Detailed information for compound 559476

Basic information

Technical information
  • TDR Targets ID: 559476
  • Name: 1-(2,6-dichlorophenyl)-N-phenyl-methanimine
  • MW: 250.123 | Formula: C13H9Cl2N
  • H donors: 0 H acceptors: 0 LogP: 4.48 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1C=Nc1ccccc1)Cl
  • InChi: 1S/C13H9Cl2N/c14-12-7-4-8-13(15)11(12)9-16-10-5-2-1-3-6-10/h1-9H/b16-9+
  • InChiKey: RSMDSQMJKAEWPT-CXUHLZMHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2,6-dichlorophenyl)-N-phenylmethanimine
  • (2,6-dichlorobenzylidene)-phenyl-amine
  • N-(2,6-dichlorobenzylidene)aniline

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0745 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.8836 0.8836
Loa Loa (eye worm) TAR-binding protein 0.0062 0.2541 0.2541
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0745 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0745 0.0745
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0537 1
Schistosoma mansoni hypothetical protein 0.0182 0.801 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0745 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0479 0.0479
Loa Loa (eye worm) hypothetical protein 0.0017 0.0479 0.0479
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0745 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1749 0.2183
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1934 0.1934
Loa Loa (eye worm) RNA binding protein 0.0062 0.2541 0.2541
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1749 0.2183
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0537 0.5
Echinococcus multilocularis geminin 0.0182 0.801 1
Echinococcus granulosus tar DNA binding protein 0.0062 0.2541 0.3172
Schistosoma mansoni hypothetical protein 0.0016 0.04 0.0499
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2541 0.3172
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1749 0.2183
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0537 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0479 0.8921
Loa Loa (eye worm) hypothetical protein 0.0017 0.0479 0.0479
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0537 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0436 0.5844
Loa Loa (eye worm) hypothetical protein 0.0023 0.0745 0.0745
Schistosoma mansoni hypothetical protein 0.0016 0.04 0.0499
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2541 0.3172
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0537 0.067
Schistosoma mansoni ap endonuclease 0.0019 0.0537 0.067
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0537 0.0537
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0745 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0745 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1749 0.2183
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0745 1
Brugia malayi TAR-binding protein 0.0062 0.2541 0.2541
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1749 0.1749
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0745 1
Brugia malayi RNA binding protein 0.0062 0.2541 0.2541
Loa Loa (eye worm) hypothetical protein 0.0034 0.1224 0.1224
Schistosoma mansoni hypothetical protein 0.0182 0.801 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1934 0.1934
Toxoplasma gondii exonuclease III APE 0.0019 0.0537 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1749 0.2183
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0745 0.0745
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0537 0.7198
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0436 0.5844
Schistosoma mansoni hypothetical protein 0.0016 0.04 0.0499
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0745 1
Onchocerca volvulus 0.0023 0.0745 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0166 0.7302 0.9116
Loa Loa (eye worm) hypothetical protein 0.02 0.8836 0.8836
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0537 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0537 0.5
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0537 0.7198
Echinococcus granulosus GPCR family 2 0.0016 0.04 0.0499
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0745 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0479 0.6421
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2541 0.3172
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.2541 0.2541
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2541 0.3172
Loa Loa (eye worm) hypothetical protein 0.0017 0.0479 0.0479
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.1224 0.1224
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0745 1
Echinococcus granulosus geminin 0.0182 0.801 1
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.2541 0.2541
Loa Loa (eye worm) hypothetical protein 0.0017 0.0479 0.0479
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0745 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0537 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0537 0.067
Schistosoma mansoni ap endonuclease 0.0019 0.0537 0.067
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0479 0.6421
Brugia malayi Latrophilin receptor protein 2 0.0016 0.04 0.04
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0537 0.7198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1749 0.2183
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0745 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0436 0.5844
Echinococcus multilocularis GPCR, family 2 0.0016 0.04 0.0499
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0537 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0745 0.0745
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0537 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1749 0.1749
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0166 0.7302 0.9116
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0023 0.0745 0.0745
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0479 0.5
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0537 0.0537
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.04 0.0499
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0745 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1749 0.2183
Loa Loa (eye worm) hypothetical protein 0.0016 0.04 0.04
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.04 0.04
Echinococcus multilocularis tar DNA binding protein 0.0062 0.2541 0.3172
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0537 0.7198
Schistosoma mansoni hypothetical protein 0.0016 0.04 0.0499
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0479 0.8921
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 1 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.0745 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0745 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0745 0.0745
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2541 0.3172
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0537 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.04 0.0499
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0745 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0745 1
Schistosoma mansoni hypothetical protein 0.0034 0.1224 0.1528
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0436 0.5844

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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