Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Probable calcium-transporting ATPase KIAA0703 | 0.0044 | 0.0315 | 0.0265 |
Echinococcus multilocularis | Ca2+ transporting ATPase plasma membrane | 0.0069 | 0.0631 | 0.0437 |
Giardia lamblia | Plasma membrane calcium-transporting ATPase 2 | 0.0066 | 0.0593 | 0.0286 |
Leishmania major | calcium motive p-type ATPase, putative | 0.0069 | 0.0631 | 0.0582 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0202 | 0.0202 |
Trypanosoma cruzi | calcium motive p-type ATPase, putative | 0.0069 | 0.0631 | 0.0564 |
Schistosoma mansoni | plasma membrane calcium-transporting atpase | 0.0069 | 0.0631 | 0.0461 |
Plasmodium vivax | calcium-transporting ATPase, putative | 0.0073 | 0.0673 | 0.0607 |
Schistosoma mansoni | plasma membrane calcium-transporting atpase | 0.0069 | 0.0631 | 0.0461 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0073 | 0.0673 | 0.0449 |
Toxoplasma gondii | sarco/endoplasmic reticulum Ca2+-ATPase | 0.0073 | 0.0673 | 0.0607 |
Echinococcus multilocularis | geminin | 0.0164 | 0.1823 | 0.1654 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0816 | 1 | 1 |
Loa Loa (eye worm) | E1-E2 ATPase | 0.0038 | 0.0235 | 0.0185 |
Mycobacterium leprae | PROBABLE CATION-TRANSPORTER ATPASE I CTPI | 0.0154 | 0.1693 | 0.165 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0816 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0202 | 0.0202 |
Schistosoma mansoni | hypothetical protein | 0.0126 | 0.1339 | 0.1183 |
Brugia malayi | Muscleblind-like protein | 0.0145 | 0.1587 | 0.1544 |
Entamoeba histolytica | plasma membrane calcium-transporting ATPase 1, putative | 0.0032 | 0.0163 | 0.0163 |
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | 0.0066 | 0.0593 | 0.0526 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0816 | 1 | 1 |
Schistosoma mansoni | ATPase | 0.0066 | 0.0593 | 0.0423 |
Echinococcus granulosus | nervana 2 | 0.0231 | 0.266 | 0.2508 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0279 | 0.3265 | 0.3126 |
Leishmania major | calcium-translocating P-type ATPase | 0.0066 | 0.0593 | 0.0545 |
Echinococcus multilocularis | sarco:endoplasmic reticulum calcium ATPase | 0.0066 | 0.0593 | 0.0399 |
Toxoplasma gondii | P-type ATPase PMA1 | 0.0038 | 0.0235 | 0.0166 |
Brugia malayi | Membrane calcium atpase protein 3 | 0.0069 | 0.0631 | 0.0582 |
Echinococcus granulosus | nervana 2 | 0.0279 | 0.3265 | 0.3126 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0066 | 0.0593 | 0.0593 |
Echinococcus granulosus | plasma membrane calcium transporting ATPase 2 | 0.0073 | 0.0673 | 0.0481 |
Echinococcus granulosus | calcium transporting atpase | 0.0069 | 0.0631 | 0.0437 |
Entamoeba histolytica | calcium-transporting P-type ATPase, putative | 0.0073 | 0.0673 | 0.0673 |
Trypanosoma brucei | calcium motive p-type ATPase, putative | 0.0069 | 0.0631 | 0.0564 |
Echinococcus multilocularis | nervana 2 | 0.0231 | 0.266 | 0.2508 |
Brugia malayi | Na,K-ATPase alpha subunit | 0.0185 | 0.2088 | 0.2048 |
Schistosoma mansoni | ATPase | 0.0066 | 0.0593 | 0.0423 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0177 | 0.0127 |
Echinococcus multilocularis | nervana 2 | 0.0279 | 0.3265 | 0.3126 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0202 | 0.0202 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0071 | 0.002 |
Trypanosoma cruzi | calcium-transporting ATPase, putative | 0.0044 | 0.0315 | 0.0246 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0177 | 0.0127 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.0066 | 0.0593 | 0.0366 |
Entamoeba histolytica | plasma membrane calcium ion-transporting ATPase, putative | 0.0038 | 0.0244 | 0.0244 |
Echinococcus multilocularis | plasma membrane calcium transporting ATPase | 0.0069 | 0.0631 | 0.0437 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0816 | 1 | 1 |
Trypanosoma brucei | P-type H+-ATPase, putative | 0.0038 | 0.0235 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.2088 | 0.2048 |
Leishmania major | P-type H -ATPase, putative | 0.0038 | 0.0235 | 0.0185 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0231 | 0.266 | 0.2508 |
Leishmania major | vacuolar-type Ca2 -ATPase, putative | 0.0066 | 0.0593 | 0.0545 |
Echinococcus granulosus | sodium:potassium transporting ATPase subunit | 0.0279 | 0.3265 | 0.3126 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0071 | 0.002 |
Onchocerca volvulus | 0.0279 | 0.3265 | 1 | |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0066 | 0.0593 | 0.0593 |
Brugia malayi | haloacid dehalogenase-like hydrolase family protein | 0.0038 | 0.0244 | 0.0193 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0066 | 0.0593 | 0.0366 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0066 | 0.0593 | 0.0593 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0505 | 0.6098 | 0.6028 |
Schistosoma mansoni | na+/k+ atpase alpha subunit | 0.0182 | 0.2046 | 0.1902 |
Schistosoma mansoni | sodium / potassium ATPase beta chain | 0.0231 | 0.266 | 0.2527 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.3265 | 0.323 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0505 | 0.6098 | 0.6028 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0066 | 0.0593 | 0.0366 |
Plasmodium vivax | P-type ATPase4, putative | 0.0073 | 0.0673 | 0.0607 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0071 | 0.002 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0816 | 1 | 1 |
Echinococcus granulosus | sarco:endoplasmic reticulum calcium ATPase | 0.0066 | 0.0593 | 0.0399 |
Loa Loa (eye worm) | calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type | 0.0044 | 0.0315 | 0.0265 |
Schistosoma mansoni | calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) | 0.0069 | 0.0631 | 0.0461 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0078 | 0.0027 |
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | 0.0066 | 0.0593 | 0.0526 |
Plasmodium falciparum | non-SERCA-type Ca2+ -transporting P-ATPase | 0.0073 | 0.0673 | 0.0607 |
Echinococcus granulosus | Na:K ATPase alpha subunit | 0.0182 | 0.2046 | 0.1881 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase 1 | 0.0066 | 0.0593 | 0.0526 |
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 0.1465 | 0.1311 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0202 | 0.0025 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0505 | 0.6098 | 0.6028 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase, putative | 0.0066 | 0.0593 | 0.0526 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.1536 | 0.1492 |
Trypanosoma cruzi | calcium motive p-type ATPase, putative | 0.0069 | 0.0631 | 0.0564 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0256 | 0.2976 | 0.2807 |
Echinococcus granulosus | Ca2 transporting ATPase plasma membrane | 0.0069 | 0.0631 | 0.0437 |
Onchocerca volvulus | 0.0231 | 0.266 | 0.8116 | |
Echinococcus granulosus | geminin | 0.0164 | 0.1823 | 0.1654 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.1335 | 0.129 |
Trypanosoma cruzi | plasma-membrane proton-efflux P-type ATPase, putative | 0.0034 | 0.0193 | 0.0123 |
Echinococcus multilocularis | calcium transporting atpase | 0.0069 | 0.0631 | 0.0437 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0202 | 0.0025 |
Brugia malayi | calcium ATPase | 0.0035 | 0.0201 | 0.0151 |
Brugia malayi | Sodium/potassium-transporting ATPase alpha-3 chain, putative | 0.0034 | 0.0193 | 0.0142 |
Leishmania major | P-type ATPase, putative | 0.0069 | 0.0631 | 0.0582 |
Trypanosoma cruzi | calcium-translocating P-type ATPase, putative | 0.0034 | 0.0193 | 0.0123 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0816 | 1 | 1 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0231 | 0.266 | 0.2527 |
Mycobacterium ulcerans | metal cation transporter p-type ATPase a | 0.0179 | 0.2008 | 0.1967 |
Brugia malayi | Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type | 0.0069 | 0.0631 | 0.0582 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase 2 | 0.0066 | 0.0593 | 0.0526 |
Trypanosoma cruzi | P-type H+-ATPase, putative | 0.0038 | 0.0235 | 0.0166 |
Loa Loa (eye worm) | sodium/potassium-transporting ATPase subunit alpha | 0.016 | 0.1773 | 0.1731 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0279 | 0.3265 | 0.3126 |
Toxoplasma gondii | calcium-translocating P-type ATPase, PMCA-type protein | 0.0066 | 0.0593 | 0.0526 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0505 | 0.6098 | 0.6028 |
Leishmania major | P-type H -ATPase, putative | 0.0038 | 0.0235 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0193 | 0.0142 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0126 | 0.1339 | 0.116 |
Plasmodium falciparum | calcium-transporting ATPase | 0.0069 | 0.0631 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0315 | 0.0265 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0688 | 0.8401 | 0.8368 |
Leishmania major | vacuolar-type Ca2 -ATPase, putative | 0.0066 | 0.0593 | 0.0545 |
Brugia malayi | E1-E2 ATPase family protein | 0.0044 | 0.0316 | 0.0266 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.1823 | 0.1676 |
Toxoplasma gondii | plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 | 0.0069 | 0.0631 | 0.0564 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0066 | 0.0593 | 0.0366 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0279 | 0.3265 | 0.3143 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0688 | 0.8401 | 0.8368 |
Trichomonas vaginalis | cation-transporting ATPase fungi, putative | 0.0066 | 0.0593 | 0.0366 |
Echinococcus multilocularis | calcium transporting ATPase type 2C member | 0.0073 | 0.0673 | 0.0481 |
Entamoeba histolytica | plasma membrane calcium ion-transporting ATPase, putative | 0.0041 | 0.0273 | 0.0273 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0202 | 0.0152 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0126 | 0.1339 | 0.116 |
Leishmania major | calcium-transporting ATPase, putative | 0.0069 | 0.0631 | 0.0582 |
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 0.1465 | 0.1311 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1587 | 0.1544 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0816 | 1 | 1 |
Brugia malayi | calcium ATPase | 0.0034 | 0.0193 | 0.0142 |
Onchocerca volvulus | 0.0179 | 0.2008 | 0.6089 | |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0369 | 0.0319 |
Toxoplasma gondii | P-type ATPase4, putative | 0.0073 | 0.0673 | 0.0607 |
Echinococcus granulosus | plasma membrane calcium transporting ATPase | 0.0069 | 0.0631 | 0.0437 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0145 | 0.1587 | 0.1414 |
Trypanosoma cruzi | P-type H+-ATPase, putative | 0.0034 | 0.0193 | 0.0123 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0066 | 0.0593 | 0.0366 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.0066 | 0.0593 | 0.0366 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0069 | 0.0631 | 0.0405 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0688 | 0.8401 | 0.8372 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0051 | 0.0051 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0816 | 1 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0816 | 1 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0816 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0816 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0078 | 0.0027 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0051 | 0.0051 |
Echinococcus multilocularis | muscleblind protein | 0.0145 | 0.1587 | 0.1414 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0593 | 0.0545 |
Mycobacterium tuberculosis | Possible metal cation transporting P-type ATPase CtpH | 0.0041 | 0.0277 | 0.0227 |
Echinococcus multilocularis | sodium:potassium transporting ATPase subunit | 0.0279 | 0.3265 | 0.3126 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0369 | 0.0319 |
Echinococcus granulosus | calcium transporting ATPase type 2C member | 0.0073 | 0.0673 | 0.0481 |
Trypanosoma brucei | P-type H+-ATPase, putative | 0.0038 | 0.0235 | 0.0166 |
Mycobacterium ulcerans | cation-transporter ATPase I CtpI | 0.0041 | 0.0277 | 0.0227 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0816 | 1 | 1 |
Trypanosoma cruzi | calcium-translocating P-type ATPase, putative | 0.0029 | 0.0121 | 0.005 |
Trypanosoma cruzi | P-type H+-ATPase, putative | 0.0038 | 0.0235 | 0.0166 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0231 | 0.266 | 0.2508 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.3265 | 0.323 |
Echinococcus multilocularis | Na+:K+ ATPase alpha subunit | 0.0182 | 0.2046 | 0.1881 |
Loa Loa (eye worm) | sodium potassium adenosine triphosphatase | 0.0034 | 0.0193 | 0.0142 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.081 | 0.9935 | 0.9934 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0136 | 0.1465 | 0.1289 |
Trypanosoma brucei | calcium-translocating P-type ATPase | 0.0069 | 0.0631 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1587 | 0.1544 |
Echinococcus granulosus | nervana 2 | 0.0231 | 0.266 | 0.2508 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1178 | 0.1133 |
Toxoplasma gondii | E1-E2 ATPase subfamily protein | 0.0034 | 0.0193 | 0.0123 |
Echinococcus granulosus | muscleblind protein | 0.0145 | 0.1587 | 0.1414 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.1823 | 0.1676 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0051 | 0.0051 |
Trypanosoma brucei | calcium-transporting ATPase, putative | 0.0044 | 0.0315 | 0.0246 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0202 | 0.0202 |
Echinococcus multilocularis | nervana 2 | 0.0279 | 0.3265 | 0.3126 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0279 | 0.3265 | 0.3126 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.0066 | 0.0593 | 0.0366 |
Brugia malayi | Sodium/potassium-transporting ATPase alpha chain, putative | 0.016 | 0.1773 | 0.1731 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0816 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0369 | 0.0319 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0816 | 1 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0816 | 1 | 1 |
Schistosoma mansoni | calcium-transporting atpase 2 (atpase 2) | 0.0069 | 0.0631 | 0.0461 |
Trypanosoma cruzi | Calcium ATPase SERCA-like | 0.0066 | 0.0593 | 0.0526 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0816 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0816 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0369 | 0.0319 |
Mycobacterium ulcerans | metal cation-transporting p-type ATPase F, CtpF | 0.0073 | 0.0673 | 0.0625 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0279 | 0.3265 | 0.3143 |
Echinococcus multilocularis | Tetracycline resistance leader peptide, TetL | 0.0073 | 0.0673 | 0.0481 |
Echinococcus granulosus | nervana 2 | 0.0279 | 0.3265 | 0.3126 |
Giardia lamblia | Potassium-transporting ATPase alpha chain 1 | 0.0182 | 0.2046 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0816 | 1 | 1 |
Schistosoma mansoni | calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) | 0.0069 | 0.0631 | 0.0461 |
Echinococcus multilocularis | nervana 2 | 0.0231 | 0.266 | 0.2508 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0279 | 0.3265 | 0.3126 |
Schistosoma mansoni | transmemberane protein | 0.0279 | 0.3265 | 0.3143 |
Loa Loa (eye worm) | Na,K-ATPase alpha subunit | 0.0185 | 0.2088 | 0.2048 |
Loa Loa (eye worm) | calcium ATPase | 0.0038 | 0.0244 | 0.0193 |
Schistosoma mansoni | Na+/K+ transporting ATPase subunit alpha | 0.0185 | 0.2088 | 0.1946 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.