Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.4816 | 0.4637 |
Echinococcus granulosus | peptidase Clp S14 family | 0.005 | 0.1658 | 0.2491 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.4816 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0031 | 0.0842 | 0.0526 |
Toxoplasma gondii | hypothetical protein | 0.0247 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0851 | 0.1278 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0019 | 0.0357 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0851 | 0.0535 |
Brugia malayi | MH2 domain containing protein | 0.0091 | 0.3395 | 0.7007 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0019 | 0.0357 | 0.0024 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.277 | 0.5 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0026 | 0.0655 | 0.1321 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0026 | 0.0655 | 0.1321 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0705 | 0.1059 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0705 | 0.1339 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0851 | 0.1278 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.002 | 0.0383 | 0.0662 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0027 | 0.0705 | 0.1059 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.002 | 0.0383 | 0.0576 |
Brugia malayi | Probable ClpP-like protease | 0.0076 | 0.277 | 0.5689 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0019 | 0.0357 | 0.0097 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0019 | 0.0357 | 0.0097 |
Echinococcus multilocularis | geminin | 0.0168 | 0.6657 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1844 | 0.1563 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.3673 | 0.3455 |
Echinococcus granulosus | acetylcholinesterase | 0.0031 | 0.0842 | 0.1266 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.002 | 0.0383 | 0.0052 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.002 | 0.0383 | 0.0576 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0851 | 0.1647 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0705 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.2367 | 0.3556 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.277 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.277 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0091 | 0.3395 | 0.3167 |
Loa Loa (eye worm) | potassium voltage-gated channel subfamily Q member 5 | 0.0054 | 0.1844 | 0.1563 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0027 | 0.0705 | 0.1059 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0334 | 0.0501 |
Brugia malayi | Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog | 0.0121 | 0.4656 | 0.9663 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.4816 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0054 | 0.1844 | 0.277 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0019 | 0.0357 | 0.0097 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0019 | 0.0357 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0031 | 0.0842 | 0.1266 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.277 | 0.4161 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0091 | 0.3395 | 0.3167 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.3673 | 0.7593 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0357 | 0.0024 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.0121 | 0.4656 | 0.6994 |
Echinococcus multilocularis | acetylcholinesterase | 0.0031 | 0.0842 | 0.1266 |
Echinococcus granulosus | acetylcholinesterase | 0.0031 | 0.0842 | 0.1266 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.002 | 0.0383 | 0.0576 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0076 | 0.277 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.005 | 0.1658 | 0.2491 |
Toxoplasma gondii | hypothetical protein | 0.0026 | 0.0655 | 0.0333 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0334 | 0.0501 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0705 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0851 | 0.1647 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0119 | 0.457 | 0.4382 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0031 | 0.0842 | 0.0526 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0705 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0026 | 0.0655 | 0.1321 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.277 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.277 | 0.252 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0121 | 0.4656 | 0.6994 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.005 | 0.1658 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.002 | 0.0383 | 0.0576 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0334 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.277 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0019 | 0.0357 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.4816 | 0.4637 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0842 | 0.0526 |
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.0121 | 0.4656 | 0.6994 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.3673 | 0.7593 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0851 | 0.1278 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.002 | 0.0383 | 0.0576 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.002 | 0.0383 | 0.0576 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0851 | 0.0535 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0027 | 0.0705 | 0.1059 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0334 | 0.0501 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.002 | 0.0383 | 0.0576 |
Brugia malayi | RNA binding protein | 0.0125 | 0.4816 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.4816 | 0.7235 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0247 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.6657 | 1 |
Echinococcus granulosus | geminin | 0.0168 | 0.6657 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0851 | 0.1278 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0851 | 0.1278 |
Brugia malayi | Carboxylesterase family protein | 0.0031 | 0.0842 | 0.1629 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0851 | 0.1278 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0705 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.005 | 0.1658 | 0.4744 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.4816 | 0.7235 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.4816 | 0.7235 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0334 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0031 | 0.0842 | 0.1266 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1844 | 0.1563 |
Brugia malayi | Pax transcription factor protein 2 | 0.0104 | 0.396 | 0.8197 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0031 | 0.0842 | 0.1266 |
Echinococcus multilocularis | acetylcholinesterase | 0.0031 | 0.0842 | 0.1266 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0851 | 0.1278 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0076 | 0.277 | 0.4161 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.005 | 0.1658 | 1 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0104 | 0.396 | 0.3751 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.277 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.277 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0851 | 0.1278 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0842 | 0.0526 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0019 | 0.0357 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.4816 | 0.7235 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0076 | 0.277 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.6657 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.277 | 0.252 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0334 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.277 | 0.252 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.2367 | 0.4841 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.277 | 0.4161 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.2367 | 0.2103 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.4816 | 0.4637 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0851 | 0.1278 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0334 | 0.0557 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.4816 | 0.7235 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0357 | 0.0607 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0334 | 0.0501 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.4816 | 0.7235 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0031 | 0.0842 | 0.1629 |
Onchocerca volvulus | 0.0104 | 0.396 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.4816 | 0.7235 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.3673 | 0.3455 |
Echinococcus granulosus | potassium voltage gated channel subfamily KQT | 0.0054 | 0.1844 | 0.277 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0851 | 0.1278 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.