Detailed information for compound 560194

Basic information

Technical information
  • TDR Targets ID: 560194
  • Name: 4-nitrobenzenesulfonyl fluoride
  • MW: 205.164 | Formula: C6H4FNO4S
  • H donors: 0 H acceptors: 4 LogP: 1.53 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc(cc1)S(=O)(=O)F
  • InChi: 1S/C6H4FNO4S/c7-13(11,12)6-3-1-5(2-4-6)8(9)10/h1-4H
  • InChiKey: HRLAPUHJWRZEIC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 349-96-2
  • p-Nitrobenzenesulfonyl fluoride
  • Benzenesulfonyl fluoride, 4-nitro-
  • PNBSF
  • para-Nitrobenzenesulfonyl fluoride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0051 0.2561 0.1857
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0154 1 1
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0154 1 1
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0028 0.0931 0.0426
Echinococcus multilocularis musashi 0.0027 0.0865 0.0865
Echinococcus granulosus intermediate filament protein 0.0027 0.0865 0.0865
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0051 0.2561 0.2561
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0051 0.2561 0.2147
Loa Loa (eye worm) hypothetical protein 0.0033 0.128 0.128
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0051 0.2561 0.2147
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0154 1 1
Echinococcus granulosus lamin 0.0027 0.0865 0.0865
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0051 0.2561 0.2147
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0051 0.2561 0.2561
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0051 0.2561 0.2147
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.128 0.128
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0154 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.2382 0.2382
Schistosoma mansoni hypothetical protein 0.0033 0.128 0.128
Schistosoma mansoni lamin 0.0027 0.0865 0.0865
Loa Loa (eye worm) hypothetical protein 0.0028 0.0931 0.0931
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0051 0.2561 0.2147
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0051 0.2561 0.2561
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0023 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0027 0.0829 0.0829
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0154 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0931 0.0931
Loa Loa (eye worm) hypothetical protein 0.0023 0.0527 0.0527
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0051 0.2561 0.2561
Trichomonas vaginalis DNA polymerase II, putative 0.0051 0.2561 0.2147
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0051 0.2561 0.2147
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0051 0.2561 0.2561
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.2382 0.2382
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0051 0.2561 0.2561
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0865 0.0865
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0051 0.2561 0.2561
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0051 0.2561 0.2147
Echinococcus multilocularis lamin 0.0027 0.0865 0.0865
Loa Loa (eye worm) hypothetical protein 0.0051 0.2561 0.2561
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0051 0.2561 0.2147
Schistosoma mansoni intermediate filament proteins 0.0027 0.0865 0.0865
Brugia malayi DNA polymerase alpha catalytic subunit 0.0051 0.2561 0.2561
Loa Loa (eye worm) hypothetical protein 0.0023 0.0527 0.0527
Echinococcus multilocularis lamin dm0 0.0027 0.0865 0.0865
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0865 0.0865
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0865 0.0865
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0154 1 1
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0028 0.0931 0.0931
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0051 0.2561 0.2561
Toxoplasma gondii DNA polymerase 0.0154 1 1
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0154 1 1
Echinococcus granulosus lamin dm0 0.0027 0.0865 0.0865
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0154 1 1
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0154 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.2382 0.2382
Schistosoma mansoni lamin 0.0027 0.0865 0.0865
Toxoplasma gondii DNA polymerase family B protein 0.0051 0.2561 0.2147
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0051 0.2561 0.2147
Loa Loa (eye worm) hypothetical protein 0.0048 0.2382 0.2382
Brugia malayi DNA polymerase family B containing protein 0.0051 0.2561 0.2561
Loa Loa (eye worm) hypothetical protein 0.0027 0.0865 0.0865
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0051 0.2561 0.1857
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0051 0.2561 0.2561
Onchocerca volvulus DNA polymerase homolog 0.0051 0.2561 0.1857
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0154 1 1
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0051 0.2561 0.2561
Brugia malayi intermediate filament protein 0.0027 0.0865 0.0865
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0154 1 1
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0051 0.2561 0.2147
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0028 0.0931 0.0426
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0154 1 1
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0126 0.7966 0.7853
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0154 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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