Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | 0.004 | 0.0589 | 0.2165 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.004 | 0.0589 | 0.2165 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0589 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0106 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.004 | 0.0589 | 0.2165 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.004 | 0.0589 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.004 | 0.0589 | 0.0589 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.004 | 0.0589 | 0.2165 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.004 | 0.0589 | 0.0589 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.004 | 0.0589 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0106 | 0.0391 |
Entamoeba histolytica | hypothetical protein | 0.0108 | 0.2719 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.004 | 0.0589 | 0.0589 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.004 | 0.0589 | 0.0589 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.004 | 0.0589 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0589 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.004 | 0.0589 | 0.0589 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.004 | 0.0589 | 0.0589 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.004 | 0.0589 | 0.2165 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.004 | 0.0589 | 0.0589 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.004 | 0.0589 | 0.2165 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.004 | 0.0589 | 0.0589 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.004 | 0.0589 | 0.0589 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.004 | 0.0589 | 0.0589 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.004 | 0.0589 | 0.0589 |
Schistosoma mansoni | thyroid hormone receptor | 0.004 | 0.0589 | 0.0589 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.004 | 0.0589 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.004 | 0.0589 | 0.0589 |
Brugia malayi | hypothetical protein | 0.0108 | 0.2719 | 1 |
Schistosoma mansoni | coup transcription factor | 0.004 | 0.0589 | 0.0589 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.004 | 0.0589 | 0.2165 |
Schistosoma mansoni | thyroid hormone receptor | 0.004 | 0.0589 | 0.0589 |
Schistosoma mansoni | hypothetical protein | 0.0108 | 0.2719 | 0.2719 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.004 | 0.0589 | 0.0589 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.004 | 0.0589 | 0.2165 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0589 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.004 | 0.0589 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.004 | 0.0589 | 0.2165 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.004 | 0.0589 | 0.0589 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.004 | 0.0589 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0108 | 0.2719 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.004 | 0.0589 | 0.2165 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.004 | 0.0589 | 0.2165 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0589 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.004 | 0.0589 | 0.2165 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.004 | 0.0589 | 0.0589 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0108 | 0.2719 | 0.2719 |
Onchocerca volvulus | 0.004 | 0.0589 | 0.5 | |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.004 | 0.0589 | 0.0589 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.004 | 0.0589 | 0.0589 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.004 | 0.0589 | 0.0589 |
Echinococcus multilocularis | FTZ F1 alpha | 0.004 | 0.0589 | 0.0589 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0589 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.004 | 0.0589 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0108 | 0.2719 | 0.2719 |
Schistosoma mansoni | nuclear hormone receptor | 0.004 | 0.0589 | 0.0589 |
Brugia malayi | ecdysteroid receptor | 0.004 | 0.0589 | 0.2165 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.004 | 0.0589 | 0.0589 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.004 | 0.0589 | 0.0589 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.004 | 0.0589 | 0.2165 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.004 | 0.0589 | 0.2165 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.004 | 0.0589 | 0.0589 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0589 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0106 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0108 | 0.2719 | 0.2719 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0106 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.004 | 0.0589 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.004 | 0.0589 | 0.2165 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.004 | 0.0589 | 0.0589 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0106 | 0.1806 |
Loa Loa (eye worm) | steroid hormone receptor | 0.004 | 0.0589 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0342 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.004 | 0.0589 | 0.0589 |
Brugia malayi | nuclear receptor NHR-88 | 0.004 | 0.0589 | 0.2165 |
Onchocerca volvulus | Bile acid receptor homolog | 0.004 | 0.0589 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.004 | 0.0589 | 0.2165 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0106 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0342 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0342 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0108 | 0.2719 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.004 | 0.0589 | 0.0589 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0106 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0589 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.004 | 0.0589 | 0.0589 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.004 | 0.0589 | 0.2165 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0106 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.004 | 0.0589 | 0.2165 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0589 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.004 | 0.0589 | 0.0589 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0106 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0106 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0108 | 0.2719 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.004 | 0.0589 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.