Detailed information for compound 560774

Basic information

Technical information
  • TDR Targets ID: 560774
  • Name: 2-bromo-5-[(E)-2-bromo-2-nitro-vinyl]furan
  • MW: 296.901 | Formula: C6H3Br2NO3
  • H donors: 0 H acceptors: 2 LogP: 3.2 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)/C(=C/c1ccc(o1)Br)/Br
  • InChi: 1S/C6H3Br2NO3/c7-5(9(10)11)3-4-1-2-6(8)12-4/h1-3H/b5-3-
  • InChiKey: MJPPGVVIDGQOQT-HYXAFXHYSA-N  

Network

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Synonyms

  • 2-bromo-5-[(E)-2-bromo-2-nitrovinyl]furan
  • 2-bromo-5-[(E)-2-bromo-2-nitro-ethenyl]furan
  • 2-bromo-5-[(E)-2-bromo-2-nitroethenyl]furan
  • 1-(5-bromofur-2-il)-2-bromo-2-nitroethene
  • 35950-55-1
  • 2-Bromo-S-(2-bromo-5-nitroethenyl)furan
  • Furan, 2-bromo-5-(2-bromo-2-nitroethenyl)-
  • Furan, 2-bromo-S-(2-bromo-5-nitroethenyl)-
  • AIDS-110348
  • AIDS110348

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0052 0.0128
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1126 0.1326
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0323 0.4037 0.8036
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0052 0.0121
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0085 0.0073
Leishmania major pyruvate kinase 0.0036 0.0226 0.0238
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0333 0.0663
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0056 0.0491 0.0656
Brugia malayi hypothetical protein 0.0044 0.0333 0.0779
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0218 0.2643 0.3753
Loa Loa (eye worm) hypothetical protein 0.0033 0.0188 0.0268
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0026 0.0037
Brugia malayi serine/threonine-protein kinase plk-2 0.0209 0.2524 0.59
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0316 0.394 0.5534
Trypanosoma cruzi phosphomannose isomerase, putative 0.0112 0.1233 0.1746
Echinococcus granulosus jumonji domain containing 1A 0.0056 0.0491 0.0977
Loa Loa (eye worm) hypothetical protein 0.0041 0.0297 0.0425
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Onchocerca volvulus 0.0027 0.0116 0.021
Plasmodium vivax SET domain protein, putative 0.0032 0.0177 0.1259
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.1278 0.1785
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0054 0.0473 0.0429
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0112 0.1233 0.1455
Brugia malayi chromobox protein homolog 3 0.0042 0.0307 0.0717
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0312 0.3885 0.7732
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0052 0.0074
Loa Loa (eye worm) hypothetical protein 0.0036 0.0226 0.0324
Chlamydia trachomatis pyruvate kinase 0.0036 0.0226 0.0202
Leishmania major hypothetical protein, conserved 0.0471 0.5991 1
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0026 0.0061
Plasmodium falciparum phd finger protein, putative 0.0065 0.061 0.4844
Loa Loa (eye worm) RGS-3 protein 0.002 0.0026 0.0037
Loa Loa (eye worm) hypothetical protein 0.0546 0.6986 1
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0052 0.0074
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0026 0.0052
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0417 0.0831
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0026 0.0052
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Brugia malayi jmjC domain containing protein 0.0056 0.0491 0.1147
Brugia malayi Cytochrome P450 family protein 0.0052 0.0443 0.1035
Echinococcus granulosus peregrin 0.0075 0.0747 0.1488
Loa Loa (eye worm) bromodomain containing protein 0.0027 0.0109 0.0156
Schistosoma mansoni hypothetical protein 0.0021 0.0035 0.0086
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0035 0.0082
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0739 0.0859
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0417 0.1034
Brugia malayi jmjC domain containing protein 0.021 0.2541 0.5939
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.1278 0.1785
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0556 0.7112 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0085 0.0504
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0054 0.0473 0.0657
Toxoplasma gondii thioredoxin reductase 0.005 0.0423 0.0558
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0303 0.0333
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0052 0.0103
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0052 0.0128
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0546 0.6986 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0065 0.061 0.1214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0035 0.0087
Loa Loa (eye worm) hypothetical protein 0.0145 0.168 0.2405
Onchocerca volvulus Alhambra homolog 0.0065 0.061 0.1832
Onchocerca volvulus 0.0044 0.0333 0.0924
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0303 0.0412
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0052 0.0103
Plasmodium falciparum LCCL domain-containing protein 0.0044 0.0333 0.2555
Loa Loa (eye worm) jmjC domain-containing protein 0.0133 0.152 0.2176
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0263 0.0523
Loa Loa (eye worm) beta-lactamase 0.0041 0.0303 0.0433
Onchocerca volvulus Serine\/threonine kinase homolog 0.0209 0.2524 0.8114
Toxoplasma gondii ABC1 family protein 0.0041 0.0303 0.0385
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1126 0.1326
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0052 0.0103
Trypanosoma brucei polo-like protein kinase 0.0209 0.2524 0.418
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0116 0.027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0052 0.0103
Onchocerca volvulus 0.0041 0.0303 0.0823
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0491 0.0703
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0161 0.0321
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0226 0.0241
Schistosoma mansoni phd/f-box containing protein 0.0056 0.0491 0.1216
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0097 0.1038 0.1444
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0338 0.0836
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0209 0.2524 0.4129
Schistosoma mansoni hypothetical protein 0.0044 0.0333 0.0826
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.1278 0.1697
Mycobacterium ulcerans beta-lactamase 0.0041 0.0303 0.0279
Loa Loa (eye worm) hypothetical protein 0.0075 0.0754 0.1079
Loa Loa (eye worm) hypothetical protein 0.0089 0.0929 0.133
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0052 0.0121
Brugia malayi PHD-finger family protein 0.0065 0.061 0.1426
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0423 0.0341
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.1448 0.2025
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0035
Schistosoma mansoni regulator of G protein signaling 0.002 0.0026 0.0064
Echinococcus multilocularis JmjC domain containing protein 4 0.0056 0.0491 0.0977
Loa Loa (eye worm) acetyltransferase 0.0323 0.4037 0.5779
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0303 0.0333
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0303 0.0749
Plasmodium falciparum histone acetyltransferase GCN5 0.0086 0.0901 0.725
Echinococcus multilocularis pyruvate kinase 0.0036 0.0226 0.045
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0443 0.0634
Echinococcus granulosus pyruvate kinase 0.0036 0.0226 0.045
Brugia malayi AF-10 protein 0.0021 0.0035 0.0081
Giardia lamblia Histone acetyltransferase GCN5 0.0086 0.0901 0.0833
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0026 0.0052
Schistosoma mansoni phosphatidylserine receptor 0.0056 0.0491 0.1216
Schistosoma mansoni axis inhibition protein axin 0.002 0.0026 0.0064
Schistosoma mansoni lipoxygenase 0.0116 0.1287 0.3187
Treponema pallidum fructose-bisphosphate aldolase 0.0647 0.8323 0.8308
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0052 0.0121
Echinococcus granulosus axis inhibition protein axin 0.002 0.0026 0.0052
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0116 0.0091
Echinococcus multilocularis citrate lyase subunit beta protein 0.0054 0.0473 0.0942
Schistosoma mansoni axis inhibition protein axin 0.002 0.0026 0.0064
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0226 0.0324
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0026 0.0052
Trypanosoma cruzi polo-like protein kinase, putative 0.0209 0.2524 0.3986
Plasmodium vivax glutathione reductase, putative 0.005 0.0423 0.3296
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0529 0.1235
Loa Loa (eye worm) hypothetical protein 0.0051 0.0434 0.0622
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0307 0.0837
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0491 0.0703
Brugia malayi MH2 domain containing protein 0.0127 0.1441 0.3367
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0333 0.0663
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0089 0.0929 0.2171
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0026 0.0064
Echinococcus multilocularis Polycystic kidney disease protein 0.0044 0.0333 0.0663
Mycobacterium tuberculosis Conserved protein 0.0041 0.0303 0.0412
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.1278 0.1785
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0303 0.0412
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0491 0.0703
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0647 0.8323 1
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0054 0.0473 0.045
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0209 0.2524 0.3613
Mycobacterium tuberculosis Conserved protein 0.0041 0.0303 0.0412
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0116 0.0091
Echinococcus granulosus chromobox protein 1 0.0074 0.0739 0.1471
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0084 0.012
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0226 0.0276
Schistosoma mansoni bromodomain containing protein 0.0075 0.0753 0.1864
Echinococcus granulosus axis inhibition protein axin 0.002 0.0026 0.0052
Mycobacterium ulcerans hypothetical protein 0.0027 0.0116 0.0091
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0074 0.0146
Brugia malayi jmjC domain containing protein 0.0342 0.4278 1
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Echinococcus multilocularis chromobox protein 1 0.0074 0.0739 0.1471
Brugia malayi steroid hormone receptor 0.0022 0.0052 0.0121
Trichomonas vaginalis set domain proteins, putative 0.0253 0.3099 0.3704
Echinococcus granulosus chromobox protein 1 0.0074 0.0739 0.1471
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0226 0.0324
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0116 0.027
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0303 0.0412
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0085 0.0061
Trypanosoma brucei hypothetical protein, conserved 0.0471 0.5991 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0303 0.0132
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0303 0.0412
Echinococcus multilocularis expressed protein 0.0398 0.5024 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0035
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0226 0.0202
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0085 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0307 0.0338
Brugia malayi ecdysteroid receptor 0.0022 0.0052 0.0121
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0112 0.1233 0.1765
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0116 0.0051
Plasmodium vivax multidomain scavenger receptor, putative 0.0044 0.0333 0.2555
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0423 0.3296
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.006 0.0556 0.067
Mycobacterium ulcerans aldehyde dehydrogenase 0.0134 0.1535 0.1514
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0116 0.0149
Onchocerca volvulus 0.0044 0.0338 0.0939
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0112 0.1233 0.1211
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0226 0.1669
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0035 0.005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0052 0.0103
Trichomonas vaginalis bromodomain-containing protein, putative 0.0097 0.1038 0.122
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0284 0.0664
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0177 0.0352
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0052 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0052 0.0121
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.006 0.0556 0.077
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0025 0.0021
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0026 0.0052
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0052 0.0103
Loa Loa (eye worm) hypothetical protein 0.0041 0.0303 0.0433
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0035
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Loa Loa (eye worm) hypothetical protein 0.0041 0.0303 0.0433
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0056 0.0491 0.0656
Brugia malayi Pre-SET motif family protein 0.0222 0.2693 0.6295
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0035 0.0087
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0303 0.0707
Loa Loa (eye worm) glutathione reductase 0.005 0.0423 0.0605
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0035 0.007
Brugia malayi hypothetical protein 0.0044 0.0333 0.0779
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0116 0.0043
Brugia malayi nuclear receptor NHR-88 0.0022 0.0052 0.0121
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0052 0.0103
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0423 0.0581
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0226 0.0322
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0052 0.0103
Schistosoma mansoni hypothetical protein 0.0022 0.0047 0.0115
Plasmodium falciparum pyruvate kinase 0.0036 0.0226 0.1669
Brugia malayi acetyltransferase, GNAT family protein 0.0323 0.4037 0.9437
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0303 0.0132
Loa Loa (eye worm) hypothetical protein 0.0041 0.0303 0.0433
Entamoeba histolytica acetyltransferase, GNAT family 0.0086 0.0901 0.1054
Mycobacterium ulcerans hypothetical protein 0.0054 0.0473 0.045
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0349 0.0389
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0026 0.0061
Toxoplasma gondii PHD-finger domain-containing protein 0.0065 0.061 0.0828
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0116 0.0051
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0226 0.0241
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0085 0.0106
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0074 0.0146
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0052 0.0103
Loa Loa (eye worm) glutaminase 0.0314 0.391 0.5596
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0026 0.0052
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0303 0.0333
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0026 0.0064
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0056 0.0491 0.0766
Echinococcus granulosus mannose 6 phosphate isomerase 0.0112 0.1233 0.2454
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0052 0.0128
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0052 0.0128
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0116 0.0108
Echinococcus granulosus PHD finger protein rhinoceros 0.0065 0.061 0.1214
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0303 0.0333
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0134 0.1535 0.3056
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0134 0.1535 0.2148
Brugia malayi PXA domain containing protein 0.002 0.0026 0.0061
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0218 0.2643 0.2625
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0035 0.0087
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.1278 0.1785
Plasmodium vivax hypothetical protein, conserved 0.0065 0.061 0.4844
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0112 0.1233 0.2882
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0116 0.0091
Loa Loa (eye worm) hypothetical protein 0.0042 0.0307 0.0439
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0264 0.3251 0.4564
Schistosoma mansoni lipoxygenase 0.0194 0.2327 0.5764
Echinococcus granulosus pyruvate kinase 0.0036 0.0226 0.045
Loa Loa (eye worm) hypothetical protein 0.0027 0.0116 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0052 0.0121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0401 0.0993
Mycobacterium tuberculosis Conserved protein 0.0041 0.0303 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0052 0.0121
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0026 0.0052
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0052 0.0121
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0323 0.4037 1
Brugia malayi jmjC domain containing protein 0.0056 0.0491 0.1147
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0529 0.0757
Schistosoma mansoni mannose-6-phosphate isomerase 0.0112 0.1233 0.3054
Onchocerca volvulus 0.0033 0.0188 0.0446
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0401 0.0798
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0054 0.0473 0.0429
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0303 0.0309
Brugia malayi PHD-finger family protein 0.0023 0.0062 0.0144
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0052 0.0103
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0052 0.0103
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0303 0.0602
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.1441 0.2062
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0035 0.005
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0316 0.394 0.5486
Brugia malayi Doublecortin family protein 0.0044 0.0333 0.0779
Mycobacterium ulcerans lipase LipD 0.0041 0.0303 0.0279
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0116 0.0108
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0774 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0052 0.0121
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.005 0.0124
Schistosoma mansoni jumonji domain containing protein 0.0298 0.3703 0.9172
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0423 0.0605
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0097 0.1038 0.122
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0218 0.2643 0.2625
Mycobacterium ulcerans hypothetical protein 0.0054 0.0473 0.045
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0047 0.0067
Echinococcus multilocularis chromobox protein 1 0.0074 0.0739 0.1471
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0085 0.0073
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0052 0.0103
Loa Loa (eye worm) PHD-finger family protein 0.0065 0.061 0.0873
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0226 0.0573
Loa Loa (eye worm) doublecortin family protein 0.0044 0.0333 0.0477
Echinococcus granulosus Polycystic kidney disease protein 0.0044 0.0333 0.0663
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0401 0.0798
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0702 0.1398
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0052 0.0121
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0112 0.1233 0.1765
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0112 0.1233 1
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0054 0.0473 0.0653
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0303 0.0602
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Brugia malayi Heterochromatin protein 1 0.0074 0.0739 0.1727
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0116 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0052 0.0074
Echinococcus multilocularis pyruvate kinase 0.0028 0.0127 0.0253
Brugia malayi PXA domain containing protein 0.002 0.0026 0.0061
Brugia malayi beta-lactamase 0.0041 0.0303 0.0707
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0052 0.0074
Loa Loa (eye worm) hypothetical protein 0.0041 0.0303 0.0433
Giardia lamblia Kinase, PLK 0.0209 0.2524 0.2838
Loa Loa (eye worm) hypothetical protein 0.0546 0.6986 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0556 0.7112 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0134 0.1535 0.1514
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0026 0.0052
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0303 0.0333
Onchocerca volvulus 0.0041 0.0303 0.0823
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0702 0.1398
Loa Loa (eye worm) hypothetical protein 0.0056 0.0491 0.0703
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0209 0.2524 0.5024
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0052 0.0121
Schistosoma mansoni zinc finger protein 0.0029 0.0136 0.0336
Brugia malayi jmjC domain containing protein 0.0056 0.0491 0.1147
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0052 0.0128
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0194 0.2327 0.4631
Brugia malayi hypothetical protein 0.002 0.0026 0.0061
Trichomonas vaginalis glutaminase, putative 0.0314 0.391 0.4681
Plasmodium vivax JmjC domain containing protein 0.0056 0.0491 0.3859
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0052 0.0103
Brugia malayi hypothetical protein 0.002 0.0026 0.0061
Onchocerca volvulus 0.0089 0.0929 0.2879
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0226 0.0529
Entamoeba histolytica hypothetical protein 0.0025 0.0085 0.0072
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0774 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0284 0.0406
Echinococcus multilocularis RUN 0.0044 0.0333 0.0663
Plasmodium falciparum glutathione reductase 0.005 0.0423 0.3296
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0035
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0058 0.0518 0.1031
Schistosoma mansoni kinase 0.0106 0.1163 0.288
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0177 0.0204
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0112 0.1233 0.2454
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0401 0.0574
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0052 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0052 0.0121
Loa Loa (eye worm) hypothetical protein 0.0058 0.0529 0.0757
Schistosoma mansoni protein phosphatase 2C 0.0056 0.0491 0.1216
Onchocerca volvulus 0.0041 0.0303 0.0823
Leishmania major phosphomannose isomerase 0.0112 0.1233 0.1943
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0739 0.1058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0052 0.0128
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0423 0.0842
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0052 0.0128
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0026 0.0052
Echinococcus multilocularis L aminoadipate semialdehyde 0.0089 0.0929 0.1849
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0146 0.0144
Schistosoma mansoni rab6-interacting 0.0044 0.0333 0.0826
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0226 0.0529
Entamoeba histolytica serine/threonine protein kinase, putative 0.0209 0.2524 0.3011
Echinococcus multilocularis lysine specific demethylase 5A 0.0208 0.2514 0.5003
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0303 0.0279
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0303 0.0279
Mycobacterium ulcerans aldehyde dehydrogenase 0.0134 0.1535 0.1514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0401 0.0993
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0026 0.0037
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0097 0.1038 0.1444
Loa Loa (eye worm) hypothetical protein 0.0027 0.0116 0.0166
Echinococcus granulosus citrate lyase subunit beta protein 0.0054 0.0473 0.0942
Echinococcus multilocularis jumonji domain containing 1A 0.0056 0.0491 0.0977
Schistosoma mansoni jumonji/arid domain-containing protein 0.021 0.2541 0.6293
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0052 0.0121
Loa Loa (eye worm) hypothetical protein 0.0041 0.0303 0.0433
Brugia malayi Thioredoxin reductase 0.005 0.0423 0.0988
Trypanosoma cruzi phosphomannose isomerase, putative 0.0112 0.1233 0.1746
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0085 0.0061
Schistosoma mansoni jumonji domain containing protein 0.0056 0.0491 0.1216
Schistosoma mansoni chromobox protein 0.0074 0.0739 0.183
Trypanosoma cruzi hypothetical protein, conserved 0.0471 0.5991 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0052 0.0103
Schistosoma mansoni chromobox protein 0.0074 0.0739 0.183
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0054 0.0473 0.045
Echinococcus multilocularis lysine specific demethylase 6a 0.0056 0.0491 0.0977
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0218 0.2643 0.3641
Loa Loa (eye worm) hypothetical protein 0.005 0.0417 0.0598
Schistosoma mansoni aldehyde dehydrogenase 0.0134 0.1535 0.3803
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0263 0.0523
Brugia malayi glutaminase DH11.1 0.0314 0.391 0.9138
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0089 0.0929 0.2301
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0097 0.1038 0.8387
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0401 0.0993
Echinococcus granulosus lysine specific demethylase 6a 0.0056 0.0491 0.0977
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0035 0.0084
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0026 0.0052
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0226 0.0322
Echinococcus granulosus jumonji domain containing protein 0.009 0.0945 0.188
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0037
Schistosoma mansoni regulator of G protein signaling 0.002 0.0026 0.0064
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0401 0.0937
Trypanosoma brucei phosphomannose isomerase 0.0112 0.1233 0.2012
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0085 0.0504
Schistosoma mansoni regulator of G protein signaling 0.002 0.0026 0.0064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Schistosoma mansoni regulator of G protein signaling 0.002 0.0026 0.0064
Onchocerca volvulus 0.0253 0.3099 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0026 0.0061
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0026 0.0061
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0085 0.0061
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0054 0.0473 0.045
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.1278 0.1785
Toxoplasma gondii PHD-finger domain-containing protein 0.0065 0.061 0.0828
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0052 0.0128
Schistosoma mansoni pyruvate kinase 0.0036 0.0226 0.056
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0077 0.018
Leishmania major hypothetical protein, conserved 0.0056 0.0491 0.0687
Echinococcus multilocularis pyruvate kinase 0.0036 0.0226 0.045
Echinococcus granulosus expressed protein 0.0398 0.5024 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0647 0.8323 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0177 0.0438
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0026 0.0064
Trypanosoma cruzi polo-like protein kinase, putative 0.0209 0.2524 0.3986
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.1448 0.1939
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0051 0.0432 0.0489
Loa Loa (eye worm) jmjC domain-containing protein 0.021 0.2541 0.3637
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0052 0.0128
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0226 0.0305
Loa Loa (eye worm) hypothetical protein 0.0053 0.0461 0.0661
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0026 0.0052
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0342 0.4278 0.8515
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0342 0.4278 0.8515
Brugia malayi Pre-SET motif family protein 0.0032 0.0177 0.0413
Brugia malayi PHD-finger family protein 0.0034 0.0211 0.0493
Echinococcus multilocularis peregrin 0.0075 0.0747 0.1488
Loa Loa (eye worm) hypothetical protein 0.0027 0.0116 0.0166
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0303 0.0412
Mycobacterium ulcerans glutaminase 0.0314 0.391 0.3895
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0146 0.0144
Echinococcus granulosus phd:f box containing protein 0.0056 0.0491 0.0977
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0052 0.0121
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.1448 0.2025
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0052 0.0128
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0303 0.045
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0333 0.0663
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0417 0.0831
Plasmodium falciparum thioredoxin reductase 0.005 0.0423 0.3296
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0035 0.0084
Leishmania major hypothetical protein, conserved 0.0041 0.0303 0.0368
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0056 0.0491 0.0459
Brugia malayi glutathione reductase 0.005 0.0423 0.0988
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0052 0.0074
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0052 0.0074
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0134 0.1535 0.3056
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0035
Brugia malayi beta-lactamase family protein 0.0041 0.0303 0.0707
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0052 0.0128
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0058 0.0518 0.1031
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0529 0.1235
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0303 0.0433
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Loa Loa (eye worm) hypothetical protein 0.0546 0.6986 1
Entamoeba histolytica phosphomannose isomerase, putative 0.0112 0.1233 0.1455
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0112 0.1233 1
Mycobacterium leprae Probable lipase LipE 0.0041 0.0303 0.0309
Brugia malayi beta-lactamase family protein 0.0041 0.0303 0.0707
Schistosoma mansoni hypothetical protein 0.0065 0.061 0.1511
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0417 0.1034
Loa Loa (eye worm) glutaminase 2 0.0314 0.391 0.5596
Schistosoma mansoni hypothetical protein 0.004 0.0284 0.0703
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0116 0.0091
Loa Loa (eye worm) hypothetical protein 0.0044 0.0333 0.0477
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0307 0.0338
Schistosoma mansoni polycystin 1-related 0.0044 0.0333 0.0826
Schistosoma mansoni regulator of G protein signaling 0.002 0.0026 0.0064
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0037
Echinococcus multilocularis jumonji domain containing protein 0.009 0.0945 0.188
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0226 0.0573
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.2693 0.3855
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0349 0.0389
Schistosoma mansoni aldehyde dehydrogenase 0.0134 0.1535 0.3803
Loa Loa (eye worm) hypothetical protein 0.0065 0.061 0.0873
Schistosoma mansoni loxhd1 0.0044 0.0333 0.0826
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0134 0.1535 0.2455
Toxoplasma gondii hypothetical protein 0.0546 0.6986 1
Echinococcus granulosus RUN 0.0044 0.0333 0.0663
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0349 0.0974
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0226 0.0573
Schistosoma mansoni serine/threonine protein kinase 0.0209 0.2524 0.6252
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0116 0.0051
Schistosoma mansoni coup transcription factor 0.0022 0.0052 0.0128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0052 0.0074
Echinococcus granulosus L aminoadipate semialdehyde 0.0089 0.0929 0.1849
Onchocerca volvulus 0.0044 0.0333 0.0924
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0052 0.0103
Echinococcus granulosus zinc finger protein 0.0029 0.0136 0.027
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0226 0.02
Brugia malayi jmjC domain containing protein 0.0056 0.0491 0.1147
Leishmania major trypanothione reductase 0.005 0.0423 0.0571
Brugia malayi Bromodomain containing protein 0.0088 0.0918 0.2146
Brugia malayi Bromodomain containing protein 0.0049 0.04 0.0935
Giardia lamblia PHD finger protein 15 0.0065 0.061 0.0474
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0303 0.0412
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0065 0.061 0.1511
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0739 0.0859
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0303 0.0412
Loa Loa (eye worm) hypothetical protein 0.0056 0.0491 0.0703
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0026 0.0052
Toxoplasma gondii aldehyde dehydrogenase 0.0134 0.1535 0.2159
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0054 0.0473 0.0539
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0316 0.394 0.3926
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0026 0.0052
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0116 0.0091
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0303 0.23
Mycobacterium ulcerans hypothetical protein 0.0041 0.0303 0.0279
Echinococcus granulosus lysine specific demethylase 5A 0.021 0.2541 0.5057
Echinococcus granulosus JmjC domain containing protein 4 0.0056 0.0491 0.0977
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0052 0.0121
Schistosoma mansoni glutaminase 0.0314 0.391 0.9684
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0052 0.0121
Echinococcus multilocularis zinc finger protein 0.0029 0.0136 0.027
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0026 0.0052
Echinococcus granulosus histone acetyltransferase KAT2B 0.0097 0.1038 0.2066
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.1441 0.2062
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0209 0.2524 0.5024
Brugia malayi Bromodomain containing protein 0.0075 0.0747 0.1747
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0116 0.0091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0401 0.0798
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0774 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0084 0.012
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0194 0.2327 0.4631
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0226 0.0324
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0052 0.0103
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0026 0.0052
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0423 0.0842
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0647 0.8323 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0116 0.027
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0037
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0052 0.0128
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0116 0.0108
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0084 0.007
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0074 0.0182
Loa Loa (eye worm) hypothetical protein 0.0023 0.0062 0.0088
Echinococcus multilocularis phd:f box containing protein 0.0056 0.0491 0.0977
Trichomonas vaginalis esterase, putative 0.0041 0.0303 0.0333
Toxoplasma gondii phosphomannose isomerase type I protein 0.0112 0.1233 0.1724
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0333 0.0663
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0112 0.1233 0.2882
Brugia malayi nuclear hormone receptor 0.0022 0.0052 0.0121
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0056 0.0491 0.1216
Trypanosoma brucei trypanothione reductase 0.005 0.0423 0.0652
Schistosoma mansoni pyruvate kinase 0.0036 0.0226 0.056
Schistosoma mansoni rab6-interacting 0.0044 0.0333 0.0826
Loa Loa (eye worm) hypothetical protein 0.0041 0.0303 0.0433
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0037
Schistosoma mansoni jumonji/arid domain-containing protein 0.021 0.2541 0.6293
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0056 0.0491 0.0459
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0303 0.0749
Plasmodium falciparum JmjC domain-containing protein, putative 0.0056 0.0491 0.3859
Trypanosoma cruzi hypothetical protein, conserved 0.0471 0.5991 1
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0052 0.0121
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0116 0.0043
Mycobacterium tuberculosis Conserved protein 0.0054 0.0473 0.0653
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.1448 0.2025
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0052 0.0103
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0026 0.0064
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0026 0.0061
Loa Loa (eye worm) hypothetical protein 0.0044 0.0333 0.0477
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0401 0.0798
Leishmania major pyruvate kinase 0.0036 0.0226 0.0238
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0116 0.0149
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0035 0.007
Mycobacterium tuberculosis Probable reductase 0.0115 0.1278 0.1785
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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