Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0459 | 0.0425 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.8433 | 0.8427 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0459 | 0.0425 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.516 | 0.516 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.8433 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0459 | 0.5 |
Echinococcus multilocularis | musashi | 0.0026 | 0.1056 | 0.1023 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.1056 | 0.1023 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0081 | 0.516 | 0.5091 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.1056 | 0.1056 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 1 | 1 |
Onchocerca volvulus | 0.0081 | 0.516 | 1 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.1765 | 0.1736 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0459 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1056 | 0.1056 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0081 | 0.516 | 0.5143 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0036 | 0.0036 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0023 | 0.0794 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.8433 | 0.8433 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.8433 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.8433 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.8433 | 0.8433 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1765 | 0.1638 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0023 | 0.0794 | 1 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0023 | 0.0794 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.8433 | 0.8411 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.1056 | 0.0928 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0459 | 0.0459 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1765 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0459 | 0.0323 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.1056 | 0.1023 |
Echinococcus multilocularis | lamin | 0.0026 | 0.1056 | 0.1023 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0794 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0023 | 0.0794 | 0.5 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0081 | 0.516 | 0.5895 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0023 | 0.0794 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.1765 | 0.1736 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1765 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.102 | 0.102 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0023 | 0.0794 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0459 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.8433 | 0.8433 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.1056 | 0.1023 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.8433 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.1765 | 0.1648 |
Schistosoma mansoni | lamin | 0.0026 | 0.1056 | 0.0748 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0794 | 1 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0081 | 0.516 | 0.5143 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0023 | 0.0794 | 1 |
Echinococcus granulosus | lamin | 0.0026 | 0.1056 | 0.1023 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0794 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0459 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0794 | 0.256 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.1056 | 0.0748 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0794 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0023 | 0.0794 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.1056 | 0.1056 |
Brugia malayi | RNA binding protein | 0.0125 | 0.8433 | 0.8411 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1765 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.8433 | 0.8411 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.8433 | 0.8427 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0459 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.1765 | 0.1638 |
Schistosoma mansoni | lamin | 0.0026 | 0.1056 | 0.0748 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0794 | 1 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.1056 | 0.0928 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1765 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.8433 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.