Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0745 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.02 | 0.8836 | 0.8836 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.2541 | 0.2541 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0745 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0745 | 0.0745 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0537 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.801 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0745 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0479 | 0.0479 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0479 | 0.0479 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0745 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1749 | 0.2183 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1934 | 0.1934 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.2541 | 0.2541 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1749 | 0.2183 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0537 | 0.5 |
Echinococcus multilocularis | geminin | 0.0182 | 0.801 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.2541 | 0.3172 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.04 | 0.0499 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2541 | 0.3172 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1749 | 0.2183 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0537 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0479 | 0.8921 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0479 | 0.0479 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0537 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0436 | 0.5844 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0745 | 0.0745 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.04 | 0.0499 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2541 | 0.3172 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0537 | 0.067 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0537 | 0.067 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0537 | 0.0537 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0745 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0745 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1749 | 0.2183 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0745 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.2541 | 0.2541 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1749 | 0.1749 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0745 | 1 |
Brugia malayi | RNA binding protein | 0.0062 | 0.2541 | 0.2541 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1224 | 0.1224 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.801 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1934 | 0.1934 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0537 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1749 | 0.2183 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0745 | 0.0745 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0537 | 0.7198 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0436 | 0.5844 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.04 | 0.0499 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0745 | 1 |
Onchocerca volvulus | 0.0023 | 0.0745 | 1 | |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0166 | 0.7302 | 0.9116 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.8836 | 0.8836 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0537 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0537 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0537 | 0.7198 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.04 | 0.0499 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0745 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0479 | 0.6421 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2541 | 0.3172 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.2541 | 0.2541 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2541 | 0.3172 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0479 | 0.0479 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1224 | 0.1224 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0745 | 1 |
Echinococcus granulosus | geminin | 0.0182 | 0.801 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.2541 | 0.2541 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0479 | 0.0479 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0745 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0537 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0537 | 0.067 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0537 | 0.067 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.0479 | 0.6421 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.04 | 0.04 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0537 | 0.7198 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1749 | 0.2183 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0745 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0436 | 0.5844 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.04 | 0.0499 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0537 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0745 | 0.0745 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0537 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1749 | 0.1749 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0166 | 0.7302 | 0.9116 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.04 | 0.04 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0745 | 0.0745 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0479 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0537 | 0.0537 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.04 | 0.0499 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0745 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1749 | 0.2183 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.04 | 0.04 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.04 | 0.04 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.2541 | 0.3172 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0537 | 0.7198 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.04 | 0.0499 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0479 | 0.8921 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0225 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0745 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0745 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0745 | 0.0745 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2541 | 0.3172 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0537 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.04 | 0.0499 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0745 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0745 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1224 | 0.1528 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0436 | 0.5844 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.