Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0253 | 0.2752 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0331 | 0.3798 | 0.3798 |
Echinococcus multilocularis | expressed conserved protein | 0.0091 | 0.058 | 0.058 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.03 | 0.3388 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.2752 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.03 | 0.3388 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0142 | 0.1271 | 0.3643 |
Onchocerca volvulus | 0.0148 | 0.1349 | 1 | |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0098 | 0.0679 | 0.2422 |
Loa Loa (eye worm) | TAR-binding protein | 0.0253 | 0.2752 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0138 | 0.1213 | 0.1213 |
Mycobacterium ulcerans | hypothetical protein | 0.0158 | 0.1486 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.2752 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0253 | 0.2752 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0659 | 0.2349 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0096 | 0.0659 | 0.1398 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.2752 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0253 | 0.2752 | 0.2752 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0096 | 0.0659 | 0.0659 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0096 | 0.0659 | 0.0978 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0046 | 0.011 |
Brugia malayi | RNA binding protein | 0.0253 | 0.2752 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.0318 | 0.1105 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.03 | 0.3388 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.2752 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0096 | 0.0659 | 1 |
Brugia malayi | hypothetical protein | 0.0148 | 0.1349 | 0.4236 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.2384 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0138 | 0.1213 | 0.257 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.0318 | 0.0318 |
Echinococcus granulosus | tumor protein p63 | 0.0331 | 0.3798 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0318 | 0.1105 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.03 | 0.3388 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0253 | 0.2752 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0253 | 0.2752 | 0.6992 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1349 | 0.4872 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.0016 | 0.5 |
Echinococcus granulosus | expressed conserved protein | 0.0091 | 0.058 | 0.0753 |
Brugia malayi | TAR-binding protein | 0.0253 | 0.2752 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.2752 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.