Detailed information for compound 56053

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 466.641 | Formula: C22H38N6O3S
  • H donors: 5 H acceptors: 3 LogP: 1.21 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCN(CC1)C(=O)[C@@H](NS(=O)(=O)c1cccc2c1NCC(C2)C)CCCNC(N)N
  • InChi: 1S/C22H38N6O3S/c1-15-8-11-28(12-9-15)21(29)18(6-4-10-25-22(23)24)27-32(30,31)19-7-3-5-17-13-16(2)14-26-20(17)19/h3,5,7,15-16,18,22,25-27H,4,6,8-14,23-24H2,1-2H3/t16?,18-/m0/s1
  • InChiKey: WQGMMPIKXADOQG-DAFXYXGESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni synaptic ras gtpase activating protein syngap 0.0017 0.0038 0.0092
Onchocerca volvulus 0.0017 0.0038 0.0457
Onchocerca volvulus 0.0134 0.0663 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Entamoeba histolytica C2 domain containing protein 0.0017 0.0038 0.0476
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0008 0.011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0017 0.0034 0.1503
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0017 0.0038 0.0113
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Echinococcus granulosus dna polymerase kappa 0.0019 0.0045 0.0109
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0017 0.0038 0.0092
Brugia malayi protein kinase C3,putative 0.0094 0.045 0.1291
Onchocerca volvulus 0.0091 0.0435 0.6512
Loa Loa (eye worm) hypothetical protein 0.0019 0.0045 0.0134
Loa Loa (eye worm) hypothetical protein 0.064 0.3376 1
Entamoeba histolytica Rap/Ran GTPase activating protein, putative 0.0017 0.0038 0.0476
Echinococcus multilocularis protein jagged 2 0.0026 0.0081 0.0196
Loa Loa (eye worm) hypothetical protein 0.0041 0.0163 0.0482
Echinococcus granulosus myotubularin protein 13 0.0091 0.0435 0.1045
Plasmodium vivax P-type ATPase4, putative 0.0028 0.0096 0.4203
Brugia malayi C2 domain containing protein 0.0017 0.0038 0.011
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0333 0.0801
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0008 0.002
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0079 0.0189
Onchocerca volvulus Putative cubilin 0.0026 0.0081 0.1117
Trichomonas vaginalis MYB72, putative 0.0067 0.0303 0.4733
Brugia malayi C2 domain containing protein 0.0017 0.0038 0.011
Schistosoma mansoni hypothetical protein 0.0341 0.1775 0.4265
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0067 0.0303 0.4675
Trichomonas vaginalis copine, putative 0.0017 0.0038 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0008 0.011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0059 0.0174
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0017 0.0038 0.0092
Schistosoma mansoni chromobox protein 0.0073 0.0334 0.0802
Loa Loa (eye worm) hypothetical protein 0.0091 0.0435 0.1288
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0017 0.0034 0.0029
Onchocerca volvulus Dual oxidase homolog 0.0079 0.0368 0.5495
Schistosoma mansoni E3 ubiquitin-protein ligase nedd-4 0.0017 0.0038 0.0092
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0008 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0014 0.02
Trichomonas vaginalis MYB, putative 0.0067 0.0304 0.476
Brugia malayi Protein kinase domain containing protein 0.0129 0.0638 0.1831
Schistosoma mansoni chromobox protein 0.0012 0.0008 0.002
Loa Loa (eye worm) helicase 0.0012 0.0008 0.0025
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0013 0.0016 0.0038
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0017 0.0034 0.1503
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0038 0.1713
Schistosoma mansoni notch 0.0026 0.0081 0.0196
Echinococcus multilocularis synaptotagmin 2 0.0017 0.0038 0.0092
Brugia malayi C2 domain containing protein 0.0017 0.0038 0.011
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0017 0.0038 0.0092
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0013 0.0016 0.0678
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0045 0.204
Trichomonas vaginalis AGC family protein kinase 0.0129 0.0638 1
Trypanosoma brucei unspecified product 0.0019 0.0045 0.0691
Brugia malayi E1-E2 ATPase family protein 0.0011 0.0001 0.0004
Schistosoma mansoni hypothetical protein 0.0017 0.0038 0.0092
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0008 0.011
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0045 0.0691
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0217 0.0781
Brugia malayi CHD4 protein 0.0012 0.0008 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0025
Onchocerca volvulus 0.0026 0.0081 0.1117
Trypanosoma brucei Coiled-coil and C2 domain-containing protein 0.0017 0.0038 0.058
Trichomonas vaginalis Circumsporozoite protein precursor, putative 0.0017 0.0038 0.058
Schistosoma mansoni hypothetical protein 0.0026 0.0081 0.0196
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0017 0.0034 0.1503
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0016 0.0234
Schistosoma mansoni diacylglycerol kinase theta 0.0091 0.0435 0.1045
Echinococcus granulosus intersectin 2 0.0017 0.0038 0.0092
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0094 0.045 0.108
Echinococcus multilocularis fibropellin Ia 0.0026 0.0081 0.0196
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0045 0.0134
Echinococcus multilocularis slit 2 protein 0.0026 0.0081 0.0196
Onchocerca volvulus Peroxidasin homolog 0.0079 0.0368 0.5495
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Trichomonas vaginalis synaptotagmin, putative 0.0017 0.0038 0.058
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0091 0.0435 0.1288
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0017 0.0038 0.0092
Schistosoma mansoni notch 0.0026 0.0081 0.0196
Schistosoma mansoni serine/threonine protein kinase 0.0787 0.4163 1
Onchocerca volvulus 0.0109 0.0528 0.7942
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0017 0.0034 0.0404
Echinococcus multilocularis neurogenic locus protein delta 0.0026 0.0081 0.0196
Echinococcus granulosus N chimaerin 0.0091 0.0435 0.1045
Loa Loa (eye worm) RasGEF domain-containing protein 0.0091 0.0435 0.1288
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0017 0.0034 0.0509
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0038 0.1713
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Trichomonas vaginalis cation-transporting ATPase, putative 0.0028 0.0096 0.1487
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0008 0.002
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0028 0.0096 0.4426
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0638 0.1532
Entamoeba histolytica C2 domain containing protein 0.0017 0.0038 0.0476
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0008 0.011
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0129 0.0638 0.1532
Schistosoma mansoni unc-13 (munc13) 0.0109 0.0528 0.1269
Brugia malayi EGF-like domain containing protein 0.0026 0.0081 0.0234
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0013 0.0016 0.0678
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0067 0.0303 0.4733
Trichomonas vaginalis AGC family protein kinase 0.0129 0.0638 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0008 0.011
Leishmania major hypothetical protein, conserved 0.0051 0.0217 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0008 0.00000000036254
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0067 0.0304 0.476
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0017 0.0038 0.0092
Schistosoma mansoni synaptotagmin 0.0017 0.0038 0.0092
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0026 0.0081 0.0196
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0129 0.0638 0.1532
Echinococcus granulosus neurogenic locus notch protein 0.0026 0.0081 0.0196
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0034 0.0509
Entamoeba histolytica hypothetical protein 0.0017 0.0038 0.0476
Echinococcus multilocularis synaptotagmin 0.0017 0.0038 0.0092
Schistosoma mansoni synaptotagmin 0.0017 0.0038 0.0092
Schistosoma mansoni ATPase 0.0028 0.0096 0.0231
Leishmania major hypothetical protein, conserved 0.0017 0.0038 0.1713
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0017 0.0038 0.0092
Trypanosoma brucei C2 domain containing protein, putative 0.0017 0.0038 0.058
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0028 0.0096 0.0091
Leishmania major hypothetical protein, conserved 0.0017 0.0038 0.1713
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0129 0.0638 0.1532
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0099 0.1536
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0008 0.011
Toxoplasma gondii Sma protein 0.0017 0.0038 0.0138
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Loa Loa (eye worm) hypothetical protein 0.0091 0.0435 0.1288
Trichomonas vaginalis splicing factor 3A subunit, putative 0.0017 0.0038 0.058
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.0091 0.0435 0.1288
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0368 0.1057
Entamoeba histolytica hypothetical protein 0.0017 0.0038 0.0476
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0638 0.1532
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1347 0.7165 1
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0017 0.0038 0.058
Leishmania major hypothetical protein, conserved 0.0017 0.0038 0.1713
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0333 0.0801
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0025 0.0078 0.0188
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0008 0.011
Onchocerca volvulus Peroxidase homolog 0.0079 0.0368 0.5495
Echinococcus granulosus synaptotagmin 15 0.0017 0.0038 0.0092
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.1091
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0017 0.0038 0.058
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0013 0.0016 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0008 0.002
Echinococcus multilocularis synaptotagmin 0.0017 0.0038 0.0092
Loa Loa (eye worm) hypothetical protein 0.0225 0.1153 0.3416
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0013 0.0016 0.023
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.1091
Loa Loa (eye worm) C2 domain-containing protein 0.0017 0.0038 0.0113
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0028 0.0096 0.0231
Brugia malayi RhoGAP domain containing protein 0.0091 0.0435 0.1248
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0017 0.0034 0.111
Brugia malayi Muscle positioning protein 4 0.0026 0.0081 0.0234
Schistosoma mansoni hypothetical protein 0.0017 0.0038 0.0092
Loa Loa (eye worm) AGC/NDR protein kinase 0.0129 0.0638 0.189
Echinococcus multilocularis Chromo domain 0.0012 0.0008 0.002
Leishmania major phospholipase c-like protein 0.0017 0.0038 0.1713
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Entamoeba histolytica hypothetical protein 0.0072 0.0333 0.5162
Brugia malayi Protein cec-1. 0.0012 0.0008 0.0024
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0045 0.204
Echinococcus multilocularis geminin 0.0341 0.1775 0.4265
Echinococcus multilocularis peroxidasin 0.0079 0.0368 0.0884
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0094 0.045 0.1332
Leishmania major c2 domain protein, putative 0.0017 0.0038 0.1713
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Leishmania major P-type ATPase, putative 0.0013 0.0016 0.0678
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0091 0.0435 0.1045
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0008 0.011
Giardia lamblia Myb 1-like protein 0.0067 0.0304 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Trichomonas vaginalis pc-MYB2, putative 0.0067 0.0303 0.4733
Trichomonas vaginalis AGC family protein kinase 0.0129 0.0638 1
Echinococcus multilocularis myoferlin 0.0017 0.0038 0.0092
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.002 0.005 0.0142
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0011 0.0005 0.0015
Entamoeba histolytica diacylglycerol kinase, putative 0.0091 0.0435 0.6774
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0008 0.011
Plasmodium falciparum ferlin, putative 0.0017 0.0038 0.1765
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0028 0.0096 0.0231
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0026 0.0081 0.0234
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0017 0.0038 0.0092
Echinococcus granulosus Immunoglobulin E set 0.0017 0.0038 0.0092
Schistosoma mansoni hypothetical protein 0.0091 0.0435 0.1045
Trypanosoma brucei C2 domain containing protein, putative 0.0017 0.0038 0.058
Echinococcus multilocularis active breakpoint cluster region 0.0017 0.0038 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0045 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0435 0.1045
Onchocerca volvulus 0.0091 0.0435 0.6512
Echinococcus granulosus active breakpoint cluster region 0.0017 0.0038 0.0092
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0017 0.0038 0.058
Echinococcus multilocularis UNCoordinated family member (unc 13) 0.0017 0.0038 0.0092
Brugia malayi Calcium binding EGF domain containing protein 0.0026 0.0081 0.0234
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0008 0.0024
Schistosoma mansoni hypothetical protein 0.0026 0.0081 0.0196
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0067 0.0303 0.4675
Onchocerca volvulus 0.0026 0.0081 0.1117
Trichomonas vaginalis Heterochromatin protein, putative 0.0012 0.0008 0.011
Entamoeba histolytica hypothetical protein, conserved 0.0017 0.0038 0.0476
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0008 0.011
Schistosoma mansoni chromobox protein 0.0012 0.0008 0.002
Brugia malayi EGF-like domain containing protein 0.0026 0.0081 0.0234
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0067 0.0303 0.4733
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0008 0.011
Brugia malayi Protein kinase domain containing protein 0.0094 0.045 0.1291
Entamoeba histolytica calcium-binding protein, putative 0.0017 0.0038 0.0476
Brugia malayi Delta serrate ligand family protein 0.0026 0.0081 0.0234
Toxoplasma gondii ferlin family protein 0.0017 0.0038 0.0138
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0129 0.0638 0.1532
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0691
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0008 0.011
Schistosoma mansoni hypothetical protein 0.0017 0.0038 0.0092
Echinococcus granulosus Protein kinase C brain isozyme 0.0787 0.4163 1
Schistosoma mansoni mctp-related 0.0017 0.0038 0.0092
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0217 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0034 0.0509
Onchocerca volvulus 0.0021 0.0059 0.0769
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Trichomonas vaginalis AGC family protein kinase 0.0129 0.0638 1
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0017 0.0034 0.0081
Toxoplasma gondii hypothetical protein 0.0017 0.0038 0.0138
Schistosoma mansoni notch 0.0026 0.0081 0.0196
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0012 0.0008 0.002
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0012 0.0008 0.002
Loa Loa (eye worm) C2 domain-containing protein 0.0017 0.0038 0.0113
Brugia malayi GCC2 and GCC3 family protein 0.0026 0.0081 0.0234
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0017 0.0034 0.0081
Loa Loa (eye worm) blistered cuticle protein 3 0.0079 0.0368 0.1091
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Onchocerca volvulus 0.0017 0.0038 0.0457
Schistosoma mansoni hypothetical protein 0.0026 0.0081 0.0196
Trichomonas vaginalis cation-transporting ATPase, putative 0.0028 0.0096 0.1487
Schistosoma mansoni unc-13 (munc13) 0.0017 0.0038 0.0092
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0017 0.0034 0.1503
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.1091
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0025 0.0078 0.0188
Toxoplasma gondii P-type ATPase PMA1 0.0011 0.0001 0.0005
Onchocerca volvulus 0.0017 0.0038 0.0457
Leishmania major hypothetical protein, conserved 0.0017 0.0038 0.1713
Brugia malayi diacylglycerol kinase 0.0091 0.0435 0.1248
Brugia malayi SET domain containing protein 0.0012 0.0008 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0025
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0067 0.0303 0.4733
Echinococcus multilocularis neurogenic locus notch protein 0.0026 0.0081 0.0196
Trypanosoma brucei unspecified product 0.0013 0.0014 0.02
Loa Loa (eye worm) Nedd4-PD 0.0017 0.0038 0.0113
Onchocerca volvulus 0.0079 0.0368 0.5495
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Echinococcus granulosus protein piccolo 0.0017 0.0038 0.0092
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0016 0.023
Entamoeba histolytica C2 domain containing protein 0.0017 0.0038 0.0476
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.0017 0.0038 0.0092
Echinococcus granulosus fibropellin Ia 0.0026 0.0081 0.0196
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0017 0.0038 0.058
Echinococcus multilocularis synaptotagmin 15 0.0017 0.0038 0.0092
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0638 0.1532
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0017 0.0038 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0038 0.1713
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0008 0.00000000036254
Trypanosoma cruzi C2 domain containing protein, putative 0.0017 0.0038 0.1713
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0529 0.2779 1
Leishmania major hypothetical protein, conserved 0.0017 0.0038 0.1713
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0079 0.1216
Entamoeba histolytica protein kinase, putative 0.002 0.0053 0.0713
Trypanosoma brucei C2 domain containing protein, putative 0.0017 0.0038 0.058
Entamoeba histolytica C2 domain containing protein 0.0017 0.0038 0.0476
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.045 0.108
Echinococcus granulosus neurogenic locus notch protein 4 0.0026 0.0081 0.0196
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0217 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0034 0.0509
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0045 0.0109
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0008 0.011
Loa Loa (eye worm) copine family protein 0.0017 0.0038 0.0113
Loa Loa (eye worm) hypothetical protein 0.0091 0.0435 0.1288
Brugia malayi Hr1 repeat family protein 0.0129 0.0638 0.1831
Loa Loa (eye worm) hypothetical protein 0.0051 0.0217 0.0643
Schistosoma mansoni hypothetical protein 0.0026 0.0081 0.0196
Schistosoma mansoni atypical protein kinase C 0.0221 0.1128 0.271
Loa Loa (eye worm) C2 domain-containing protein 0.0017 0.0038 0.0113
Echinococcus multilocularis calcium transporting atpase 0.0025 0.0078 0.0188
Schistosoma mansoni peroxidasin 0.0079 0.0368 0.0884
Toxoplasma gondii hypothetical protein 0.0017 0.0038 0.0138
Entamoeba histolytica C2 domain containing protein 0.0017 0.0038 0.0476
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0179 0.2796
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0016 0.0126
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0368 0.1091
Trypanosoma cruzi synaptotagmin, putative 0.0017 0.0038 0.1713
Plasmodium vivax ferlin, putative 0.0017 0.0038 0.1435
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0045 0.004
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0368 0.1057
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0091 0.0435 0.1288
Echinococcus granulosus myoferlin 0.0017 0.0038 0.0092
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0008 0.0000000010941
Entamoeba histolytica C2 domain containing protein 0.0017 0.0038 0.0476
Onchocerca volvulus 0.0017 0.0038 0.0457
Entamoeba histolytica hypothetical protein 0.0017 0.0038 0.0476
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0017 0.0038 0.0092
Brugia malayi C2 domain containing protein 0.0017 0.0038 0.011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0025
Brugia malayi protein kinase C II. 0.0238 0.1222 0.3506
Trypanosoma brucei calcium-translocating P-type ATPase 0.0025 0.0078 0.1207
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0017 0.0038 0.058
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Echinococcus granulosus synaptotagmin 2 0.0017 0.0038 0.0092
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0129 0.0638 0.189
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0017 0.0038 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0691
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0017 0.0038 0.0092
Echinococcus granulosus synaptotagmin 0.0017 0.0038 0.0092
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1347 0.7165 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Onchocerca volvulus 0.0017 0.0038 0.0457
Brugia malayi Copine family protein 0.0017 0.0038 0.011
Trypanosoma brucei C2 domain containing protein, putative 0.0017 0.0038 0.058
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0691
Schistosoma mansoni synaptotagmin 12 0.0017 0.0038 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0691
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Onchocerca volvulus Peroxidasin homolog 0.0079 0.0368 0.5495
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0129 0.0638 0.189
Plasmodium vivax double C2-like domain-containing protein, putative 0.0017 0.0038 0.1435
Schistosoma mansoni vav2 0.0091 0.0435 0.1045
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.1091
Onchocerca volvulus 0.0079 0.0368 0.5495
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.1091
Leishmania major calcium-translocating P-type ATPase 0.0028 0.0096 0.4391
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0017 0.0038 0.011
Echinococcus multilocularis protein kinase c epsilon type 0.0238 0.1222 0.2935
Echinococcus granulosus protein jagged 2 0.0026 0.0081 0.0196
Schistosoma mansoni laminin gamma-3 chain 0.0026 0.0081 0.0196
Brugia malayi RhoGAP domain containing protein 0.0091 0.0435 0.1248
Trypanosoma cruzi cAMP binding protein, putative 0.0017 0.0038 0.1713
Entamoeba histolytica C2 domain containing protein 0.0017 0.0038 0.0476
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0091 0.0435 0.1288
Echinococcus multilocularis myotubularin protein 13 0.0091 0.0435 0.1045
Echinococcus granulosus protein kinase c iota type 0.0221 0.1128 0.271
Loa Loa (eye worm) hypothetical protein 0.0134 0.0663 0.1965
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0067 0.0303 0.4675
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0094 0.045 0.1291
Echinococcus multilocularis protein jagged 1 0.0026 0.0081 0.0196
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0638 0.1532
Onchocerca volvulus 0.0026 0.0081 0.1117
Plasmodium vivax calcium-transporting ATPase, putative 0.0028 0.0096 0.4203
Brugia malayi hypothetical protein 0.0033 0.012 0.0346
Echinococcus granulosus Rac GTPase activating protein 1 0.0091 0.0435 0.1045
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Trichomonas vaginalis calcium-dependent lipid-binding protein, putative 0.0017 0.0038 0.058
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0008 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0008 0.011
Schistosoma mansoni protein kinase C 0.0109 0.0528 0.1269
Entamoeba histolytica diacylglycerol kinase, putative 0.0091 0.0435 0.6774
Brugia malayi Cadherin domain containing protein 0.0026 0.0081 0.0234
Trichomonas vaginalis ion channel nompc, putative 0.0017 0.0038 0.058
Trypanosoma cruzi synaptotagmin, putative 0.0017 0.0038 0.1713
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0045 0.004
Echinococcus granulosus delta-like protein 1 0.0026 0.0081 0.0196
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0045 0.0691
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Brugia malayi EGF-like domain containing protein 0.0026 0.0081 0.0234
Loa Loa (eye worm) RecQ helicase 0.0025 0.0079 0.0233
Brugia malayi hypothetical protein 0.0012 0.001 0.0028
Brugia malayi Cadherin domain containing protein 0.0026 0.0081 0.0234
Echinococcus multilocularis Rac GTPase activating protein 1 0.0091 0.0435 0.1045
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0013 0.0016 0.0038
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0067 0.0303 0.4733
Brugia malayi Peroxidasin 0.0079 0.0368 0.1057
Trichomonas vaginalis synaptotagmin, putative 0.0017 0.0038 0.058
Trichomonas vaginalis synaptotagmin, putative 0.0017 0.0038 0.058
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0045 0.0691
Trichomonas vaginalis pc-MYB2, putative 0.0067 0.0303 0.4733
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.000000000025208 0.000000000090698
Trypanosoma brucei predicted C2 domain protein 0.0017 0.0038 0.058
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0067 0.016
Brugia malayi Blistered cuticle protein 3 0.0079 0.0368 0.1057
Brugia malayi Na,K-ATPase alpha subunit 0.0017 0.0034 0.0097
Loa Loa (eye worm) C2 domain-containing protein 0.0017 0.0038 0.0113
Echinococcus granulosus protein kinase c epsilon type 0.0238 0.1222 0.2935
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0217 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Brugia malayi Synapse defective protein 1 0.0017 0.0038 0.011
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0026 0.0081 0.1117
Schistosoma mansoni Mername-AA248 (C02 family) 0.0017 0.0038 0.0092
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0529 0.2779 0.2776
Toxoplasma gondii Elicitor-responsive protein, putative 0.0017 0.0038 0.0138
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.045 0.108
Echinococcus multilocularis raf serine:threonine protein kinase 0.0091 0.0435 0.1045
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0045 0.0588
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0008 0.011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0105
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0045 0.204
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0008 0.011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0025
Entamoeba histolytica hypothetical protein 0.0072 0.0333 0.5162
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0038 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Echinococcus granulosus neurogenic locus notch protein 0.0026 0.0081 0.0196
Onchocerca volvulus 0.0017 0.0038 0.0457
Echinococcus granulosus copine 9 0.0017 0.0038 0.0092
Echinococcus multilocularis calpain 5 0.0017 0.0038 0.0092
Brugia malayi C2 domain containing protein 0.0017 0.0038 0.011
Echinococcus multilocularis protein kinase c eta type 0.0091 0.0435 0.1045
Leishmania major copine i-like protein 0.0017 0.0038 0.1713
Loa Loa (eye worm) C2 domain-containing protein 0.0017 0.0038 0.0113
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0017 0.0034 0.0509
Echinococcus granulosus bloom syndrome protein 0.0025 0.0079 0.0189
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0059 0.0141
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0045 0.0691
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.1091
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0529 0.2779 0.3875
Brugia malayi C2 domain containing protein 0.0017 0.0038 0.011
Schistosoma mansoni synaptotagmin-like protein 0.0017 0.0038 0.0092
Schistosoma mansoni hypothetical protein 0.0017 0.0038 0.0092
Echinococcus multilocularis synaptotagmin protein 4 0.0017 0.0038 0.0092
Onchocerca volvulus 0.0012 0.0008 0.00000013574
Trichomonas vaginalis cation-transporting ATPase, putative 0.0017 0.0034 0.0509
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0129 0.0638 0.189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Schistosoma mansoni synaptotagmin 0.0017 0.0038 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Brugia malayi C2 domain containing protein 0.0017 0.0038 0.011
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0016 0.0692
Echinococcus multilocularis dna polymerase eta 0.0019 0.0045 0.0109
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0179 0.2796
Brugia malayi C2 domain containing protein 0.0017 0.0038 0.011
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0045 0.0691
Echinococcus multilocularis neurogenic locus notch protein 0.0026 0.0081 0.0196
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.1091
Onchocerca volvulus 0.0017 0.0038 0.0457
Trichomonas vaginalis synaptotagmin, putative 0.0017 0.0038 0.058
Onchocerca volvulus 0.0017 0.0034 0.0388
Echinococcus granulosus neural cadherin 0.0026 0.0081 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0691
Onchocerca volvulus Chorion peroxidase homolog 0.0079 0.0368 0.5495
Schistosoma mansoni serine/threonine kinase 0.0129 0.0638 0.1532
Echinococcus granulosus slit 2 protein 0.0026 0.0081 0.0196
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.002 0.005 0.0147
Schistosoma mansoni rho gtpase activating protein 0.0017 0.0038 0.0092
Toxoplasma gondii diacylglycerol kinase, putative 0.0091 0.0435 0.1564
Schistosoma mansoni copine 0.0017 0.0038 0.0092
Schistosoma mansoni hypothetical protein 0.0341 0.1775 0.4265
Plasmodium falciparum double C2-like domain-containing protein 0.0017 0.0038 0.1765
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0013 0.0016 0.0038
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0368 0.1057
Brugia malayi C2 domain containing protein 0.0017 0.0038 0.011
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0016 0.0692
Trichomonas vaginalis C-MYB, putative 0.0067 0.0303 0.4733
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.0059 0.2707
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Schistosoma mansoni synaptotagmin 0.0017 0.0038 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0059 0.2661
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Echinococcus granulosus extended synaptotagmin 2 0.0017 0.0038 0.0092
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0017 0.0038 0.0092
Echinococcus granulosus Na:K ATPase alpha subunit 0.0013 0.0016 0.0038
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0013 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Brugia malayi LD23056p 0.0017 0.0038 0.011
Leishmania major hypothetical protein, conserved 0.0017 0.0038 0.1713
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase A CtpF 0.0012 0.0007 0.0002
Trypanosoma brucei predicted C2 domain protein 0.0017 0.0038 0.058
Schistosoma mansoni notch 0.0026 0.0081 0.0196
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Schistosoma mansoni hypothetical protein 0.0023 0.0067 0.016
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0008 0.0024
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0017 0.0038 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0008 0.002
Brugia malayi Calcium binding EGF domain containing protein 0.0026 0.0081 0.0234
Echinococcus granulosus RNA directed DNA polymerase 0.0549 0.2886 0.6932
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0129 0.0638 0.189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0017 0.0038 0.1765
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Trichomonas vaginalis AGC family protein kinase 0.0129 0.0638 1
Brugia malayi Protein kinase domain containing protein 0.0129 0.0638 0.1831
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0014 0.02
Leishmania major calcium motive p-type ATPase, putative 0.0013 0.0016 0.0678
Brugia malayi C2 domain containing protein 0.0017 0.0038 0.011
Trypanosoma brucei synaptotagmin, putative 0.0017 0.0038 0.058
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1876 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0109 0.0528 0.1269
Schistosoma mansoni chromobox protein 0.0073 0.0334 0.0802
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Onchocerca volvulus 0.0026 0.0081 0.1117
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0691
Leishmania major hypothetical protein, conserved 0.0017 0.0038 0.1713
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0062 0.2879
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0017 0.0038 0.058
Giardia lamblia DINP protein human, muc B family 0.0019 0.0045 0.149
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0017 0.0038 0.0092
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0045 0.013
Loa Loa (eye worm) AGC/AKT protein kinase 0.0129 0.0638 0.189
Entamoeba histolytica hypothetical protein 0.0017 0.0038 0.0476
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.1091
Loa Loa (eye worm) hypothetical protein 0.0091 0.0435 0.1288
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0691
Brugia malayi phospholipase C homolog 0.0017 0.0038 0.011
Entamoeba histolytica protein kinase, putative 0.0129 0.0638 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0034 0.0509
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0008 0.011
Schistosoma mansoni nedd-4-like E3 ubiquitin-protein ligase 0.0017 0.0038 0.0092
Schistosoma mansoni rac gtpase activating protein 0.0091 0.0435 0.1045
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0045 0.013
Schistosoma mansoni ATPase 0.0028 0.0096 0.0231
Schistosoma mansoni fer-1-related 0.0017 0.0038 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0568 0.1681
Echinococcus granulosus synaptotagmin 0.0017 0.0038 0.0092
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0091 0.0435 0.1045
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0017 0.0038 0.0113
Brugia malayi C1-like domain containing protein 0.0094 0.045 0.1291
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0333 0.0801
Echinococcus multilocularis neural cell expressed, developmentally 0.0017 0.0038 0.0092
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0008 0.011
Entamoeba histolytica hypothetical protein 0.0072 0.0333 0.5162
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0691
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0017 0.0038 0.0092
Entamoeba histolytica hypothetical protein 0.0017 0.0038 0.0476
Echinococcus multilocularis chromobox protein 2 0.0012 0.0008 0.002
Echinococcus multilocularis fat cadherin tumor suppressor 0.0026 0.0081 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0008 0.011
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0028 0.0096 0.0231
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.1091
Echinococcus granulosus neural cell expressed developmentally 0.0017 0.0038 0.0092
Entamoeba histolytica hypothetical protein 0.0017 0.0038 0.0476
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0334 0.5223
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0045 0.0691
Brugia malayi Protein kinase domain containing protein 0.0021 0.0059 0.0169
Trichomonas vaginalis copine, putative 0.0017 0.0038 0.058
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0038 0.1713
Echinococcus multilocularis serine threonine protein kinase 0.0695 0.3672 0.8823
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Trypanosoma brucei unspecified product 0.0013 0.0014 0.02
Schistosoma mansoni notch 0.0026 0.0081 0.0196
Entamoeba histolytica protein kinase, putative 0.0129 0.0638 1
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0025 0.0078 0.0224
Brugia malayi C2 domain containing protein 0.0017 0.0038 0.011
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0017 0.0038 0.0092
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0008 0.011
Brugia malayi Variant SH3 domain containing protein 0.0017 0.0038 0.011
Onchocerca volvulus Putative cc2d1b protein 0.0017 0.0038 0.0457
Brugia malayi Membrane calcium atpase protein 3 0.0013 0.0016 0.0046
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0045 0.204
Echinococcus multilocularis intersectin 2 0.0017 0.0038 0.0092
Schistosoma mansoni protein kinase C mu 0.0094 0.045 0.108
Echinococcus granulosus Chromo domain 0.0012 0.0008 0.002
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0217 1
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0011 0.0005 0.0015
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0034 0.0123
Loa Loa (eye worm) raf kinase 0.0091 0.0435 0.1288
Echinococcus multilocularis serine:threonine protein kinase 38 0.0129 0.0638 0.1532
Echinococcus multilocularis protein piccolo 0.0017 0.0038 0.0092
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0059 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0008 0.011
Trichomonas vaginalis AGC family protein kinase 0.0129 0.0638 1
Entamoeba histolytica C2 domain containing protein 0.0017 0.0038 0.0476
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.1091
Echinococcus granulosus synaptotagmin 0.0017 0.0038 0.0092
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0549 0.2886 0.6932
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0017 0.0038 0.0092
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0045 0.0109
Brugia malayi RhoGEF domain containing protein 0.0091 0.0435 0.1248
Entamoeba histolytica C2 domain protein, putative 0.0017 0.0038 0.0476
Brugia malayi Protein kinase c protein 2 0.066 0.3484 1
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0017 0.0038 0.1713
Loa Loa (eye worm) hypothetical protein 0.0549 0.2886 0.8548
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0334 0.5223
Onchocerca volvulus Neurogenic locus notch homolog 0.0026 0.0083 0.1137
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0691
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0008 0.011
Schistosoma mansoni septate junction protein 0.0026 0.0081 0.0196
Echinococcus multilocularis extended synaptotagmin 2 0.0017 0.0038 0.0092
Brugia malayi Copine VIII 0.0017 0.0038 0.011
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0179 0.2612
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0017 0.0038 0.0092
Leishmania major hypothetical protein, conserved 0.0017 0.0038 0.1713
Loa Loa (eye worm) hypothetical protein 0.0032 0.0116 0.0343
Brugia malayi NEDD4.2 0.0017 0.0038 0.011
Schistosoma mansoni otoferlin 0.0017 0.0038 0.0092
Schistosoma mansoni hypothetical protein 0.0026 0.0081 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Brugia malayi EGF-like domain containing protein 0.0026 0.0081 0.0234
Toxoplasma gondii P-type ATPase4, putative 0.0017 0.0034 0.0122
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0008 0.0385
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.0059 0.2415
Loa Loa (eye worm) hypothetical protein 0.0126 0.062 0.1835
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0217 0.3387
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0034 0.0404
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0008 0.011
Giardia lamblia High cysteine protein 0.0026 0.0081 0.2678
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0067 0.0303 0.4675
Schistosoma mansoni rabphilin-3a 0.0017 0.0038 0.0092
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0013 0.0016 0.0038
Echinococcus granulosus protein jagged 2 0.0026 0.0081 0.0196
Schistosoma mansoni slit 0.0026 0.0081 0.0196
Brugia malayi C2 domain containing protein 0.0017 0.0038 0.011
Onchocerca volvulus Slit protein homolog 0.0026 0.0081 0.1117
Loa Loa (eye worm) hypothetical protein 0.0134 0.0663 0.1965
Echinococcus multilocularis copine 9 0.0017 0.0038 0.0092
Echinococcus granulosus NEDD4 E3 ubiquitin protein ligase WWP1 0.0017 0.0038 0.0092
Echinococcus granulosus Chromobox protein 3 0.0012 0.0008 0.002
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0091 0.0435 0.1045
Brugia malayi notch-like transmembrane receptor 0.0026 0.0081 0.0234
Plasmodium falciparum calcium-transporting ATPase 0.0025 0.0078 0.3606
Trichomonas vaginalis vab10 spectraplakin, putative 0.0017 0.0038 0.058
Brugia malayi C2 domain containing protein 0.0017 0.0038 0.011
Brugia malayi EGF-like domain containing protein 0.0026 0.0081 0.0234
Trichomonas vaginalis copine, putative 0.0017 0.0038 0.058
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0017 0.0034 0.0122
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0017 0.0034 0.01
Plasmodium falciparum ferlin, putative 0.0017 0.0038 0.1765
Echinococcus multilocularis copine 9 0.0017 0.0038 0.0092
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0067 0.0304 0.1095
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0025
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0368 0.1091
Loa Loa (eye worm) hypothetical protein 0.0134 0.0663 0.1965
Loa Loa (eye worm) CHromoDomain protein family member 0.0012 0.0008 0.0025
Schistosoma mansoni hypothetical protein 0.0026 0.0081 0.0196
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0067 0.0303 0.4733
Schistosoma mansoni DNA polymerase eta 0.0019 0.0045 0.0109
Trichomonas vaginalis synaptotagmin, putative 0.0017 0.0038 0.058
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0034 0.0404
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0025
Echinococcus granulosus chromobox protein 1 0.0073 0.0334 0.0802
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.01
Toxoplasma gondii AGC kinase 0.0129 0.0638 0.2295
Trypanosoma brucei predicted C2 domain protein 0.0017 0.0038 0.058
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0368 0.1057
Brugia malayi Ras association domain family 1 isoform A 0.0091 0.0435 0.1248
Trichomonas vaginalis copine, putative 0.0017 0.0038 0.058
Echinococcus granulosus Diacylglycerol kinase theta 0.0091 0.0435 0.1045
Loa Loa (eye worm) notch protein 0.0026 0.0081 0.0241
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0017 0.0038 0.1713
Schistosoma mansoni notch 0.0026 0.0083 0.0199
Schistosoma mansoni hypothetical protein 0.0017 0.0038 0.0092
Echinococcus multilocularis neurogenic locus protein delta 0.0026 0.0081 0.0196
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0568 0.1681
Brugia malayi p70 ribosomal S6 kinase beta 0.0129 0.0638 0.1831
Brugia malayi calpain 5 0.0017 0.0038 0.011
Trichomonas vaginalis annexin VII, putative 0.0017 0.0038 0.058
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0079 0.1216
Echinococcus multilocularis synaptotagmin 0.0017 0.0038 0.0092
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0013 0.0016 0.0525
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0334 0.0989
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0038 0.058
Onchocerca volvulus Peroxidase homolog 0.0079 0.0368 0.5495
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0129 0.0638 0.1532
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0129 0.0638 0.1532
Echinococcus granulosus UNCoordinated family member unc 13 0.0017 0.0038 0.0092
Schistosoma mansoni hypothetical protein 0.0012 0.0008 0.002
Toxoplasma gondii EGF family domain-containing protein 0.0026 0.0081 0.0293
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0091 0.0435 0.1045
Entamoeba histolytica hypothetical protein 0.0012 0.0008 0.00000000036254
Echinococcus multilocularis synaptotagmin 0.0017 0.0038 0.0092
Entamoeba histolytica hypothetical protein 0.0072 0.0333 0.5162
Echinococcus multilocularis synaptotagmin 0.0017 0.0038 0.0092
Trichomonas vaginalis AGC family protein kinase 0.0129 0.0638 1
Entamoeba histolytica hypothetical protein 0.0091 0.0435 0.6774
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Brugia malayi chromobox protein homolog 3 0.0041 0.0163 0.0467
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0018 0.0039 0.176
Echinococcus multilocularis chromobox protein 1 0.0073 0.0334 0.0802
Schistosoma mansoni cell polarity protein 0.0026 0.0081 0.0196
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0017 0.0034 0.0081
Loa Loa (eye worm) hypothetical protein 0.0263 0.1356 0.4018
Schistosoma mansoni glut4 vesicle protein-related 0.0017 0.0038 0.0092
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0008 0.00000000036254
Entamoeba histolytica DENN domain protein 0.0017 0.0038 0.0476
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0013 0.0016 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0008 0.011
Brugia malayi Heterochromatin protein 1 0.0073 0.0334 0.0958
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0028 0.0096 0.0345
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0045 0.0109
Schistosoma mansoni hypothetical protein 0.0021 0.0059 0.0141
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0109 0.0528 0.1269
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0017 0.0038 0.0092
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Echinococcus multilocularis RNA directed DNA polymerase 0.0549 0.2886 0.6932
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0045 0.0109
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0094 0.045 0.108
Schistosoma mansoni protein kinase C mu 0.0091 0.0435 0.1045
Toxoplasma gondii hypothetical protein 0.0017 0.0038 0.0138
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0017 0.0038 0.0138
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0034 0.0404
Echinococcus multilocularis chromobox protein 1 0.0073 0.0334 0.0802
Echinococcus granulosus protein kinase c eta type 0.0091 0.0435 0.1045
Trichomonas vaginalis AGC family protein kinase 0.0129 0.0638 1
Echinococcus granulosus notch 0.0026 0.0081 0.0196
Schistosoma mansoni peroxidasin 0.0079 0.0368 0.0884
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0028 0.0096 0.4391
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0017 0.0038 0.0092
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0017 0.0034 0.0509
Echinococcus granulosus otoferlin 0.0017 0.0038 0.0092
Schistosoma mansoni serine/threonine protein kinase 0.0787 0.4163 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.0045 0.204
Loa Loa (eye worm) hypothetical protein 0.0091 0.0435 0.1288
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0127 0.0623 0.9765
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0368 0.1057
Brugia malayi C2 domain containing protein 0.0017 0.0038 0.011
Trichomonas vaginalis hypothetical protein 0.0012 0.0008 0.011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Schistosoma mansoni unc-13 (munc13) 0.0109 0.0528 0.1269
Brugia malayi EGF-like domain containing protein 0.0026 0.0081 0.0234
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0174
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0067 0.0303 0.4733
Brugia malayi Synapse defective protein 1 0.0017 0.0038 0.011
Trichomonas vaginalis synaptotagmin, putative 0.0017 0.0038 0.058
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0028 0.0096 0.0231
Entamoeba histolytica protein kinase, putative 0.0129 0.0638 1
Echinococcus granulosus protein jagged 1 0.0026 0.0081 0.0196
Echinococcus granulosus chromobox protein 2 0.0012 0.0008 0.002
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0038 0.058
Trichomonas vaginalis copine, putative 0.0017 0.0038 0.058
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0079 0.0226
Trypanosoma cruzi C2 domain/Ankyrin repeats (3 copies), putative 0.0017 0.0038 0.1713
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0008 0.003
Echinococcus multilocularis serine:threonine protein kinase N2 0.0129 0.0638 0.1532
Loa Loa (eye worm) synaptotagmin-1 0.0017 0.0038 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0163 0.2536
Trypanosoma brucei cAMP binding protein, putative 0.0017 0.0038 0.058
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0691
Leishmania major calcium-transporting ATPase, putative 0.0013 0.0016 0.0678
Onchocerca volvulus 0.0026 0.0081 0.1117
Echinococcus multilocularis neural cadherin 0.0026 0.0081 0.0196
Echinococcus multilocularis Diacylglycerol kinase theta 0.0091 0.0435 0.1045
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0017 0.0038 0.1713
Entamoeba histolytica C2 domain containing protein 0.0017 0.0038 0.0476
Brugia malayi Kringle domain containing protein 0.0021 0.0059 0.0169
Brugia malayi EGF-like domain containing protein 0.0026 0.0081 0.0234
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0045 0.204
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0051 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Schistosoma mansoni hypothetical protein 0.0072 0.0333 0.0801
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Brugia malayi MH2 domain containing protein 0.0116 0.0568 0.1629
Trichomonas vaginalis MYB3r3, putative 0.0067 0.0303 0.4733
Brugia malayi Synaptotagmin I 0.0017 0.0038 0.011
Echinococcus multilocularis serine:threonine protein kinase N2 0.0129 0.0638 0.1532
Trichomonas vaginalis Proline-rich protein, putative 0.0017 0.0038 0.058
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0163 0.2359
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0008 0.0024
Loa Loa (eye worm) E1-E2 ATPase 0.0011 0.0001 0.0004
Schistosoma mansoni synaptotagmin 0.0017 0.0038 0.0092
Onchocerca volvulus 0.0032 0.0116 0.1639
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0008 0.011
Echinococcus granulosus unc 13 munc13 0.0109 0.0528 0.1269
Entamoeba histolytica protein kinase, putative 0.0129 0.0638 1
Trichomonas vaginalis AGC family protein kinase 0.0129 0.0638 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Leishmania major hypothetical protein, conserved 0.0021 0.0059 0.2661
Echinococcus granulosus synaptotagmin protein 4 0.0017 0.0038 0.0092
Echinococcus multilocularis unc 13 (munc13) 0.0109 0.0528 0.1269
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.1091
Echinococcus multilocularis 0.0017 0.0038 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0368 0.1091
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1876 1 0.5
Echinococcus multilocularis notch 0.0026 0.0081 0.0196
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0038 0.1713
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Echinococcus granulosus neurogenic locus protein delta 0.0026 0.0081 0.0196
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.1091
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0067 0.016
Schistosoma mansoni synaptotagmin 12 0.0017 0.0038 0.0092
Loa Loa (eye worm) hypothetical protein 0.0091 0.0435 0.1288
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0008 0.0385
Loa Loa (eye worm) AGC/PKN protein kinase 0.0129 0.0638 0.189
Trichomonas vaginalis AGC family protein kinase 0.0129 0.0638 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0129 0.0638 0.1532
Loa Loa (eye worm) hypothetical protein 0.0028 0.0096 0.0284
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0016 0.0234
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0008 0.0385
Echinococcus multilocularis NEDD4 E3 ubiquitin protein ligase WWP1 0.0017 0.0038 0.0092
Entamoeba histolytica protein kinase, putative 0.002 0.0053 0.0713
Brugia malayi hypothetical protein 0.0072 0.0333 0.0957
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0008 0.003
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0017 0.0034 0.0509
Echinococcus granulosus dna polymerase eta 0.0019 0.0045 0.0109
Echinococcus granulosus peroxidasin 0.0079 0.0368 0.0884
Entamoeba histolytica hypothetical protein, conserved 0.0017 0.0038 0.0476
Trichomonas vaginalis synaptotagmin, putative 0.0017 0.0038 0.058
Loa Loa (eye worm) hypothetical protein 0.0109 0.0528 0.1565
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0017 0.0038 0.0092
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0045 0.204
Plasmodium vivax ferlin, putative 0.0017 0.0038 0.1435
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0569 0.2994 0.887
Toxoplasma gondii C2 domain-containing protein 0.0017 0.0038 0.0138
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.1091
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Loa Loa (eye worm) hypothetical protein 0.0079 0.0368 0.1091
Brugia malayi WW domain containing protein 0.0017 0.0038 0.011
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0787 0.4163 1
Brugia malayi Protein kinase domain containing protein 0.0129 0.0638 0.1831
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0034 0.0509
Echinococcus granulosus NDR protein kinase 0.0129 0.0638 0.1532
Loa Loa (eye worm) hypothetical protein 0.0091 0.0435 0.1288
Onchocerca volvulus Multiple C2 domain and transmembrane region protein homolog 0.0017 0.0038 0.0457
Echinococcus granulosus geminin 0.0341 0.1775 0.4265
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Trypanosoma brucei rac serine-threonine kinase, putative 0.0129 0.0638 1
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0038 0.1435
Loa Loa (eye worm) hypothetical protein 0.0091 0.0435 0.1288
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0013 0.0016 0.0038
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0045 0.0056
Schistosoma mansoni synaptotagmin 0.0017 0.0038 0.0092
Echinococcus granulosus protein kinase C gamma type 0.0695 0.3672 0.8823
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0014 0.02
Echinococcus granulosus chromobox protein 1 0.0073 0.0334 0.0802
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1876 1 1
Brugia malayi Pleckstrin Homology Domain 0.0091 0.0435 0.1248
Echinococcus multilocularis protein jagged 1 0.0026 0.0081 0.0196
Trichomonas vaginalis C-MYB, putative 0.0067 0.0303 0.4733
Leishmania major c2 domain protein, putative 0.0017 0.0038 0.1713
Toxoplasma gondii kringle domain-containing protein 0.0021 0.0059 0.0211
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0217 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Brugia malayi Calcium binding EGF domain containing protein 0.0026 0.0081 0.0234
Onchocerca volvulus 0.0079 0.0368 0.5495
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0035 0.1293
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0241
Echinococcus multilocularis N chimaerin 0.0091 0.0435 0.1045
Brugia malayi hypothetical protein 0.0051 0.0217 0.0623
Echinococcus granulosus copine 9 0.0017 0.0038 0.0092
Loa Loa (eye worm) Notch2 0.0026 0.0081 0.0241
Echinococcus granulosus calpain 5 0.0017 0.0038 0.0092
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0013 0.0016 0.0057
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0029
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0067 0.0303 0.4675
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0008 0.002
Schistosoma mansoni hypothetical protein 0.0026 0.0081 0.0196
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0094 0.045 0.1332
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Echinococcus granulosus synaptotagmin 0.0017 0.0038 0.0092
Brugia malayi diacylglycerol kinase 0.0091 0.0435 0.1248
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0038 0.1713
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0013 0.0016 0.0525
Leishmania major DNA polymerase eta, putative 0.0019 0.0045 0.204
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.1222 0.2935
Echinococcus granulosus protein jagged 1 0.0026 0.0081 0.0196
Echinococcus granulosus synaptotagmin 0.0017 0.0038 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0038 0.058
Schistosoma mansoni diacylglycerol kinase theta 0.0091 0.0435 0.1045
Echinococcus multilocularis neurogenic locus notch protein 4 0.0026 0.0081 0.0196
Trichomonas vaginalis AGC family protein kinase 0.0129 0.0638 1
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0025 0.0078 0.0188
Brugia malayi Variant SH3 domain containing protein 0.0091 0.0435 0.1248
Loa Loa (eye worm) C2 domain-containing protein 0.0017 0.0038 0.0113
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0045 0.0056
Echinococcus granulosus raf serine:threonine protein kinase 0.0091 0.0435 0.1045
Brugia malayi Synaptotagmin protein 3 0.0017 0.0038 0.011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0113
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0017 0.0038 0.058
Brugia malayi hypothetical protein 0.0079 0.0368 0.1057
Echinococcus multilocularis protein kinase c iota type 0.0221 0.1128 0.271
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0038 0.1713
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0099 0.1536
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0067 0.0304 0.476
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0008 0.003
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0368 0.1091
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0163 0.2536
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0238 0.1222 0.3619
Echinococcus granulosus calcium transporting atpase 0.0025 0.0078 0.0188
Trypanosoma brucei C2 domain/Ankyrin repeats (3 copies), putative 0.0017 0.0038 0.058
Trypanosoma cruzi Coiled-coil and C2 domain-containing protein 0.0017 0.0038 0.1713

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.03 uM Inhibition constant against human thrombin ChEMBL. 9154975
Ki (binding) = 0.03 uM Inhibition constant against human thrombin ChEMBL. 9154975

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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