Detailed information for compound 560209

Basic information

Technical information
  • TDR Targets ID: 560209
  • Name: 3494-35-7
  • MW: 918.613 | Formula: C29H36N12O19P2
  • H donors: 11 H acceptors: 16 LogP: -8.8 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1[nH]c(N)nc2=O)O)O)n1ccc(=O)[nH]c1=O)O)O)n1cnc2c1ncnc2N
  • InChi: 1S/C29H36N12O19P2/c30-21-13-22(33-6-32-21)40(7-34-13)27-17(46)19(9(3-42)56-27)59-62(52,53)55-5-11-20(18(47)26(58-11)39-2-1-12(43)36-29(39)49)60-61(50,51)54-4-10-15(44)16(45)25(57-10)41-8-35-14-23(41)37-28(31)38-24(14)48/h1-2,6-11,15-20,25-27,42,44-47H,3-5H2,(H,50,51)(H,52,53)(H2,30,32,33)(H,36,43,49)(H3,31,37,38,48)/t9-,10-,11-,15-,16-,17-,18-,19-,20-,25-,26-,27-/m1/s1
  • InChiKey: IPRPWOOUPLMMGU-POYLIAOGSA-N  

Network

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Synonyms

  • Adenylyl-(3'.5')-uridylyl-(3'.5')-guanosine
  • ApUpG
  • EINECS 222-488-6
  • [(2R,3S,4R,5R)-3-[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-tetrahydrofuran-2-yl]methyl [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl] hydrogen phosphate
  • [(2R,3S,4R,5R)-3-[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-2-tetrahydrofuranyl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxo-1-pyrimidinyl)-4-hydroxy-2-tetrahydrofuranyl]methyl [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)-3-tetrahydrofuranyl] hydrogen phosphate
  • [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2R,3S,4R,5R)-3-[[(2R,3S,4R,5R)-5-(2-azanyl-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-oxolan-2-yl]methyl hydrogen phosphate
  • [(2R,3S,4R,5R)-5-adenin-9-yl-4-hydroxy-2-methylol-tetrahydrofuran-3-yl] [(2R,3S,4R,5R)-3-[[(2R,3S,4R,5R)-5-(2-amino-6-keto-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-5-(2,4-diketopyrimidin-1-yl)-4-hydroxy-tetrahydrofuran-2-yl]methyl hydrogen phosphate
  • [(2R,3S,4R,5R)-3-[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(2,4-dioxopyrimidin-1-yl)-4-hydroxyoxolan-2-yl]methyl [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate
  • [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [(2R,3S,4R,5R)-2-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]-5-(2,4-dioxopyrimidin-1-yl)-4-hydroxyoxolan-3-yl] hydrogen phosphate
  • [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [(2R,3S,4R,5R)-2-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]oxy-hydroxy-phosphoryl]oxymethyl]-5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-tetrahydrofuran-3-yl] hydrogen phosphate
  • [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-2-tetrahydrofuranyl]methyl [(2R,3S,4R,5R)-2-[[[(2R,3S,4R,5R)-5-(6-amino-9-purinyl)-4-hydroxy-2-(hydroxymethyl)-3-tetrahydrofuranyl]oxy-hydroxyphosphoryl]oxymethyl]-5-(2,4-dioxo-1-pyrimidinyl)-4-hydroxy-3-tetrahydrofuranyl] hydrogen phosphate
  • [(2R,3S,4R,5R)-5-(2-amino-6-keto-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [(2R,3S,4R,5R)-2-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-methylol-tetrahydrofuran-3-yl]oxy-hydroxy-phosphoryl]oxymethyl]-5-(2,4-diketopyrimidin-1-yl)-4-hydroxy-tetrahydrofuran-3-yl] hydrogen phosphate
  • [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [(2R,3S,4R,5R)-2-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy-hydroxy-phosphoryl]oxymethyl]-5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-oxolan-3-yl] hydrogen phosphate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei glucosidase, putative 0.0036 0.0116 0.1789
Echinococcus multilocularis expressed conserved protein 0.009 0.0398 0.0378
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0173 0.0153
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0102 0.046 0.9464
Brugia malayi cytosol aminopeptidase 0.0021 0.0036 0.0078
Brugia malayi glutathione reductase 0.0039 0.013 0.0285
Schistosoma mansoni alpha-glucosidase 0.0141 0.0667 0.0648
Schistosoma mansoni lamin 0.0027 0.0066 0.0045
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0644 0.0625
Toxoplasma gondii leucyl aminopeptidase LAP 0.0106 0.0484 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0089 0.0393 0.7452
Echinococcus granulosus lamin 0.0027 0.0066 0.0045
Brugia malayi hypothetical protein 0.0102 0.046 0.1009
Echinococcus multilocularis adam 0.0058 0.0228 0.0208
Loa Loa (eye worm) hypothetical protein 0.0027 0.0066 0.0066
Schistosoma mansoni intermediate filament proteins 0.0027 0.0066 0.0045
Leishmania major trypanothione reductase 0.0039 0.013 0.2104
Loa Loa (eye worm) TATA binding protein associated factor 0.0102 0.046 0.046
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0116 0.0212
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.0788 0.0788
Toxoplasma gondii aminopeptidase n, putative 0.0102 0.046 0.9347
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0173 0.0153
Brugia malayi Reprolysin 0.0078 0.0333 0.073
Schistosoma mansoni hypothetical protein 0.0293 0.1461 0.1444
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0099 0.0446 0.8933
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0021 0.0036 0.0036
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0141 0.012
Echinococcus multilocularis leucine aminopeptidase protein 0.0106 0.0484 0.0464
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0102 0.046 0.9321
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0089 0.0393 0.7452
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0106 0.0484 1
Echinococcus granulosus leucyl aminopeptidase 0.0021 0.0036 0.0015
Brugia malayi N-terminal motif family protein 0.0179 0.0862 0.1892
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0102 0.046 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0141 0.012
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0102 0.046 0.9321
Schistosoma mansoni hypothetical protein 0.0035 0.0108 0.0088
Onchocerca volvulus 0.0095 0.0424 0.4494
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0106 0.0484 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0189 0.0189
Echinococcus multilocularis musashi 0.0027 0.0066 0.0045
Schistosoma mansoni alpha-glucosidase 0.0141 0.0667 0.0648
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.092 0.0902
Echinococcus multilocularis protein patched 0.0041 0.0141 0.012
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0106 0.0484 1
Schistosoma mansoni hypothetical protein 0.004 0.0133 0.0113
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.013 0.013
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0102 0.046 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0173 0.0153
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0212 0.0192
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.0788 0.0769
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0066 0.0066
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0066 0.0066
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0089 0.0393 0.7452
Trypanosoma brucei trypanothione reductase 0.0039 0.013 0.2104
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0102 0.046 0.9321
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0141 0.0718
Brugia malayi Peptidase family M1 containing protein 0.0102 0.046 0.1009
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Schistosoma mansoni alpha glucosidase 0.0036 0.0116 0.0096
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0106 0.0484 1
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0021 0.0036 0.0078
Echinococcus multilocularis aminopeptidase N 0.0102 0.046 0.044
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0177 0.0157
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0177 0.0157
Schistosoma mansoni hypothetical protein 0.004 0.0133 0.0113
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0102 0.046 0.044
Onchocerca volvulus 0.0102 0.046 0.4944
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0102 0.046 0.9464
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0063
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0177 0.1398
Loa Loa (eye worm) hypothetical protein 0.0044 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0102 0.046 0.046
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0108 0.0088
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0102 0.046 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0102 0.046 0.044
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0102 0.046 0.9464
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0428 0.0409
Trypanosoma brucei Aminopeptidase M1, putative 0.0102 0.046 0.9464
Schistosoma mansoni leucine aminopeptidase 0.0021 0.0036 0.0015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0173 0.0153
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0108 0.0088
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0141 0.0141
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0428 0.094
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0102 0.046 0.044
Brugia malayi hypothetical protein 0.0058 0.0228 0.05
Echinococcus granulosus adam 0.0058 0.0228 0.0208
Toxoplasma gondii thioredoxin reductase 0.0039 0.013 0.0383
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0021 0.0036 0.0078
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0102 0.046 0.9464
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0099 0.0446 0.8933
Brugia malayi ADAMTS-like protease 0.0026 0.006 0.0131
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0116 0.0212
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0021 0.0036 0.0015
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0096 0.0429 0.0409
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0212 0.0192
Brugia malayi Peptidase family M1 containing protein 0.0102 0.046 0.1009
Brugia malayi intermediate filament protein 0.0027 0.0066 0.0144
Trypanosoma brucei aminopeptidase, putative 0.0102 0.046 0.9464
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0428 0.0409
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0212 0.0192
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0021 0.0036 0.0015
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Echinococcus granulosus neuropeptide s receptor 0.0467 0.2375 0.2359
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0106 0.0484 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.0788 0.0769
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.013 0.2104
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0021 0.0036 0.0036
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0036 0.0015
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0177 0.0157
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.092 0.0902
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0116 0.0254
Loa Loa (eye worm) reprolysin 0.0096 0.0429 0.0429
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0173 0.0173
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0089 0.0393 0.7452
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0173 0.0153
Schistosoma mansoni aminopeptidase A (M01 family) 0.0102 0.046 0.044
Echinococcus granulosus leucine aminopeptidase protein 0.0106 0.0484 0.0464
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0644 0.0625
Echinococcus multilocularis protein dispatched 1 0.0047 0.0171 0.0151
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0173 0.0153
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0141 0.012
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0102 0.046 0.9464
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0096 0.0429 0.0409
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.002
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0102 0.046 0.9464
Trypanosoma cruzi Aminopeptidase M1, putative 0.0102 0.046 0.9464
Trypanosoma brucei Aminopeptidase M1, putative 0.0102 0.046 0.9464
Loa Loa (eye worm) hypothetical protein 0.0102 0.046 0.046
Mycobacterium tuberculosis Probable reductase 0.0089 0.0393 0.7452
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0108 0.0088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0173 0.038
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0177 0.0157
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0116 0.0116
Loa Loa (eye worm) aminopeptidase N 0.0102 0.046 0.046
Loa Loa (eye worm) hypothetical protein 0.0026 0.006 0.006
Chlamydia trachomatis cytosol aminopeptidase 0.0106 0.0484 0.5
Loa Loa (eye worm) hypothetical protein 0.0102 0.046 0.046
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0436 0.0416
Loa Loa (eye worm) hypothetical protein 0.0179 0.0862 0.0862
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Loa Loa (eye worm) hypothetical protein 0.0041 0.0141 0.0141
Onchocerca volvulus 0.0102 0.046 0.4944
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0102 0.046 0.9321
Brugia malayi CHE-14 protein 0.0041 0.0141 0.0308
Loa Loa (eye worm) hypothetical protein 0.0096 0.0428 0.0428
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1918 1 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0099 0.0446 0.5811
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0428 0.9108
Schistosoma mansoni lamin 0.0027 0.0066 0.0045
Echinococcus granulosus aminopeptidase N 0.0102 0.046 0.044
Brugia malayi hypothetical protein 0.0882 0.4557 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0177 0.0177
Entamoeba histolytica aminopeptidase, putative 0.0102 0.046 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0116 0.0096
Brugia malayi mbt repeat family protein 0.0048 0.0177 0.0389
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0102 0.046 0.9464
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1918 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.006 0.006
Mycobacterium ulcerans leucyl aminopeptidase 0.0106 0.0484 1
Trypanosoma cruzi aminopeptidase, putative 0.0102 0.046 0.9464
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0212 0.0192
Schistosoma mansoni patched 1 0.0041 0.0141 0.012
Loa Loa (eye worm) hypothetical protein 0.0055 0.0212 0.0212
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0173 0.0153
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0096 0.0429 0.0409
Brugia malayi hypothetical protein 0.0035 0.0108 0.0238
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.0862 1
Brugia malayi Disintegrin family protein 0.0018 0.002 0.0045
Echinococcus granulosus neuropeptide receptor A26 0.0467 0.2375 0.2359
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0102 0.046 0.9464
Echinococcus granulosus lamin dm0 0.0027 0.0066 0.0045
Loa Loa (eye worm) glutathione reductase 0.0039 0.013 0.013
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Echinococcus multilocularis lamin 0.0027 0.0066 0.0045
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0177 0.0157
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.0788 0.1729
Echinococcus granulosus intermediate filament protein 0.0027 0.0066 0.0045
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0058 0.0228 0.0208
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0036 0.0015
Echinococcus multilocularis neuropeptide receptor A26 0.0467 0.2375 0.2359
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0096 0.0429 0.0409
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0212 0.0465
Toxoplasma gondii aminopeptidase N protein 0.0102 0.046 0.9347
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0106 0.0484 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0089 0.0393 0.7452
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0212 0.0192
Echinococcus granulosus leucyl aminopeptidase 0.0021 0.0036 0.0015
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0177 0.0157
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0106 0.0484 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0066 0.0144
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0102 0.046 0.9464
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0116 0.1789
Trypanosoma cruzi aminopeptidase, putative 0.0102 0.046 0.9464
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0021 0.0036 0.0078
Brugia malayi TATA binding protein associated factor 0.0102 0.046 0.1009
Brugia malayi ADAM-TS Spacer 1 family protein 0.0026 0.006 0.0131
Echinococcus multilocularis lamin dm0 0.0027 0.0066 0.0045
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0133 0.0112
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0102 0.046 0.044
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Brugia malayi angiogenesis inhibito 0.0026 0.006 0.0131
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0116 0.0096
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0036 0.0015
Brugia malayi hypothetical protein 0.0102 0.046 0.1009
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0116 0.1789
Loa Loa (eye worm) MBCTL1 0.0055 0.0212 0.0212
Loa Loa (eye worm) peptidase family M1 containing protein 0.0102 0.046 0.046
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0106 0.0484 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0467 0.2375 0.2359
Brugia malayi Peptidase family M1 containing protein 0.0102 0.046 0.1009
Echinococcus granulosus expressed conserved protein 0.009 0.0398 0.0378
Brugia malayi Thioredoxin reductase 0.0039 0.013 0.0285
Schistosoma mansoni hypothetical protein 0.004 0.0133 0.0113
Onchocerca volvulus 0.0048 0.0177 0.1398
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0102 0.046 0.9464
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0133 0.0112
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Onchocerca volvulus 0.0102 0.046 0.4944
Plasmodium falciparum M17 leucyl aminopeptidase 0.0106 0.0484 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0099 0.0446 0.8933
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.0788 0.0769
Schistosoma mansoni hypothetical protein 0.004 0.0133 0.0113
Brugia malayi mbt repeat family protein 0.0048 0.0177 0.0389
Toxoplasma gondii aminopeptidase N, putative 0.0102 0.046 0.9347
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0177 0.0177
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0177 0.0157
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1918 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0116 0.1789

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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