Detailed information for compound 56075

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 360.361 | Formula: C18H20N2O6
  • H donors: 1 H acceptors: 4 LogP: 2.21 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCO/C(=C/1\C(=NC(=C(C1c1ccc(cc1)[N+](=O)[O-])C(=O)OC)C)C)/O
  • InChi: 1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-6-8-13(9-7-12)20(23)24/h6-9,16,22H,5H2,1-4H3/b18-15+
  • InChiKey: APUDCNQYHMVMEC-OBGWFSINSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A3 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.0591 0.0777
Echinococcus granulosus peroxidasin 0.0193 0.0949 0.2914
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0062 0.0154
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0038 0.0117
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.004 0.1359
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.002
Brugia malayi hypothetical protein 0.0011 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.013 0.0322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0026 0.0871
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0006 0.0202
Brugia malayi EGF-like domain containing protein 0.0062 0.0272 0.0835
Leishmania major DNA polymerase eta, putative 0.0066 0.0292 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.0526 0.0687
Echinococcus granulosus Chromo domain 0.0011 0.0006 0.0019
Schistosoma mansoni peroxidasin 0.0193 0.0949 0.2914
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.0526 0.0687
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.004 0.1365
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0036 0.0116
Brugia malayi nuclear receptor NHR-88 0.0011 0.0007 0.002
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1943 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0023 0.078
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0026 0.0871
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0299 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Onchocerca volvulus 0.003 0.0103 0.1025
Brugia malayi CXXC zinc finger family protein 0.0032 0.0113 0.0348
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0149 0.5115
Brugia malayi Animal haem peroxidase family protein 0.0193 0.0949 0.2914
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0006 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Plasmodium vivax glutathione reductase, putative 0.0049 0.0202 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0155 0.5229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0097 0.323
Echinococcus multilocularis neurogenic locus protein delta 0.0062 0.0272 0.0675
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0056 0.1924
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0062 0.0272 0.0835
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0258 0.0641
Brugia malayi Protein kinase domain containing protein 0.0204 0.1005 0.3088
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0036 0.1625
Plasmodium vivax DNA repair protein REV1, putative 0.0012 0.0013 0.043
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0097 0.323
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.002
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0155 0.0477
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0007 0.002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.004 0.0122
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.0037 0.0142 0.0435
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0155 0.0477
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0155 0.5229
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0062 0.0191
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0062 0.0272 0.0835
Brugia malayi GCC2 and GCC3 family protein 0.0062 0.0272 0.0835
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.004 0.0962
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0036 0.1069
Schistosoma mansoni zinc finger protein 0.0015 0.0026 0.0079
Brugia malayi Animal haem peroxidase family protein 0.0193 0.0949 0.2914
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0202 1
Brugia malayi steroid hormone receptor 0.0011 0.0007 0.002
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.002
Schistosoma mansoni hypothetical protein 0.0062 0.0272 0.0835
Loa Loa (eye worm) hypothetical protein 0.0193 0.0949 0.2914
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0036 0.0112
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0011 0.0006 0.0005
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0155 0.0386
Onchocerca volvulus Neurogenic locus notch homolog 0.0062 0.0272 0.2819
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0006 0.0019
Plasmodium falciparum DNA repair protein REV1, putative 0.0012 0.0013 0.0347
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.013 0.0398
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0074 0.2371
Echinococcus granulosus epidermal growth factor receptor 0.0343 0.1725 0.53
Echinococcus granulosus chromobox protein 2 0.0011 0.0006 0.0019
Onchocerca volvulus 0.0193 0.0949 1
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0007 0.002
Schistosoma mansoni hypothetical protein 0.0453 0.2291 0.7037
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.0526 0.0687
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0006 0.0019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0036 0.1249
Trichomonas vaginalis MYB72, putative 0.0029 0.0097 0.323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Trichomonas vaginalis C-MYB, putative 0.0029 0.0097 0.323
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0007 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0036 0.1249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0091 0.2986
Toxoplasma gondii thioredoxin reductase 0.0049 0.0202 0.0711
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Loa Loa (eye worm) TK/EGFR protein kinase 0.0639 0.3256 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Onchocerca volvulus 0.0062 0.0272 0.2819
Brugia malayi Calcium binding EGF domain containing protein 0.0062 0.0272 0.0835
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0155 0.5325
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0043 0.1448
Mycobacterium tuberculosis Probable reductase 0.0112 0.0526 0.0687
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0155 0.5229
Echinococcus multilocularis fibropellin Ia 0.0062 0.0272 0.0675
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.004 0.0122
Brugia malayi Bromodomain containing protein 0.0037 0.0141 0.0434
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0062 0.2079
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.004 0.1359
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0129 0.0398
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0036 0.0024
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0006 0.039
Trypanosoma brucei unspecified product 0.0028 0.0091 0.2986
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0029 0.0097 0.6218
Schistosoma mansoni tyrosine kinase 0.034 0.1707 0.5242
Loa Loa (eye worm) TK/INSR protein kinase 0.0204 0.1005 0.3088
Brugia malayi polk-prov protein 0.0012 0.0013 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0155 0.5229
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0029 0.0097 0.6218
Trichomonas vaginalis pc-MYB2, putative 0.0029 0.0097 0.323
Brugia malayi Calcium binding EGF domain containing protein 0.0062 0.0272 0.0835
Loa Loa (eye worm) hypothetical protein 0.0193 0.0949 0.2914
Brugia malayi SET domain containing protein 0.0012 0.001 0.003
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0007 0.0421
Onchocerca volvulus 0.0193 0.0949 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.001 0.003
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0013 0.0031
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0007 0.0008
Trypanosoma brucei unspecified product 0.0028 0.0091 0.2986
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0036 0.1069
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0036 0.0024
Echinococcus multilocularis notch 0.0062 0.0272 0.0675
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.002
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0074 0.0183
Schistosoma mansoni hypothetical protein 0.0062 0.0272 0.0835
Schistosoma mansoni hypothetical protein 0.002 0.0052 0.0161
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0036 0.1249
Schistosoma mansoni chromobox protein 0.0011 0.0006 0.0019
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0013 0.0039
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0062 0.1905
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0038 0.0115
Schistosoma mansoni notch 0.0062 0.0272 0.0835
Trichomonas vaginalis C-MYB, putative 0.0029 0.0097 0.323
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0155 0.5325
Leishmania major trypanothione reductase 0.0049 0.0202 0.6778
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0007 0.002
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0097 0.323
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0007 0.002
Echinococcus granulosus insulin receptor 0.0204 0.1005 0.3088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0019
Loa Loa (eye worm) RecQ helicase 0.0022 0.0062 0.0191
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0036 0.0846
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0179 0.0549
Schistosoma mansoni zinc finger protein 0.0021 0.0057 0.0174
Leishmania major hypothetical protein, conserved 0.0015 0.0026 0.0459
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0006 0.0202
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0025 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0145 0.4852
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0036 0.1249
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0071 0.022
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0036 0.1625
Toxoplasma gondii EGF family domain-containing protein 0.0062 0.0272 0.0963
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0013 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0006 0.0202
Onchocerca volvulus 0.0032 0.0113 0.1136
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0193 0.0949 0.2914
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.004 0.1182
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.004 0.0968
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0007 0.002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0036 0.1069
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0062 0.1769
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0006 0.0006
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0007 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0043 0.1448
Echinococcus multilocularis neurogenic locus notch protein 0.0062 0.0272 0.0675
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0004 0.0279
Echinococcus granulosus protein jagged 2 0.0062 0.0272 0.0835
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0145 0.1475
Brugia malayi Cadherin domain containing protein 0.0062 0.0272 0.0835
Trichomonas vaginalis hypothetical protein 0.0011 0.0006 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0062 0.4003
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0074 0.0249
Schistosoma mansoni hypothetical protein 0.0175 0.0856 0.2629
Trypanosoma cruzi ISWI complex protein 0.0015 0.0026 0.0879
Echinococcus granulosus fibropellin Ia 0.0062 0.0272 0.0835
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0097 0.3253
Onchocerca volvulus Peroxidase homolog 0.0193 0.0949 1
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0029 0.0097 0.0335
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0091 0.2986
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0155 0.5229
Onchocerca volvulus Slit protein homolog 0.0062 0.0272 0.2819
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0074 0.0226
Entamoeba histolytica hypothetical protein 0.0035 0.013 0.8346
Schistosoma mansoni chromobox protein 0.0068 0.0299 0.0919
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0006 0.0196
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0025 0.0062
Echinococcus multilocularis chromobox protein 1 0.0068 0.0299 0.0743
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0036 0.0846
Brugia malayi Furin-like cysteine rich region family protein 0.0639 0.3256 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0019
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0013 0.0244
Schistosoma mansoni chromobox protein 0.0011 0.0006 0.0019
Loa Loa (eye worm) Notch2 0.0062 0.0272 0.0835
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0009 0.0026
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Schistosoma mansoni DNA helicase recq1 0.0022 0.0062 0.0191
Schistosoma mansoni hypothetical protein 0.0062 0.0272 0.0835
Schistosoma mansoni cpg binding protein 0.0035 0.0132 0.0406
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0062 0.0191
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0179 0.0444
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.003 0.0103 0.0315
Brugia malayi EGF-like domain containing protein 0.0062 0.0272 0.0835
Echinococcus multilocularis 0.0198 0.0972 0.2414
Onchocerca volvulus 0.0012 0.001 0.0038
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0006 0.0019
Echinococcus granulosus chromobox protein 1 0.0068 0.0299 0.0919
Echinococcus multilocularis fat cadherin tumor suppressor 0.0062 0.0272 0.0675
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.016 0.1633
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0097 0.323
Schistosoma mansoni peroxidasin 0.0193 0.0949 0.2914
Brugia malayi ImpB/MucB/SamB family protein 0.0066 0.0292 0.0896
Leishmania major DNA polymerase eta, putative 0.0039 0.0149 0.489
Brugia malayi CHD4 protein 0.0015 0.0025 0.0077
Echinococcus granulosus neurogenic locus notch protein 0.0062 0.0272 0.0835
Schistosoma mansoni notch 0.0062 0.0272 0.0835
Schistosoma mansoni hypothetical protein 0.0062 0.0272 0.0835
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0145 0.4852
Trypanosoma brucei ISWI complex protein 0.0015 0.0026 0.0692
Brugia malayi EGF-like domain containing protein 0.0062 0.0272 0.0835
Echinococcus granulosus cpg binding protein 0.0035 0.0132 0.0406
Echinococcus multilocularis chromobox protein 1 0.0068 0.0299 0.0743
Echinococcus multilocularis protein jagged 1 0.0062 0.0272 0.0675
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0155 0.5229
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0179 0.0549
Schistosoma mansoni hypothetical protein 0.0175 0.0856 0.2629
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0062 0.0208
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0007 0.002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0007 0.0016
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0202 0.0501
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0013 0.0244
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0043 0.1448
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0036 0.1069
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0548 0.2782 0.2773
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.004 0.1182
Brugia malayi hypothetical protein 0.0193 0.0949 0.2914
Schistosoma mansoni cell polarity protein 0.0062 0.0272 0.0835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0062 0.197
Schistosoma mansoni notch 0.0062 0.0272 0.0835
Loa Loa (eye worm) animal heme peroxidase 0.0193 0.0949 0.2914
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0071 0.022
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.004 0.0122
Echinococcus multilocularis insulin receptor 0.0204 0.1005 0.2496
Onchocerca volvulus Peroxidasin homolog 0.0193 0.0949 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0013 0.0031
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0062 0.0154
Schistosoma mansoni septate junction protein 0.0062 0.0272 0.0835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Echinococcus granulosus protein jagged 2 0.0062 0.0272 0.0835
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.004 0.0098
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0043 0.1448
Entamoeba histolytica hypothetical protein 0.0024 0.0074 0.474
Onchocerca volvulus 0.0193 0.0949 1
Brugia malayi Delta serrate ligand family protein 0.0062 0.0272 0.0835
Trichomonas vaginalis pc-MYB2, putative 0.0029 0.0097 0.323
Brugia malayi glutathione reductase 0.0049 0.0202 0.062
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1395 0.7166 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0007 0.0224
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0155 0.5325
Loa Loa (eye worm) hypothetical protein 0.0066 0.0292 0.0896
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0074 0.0226
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0029 0.0097 0.6218
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Onchocerca volvulus 0.0062 0.0272 0.2819
Brugia malayi Animal haem peroxidase family protein 0.0193 0.0949 0.2914
Echinococcus multilocularis zinc finger protein 0.0021 0.0057 0.014
Entamoeba histolytica hypothetical protein 0.0011 0.0006 0.039
Loa Loa (eye worm) hypothetical protein 0.0193 0.0949 0.2914
Echinococcus multilocularis geminin 0.0175 0.0856 0.2125
Echinococcus multilocularis cpg binding protein 0.0035 0.0132 0.0328
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0155 0.5229
Onchocerca volvulus Putative cubilin 0.0062 0.0272 0.2819
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.004 0.0962
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0062 0.2866
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0006 0.0202
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0204 0.1005 0.3088
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0036 0.0112
Schistosoma mansoni slit 0.0062 0.0272 0.0835
Echinococcus multilocularis Chromo domain 0.0011 0.0006 0.0015
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0062 0.2079
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0062 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0006 0.0202
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0343 0.1725 0.53
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0034 0.0106
Loa Loa (eye worm) hypothetical protein 0.0193 0.0949 0.2914
Entamoeba histolytica hypothetical protein 0.0035 0.013 0.8346
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0548 0.2782 0.3398
Trypanosoma cruzi DNA polymerase eta, putative 0.0066 0.0292 1
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0202 0.6919
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.004 0.2553
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0007 0.002
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0025 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0007 0.002
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0013 0.004
Trypanosoma cruzi ISWI complex protein 0.0015 0.0026 0.0879
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.002
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.004 0.1182
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0007 0.002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0179 0.0549
Giardia lamblia High cysteine protein 0.0062 0.0272 1
Brugia malayi notch-like transmembrane receptor 0.0062 0.0272 0.0835
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0007 0.0016
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0007 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0013 0.0244
Onchocerca volvulus Peroxidasin homolog 0.0193 0.0949 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0179 0.0444
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0007 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0036 0.1249
Schistosoma mansoni tyrosine kinase 0.0343 0.1725 0.53
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0006 0.039
Brugia malayi Muscle positioning protein 4 0.0062 0.0272 0.0835
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0007 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0007 0.002
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0013 0.0244
Brugia malayi MH2 domain containing protein 0.0124 0.0588 0.1806
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0548 0.2782 0.2756
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0036 0.1249
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0036 0.1218
Echinococcus multilocularis epidermal growth factor receptor 0.0343 0.1725 0.4284
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Schistosoma mansoni cpg binding protein 0.0035 0.0132 0.0406
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0179 0.0549
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.004 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0155 0.5229
Echinococcus granulosus dnaJ subfamily B 0.0453 0.2291 0.7037
Schistosoma mansoni chromobox protein 0.0068 0.0299 0.0919
Echinococcus granulosus neural cadherin 0.0062 0.0272 0.0835
Loa Loa (eye worm) hypothetical protein 0.0193 0.0949 0.2914
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0155 0.0143
Echinococcus granulosus slit 2 protein 0.0062 0.0272 0.0835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0155 0.0477
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0006 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0006 0.0202
Onchocerca volvulus Dual oxidase homolog 0.0193 0.0949 1
Schistosoma mansoni notch 0.0062 0.0272 0.0835
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0007 0.002
Brugia malayi Heterochromatin protein 1 0.0068 0.0299 0.0919
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.004 0.0962
Brugia malayi Blistered cuticle protein 3 0.0193 0.0949 0.2914
Giardia lamblia GTOR 0.0018 0.004 0.1036
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0006 0.0019
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0097 0.323
Loa Loa (eye worm) hypothetical protein 0.0193 0.0949 0.2914
Brugia malayi EGF-like domain containing protein 0.0062 0.0272 0.0835
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0029 0.0097 0.6218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.002
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.004 0.0122
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0043 0.1448
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.004 0.1359
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0036 0.0024
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.004 0.1182
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0007 0.0016
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0006 0.0006
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0548 0.2782 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0155 0.5229
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0036 0.1551
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0006 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0013 0.0244
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.004 0.0962
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1943 1 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0062 0.2131
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.0591 0.0777
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0299 1
Trypanosoma brucei trypanothione reductase 0.0049 0.0202 0.6856
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0007 0.002
Plasmodium falciparum glutathione reductase 0.0017 0.0036 0.1551
Schistosoma mansoni cpg binding protein 0.0032 0.0113 0.0348
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0034 0.0106
Loa Loa (eye worm) hypothetical protein 0.0193 0.0949 0.2914
Schistosoma mansoni tyrosine kinase 0.034 0.1707 0.5242
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0006 0.0202
Loa Loa (eye worm) animal heme peroxidase 0.0193 0.0949 0.2914
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Brugia malayi chromobox protein homolog 3 0.0038 0.0145 0.0446
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0007 0.002
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0062 0.0191
Trichomonas vaginalis MYB, putative 0.0029 0.0097 0.3253
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0007 0.0005
Leishmania major DNA polymerase kappa, putative 0.004 0.0155 0.511
Schistosoma mansoni bromodomain containing protein 0.0063 0.0276 0.0849
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0155 0.5229
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0258 0.0794
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0004 0.0013
Brugia malayi EGF-like domain containing protein 0.0062 0.0272 0.0835
Brugia malayi hypothetical protein 0.0035 0.013 0.0398
Loa Loa (eye worm) helicase 0.0011 0.0006 0.0019
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0202 0.062
Echinococcus multilocularis dna polymerase eta 0.0066 0.0292 0.0724
Onchocerca volvulus Chorion peroxidase homolog 0.0193 0.0949 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.004 0.1359
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.002
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1395 0.7166 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0155 0.5325
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0155 0.0167
Loa Loa (eye worm) hypothetical protein 0.0022 0.0062 0.0191
Entamoeba histolytica hypothetical protein 0.0011 0.0006 0.039
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0013 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0006 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0007 0.002
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0155 0.5194
Brugia malayi Calcium binding EGF domain containing protein 0.0062 0.0272 0.0835
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0029 0.0097 0.6218
Echinococcus multilocularis dnaJ subfamily B 0.0453 0.2291 0.5688
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0272 0.0964
Trichomonas vaginalis MYB3r3, putative 0.0029 0.0097 0.323
Echinococcus granulosus dna polymerase eta 0.0066 0.0292 0.0896
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0006 0.0015
Schistosoma mansoni tyrosine kinase 0.0639 0.3256 1
Echinococcus multilocularis protein jagged 2 0.0062 0.0272 0.0675
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0113 0.0348
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0007 0.002
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0036 0.1551
Giardia lamblia Myb 1-like protein 0.0029 0.0097 0.3261
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0007 0.0016
Echinococcus multilocularis neurogenic locus notch protein 0.0062 0.0272 0.0675
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0007 0.002
Loa Loa (eye worm) animal heme peroxidase 0.0193 0.0949 0.2914
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0062 0.0191
Echinococcus granulosus neurogenic locus protein delta 0.0062 0.0272 0.0835
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0018
Schistosoma mansoni coup transcription factor 0.0011 0.0007 0.002
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.0006 0.0202
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0013 0.044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0019
Entamoeba histolytica hypothetical protein 0.0035 0.013 0.8346
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0129 0.0321
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0155 0.5229
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.004 0.0122
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0074 0.0226
Loa Loa (eye worm) hypothetical protein 0.0193 0.0949 0.2914
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0038 0.0117
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0007 0.002
Echinococcus granulosus bloom syndrome protein 0.0022 0.0062 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0007 0.0016
Echinococcus multilocularis dna polymerase kappa 0.004 0.0155 0.0386
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0036 0.0911
Schistosoma mansoni hypothetical protein 0.0062 0.0272 0.0835
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.004 0.0098
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0117
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.002
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0155 1
Onchocerca volvulus Peroxidase homolog 0.0193 0.0949 1
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0062 0.0154
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0007 0.0016
Entamoeba histolytica hypothetical protein 0.0035 0.013 0.8346
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.0591 0.0777
Schistosoma mansoni tyrosine kinase 0.0343 0.1725 0.53
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0155 0.0477
Brugia malayi Peroxidasin 0.0193 0.0949 0.2914
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0039 0.0149 0.0522
Echinococcus multilocularis protein jagged 1 0.0062 0.0272 0.0675
Brugia malayi Bromodomain containing protein 0.0075 0.0335 0.103
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0036 0.0116
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0013 0.0244
Loa Loa (eye worm) hypothetical protein 0.0193 0.0949 0.2914
Onchocerca volvulus 0.0011 0.0007 0.0005
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0202 0.0232
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.0526 0.0687
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0071 0.0177
Echinococcus granulosus neurogenic locus notch protein 0.0062 0.0272 0.0835
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0006 0.0202
Brugia malayi nuclear hormone receptor 0.0011 0.0007 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0091 0.2986
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0006 0.0202
Onchocerca volvulus 0.0062 0.0272 0.2819
Trypanosoma brucei unspecified product 0.004 0.0155 0.5229
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0006 0.0019
Schistosoma mansoni laminin gamma-3 chain 0.0062 0.0272 0.0835
Brugia malayi Thioredoxin reductase 0.0049 0.0202 0.062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0179 0.0549
Trypanosoma brucei DNA polymerase eta, putative 0.0066 0.0292 1
Schistosoma mansoni hypothetical protein 0.0015 0.0026 0.0079
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0007 0.002
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.004 0.1182
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0007 0.0111
Entamoeba histolytica hypothetical protein 0.0011 0.0006 0.039
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0155 0.5229
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0007 0.0005
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0007 0.0224
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.002
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0036 0.0846
Echinococcus granulosus protein jagged 1 0.0062 0.0272 0.0835
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0062 0.0191
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0006 0.0202
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0006 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0013 0.044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0007 0.002
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0155 0.0143
Schistosoma mansoni hypothetical protein 0.0062 0.0272 0.0835
Echinococcus granulosus delta-like protein 1 0.0062 0.0272 0.0835
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Brugia malayi Animal haem peroxidase family protein 0.0193 0.0949 0.2914
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0007 0.002
Schistosoma mansoni tyrosine kinase 0.0204 0.1005 0.3088
Schistosoma mansoni DNA helicase recq5 0.0022 0.0062 0.0191
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0019
Echinococcus granulosus epidermal growth factor receptor 0.0639 0.3256 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0036 0.1249
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0006 0.0087
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.004 0.1359
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0172
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0298 0.0914
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.002
Plasmodium falciparum thioredoxin reductase 0.0049 0.0202 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.004 0.0122
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0007 0.002
Brugia malayi Animal haem peroxidase family protein 0.0193 0.0949 0.2914
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0006 0.0006
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0006 0.039
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0007 0.002
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0043 0.1448
Brugia malayi EGF-like domain containing protein 0.0062 0.0272 0.0835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Schistosoma mansoni notch 0.0062 0.0272 0.0835
Loa Loa (eye worm) hypothetical protein 0.0193 0.0949 0.2914
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0088 0.2934
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0006 0.0087
Echinococcus granulosus zinc finger protein 0.0021 0.0057 0.0174
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0204 0.1005 0.2496
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.004 0.0127
Schistosoma mansoni tyrosine kinase 0.0204 0.1005 0.3088
Loa Loa (eye worm) hypothetical protein 0.0193 0.0949 0.2914
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0062 0.0191
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0179 0.0549
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0036 0.0846
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0007 0.002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0179 0.0549
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0007 0.002
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0007 0.002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0193 0.0949 0.2914
Echinococcus granulosus chromobox protein 1 0.0068 0.0299 0.0919
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0019
Echinococcus granulosus Chromobox protein 3 0.0011 0.0006 0.0019
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0069 0.0304 0.0935
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0007 0.002
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0155 0.5229
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0038 0.0117
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0036 0.009
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0007 0.0016
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0013 0.044
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0006 0.0202
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0155 0.5194
Onchocerca volvulus 0.0062 0.0272 0.2819
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0006 0.0202
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.013 0.0398
Loa Loa (eye worm) hypothetical protein 0.004 0.0154 0.0472
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0299 0.0919
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0043 0.1448
Schistosoma mansoni hypothetical protein 0.0035 0.013 0.0398
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0155 0.511
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0036 0.0112
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0006 0.0000000023897
Echinococcus multilocularis epidermal growth factor receptor 0.0639 0.3256 0.8084
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.002
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0007 0.002
Loa Loa (eye worm) animal heme peroxidase 0.0193 0.0949 0.2914
Echinococcus multilocularis chromobox protein 2 0.0011 0.0006 0.0015
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.0588 0.1806
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0036 0.1249
Loa Loa (eye worm) glutathione reductase 0.0049 0.0202 0.062
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.004 0.0122
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0025 0.0077
Echinococcus granulosus geminin 0.0175 0.0856 0.2629
Brugia malayi Protein cec-1. 0.0011 0.0006 0.0019
Brugia malayi EGF-like domain containing protein 0.0062 0.0272 0.0835
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Trichomonas vaginalis chromobox protein, putative 0.0041 0.016 0.535
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0007 0.0016
Echinococcus multilocularis neurogenic locus notch protein 4 0.0062 0.0272 0.0675
Giardia lamblia DINP protein human, muc B family 0.004 0.0155 0.5503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0074 0.2462
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1943 1 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.004 0.0962
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0062 0.2866
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0019
Schistosoma mansoni notch 0.0062 0.0272 0.0835
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0062 0.0272 0.2819
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0036 0.1218
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.0588 0.1806
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0088 0.2934
Loa Loa (eye worm) hypothetical protein 0.0038 0.0145 0.0446
Echinococcus multilocularis peroxidasin 0.0193 0.0949 0.2356
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0062 0.2079
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0013 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Echinococcus granulosus notch 0.0062 0.0272 0.0835
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0038 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0173 0.053
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.002
Echinococcus multilocularis slit 2 protein 0.0062 0.0272 0.0675
Brugia malayi PHD-finger family protein 0.0026 0.0083 0.0256
Echinococcus multilocularis neurogenic locus protein delta 0.0062 0.0272 0.0675
Schistosoma mansoni DNA polymerase eta 0.0066 0.0292 0.0896
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0034 0.0106
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0036 0.1249
Echinococcus multilocularis neural cadherin 0.0062 0.0272 0.0675
Echinococcus granulosus dna polymerase kappa 0.004 0.0155 0.0477
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.004 0.1326
Plasmodium falciparum thioredoxin reductase 0.0017 0.0036 0.1551
Brugia malayi ecdysteroid receptor 0.0011 0.0007 0.002
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0006 0.0015
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.4027 1
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0052 0.0161
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0155 0.0167
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0007 0.002
Loa Loa (eye worm) blistered cuticle protein 3 0.0193 0.0949 0.2914
Loa Loa (eye worm) notch protein 0.0062 0.0272 0.0835
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0074 0.2524
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.0526 0.0687
Plasmodium falciparum glutathione reductase 0.0049 0.0202 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0007 0.002
Schistosoma mansoni tyrosine kinase 0.034 0.1707 0.5242
Schistosoma mansoni hypothetical protein 0.0062 0.0272 0.0835
Echinococcus granulosus protein jagged 1 0.0062 0.0272 0.0835
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0034 0.0086
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0097 0.323
Trichomonas vaginalis chromobox protein, putative 0.0041 0.016 0.535
Onchocerca volvulus 0.0062 0.0272 0.2819
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.004 0.2553
Brugia malayi Cadherin domain containing protein 0.0062 0.0272 0.0835
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0202 0.062
Treponema pallidum NADH oxidase 0.0017 0.0036 0.003
Loa Loa (eye worm) hypothetical protein 0.0193 0.0949 0.2914
Loa Loa (eye worm) hypothetical protein 0.0062 0.0272 0.0835
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0006 0.0087
Echinococcus granulosus neurogenic locus notch protein 4 0.0062 0.0272 0.0835
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0043 0.1448
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.0591 0.0097
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0097 0.3253
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0007 0.002
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0155 0.0477

Activities

Activity type Activity value Assay description Source Reference
clogP = 2.61 Calculated partition coefficient (clogP) (PALLAS) ChEMBL. 9154974
I (functional) = 85.8 % Inhibitory effect on L-tri-iodothyronine (L-T3) uptake by human HepG2 hepatoma cells at an application dose 10E-5 M ChEMBL. 9154974
I (functional) = 85.8 % Inhibitory effect on L-tri-iodothyronine (L-T3) uptake by human HepG2 hepatoma cells at an application dose 10E-5 M ChEMBL. 9154974
Inhibition (binding) = 37 % Displacement of [3H]-(R)-PIA binding to Adenosine A1 receptor in rat brain membranes ChEMBL. 8709132
Inhibition (binding) = 37 % Displacement of [3H]-(R)-PIA binding to Adenosine A1 receptor in rat brain membranes ChEMBL. 8709132
Ki (binding) = 5.9 uM Displacement of [125]AB-MECA binding to human Adenosine A3 receptor expressed in HEK cells ChEMBL. 8709132
Ki (binding) = 5.9 uM Displacement of [125]AB-MECA binding to human Adenosine A3 receptor expressed in HEK cells ChEMBL. 8709132
Ki (binding) = 35.6 uM Displacement of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal membranes ChEMBL. 8709132
Ki (binding) = 35.6 uM Displacement of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal membranes ChEMBL. 8709132
logP (ADMET) = 3.6 Partition coefficient (logP) ChEMBL. 9154974

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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