Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tumor protein p63 | 0.0335 | 0.3798 | 0.3798 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0337 | 0.3834 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0098 | 0.0659 | 0.0659 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0659 | 0.1696 |
Echinococcus granulosus | expressed conserved protein | 0.0092 | 0.058 | 0.0542 |
Brugia malayi | RNA binding protein | 0.0337 | 0.3834 | 1 |
Brugia malayi | hypothetical protein | 0.0078 | 0.0394 | 0.1003 |
Schistosoma mansoni | tar DNA-binding protein | 0.0337 | 0.3834 | 1 |
Echinococcus multilocularis | expressed conserved protein | 0.0092 | 0.058 | 0.058 |
Toxoplasma gondii | hypothetical protein | 0.0052 | 0.0051 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta | 0.032 | 0.3607 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0046 | 0.0095 |
Echinococcus multilocularis | geminin | 0.0333 | 0.3771 | 0.3771 |
Schistosoma mansoni | hypothetical protein | 0.0333 | 0.3771 | 0.9833 |
Schistosoma mansoni | tar DNA-binding protein | 0.0337 | 0.3834 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0337 | 0.3834 | 0.3834 |
Loa Loa (eye worm) | RNA binding protein | 0.0337 | 0.3834 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0337 | 0.3834 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0098 | 0.0659 | 0.077 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0099 | 0.0679 | 0.1735 |
Schistosoma mansoni | tar DNA-binding protein | 0.0337 | 0.3834 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.032 | 0.3607 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0139 | 0.1213 | 0.1213 |
Schistosoma mansoni | tar DNA-binding protein | 0.0337 | 0.3834 | 1 |
Brugia malayi | hypothetical protein | 0.0165 | 0.1556 | 0.4042 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0098 | 0.0659 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.032 | 0.3607 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0078 | 0.0394 | 0.0989 |
Echinococcus granulosus | tar DNA binding protein | 0.0337 | 0.3834 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0139 | 0.1213 | 0.238 |
Onchocerca volvulus | 0.0165 | 0.1556 | 1 | |
Echinococcus granulosus | tumor protein p63 | 0.0335 | 0.3798 | 0.9895 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.032 | 0.3607 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0333 | 0.3771 | 0.9833 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0394 | 0.0989 |
Schistosoma mansoni | tar DNA-binding protein | 0.0337 | 0.3834 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.1556 | 0.4042 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0337 | 0.3834 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0228 | 0.2384 | 1 |
Brugia malayi | TAR-binding protein | 0.0337 | 0.3834 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0078 | 0.0394 | 0.0394 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0016 | 0.0016 |
Echinococcus granulosus | geminin | 0.0333 | 0.3771 | 0.9815 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0098 | 0.0659 | 0.1696 |
Mycobacterium ulcerans | hypothetical protein | 0.0169 | 0.1601 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0152 | 0.1374 | 0.3643 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.