Detailed information for compound 559768

Basic information

Technical information
  • TDR Targets ID: 559768
  • Name: 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl ]-3-phenyl-propan-1-one hydrochloride
  • MW: 377.905 | Formula: C21H28ClNO3
  • H donors: 2 H acceptors: 2 LogP: 4.11 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O.Cl
  • InChi: 1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
  • InChiKey: XWIHRGFIPXWGEF-UHFFFAOYSA-N  

Network

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Synonyms

  • 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone hydrochloride
  • 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one hydrochloride
  • Propafenone
  • 1-[2-(2-hydroxy-3-propylaminopropoxy)phenyl]-3-phenylpropan-1-one hydrochloride
  • hydron; 1-[2-(2-hydroxy-3-propylaminopropoxy)phenyl]-3-phenylpropan-1-one; chloride
  • hydron; 1-[2-(2-hydroxy-3-propylamino-propoxy)phenyl]-3-phenyl-propan-1-one; chloride
  • 1-[2-(2-hydroxy-3-propylamino-propoxy)phenyl]-3-phenyl-propan-1-one hydrochloride
  • 54063-53-5
  • 34183-22-7
  • NCGC00094230-02
  • NCGC00094230-03
  • SPECTRUM1503935
  • EU-0100919
  • MLS000069682
  • SMR000058493
  • Prestwick_831
  • D00640
  • Propafenone hydrochloride (JAN/USP)
  • Rythmol (TN)
  • 1-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenylpropan-1-one hydrochloride
  • 1-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-, hydrochloride
  • 2'-(2-Hydroxy-3-(propylamino)propoxy)-3-phenylpropiophenone hydrochloride
  • Baxarytmon
  • EINECS 251-867-9
  • Fenoprain
  • PROPAFENONE HYDROCHLORIDE
  • Propafenon hydrochlorid [German]
  • Propafenone hydrochloirde
  • Propafenone hydrochloride [USAN:JAN]
  • Propiophenone, 2'-(2-hydroxy-3-(propylamino)propoxy)-3-phenyl-, hydrochloride
  • Rhythmonorm
  • Rythmol
  • Rythmol SR
  • Rytmonorm
  • SA 79
  • WZ 884

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0024 0.0096 0.0194
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Loa Loa (eye worm) hypothetical protein 0.0122 0.0806 0.1639
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0023 0.0006
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0066 0.0042
Toxoplasma gondii endonuclease IV APN 0.0093 0.0591 0.1663
Onchocerca volvulus 0.0287 0.1996 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0863 0.5492
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0095 0.1274
Echinococcus granulosus cpg binding protein 0.0062 0.0374 0.0358
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0096 0.2125
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0176 0.0878
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0023 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.005 0.0034
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0018 0.005 0.0034
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0095 0.0079
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0047
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0018 0.005 0.0102
Loa Loa (eye worm) hypothetical protein 0.005 0.0286 0.0582
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0018 0.005 0.0034
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0124
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0202
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0193 0.0177
Mycobacterium tuberculosis Conserved hypothetical protein 0.0024 0.0099 0.0363
Mycobacterium ulcerans hypothetical protein 0.0035 0.0176 0.0425
Brugia malayi mbt repeat family protein 0.005 0.0286 0.055
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0358
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0591 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0176 0.0878
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.1352 0.1337
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0023 0.0014
Entamoeba histolytica hypothetical protein 0.0036 0.0185 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0221 0.0416
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0176 0.0159
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0066 0.1168
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0023 0.0014
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0066 0.0764
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0176 0.0878
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0185 0.0168
Loa Loa (eye worm) hypothetical protein 0.0024 0.0095 0.0194
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0065 0.0048
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0298 0.2071 1
Plasmodium vivax glutathione reductase, putative 0.0057 0.0336 0.55
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0047
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0336 0.032
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0066 0.1168
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0692 0.4916 0.4907
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0066 0.0104
Plasmodium falciparum thioredoxin reductase 0.002 0.0066 0.0764
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.005 0.0034
Onchocerca volvulus 0.0018 0.005 0.0138
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.019 0.1292 0.8373
Loa Loa (eye worm) hypothetical protein 0.0024 0.0095 0.0194
Schistosoma mansoni tar DNA-binding protein 0.013 0.0864 0.0849
Onchocerca volvulus 0.0018 0.005 0.0138
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0286 0.027
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0023 0.0014
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0031 0.0063
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0018 0.005 0.0034
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0336 0.032
Echinococcus multilocularis RUN 0.0024 0.0095 0.0079
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0096 0.0339
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0358
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0336 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0066 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0176 0.0878
Onchocerca volvulus 0.0018 0.005 0.0138
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.012 0.0503
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0358 0.0696
Trichomonas vaginalis pten, drome, putative 0.0018 0.005 0.0152
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0066 0.005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0358
Brugia malayi Pre-SET motif family protein 0.0253 0.1746 0.3529
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0106
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0863 0.2295
Loa Loa (eye worm) RNA binding protein 0.013 0.0864 0.1758
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0176 0.0878
Onchocerca volvulus 0.0018 0.005 0.0138
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0024 0.0099 0.0386
Echinococcus granulosus chromobox protein 1 0.0014 0.0023 0.0006
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0066 0.0764
Loa Loa (eye worm) hypothetical protein 0.0024 0.0096 0.0194
Schistosoma mansoni rab6-interacting 0.0024 0.0095 0.0079
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0018 0.005 0.0034
Loa Loa (eye worm) helicase 0.0014 0.0023 0.0047
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0039 0.0022
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0336 0.0319
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.0838 0.0822
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0018 0.005 0.0034
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0018 0.005 0.0102
Schistosoma mansoni hypothetical protein 0.0842 0.5997 0.5991
Schistosoma mansoni 3-dehydroquinate synthase 0.019 0.1292 0.1278
Echinococcus granulosus protein tyrosine phosphatase n9 0.0018 0.005 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0023 0.0014
Brugia malayi hypothetical protein 0.0018 0.005 0.0068
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0066 0.1168
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0176 0.0325
Brugia malayi RNA binding protein 0.013 0.0864 0.173
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.005 0.0034
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0066 0.0101
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0245 0.0229
Onchocerca volvulus 0.0024 0.0095 0.0367
Onchocerca volvulus 0.0018 0.005 0.0138
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.0864 0.1758
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0023 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0051 0.0292 0.0276
Onchocerca volvulus 0.0059 0.035 0.1658
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.005 0.0034
Schistosoma mansoni hypothetical protein 0.0305 0.2127 0.2114
Onchocerca volvulus 0.0018 0.005 0.0138
Schistosoma mansoni rab6-interacting 0.0024 0.0095 0.0079
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.005 0.0637
Brugia malayi CHD4 protein 0.0017 0.0047 0.0062
Schistosoma mansoni microtubule-associated protein tau 0.1397 1 1
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0018 0.005 0.0034
Schistosoma mansoni lipoxygenase 0.01 0.0642 0.0626
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.005 0.0034
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.005 0.0034
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.005 0.0034
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0023 0.0006
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0096 0.4493
Schistosoma mansoni hypothetical protein 0.0019 0.0061 0.0044
Mycobacterium ulcerans beta-lactamase 0.0035 0.0176 0.0425
Onchocerca volvulus 0.0035 0.0176 0.0774
Plasmodium vivax SET domain protein, putative 0.0037 0.0193 0.2992
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Brugia malayi Protein-tyrosine phosphatase 0.0018 0.005 0.0068
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0336 0.55
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0336 0.0683
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0096 0.019
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.005 0.0102
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Schistosoma mansoni chromobox protein 0.0014 0.0023 0.0006
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0692 0.4916 0.4907
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.005 0.0034
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0109 0.0707 0.0691
Echinococcus multilocularis GPCR, family 2 0.0019 0.0061 0.0044
Schistosoma mansoni loxhd1 0.0024 0.0095 0.0079
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Loa Loa (eye worm) hypothetical protein 0.0122 0.0806 0.1639
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0047 0.0031
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0286 0.027
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.005 0.0034
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0096 0.4493
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0065 0.0048
Leishmania major trypanothione reductase 0.0057 0.0336 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.005 0.0034
Toxoplasma gondii ABC1 family protein 0.0035 0.0176 0.0447
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.012 0.0503
Mycobacterium tuberculosis Conserved protein 0.0035 0.0176 0.0878
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Schistosoma mansoni tar DNA-binding protein 0.013 0.0864 0.0849
Brugia malayi chromobox protein homolog 3 0.0014 0.0023 0.0013
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0286 0.0582
Onchocerca volvulus 0.0018 0.005 0.0138
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0066 0.1168
Mycobacterium ulcerans endonuclease IV 0.0093 0.0591 0.1644
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0099 0.0011
Echinococcus multilocularis chromobox protein 1 0.0014 0.0023 0.0006
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0096 0.4493
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0863 0.5492
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0358
Schistosoma mansoni cpg binding protein 0.0062 0.0374 0.0358
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.0023 0.0013
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0176 0.0878
Brugia malayi hypothetical protein 0.0286 0.1983 0.4014
Loa Loa (eye worm) hypothetical protein 0.0039 0.0203 0.0412
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0193 0.0177
Onchocerca volvulus 0.0018 0.005 0.0138
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0741 0.2102
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0023 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0176 0.2689
Schistosoma mansoni chromobox protein 0.0014 0.0023 0.0006
Brugia malayi Valyl-tRNA synthetase 0.0014 0.0023 0.0013
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0968 0.6196
Chlamydia trachomatis endonuclease IV 0.0093 0.0591 0.1592
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0018 0.005 0.0068
Brugia malayi beta-lactamase 0.0035 0.0176 0.0325
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0047
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0286 0.027
Onchocerca volvulus 0.0035 0.0176 0.0774
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Loa Loa (eye worm) MBCTL1 0.0057 0.0336 0.0684
Brugia malayi hypothetical protein 0.0024 0.0095 0.0161
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.0023 0.0006
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0176 0.0787
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0018 0.005 0.0034
Onchocerca volvulus 0.0018 0.005 0.0138
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0095 0.0079
Echinococcus multilocularis microtubule associated protein 2 0.1397 1 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.005 0.0034
Schistosoma mansoni hypothetical protein 0.0205 0.14 0.1385
Mycobacterium tuberculosis Probable reductase 0.013 0.0863 0.5492
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.012 0.0503
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.005 0.0034
Echinococcus multilocularis chromobox protein 1 0.0014 0.0023 0.0006
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.012 0.0503
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0023 0.0014
Onchocerca volvulus 0.0122 0.0806 0.3967
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0358 0.0728
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.005 0.0102
Trichomonas vaginalis esterase, putative 0.0035 0.0176 0.0787
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0245 0.0466
Onchocerca volvulus 0.0018 0.005 0.0138
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0061 0.0044
Chlamydia trachomatis dehyroquinate synthase 0.019 0.1292 0.3661
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.005 0.0034
Loa Loa (eye worm) hypothetical protein 0.0247 0.1709 0.3476
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0052 0.0063
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0095 0.0194
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.005 0.0034
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0358 0.0696
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0066 0.1168
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0096 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0023 0.0014
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0692 0.4916 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.0014
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0014 0.0023 0.0013
Echinococcus multilocularis cpg binding protein 0.0062 0.0374 0.0358
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0095 0.0079
Brugia malayi Heterochromatin protein 1 0.0014 0.0023 0.0013
Brugia malayi Protein-tyrosine phosphatase 0.0018 0.005 0.0068
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0096 0.019
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.005 0.0034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0066 0.1168
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0023 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0176 0.4759
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.005 0.0102
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.005 0.0102
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0023 0.0014
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0286 0.027
Brugia malayi mbt repeat family protein 0.005 0.0286 0.055
Schistosoma mansoni polycystin 1-related 0.0024 0.0095 0.0079
Mycobacterium tuberculosis Conserved protein 0.0035 0.0176 0.0878
Mycobacterium ulcerans 3-dehydroquinate synthase 0.019 0.1292 0.3701
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0336 0.032
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0018 0.005 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0023 0.0014
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.005 0.0034
Brugia malayi Doublecortin family protein 0.0024 0.0095 0.0161
Brugia malayi Cytochrome P450 family protein 0.0015 0.0031 0.0029
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0031 0.0063
Echinococcus granulosus chromobox protein 1 0.0014 0.0023 0.0006
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0286 0.027
Trypanosoma brucei protein tyrosine phosphatase 1 0.0018 0.005 0.0637
Brugia malayi beta-lactamase family protein 0.0035 0.0176 0.0325
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0047
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.005 0.0034
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.0951 0.0936
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0023 0.0014
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.005 0.0102
Brugia malayi photoreceptor-specific nuclear receptor 0.0247 0.1709 0.3453
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0487 0.344 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0018 0.005 0.0034
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.005 0.0034
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.005 0.0034
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0176 0.024
Schistosoma mansoni survival motor neuron protein 0.0058 0.0344 0.0328
Schistosoma mansoni hypothetical protein 0.0036 0.0185 0.0168
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0096 0.0161
Echinococcus multilocularis 0.0018 0.005 0.0034
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0106
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0024 0.0099 0.0201
Onchocerca volvulus 0.0018 0.005 0.0138
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.005 0.0034
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0245 0.0229
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0066 0.1168
Onchocerca volvulus 0.0035 0.0176 0.0774
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0096 0.019
Schistosoma mansoni hypothetical protein 0.0205 0.14 0.1385
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0066 0.0764
Onchocerca volvulus 0.0018 0.005 0.0138
Brugia malayi hypothetical protein 0.0018 0.005 0.0068
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0018 0.005 0.0034
Brugia malayi hypothetical protein 0.0018 0.005 0.0068
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.005 0.0034
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.005 0.0034
Schistosoma mansoni chromobox protein 0.0014 0.0023 0.0006
Onchocerca volvulus 0.0018 0.005 0.0138
Loa Loa (eye worm) heterochromatin protein 1 0.0014 0.0023 0.0047
Brugia malayi hypothetical protein 0.0036 0.0185 0.0342
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0052 0.0047
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.005 0.0034
Schistosoma mansoni hypothetical protein 0.0019 0.0061 0.0044
Entamoeba histolytica hypothetical protein 0.0036 0.0185 1
Trypanosoma brucei trypanothione reductase 0.0057 0.0336 1
Brugia malayi hypothetical protein 0.0018 0.005 0.0068
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Brugia malayi beta-lactamase family protein 0.0035 0.0176 0.0325
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0968 0.6196
Echinococcus granulosus Chromo domain 0.0014 0.0023 0.0006
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0066 0.1168
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0075 0.0276
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0018 0.005 0.0034
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0066 0.0233
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.005 0.0034
Onchocerca volvulus 0.0018 0.005 0.0138
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0336 0.0652
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0031 0.0063
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0066 0.0143
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1983 0.197
Schistosoma mansoni hypothetical protein 0.0019 0.0061 0.0044
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0253 0.1746 0.3551
Plasmodium falciparum thioredoxin reductase 0.0057 0.0336 0.55
Onchocerca volvulus 0.0018 0.005 0.0138
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0096 0.019
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0093 0.0591 0.1173
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0176 0.0878
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0095 0.0079
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0176 0.0425
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0286 0.027
Onchocerca volvulus 0.0018 0.005 0.0138
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0018 0.005 0.0034
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0018 0.005 0.1686
Onchocerca volvulus 0.0018 0.005 0.0138
Brugia malayi Protein-tyrosine phosphatase 1 0.0018 0.005 0.0068
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.005 0.0102
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0095 0.1274
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0066 0.0104
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0066 0.1168
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0358
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0018 0.005 0.1686
Brugia malayi RNA recognition motif domain containing protein 0.013 0.0864 0.173
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0023 0.0014
Schistosoma mansoni tar DNA-binding protein 0.013 0.0864 0.0849
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0047 0.0031
Brugia malayi SET domain containing protein 0.0016 0.0042 0.0051
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0061 0.0124
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.005 0.0637
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0863 0.5492
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0176 0.4759
Onchocerca volvulus 0.0051 0.0292 0.1365
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0968 0.6196
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0052 0.0512
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0096 0.019
Mycobacterium ulcerans hypothetical protein 0.0024 0.0099 0.0201
Onchocerca volvulus 0.0024 0.0096 0.0368
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0096 0.019
Onchocerca volvulus 0.0018 0.005 0.0138
Schistosoma mansoni hypothetical protein 0.0041 0.0221 0.0204
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0018 0.005 0.0637
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.005 0.0034
Entamoeba histolytica hypothetical protein 0.0036 0.0185 1
Loa Loa (eye worm) protein tyrosine phosphatase 0.0018 0.005 0.0102
Onchocerca volvulus 4.1 G protein, putative homolog 0.0018 0.005 0.0138
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Trichomonas vaginalis hypothetical protein 0.0014 0.0023 0.0014
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.005 0.0102
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0066 0.005
Loa Loa (eye worm) hypothetical protein 0.0037 0.0193 0.0393
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.012 0.0503
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0336 0.032
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0061 0.009
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0692 0.4916 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0193 0.0498
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0018 0.005 0.0034
Loa Loa (eye worm) glutathione reductase 0.0057 0.0336 0.0683
Echinococcus multilocularis Chromobox protein 3 0.0014 0.0023 0.0006
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0193 0.0177
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0039 0.0022
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0066 0.1168
Schistosoma mansoni hypothetical protein 0.0019 0.0061 0.0044
Schistosoma mansoni tar DNA-binding protein 0.013 0.0864 0.0849
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0023 0.0014
Loa Loa (eye worm) hypothetical protein 0.0286 0.1983 0.4035
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0591 1
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0298 0.2071 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0023 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0066 0.1168
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0034
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Onchocerca volvulus 0.0058 0.0344 0.1626
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0185 0.0168
Echinococcus multilocularis chromobox protein 2 0.0014 0.0023 0.0006
Loa Loa (eye worm) hypothetical protein 0.0093 0.0591 0.1203
Echinococcus multilocularis tar DNA binding protein 0.013 0.0864 0.0849
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0093 0.0591 0.1482
Schistosoma mansoni lipoxygenase 0.0142 0.0951 0.0936
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0109 0.0707 0.0691
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.005 0.0102
Schistosoma mansoni pcd6 interacting protein-related 0.0018 0.005 0.0034
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0336 0.195
Onchocerca volvulus 0.0018 0.005 0.0138
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0066 0.0233
Schistosoma mansoni hypothetical protein 0.0014 0.0023 0.0006
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0176 0.0878
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0018 0.005 0.0034
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0336 0.032
Echinococcus multilocularis geminin 0.0205 0.14 0.1385
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0176 0.0159
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0047 0.0031
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Mycobacterium ulcerans epimerase 0.0024 0.0099 0.0201
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0066 0.1168
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0018 0.005 0.0034
Echinococcus multilocularis dnaJ subfamily B 0.0842 0.5997 0.5991
Leishmania major tyrosine specific protein phosphatase, putative 0.0018 0.005 0.0637
Brugia malayi hypothetical protein 0.0018 0.005 0.0068
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0066 0.1168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0106
Brugia malayi CXXC zinc finger family protein 0.0059 0.035 0.068
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.005 0.0102
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.019 0.1292 0.8373
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0096 0.0161
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0066 0.0764
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0018 0.005 0.0034
Loa Loa (eye worm) hypothetical protein 0.0024 0.0096 0.0194
Loa Loa (eye worm) beta-lactamase 0.0035 0.0176 0.0358
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0066 0.0127
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0018 0.005 0.0034
Leishmania major hypothetical protein, conserved 0.0035 0.0176 0.4759
Echinococcus granulosus chromobox protein 2 0.0014 0.0023 0.0006
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.005 0.0102
Brugia malayi TAR-binding protein 0.013 0.0864 0.173
Trichomonas vaginalis Heterochromatin protein, putative 0.0014 0.0023 0.0014
Brugia malayi hypothetical protein 0.0024 0.0095 0.0161
Entamoeba histolytica hypothetical protein 0.0036 0.0185 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0029 0.0024
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0298 0.2071 0.5985
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.005 0.0102
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.005 0.0102
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.005 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0023 0.0014
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0224 0.103
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.012 0.0503
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0066 0.1168
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.005 0.0034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.012 0.0503
Mycobacterium ulcerans hypothetical protein 0.0024 0.0096 0.019
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0344 0.0668
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0298 0.2071 0.596
Brugia malayi Pre-SET motif family protein 0.0037 0.0193 0.036
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0096 0.019
Schistosoma mansoni tar DNA-binding protein 0.013 0.0864 0.0849
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0023 0.0014
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0093 0.0591 0.3667
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0487 0.344 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.005 0.0034
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0018 0.005 0.0068
Trichomonas vaginalis set domain proteins, putative 0.0287 0.1996 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0185 0.0168
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0066 0.0104
Onchocerca volvulus 0.0024 0.0095 0.0367
Mycobacterium ulcerans lipase LipD 0.0035 0.0176 0.0425
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.005 0.0034
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0018 0.005 0.0034
Plasmodium falciparum glutathione reductase 0.0057 0.0336 0.55
Echinococcus granulosus geminin 0.0205 0.14 0.1385
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0018 0.005 0.0637
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.0023 0.0006
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0066 0.005
Loa Loa (eye worm) hypothetical protein 0.0057 0.0336 0.0684
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0176 0.0159
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0863 0.5492
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.019 0.1292 0.3579
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0109 0.0707 0.0691
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0029 0.0024
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.005 0.0034
Plasmodium falciparum glutathione reductase 0.002 0.0066 0.0764
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0487 0.344 1
Schistosoma mansoni hypothetical protein 0.0058 0.0344 0.0328
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0176 0.0425
Brugia malayi glutathione reductase 0.0057 0.0336 0.0651
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.005 0.0034
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.005 0.0034
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0023 0.0006
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0018 0.005 0.0102
Brugia malayi Protein cec-1. 0.0014 0.0023 0.0013
Onchocerca volvulus 0.0018 0.005 0.0138
Echinococcus multilocularis hypothetical protein 0.0018 0.005 0.0034
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1983 0.197
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.005 0.0102
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0968 0.2609
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Echinococcus granulosus Chromobox protein 3 0.0014 0.0023 0.0006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0047
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0176 0.0787
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0039 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0096 0.2125
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0286 0.1333
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Loa Loa (eye worm) histone methyltransferase 0.002 0.0065 0.0133
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0176 0.0159
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.035 0.0712
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0176 0.0358
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0096 0.0339
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0024 0.0099 0.0168
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0109 0.0707 0.0691
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0193 0.0177
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0018 0.005 0.0034
Loa Loa (eye worm) TAR-binding protein 0.013 0.0864 0.1758
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0064 0.0095
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Mycobacterium leprae Probable lipase LipE 0.0035 0.0176 0.024
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0061 0.0044
Echinococcus granulosus dnaJ subfamily B 0.0842 0.5997 0.5991
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0358
Brugia malayi Cytochrome P450 family protein 0.0015 0.0031 0.0029
Echinococcus granulosus GPCR family 2 0.0019 0.0061 0.0044
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0336 0.0319
Echinococcus granulosus RUN 0.0024 0.0095 0.0079
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0863 0.5492
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0487 0.344 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0052 0.0512
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.005 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0193 0.0177
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Loa Loa (eye worm) hypothetical protein 0.0041 0.0221 0.0449
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.0951 0.0936
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.005 0.0102
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0061 0.009
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.1535 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.005 0.0034
Echinococcus granulosus tar DNA binding protein 0.013 0.0864 0.0849
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0039 0.0022
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0224 0.103
Onchocerca volvulus 0.0018 0.005 0.0138
Onchocerca volvulus 0.0018 0.005 0.0138
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0106
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0061 0.0044
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Onchocerca volvulus 0.0122 0.0806 0.3967
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0066 0.1168
Brugia malayi hypothetical protein 0.0122 0.0806 0.1611
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0066 0.0127
Toxoplasma gondii thioredoxin reductase 0.0057 0.0336 0.0915
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0061 0.0044
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0096 0.2125
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0193 0.0177
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102
Schistosoma mansoni cpg binding protein 0.0062 0.0374 0.0358
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0075 0.0276
Onchocerca volvulus 0.0018 0.005 0.0138
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0286 0.027
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0095 0.0079
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0176 0.0787
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0176 0.0787
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.005 0.0034
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0018 0.005 0.0034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0066 0.1168
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.1352 0.1337
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0174 0.0158
Loa Loa (eye worm) hypothetical protein 0.006 0.0358 0.0728
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0023 0.0014
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0039 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0176 0.0787
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0095 0.0079
Brugia malayi Thioredoxin reductase 0.0057 0.0336 0.0651
Brugia malayi M-phase phosphoprotein, mpp8 0.0122 0.0806 0.1611
Schistosoma mansoni hypothetical protein 0.0024 0.0095 0.0079
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0066 0.1168
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0245 0.0498
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0106
Onchocerca volvulus 0.005 0.0286 0.1333
Schistosoma mansoni cpg binding protein 0.0059 0.035 0.0334
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0692 0.4916 0.4907
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.005 0.0068
Echinococcus multilocularis Chromo domain 0.0014 0.0023 0.0006
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0176 0.4759
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0047 0.0096
Schistosoma mansoni chromobox protein 0.0014 0.0023 0.0006
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0018 0.005 0.1686
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0274 0.0258
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0068 0.024
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0018 0.005 0.0102
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0274 0.0258
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.012 0.0503
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0102

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = -6.6 Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -6.5 Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -6.5 Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -6 Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -6 Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -6 Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -5.8 Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = 0.23 nM Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = 0.33 nM Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = 0.35 nM Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = 0.93 nM Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = 0.93 nM Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = 1.05 nM Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = 1.78 nM Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay ChEMBL. 19734910
Inhibition (ADMET) = 105.3159824 % Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Inhibition (ADMET) = 135.020914 % Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Potency (functional) = 0.0008 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0224 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 1.1689 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488774] ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774] ChEMBL. No reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (ADMET) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) 8.4368 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 47.7548 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Human Peripheral Myelin Protein 22 (PMP22) Expression/Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23 19734910

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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