Detailed information for compound 56016

Basic information

Technical information
  • TDR Targets ID: 56016
  • Name: 2-[2-[4-[3-(2H-tetrazol-5-yl)propoxy]phenyl]e thyl]isoindole-1,3-dione
  • MW: 377.397 | Formula: C20H19N5O3
  • H donors: 1 H acceptors: 5 LogP: 2.73 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(CCc2ccc(cc2)OCCCc2nn[nH]n2)C(=O)c2c1cccc2
  • InChi: 1S/C20H19N5O3/c26-19-16-4-1-2-5-17(16)20(27)25(19)12-11-14-7-9-15(10-8-14)28-13-3-6-18-21-23-24-22-18/h1-2,4-5,7-10H,3,6,11-13H2,(H,21,22,23,24)
  • InChiKey: ANEIGIGOUVTUAA-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-[2-[4-[3-(2H-tetrazol-5-yl)propoxy]phenyl]ethyl]isoindoline-1,3-dione
  • 2-[2-[4-[3-(2H-1,2,3,4-tetrazol-5-yl)propoxy]phenyl]ethyl]isoindole-1,3-dione
  • 2-[2-[4-[3-(2H-tetrazol-5-yl)propoxy]phenyl]ethyl]isoindoline-1,3-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0016 0.0074
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0047 0.0209
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0155 0.0767 0.3446
Echinococcus multilocularis Smad4 0.0017 0.0047 0.0209
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0016 0.0074
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0108 0.1336
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0016 0.0074
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0161 0.3389
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0024 0.011
Schistosoma mansoni glutamate synthase 0.0009 0.0007 0.0029
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0016 0.0074
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0167 0.3523
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0043 0.0194
Brugia malayi RNA binding protein 0.0064 0.0293 0.235
Treponema pallidum ATP-dependent DNA helicase 0.0011 0.0016 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0103 0.2115
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0047 0.0209
Brugia malayi nuclear hormone receptor 0.0011 0.0016 0.0082
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0134 0.2803
Echinococcus granulosus smad 0.0017 0.0047 0.0209
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0082
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.004 0.017 0.2144
Echinococcus multilocularis smad 0.0017 0.0047 0.0209
Echinococcus granulosus Smad4 0.0017 0.0047 0.0209
Plasmodium falciparum thioredoxin reductase 0.0096 0.0461 0.5977
Brugia malayi MH2 domain containing protein 0.0243 0.1225 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0222 0.1769
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0155 0.0767 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0108 0.1336
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0222 0.1769
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0109 0.1345
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0167 0.3523
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0134 0.0602
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0016 0.013
Brugia malayi MH1 domain containing protein 0.0009 0.0008 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0024 0.0395
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0115 0.0558 0.725
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0016 0.0074
Entamoeba histolytica hypothetical protein 0.0036 0.0149 0.1876
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.012 0.0928
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0134 0.1676
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0016 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0016 0.0082
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0009 0.0007 0.0029
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0134 0.2803
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.004 0.017 0.1339
Trichomonas vaginalis MYB3r3, putative 0.0028 0.0108 0.1336
Trypanosoma brucei unspecified product 0.0027 0.0103 0.2115
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0007 0.0029
Plasmodium falciparum thioredoxin reductase 0.0033 0.0134 0.1676
Echinococcus multilocularis bloom syndrome protein 0.0021 0.007 0.0316
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0047 0.0209
Schistosoma mansoni hypothetical protein 0.0009 0.0007 0.0029
Giardia lamblia DNA damage repair protein 0.0012 0.0024 0.0236
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.007 0.1402
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0134 0.1676
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0167 0.3523
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.007 0.0523
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0134 0.2803
Echinococcus multilocularis dnaJ subfamily B 0.0435 0.2227 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0167 0.3523
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0147
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0167 0.3523
Toxoplasma gondii hypothetical protein 0.004 0.017 0.0586
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0244 0.123 0.1709
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0167 0.3523
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0016 0.0082
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0009 0.0007 0.0029
Schistosoma mansoni hypothetical protein 0.0016 0.0043 0.0194
Brugia malayi polk-prov protein 0.0012 0.0024 0.0147
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0043 0.0301
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0007 0.0029
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0134 0.2803
Mycobacterium tuberculosis Probable reductase 0.0219 0.1103 0.1531
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0016 0.0074
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0016 0.0074
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0219 0.1103 0.1531
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0134 0.2803
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0024 0.0395
Brugia malayi CXXC zinc finger family protein 0.0031 0.012 0.0928
Trypanosoma cruzi trypanothione reductase, putative 0.0096 0.0461 1
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0016 0.0074
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0024 0.0395
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.007 0.0523
Echinococcus multilocularis dna polymerase eta 0.0066 0.0303 0.136
Leishmania major DNA polymerase kappa, putative 0.0012 0.0024 0.0395
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0082
Trypanosoma cruzi DNA polymerase eta, putative 0.0066 0.0303 0.6517
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.004 0.017 0.3587
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0043 0.0194
Schistosoma mansoni hypothetical protein 0.0016 0.0043 0.0194
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0134 0.2803
Schistosoma mansoni smad1 5 8 and 0.0017 0.0047 0.0209
Schistosoma mansoni coup transcription factor 0.0011 0.0016 0.0074
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0155 0.0767 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0016 0.0074
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0016 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0016 0.0082
Brugia malayi steroid hormone receptor 0.0011 0.0016 0.0082
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.004 0.017 0.2144
Leishmania major DNA polymerase eta, putative 0.0066 0.0303 0.6517
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0219 0.1103 0.1531
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0134 0.1676
Plasmodium vivax DNA repair protein REV1, putative 0.0012 0.0024 0.0236
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0016 0.0074
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.007 0.0316
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.004 0.017 0.3587
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0108 0.1336
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0016 0.0074
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0301
Loa Loa (eye worm) Smad1 0.0017 0.0047 0.0329
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0024 0.0395
Brugia malayi MH1 domain containing protein 0.0017 0.0047 0.0329
Onchocerca volvulus 0.0011 0.0016 0.0609
Treponema pallidum NADH oxidase 0.0033 0.0134 0.0128
Schistosoma mansoni cpg binding protein 0.0032 0.0129 0.0578
Brugia malayi MH1 domain containing protein 0.0009 0.0008 0.0013
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0149 0.067
Echinococcus multilocularis thioredoxin glutathione reductase 0.0096 0.0461 0.2072
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0167 0.016
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0167 0.3523
Trichomonas vaginalis MYB, putative 0.0028 0.0109 0.1345
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.007 0.0838
Trichomonas vaginalis C-MYB, putative 0.0028 0.0108 0.1336
Toxoplasma gondii thioredoxin reductase 0.0096 0.0461 0.1633
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0047 0.0329
Echinococcus multilocularis dna polymerase kappa 0.004 0.0167 0.0749
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0108 0.1336
Schistosoma mansoni DNA helicase recq5 0.0021 0.007 0.0316
Echinococcus multilocularis GPCR, family 2 0.0016 0.0043 0.0194
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0096 0.0461 0.0635
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0016 0.0074
Loa Loa (eye worm) nuclear factor I 0.0009 0.0008 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0024 0.0395
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0298 0.1338
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0134 0.1676
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0167 0.016
Mycobacterium ulcerans hypothetical protein 0.0012 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.005 0.0222 0.1769
Mycobacterium tuberculosis Probable oxidoreductase 0.0244 0.123 0.1709
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.1225 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1383 0.717 1
Brugia malayi ImpB/MucB/SamB family protein 0.0066 0.0303 0.2432
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0134 0.0602
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0016 0.0074
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.007 0.0838
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0016 0.0082
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0016 0.0074
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0016 0.0074
Brugia malayi MH2 domain containing protein 0.0017 0.0047 0.0329
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.004 0.017 0.3587
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0134 0.1676
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0543 0.2791 0.2786
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0016 0.0074
Giardia lamblia Myb 1-like protein 0.0028 0.0109 0.1345
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0167 0.3523
Trypanosoma brucei DNA polymerase eta, putative 0.0066 0.0303 0.6517
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.007 0.0229
Echinococcus granulosus glutamate synthase 0.0009 0.0007 0.0029
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0081
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0016 0.0074
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0293 0.1315
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0149 0.067
Loa Loa (eye worm) thioredoxin reductase 0.0096 0.0461 0.3732
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0016 0.0074
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0043 0.0301
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0167 0.2106
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0016 0.0082
Trypanosoma brucei unspecified product 0.004 0.0167 0.3523
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0167 0.3523
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0134 0.0128
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.004 0.017 0.0762
Loa Loa (eye worm) hypothetical protein 0.0155 0.0767 0.6245
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.004 0.017 0.0762
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0014 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0016 0.0082
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0134 0.0128
Plasmodium vivax thioredoxin reductase, putative 0.0096 0.0461 0.5977
Plasmodium vivax glutathione reductase, putative 0.0096 0.0461 0.5977
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0167 0.0749
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0024 0.0395
Schistosoma mansoni Smad4 0.0017 0.0047 0.0209
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0024 0.0395
Echinococcus multilocularis glutamate synthase 0.0009 0.0007 0.0029
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0155 0.0767 1
Echinococcus granulosus protein prenyltransferase alpha subunit 0.004 0.017 0.0762
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0009 0.0007 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0024 0.0395
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1925 1 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0009 0.0007 0.0029
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0009 0.0007 0.0029
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0024 0.0065
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0108 0.1336
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.007 0.0316
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0028 0.0109 0.0367
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.007 0.0316
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0155 0.0767 0.3446
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0014 0.0028
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.004 0.017 0.0762
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0016 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0134 0.2803
Schistosoma mansoni hypothetical protein 0.0344 0.1755 0.7882
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0016 0.0609
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0293 0.1315
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0016 0.0074
Schistosoma mansoni glutamate synthase 0.0009 0.0007 0.0029
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1925 1 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.007 0.0523
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0293 0.235
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0016 0.0609
Brugia malayi MH2 domain containing protein 0.0017 0.0047 0.0329
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0082
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0293 0.1315
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0108 0.1336
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0149 0.067
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0016 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.017 0.3587
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0007 0.0029
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0167 0.3523
Loa Loa (eye worm) hypothetical protein 0.0066 0.0303 0.2432
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0134 0.0602
Brugia malayi nuclear receptor NHR-88 0.0011 0.0016 0.0082
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0134 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0134 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0134 0.2803
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0088 0.0668
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0016 0.0082
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0244 0.123 0.1709
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0134 0.0128
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0543 0.2791 0.2786
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0088 0.0668
Loa Loa (eye worm) RecQ helicase 0.0021 0.007 0.0523
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0167 0.3523
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0016 0.0074
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0167 0.0749
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0262 0.0917
Schistosoma mansoni DNA helicase recq1 0.0021 0.007 0.0316
Brugia malayi Thioredoxin reductase 0.0096 0.0461 0.3732
Echinococcus granulosus cpg binding protein 0.0032 0.0129 0.0578
Loa Loa (eye worm) hypothetical protein 0.0034 0.0139 0.1089
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0244 0.123 0.1709
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0134 0.0128
Entamoeba histolytica hypothetical protein 0.0036 0.0149 0.1876
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0219 0.1103 0.1531
Trichomonas vaginalis pc-MYB2, putative 0.0028 0.0108 0.1336
Schistosoma mansoni hypothetical protein 0.0344 0.1755 0.7882
Trypanosoma brucei trypanothione reductase 0.0096 0.0461 1
Echinococcus granulosus bloom syndrome protein 0.0021 0.007 0.0316
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0134 0.2803
Trichomonas vaginalis pc-MYB2, putative 0.0028 0.0108 0.1336
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0108 0.1336
Schistosoma mansoni disulfide oxidoreductase 0.0009 0.0007 0.0029
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0024 0.0395
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0134 0.2803
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0167 0.3523
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.001 0.0044
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0024 0.0065
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.007 0.0838
Leishmania major trypanothione reductase 0.0096 0.0461 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.007 0.1402
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.007 0.1402
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0139 0.1089
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0024 0.0395
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0222 0.1769
Echinococcus multilocularis geminin 0.0344 0.1755 0.7882
Entamoeba histolytica recQ family helicase, putative 0.001 0.0014 0.0102
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0167 0.3523
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0167 0.3523
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0134 0.0128
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0155 0.0767 0.6245
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0167 0.3523
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0016 0.0082
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0108 0.1336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0016 0.0082
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0155 0.0767 0.3446
Brugia malayi TAR-binding protein 0.0064 0.0293 0.235
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0293 0.1315
Plasmodium falciparum glutathione reductase 0.0096 0.0461 0.5977
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0134 0.0458
Schistosoma mansoni smad1 5 8 and 0.0017 0.0047 0.0209
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0016 0.0074
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0043 0.0301
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.004 0.017 0.3587
Trichomonas vaginalis C-MYB, putative 0.0028 0.0108 0.1336
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0155 0.0767 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0016 0.0074
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0293 0.1315
Loa Loa (eye worm) histone methyltransferase 0.0009 0.001 0.0026
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0134 0.2803
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.1225 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.007 0.0838
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0016 0.0082
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0016 0.0074
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.004 0.017 0.3587
Toxoplasma gondii hypothetical protein 0.0115 0.0558 0.1982
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0016 0.0082
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0016 0.013
Brugia malayi MH1 domain containing protein 0.0017 0.0047 0.0329
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1925 1 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0007 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0167 0.3523
Leishmania major DNA polymerase kappa, putative 0.004 0.0167 0.3523
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0108 0.1336
Schistosoma mansoni hypothetical protein 0.0435 0.2227 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0043 0.0194
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0134 0.1676
Trypanosoma brucei hypothetical protein, conserved 0.004 0.017 0.3587
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0082
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0009 0.0007 0.0029
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0167 0.1315
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0155 0.0767 0.6245
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0082
Schistosoma mansoni cpg binding protein 0.0031 0.012 0.0537
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0016 0.0074
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0043 0.0194
Leishmania major DNA polymerase eta, putative 0.0038 0.0161 0.3389
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0134 0.0458
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0016 0.0082
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0167 0.2106
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0047 0.0209
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0293 0.1315
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0016 0.0074
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0219 0.1103 0.1531
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0016 0.0082
Trypanosoma brucei unspecified product 0.0027 0.0103 0.2115
Entamoeba histolytica recQ family helicase, putative 0.0021 0.007 0.0838
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0134 0.2803
Brugia malayi ecdysteroid receptor 0.0011 0.0016 0.0082
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0108 0.1336
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0108 0.1336
Brugia malayi glutathione reductase 0.0096 0.0461 0.3732
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0082
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0155 0.0767 1
Loa Loa (eye worm) RNA binding protein 0.0064 0.0293 0.235
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.004 0.017 0.1339
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0103 0.2115
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0014 0.0064
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0009 0.0021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0016 0.0074
Entamoeba histolytica hypothetical protein 0.0036 0.0149 0.1876
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0016 0.0609
Loa Loa (eye worm) glutathione reductase 0.0096 0.0461 0.3732
Brugia malayi hypothetical protein 0.0036 0.0149 0.1171
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.004 0.017 0.2144
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0007 0.0029
Echinococcus granulosus geminin 0.0344 0.1755 0.7882
Echinococcus granulosus dna polymerase eta 0.0066 0.0303 0.136
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0016 0.0218
Onchocerca volvulus 0.0031 0.012 0.693
Schistosoma mansoni hypothetical protein 0.0016 0.0043 0.0194
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0016 0.0082
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.007 0.0523
Entamoeba histolytica hypothetical protein 0.0036 0.0149 0.1876
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.008 0.0376 0.1688
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0013
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0219 0.1103 0.1531
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0523
Schistosoma mansoni smad 0.0017 0.0047 0.0209
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0024 0.0395
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0016 0.0082
Schistosoma mansoni glutamate synthase 0.0009 0.0007 0.0029
Giardia lamblia Rab geranylgeranyltransferase 0.004 0.017 0.2144
Schistosoma mansoni DNA polymerase eta 0.0066 0.0303 0.136
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.007 0.0229
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0009 0.0007 0.0029
Schistosoma mansoni hypothetical protein 0.0034 0.0139 0.0625
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.017 0.3587
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0016 0.0074
Brugia malayi Smad1 0.0017 0.0047 0.0329
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0109 0.1345
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0543 0.2791 0.3887
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1383 0.717 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0016 0.0082
Echinococcus multilocularis cpg binding protein 0.0032 0.0129 0.0578
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.007 0.0838
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0134 0.0178
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0167 0.3523
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0047 0.0209
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.001 0.0044
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.004 0.017 0.3587
Onchocerca volvulus 0.004 0.017 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0016 0.0074
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0082
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0134 0.2803
Echinococcus granulosus tar DNA binding protein 0.0064 0.0293 0.1315
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0016 0.0218
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0082
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0007 0.0029
Giardia lamblia DINP protein human, muc B family 0.004 0.0167 0.2106
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0016 0.0082
Echinococcus granulosus GPCR family 2 0.0016 0.0043 0.0194
Giardia lamblia Rab geranylgeranyltransferase 0.0155 0.0767 1
Plasmodium falciparum glutathione reductase 0.0033 0.0134 0.1676
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0016 0.0082
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0047 0.0329
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0134 0.1046
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.007 0.0838
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.004 0.017 0.2144
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0016 0.0082
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0167 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0016 0.0082
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0167 0.0224
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0293 0.235
Schistosoma mansoni cpg binding protein 0.0032 0.0129 0.0578
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0016 0.0082
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0134 0.1676
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0016 0.0082
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0543 0.2791 1
Echinococcus granulosus dnaJ subfamily B 0.0435 0.2227 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0219 0.1103 0.1531
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0016 0.0074
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0167 0.2106
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0016 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0103 0.2115
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0161 0.0554
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0081
Schistosoma mansoni hypothetical protein 0.0016 0.0043 0.0194
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0134 0.0128
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0167 0.1315
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0167 0.0749
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0009 0.0007 0.0029
Echinococcus granulosus dna polymerase kappa 0.004 0.0167 0.0749
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0155 0.0767 1
Plasmodium falciparum DNA repair protein REV1, putative 0.0012 0.0024 0.0236
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0134 0.2803
Trichomonas vaginalis MYB72, putative 0.0028 0.0108 0.1336
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0167 0.3523
Schistosoma mansoni hypothetical protein 0.0036 0.0149 0.067
Leishmania major DNA damage repair protein, putative 0.0012 0.0024 0.0395
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0293 0.235
Leishmania major protein farnesyltransferase alpha subunit, putative 0.004 0.017 0.3587
Schistosoma mansoni smad1 5 8 and 0.0017 0.0047 0.0209
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.007 0.0316
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0134 0.2803
Echinococcus granulosus thioredoxin glutathione reductase 0.0096 0.0461 0.2072

Activities

Activity type Activity value Assay description Source Reference
Contraction (functional) = 52.4 % Inhibitory contractile effect of compound in guinea-pig tracheal strips induced by LTD4 (100 nM) (% contraction, obtained in the vehicle presence 100.0%) ChEMBL. 12031336
Emax (functional) = 100 % Maximum effect of the compound on the LTD4 (100 nM) induced contraction of guinea-pig tracheal strips bioassay ChEMBL. 12031336
IC50 (functional) = 0.0000312 M 50% inhibitory concentration on the LTD4 (100 nM) induced contraction of guinea-pig tracheal strip bioassay ChEMBL. 12031336
Inhibition (functional) = 47.6 % Inhibitory contractile effect of compound in guinea-pig tracheal strips induced by LTD4 (100 nM) (% inhibition obtained by comparison with control group) ChEMBL. 12031336

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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