.009 0.0696 0.172
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.009 0.0696 0.172
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0041
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0093 0.073 0.5
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.009 0.0696 0.172
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0053 0.0134
Schistosoma mansoni hypothetical protein 0.0047 0.0314 0.0792
Entamoeba histolytica hypothetical protein 0.0071 0.0532 0.1304
Giardia lamblia Proteasome subunit beta type 4 precursor 0.009 0.0696 0.172
Echinococcus granulosus Proteasome subunit alpha beta 0.009 0.0696 0.1754
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0314 0.0792
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.009 0.0696 0.172
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0456 0.397 1
Brugia malayi Proteasome A-type and B-type family protein 0.0456 0.397 1
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.009 0.0696 0.172
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.009 0.0696 0.172
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0305 0.0768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.251 0.6308
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0208 0.0192
Leishmania major hypothetical protein, conserved 0.0026 0.0125 0.0276
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.009 0.0696 0.172
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.009 0.0696 0.0681
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.009 0.0696 0.0681
Loa Loa (eye worm) proteasome subunit alpha type 1 0.009 0.0696 0.1754
Brugia malayi proteasome subunit beta type 2 0.0219 0.1857 0.4678
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0208 0.0192
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0456 0.397 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.1173 0.1159
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0102 0.0804 0.1993
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.009 0.0696 0.0681
Entamoeba histolytica proteasome subunit beta type 3, putative 0.009 0.0696 0.172
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.251 0.6308
Plasmodium vivax proteasome subunit beta type-7, putative 0.009 0.0696 0.0681
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0525
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0219 0.1857 0.4656
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.009 0.0696 0.0681
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.009 0.0696 0.0681
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.009 0.0696 0.1754
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0048 0.0121
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0235
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0093 0.0235
Onchocerca volvulus 0.0028 0.0147 0.1923
Brugia malayi beta-lactamase family protein 0.0035 0.0208 0.0525
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0041
Toxoplasma gondii proteasome subunit alpha1, putative 0.009 0.0696 0.172
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.009 0.0696 0.172
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.009 0.0696 0.172
Brugia malayi 20S proteasome alpha5 subunit 0.009 0.0696 0.1754
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.009 0.0696 0.172
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.009 0.0696 0.1754
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0216 0.031
Echinococcus multilocularis proteasome subunit alpha type 2 0.009 0.0696 0.0996
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0208 0.0192
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.009 0.0696 0.172
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0093 0.0235
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0102 0.0804 0.0789
Leishmania major proteasome beta 7 subunit, putative 0.009 0.0696 0.172
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0354 0.3061 0.4379
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.009 0.0696 0.172
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0219 0.1857 0.4656
Giardia lamblia 20S proteasome alpha subunit 5 0.009 0.0696 0.172
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0305 0.0436
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0125 0.0109
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0305 0.0436
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0354 0.3061 0.305
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0093 0.0235
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0093 0.073 0.1805
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.009 0.0696 0.1754
Brugia malayi CXXC zinc finger family protein 0.0028 0.0147 0.037
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0125 0.0276
Plasmodium falciparum proteasome subunit beta type-7, putative 0.009 0.0696 0.0681
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.009 0.0696 0.1754
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0219 0.1857 0.4656
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0093 0.0235
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.1255 0.1796
Leishmania major hypothetical protein, conserved 0.0035 0.0208 0.0486
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.113 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0093 0.0235
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0111 0.028
Mycobacterium ulcerans proteasome PrcB 0.0456 0.397 0.3961
Plasmodium vivax proteasome subunit alpha type-4, putative 0.009 0.0696 0.0681
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0235
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0093 0.0235
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0093 0.1133
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0093 0.0235
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0134
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0532 0.076
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.009 0.0696 0.172
Brugia malayi proteasome subunit alpha type 1 0.009 0.0696 0.1754
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.009 0.0696 0.172
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.009 0.0696 0.1754
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.009 0.0696 0.172
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0093 0.0235
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.009 0.0696 0.1754
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.009 0.0696 0.172
Trypanosoma cruzi 20S proteasome subunit 0.0219 0.1857 0.4656
Onchocerca volvulus 0.0047 0.0314 0.4386
Loa Loa (eye worm) beta-lactamase 0.0035 0.0208 0.0525
Toxoplasma gondii peptidase, T1 family protein 0.009 0.0696 0.172
Schistosoma mansoni hypothetical protein 0.0015 0.0032 0.0081
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0125 0.0109
Leishmania major proteasome alpha 2 subunit, putative 0.009 0.0696 0.172
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0093 0.073 0.0715
Loa Loa (eye worm) proteasome subunit beta type 1 0.0354 0.3061 0.7711
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0219 0.1857 0.4656
Echinococcus granulosus nicotinamide mononucleotide adenylyltransferase 0.0013 0.0016 0.0041
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.009 0.0696 0.172
Brugia malayi hypothetical protein 0.0071 0.0532 0.1339
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.009 0.0696 0.0681
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0208 0.0525
Plasmodium vivax proteasome subunit beta type-6, putative 0.009 0.0696 0.0681
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.113 1 1
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0219 0.1857 0.4656
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.009 0.0696 0.1754
Echinococcus granulosus choline phosphate cytidylyltransferase B 0.0013 0.0016 0.0041
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0093 0.0235

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of bovine liver MAOA ChEMBL. 18834112
Activity (binding) Inhibition of bovine liver MAOB ChEMBL. 18834112
IZ (functional) = 0.6 cm Antifungal activity against yeast AD1-8u expressing Candida albicans CaMdr1p by agar disk diffusion assay ChEMBL. 20739103
IZ (functional) = 0.8 cm Antifungal activity against yeast AD1-8u expressing Candida albicans CaCdr1p by agar disk diffusion assay ChEMBL. 20739103
Potency (functional) 0.3981 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of thyroid hormone receptor beta signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 34.3762 uM PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway measured by Nrf2-dependant transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 49.182 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of vitamin D receptor signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 61.1306 uM PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 61.6448 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 76.9588 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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