Detailed information for compound 560774

Basic information

Technical information
  • TDR Targets ID: 560774
  • Name: 2-bromo-5-[(E)-2-bromo-2-nitro-vinyl]furan
  • MW: 296.901 | Formula: C6H3Br2NO3
  • H donors: 0 H acceptors: 2 LogP: 3.2 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)/C(=C/c1ccc(o1)Br)/Br
  • InChi: 1S/C6H3Br2NO3/c7-5(9(10)11)3-4-1-2-6(8)12-4/h1-3H/b5-3-
  • InChiKey: MJPPGVVIDGQOQT-HYXAFXHYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-bromo-5-[(E)-2-bromo-2-nitrovinyl]furan
  • 2-bromo-5-[(E)-2-bromo-2-nitro-ethenyl]furan
  • 2-bromo-5-[(E)-2-bromo-2-nitroethenyl]furan
  • 1-(5-bromofur-2-il)-2-bromo-2-nitroethene
  • 35950-55-1
  • 2-Bromo-S-(2-bromo-5-nitroethenyl)furan
  • Furan, 2-bromo-5-(2-bromo-2-nitroethenyl)-
  • Furan, 2-bromo-S-(2-bromo-5-nitroethenyl)-
  • AIDS-110348
  • AIDS110348

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum histone acetyltransferase GCN5 0.0086 0.0901 0.725
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0037
Loa Loa (eye worm) hypothetical protein 0.0027 0.0116 0.0166
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0054 0.0473 0.0657
Mycobacterium tuberculosis Probable reductase 0.0115 0.1278 0.1785
Schistosoma mansoni axis inhibition protein axin 0.002 0.0026 0.0064
Brugia malayi acetyltransferase, GNAT family protein 0.0323 0.4037 0.9437
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0303 0.0132
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0116 0.0108
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0026 0.0064
Onchocerca volvulus 0.0041 0.0303 0.0823
Schistosoma mansoni loxhd1 0.0044 0.0333 0.0826
Schistosoma mansoni phosphatidylserine receptor 0.0056 0.0491 0.1216
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0085 0.0061
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0052 0.0121
Schistosoma mansoni kinase 0.0106 0.1163 0.288
Mycobacterium ulcerans glutaminase 0.0314 0.391 0.3895
Brugia malayi glutathione reductase 0.005 0.0423 0.0988
Loa Loa (eye worm) hypothetical protein 0.0023 0.0062 0.0088
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0026 0.0064
Echinococcus granulosus jumonji domain containing 1A 0.0056 0.0491 0.0977
Brugia malayi PHD-finger family protein 0.0034 0.0211 0.0493
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0423 0.0581
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0303 0.0412
Echinococcus granulosus axis inhibition protein axin 0.002 0.0026 0.0052
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0074 0.0146
Echinococcus granulosus phd:f box containing protein 0.0056 0.0491 0.0977
Plasmodium falciparum thioredoxin reductase 0.005 0.0423 0.3296
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0052 0.0128
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0342 0.4278 0.8515
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0052 0.0128
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0026 0.0052
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0054 0.0473 0.0429
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0218 0.2643 0.3753
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0035 0.0082
Echinococcus multilocularis JmjC domain containing protein 4 0.0056 0.0491 0.0977
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0177 0.0204
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0025 0.0021
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0085 0.0504
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0026 0.0052
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0702 0.1398
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0052 0.0103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0401 0.0993
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.1448 0.2025
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0058 0.0518 0.1031
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0333 0.0663
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0056 0.0491 0.0459
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0052 0.0121
Onchocerca volvulus 0.0044 0.0338 0.0939
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0052 0.0128
Echinococcus granulosus lysine specific demethylase 6a 0.0056 0.0491 0.0977
Schistosoma mansoni regulator of G protein signaling 0.002 0.0026 0.0064
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0026 0.0052
Loa Loa (eye worm) glutathione reductase 0.005 0.0423 0.0605
Schistosoma mansoni hypothetical protein 0.004 0.0284 0.0703
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0333 0.0663
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0052 0.0121
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0112 0.1233 0.2882
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.1278 0.1785
Mycobacterium ulcerans hypothetical protein 0.0041 0.0303 0.0279
Schistosoma mansoni jumonji/arid domain-containing protein 0.021 0.2541 0.6293
Schistosoma mansoni coup transcription factor 0.0022 0.0052 0.0128
Loa Loa (eye worm) hypothetical protein 0.0056 0.0491 0.0703
Echinococcus multilocularis jumonji domain containing 1A 0.0056 0.0491 0.0977
Brugia malayi hypothetical protein 0.0044 0.0333 0.0779
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0052 0.0103
Schistosoma mansoni protein phosphatase 2C 0.0056 0.0491 0.1216
Schistosoma mansoni hypothetical protein 0.0044 0.0333 0.0826
Echinococcus granulosus JmjC domain containing protein 4 0.0056 0.0491 0.0977
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0342 0.4278 0.8515
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0035 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0026 0.0052
Mycobacterium ulcerans hypothetical protein 0.0054 0.0473 0.045
Echinococcus multilocularis lysine specific demethylase 5A 0.0208 0.2514 0.5003
Schistosoma mansoni jumonji domain containing protein 0.0298 0.3703 0.9172
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0116 0.0091
Brugia malayi Bromodomain containing protein 0.0088 0.0918 0.2146
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0349 0.0389
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0084 0.012
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0054 0.0473 0.0429
Schistosoma mansoni lipoxygenase 0.0116 0.1287 0.3187
Brugia malayi jmjC domain containing protein 0.0342 0.4278 1
Echinococcus granulosus Polycystic kidney disease protein 0.0044 0.0333 0.0663
Echinococcus multilocularis pyruvate kinase 0.0036 0.0226 0.045
Brugia malayi nuclear hormone receptor 0.0022 0.0052 0.0121
Brugia malayi glutaminase DH11.1 0.0314 0.391 0.9138
Brugia malayi hypothetical protein 0.0044 0.0333 0.0779
Leishmania major pyruvate kinase 0.0036 0.0226 0.0238
Brugia malayi PHD-finger family protein 0.0023 0.0062 0.0144
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0401 0.0574
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1126 0.1326
Giardia lamblia Kinase, PLK 0.0209 0.2524 0.2838
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0423 0.3296
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0303 0.0279
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0529 0.1235
Loa Loa (eye worm) hypothetical protein 0.0044 0.0333 0.0477
Brugia malayi nuclear receptor NHR-88 0.0022 0.0052 0.0121
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0401 0.0798
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0491 0.0703
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0026 0.0037
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0035 0.007
Echinococcus granulosus mannose 6 phosphate isomerase 0.0112 0.1233 0.2454
Loa Loa (eye worm) hypothetical protein 0.0025 0.0084 0.012
Brugia malayi hypothetical protein 0.002 0.0026 0.0061
Mycobacterium tuberculosis Conserved protein 0.0041 0.0303 0.0412
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0085 0.0085
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0084 0.007
Onchocerca volvulus 0.0044 0.0333 0.0924
Schistosoma mansoni regulator of G protein signaling 0.002 0.0026 0.0064
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0056 0.0491 0.0656
Schistosoma mansoni aldehyde dehydrogenase 0.0134 0.1535 0.3803
Echinococcus multilocularis pyruvate kinase 0.0036 0.0226 0.045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0491 0.0703
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0026 0.0061
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0116 0.0043
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0052 0.0103
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0052 0.0103
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0052 0.0103
Loa Loa (eye worm) jmjC domain-containing protein 0.0133 0.152 0.2176
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0052 0.0103
Giardia lamblia Histone acetyltransferase GCN5 0.0086 0.0901 0.0833
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0052 0.0103
Echinococcus multilocularis PHD finger protein rhinoceros 0.0065 0.061 0.1214
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Echinococcus granulosus pyruvate kinase 0.0036 0.0226 0.045
Loa Loa (eye worm) hypothetical protein 0.0546 0.6986 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0316 0.394 0.5486
Giardia lamblia PHD finger protein 15 0.0065 0.061 0.0474
Loa Loa (eye worm) hypothetical protein 0.0041 0.0303 0.0433
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0226 0.0241
Loa Loa (eye worm) hypothetical protein 0.0058 0.0529 0.0757
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0065 0.061 0.1511
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0035 0.0084
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0037
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0097 0.1038 0.8387
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0052 0.0103
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0423 0.0842
Schistosoma mansoni jumonji/arid domain-containing protein 0.021 0.2541 0.6293
Brugia malayi beta-lactamase family protein 0.0041 0.0303 0.0707
Schistosoma mansoni axis inhibition protein axin 0.002 0.0026 0.0064
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0026 0.0061
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0052 0.0103
Schistosoma mansoni zinc finger protein 0.0029 0.0136 0.0336
Echinococcus granulosus citrate lyase subunit beta protein 0.0054 0.0473 0.0942
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0052 0.0103
Echinococcus multilocularis zinc finger protein 0.0029 0.0136 0.027
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0089 0.0929 0.2171
Brugia malayi jmjC domain containing protein 0.0056 0.0491 0.1147
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0112 0.1233 0.1765
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0037
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0056 0.0491 0.0459
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0218 0.2643 0.3641
Onchocerca volvulus 0.0089 0.0929 0.2879
Echinococcus granulosus peregrin 0.0075 0.0747 0.1488
Trypanosoma cruzi phosphomannose isomerase, putative 0.0112 0.1233 0.1746
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0052 0.0103
Brugia malayi PXA domain containing protein 0.002 0.0026 0.0061
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0116 0.0091
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0194 0.2327 0.4631
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0052 0.0103
Loa Loa (eye worm) hypothetical protein 0.0027 0.0116 0.0166
Schistosoma mansoni chromobox protein 0.0074 0.0739 0.183
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0054 0.0473 0.045
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0303 0.0333
Leishmania major hypothetical protein, conserved 0.0041 0.0303 0.0368
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0052 0.0103
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.1448 0.2025
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0085 0.0073
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0056 0.0491 0.0766
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.1448 0.2025
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0116 0.0108
Echinococcus multilocularis pyruvate kinase 0.0028 0.0127 0.0253
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0052 0.0128
Plasmodium vivax SET domain protein, putative 0.0032 0.0177 0.1259
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0303 0.045
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0026 0.0052
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0263 0.0523
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0417 0.0831
Mycobacterium ulcerans beta-lactamase 0.0041 0.0303 0.0279
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0303 0.0749
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0303 0.0333
Toxoplasma gondii phosphomannose isomerase type I protein 0.0112 0.1233 0.1724
Plasmodium falciparum JmjC domain-containing protein, putative 0.0056 0.0491 0.3859
Schistosoma mansoni hypothetical protein 0.0021 0.0035 0.0086
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0226 0.0241
Echinococcus granulosus expressed protein 0.0398 0.5024 1
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0052 0.0103
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0056 0.0491 0.0656
Brugia malayi jmjC domain containing protein 0.0056 0.0491 0.1147
Brugia malayi jmjC domain containing protein 0.021 0.2541 0.5939
Loa Loa (eye worm) glutaminase 2 0.0314 0.391 0.5596
Loa Loa (eye worm) hypothetical protein 0.0042 0.0307 0.0439
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0035
Mycobacterium tuberculosis Conserved protein 0.0041 0.0303 0.0412
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0194 0.2327 0.4631
Loa Loa (eye worm) RGS-3 protein 0.002 0.0026 0.0037
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0112 0.1233 0.2454
Plasmodium falciparum phd finger protein, putative 0.0065 0.061 0.4844
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0134 0.1535 0.3056
Loa Loa (eye worm) jmjC domain-containing protein 0.021 0.2541 0.3637
Brugia malayi PXA domain containing protein 0.002 0.0026 0.0061
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0209 0.2524 0.4129
Onchocerca volvulus 0.0041 0.0303 0.0823
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0026 0.0052
Loa Loa (eye worm) hypothetical protein 0.0041 0.0303 0.0433
Onchocerca volvulus 0.0041 0.0303 0.0823
Loa Loa (eye worm) hypothetical protein 0.0145 0.168 0.2405
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0303 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0307 0.0338
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0077 0.018
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0035 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0052 0.0121
Schistosoma mansoni pyruvate kinase 0.0036 0.0226 0.056
Schistosoma mansoni phd/f-box containing protein 0.0056 0.0491 0.1216
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0209 0.2524 0.3613
Toxoplasma gondii thioredoxin reductase 0.005 0.0423 0.0558
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0349 0.0974
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0116 0.0149
Echinococcus multilocularis RUN 0.0044 0.0333 0.0663
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0303 0.0602
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0112 0.1233 0.1455
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0026 0.0052
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0116 0.0091
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0052 0.0103
Echinococcus multilocularis phd:f box containing protein 0.0056 0.0491 0.0977
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0037
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0116 0.0051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0401 0.0993
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.006 0.0556 0.067
Echinococcus granulosus jumonji domain containing protein 0.009 0.0945 0.188
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0052 0.0121
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0054 0.0473 0.0653
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0218 0.2643 0.2625
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0052 0.0121
Toxoplasma gondii PHD-finger domain-containing protein 0.0065 0.061 0.0828
Brugia malayi chromobox protein homolog 3 0.0042 0.0307 0.0717
Echinococcus multilocularis L aminoadipate semialdehyde 0.0089 0.0929 0.1849
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0264 0.3251 0.4564
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0702 0.1398
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0338 0.0836
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0052 0.0074
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0739 0.1058
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0323 0.4037 1
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0226 0.0324
Entamoeba histolytica acetyltransferase, GNAT family 0.0086 0.0901 0.1054
Trypanosoma cruzi hypothetical protein, conserved 0.0471 0.5991 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0177 0.0352
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0116 0.0091
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0052 0.0121
Schistosoma mansoni regulator of G protein signaling 0.002 0.0026 0.0064
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0052 0.0128
Echinococcus granulosus RUN 0.0044 0.0333 0.0663
Trichomonas vaginalis glutaminase, putative 0.0314 0.391 0.4681
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0739 0.0859
Treponema pallidum fructose-bisphosphate aldolase 0.0647 0.8323 0.8308
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0303 0.0602
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0054 0.0473 0.045
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0026 0.0061
Schistosoma mansoni mannose-6-phosphate isomerase 0.0112 0.1233 0.3054
Loa Loa (eye worm) hypothetical protein 0.0546 0.6986 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0134 0.1535 0.1514
Loa Loa (eye worm) PHD-finger family protein 0.0065 0.061 0.0873
Echinococcus granulosus histone acetyltransferase KAT2B 0.0312 0.3885 0.7732
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0116 0.0108
Schistosoma mansoni hypothetical protein 0.0022 0.0047 0.0115
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0647 0.8323 1
Loa Loa (eye worm) beta-lactamase 0.0041 0.0303 0.0433
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.2693 0.3855
Leishmania major hypothetical protein, conserved 0.0056 0.0491 0.0687
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0052 0.0128
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0307 0.0837
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0226 0.0573
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0035 0.007
Trypanosoma cruzi polo-like protein kinase, putative 0.0209 0.2524 0.3986
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0112 0.1233 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0529 0.0757
Brugia malayi beta-lactamase family protein 0.0041 0.0303 0.0707
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0303 0.0412
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0417 0.0831
Loa Loa (eye worm) hypothetical protein 0.0041 0.0303 0.0433
Schistosoma mansoni jumonji domain containing protein 0.0056 0.0491 0.1216
Onchocerca volvulus 0.0253 0.3099 1
Trichomonas vaginalis esterase, putative 0.0041 0.0303 0.0333
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0085 0.0504
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Plasmodium falciparum pyruvate kinase 0.0036 0.0226 0.1669
Brugia malayi Heterochromatin protein 1 0.0074 0.0739 0.1727
Loa Loa (eye worm) acetyltransferase 0.0323 0.4037 0.5779
Plasmodium vivax hypothetical protein, conserved 0.0065 0.061 0.4844
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0026 0.0061
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0209 0.2524 0.5024
Echinococcus multilocularis chromobox protein 1 0.0074 0.0739 0.1471
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0112 0.1233 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0491 0.0703
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0226 0.0276
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0052 0.0128
Plasmodium falciparum glutathione reductase 0.005 0.0423 0.3296
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0026 0.0037
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0226 0.0529
Loa Loa (eye worm) hypothetical protein 0.0053 0.0461 0.0661
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0417 0.1034
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0491 0.0703
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0085 0.0061
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.1441 0.2062
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0116 0.027
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0116 0.027
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0026 0.0052
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.1278 0.1785
Brugia malayi Thioredoxin reductase 0.005 0.0423 0.0988
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0116 0.0091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0401 0.0993
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.1448 0.1939
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0774 1 1
Echinococcus multilocularis citrate lyase subunit beta protein 0.0054 0.0473 0.0942
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0097 0.1038 0.1444
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0116 0.027
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0303 0.0412
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0026 0.0064
Brugia malayi serine/threonine-protein kinase plk-2 0.0209 0.2524 0.59
Trichomonas vaginalis bromodomain-containing protein, putative 0.0097 0.1038 0.122
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0774 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0052 0.0074
Brugia malayi Bromodomain containing protein 0.0075 0.0747 0.1747
Leishmania major trypanothione reductase 0.005 0.0423 0.0571
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0226 0.0573
Schistosoma mansoni polycystin 1-related 0.0044 0.0333 0.0826
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0035 0.0084
Trypanosoma brucei polo-like protein kinase 0.0209 0.2524 0.418
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0226 0.1669
Echinococcus granulosus histone acetyltransferase KAT2B 0.0097 0.1038 0.2066
Brugia malayi beta-lactamase 0.0041 0.0303 0.0707
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0112 0.1233 0.1211
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0052 0.0121
Schistosoma mansoni hypothetical protein 0.0065 0.061 0.1511
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.1278 0.1785
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0546 0.6986 1
Echinococcus granulosus lysine specific demethylase 5A 0.021 0.2541 0.5057
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0316 0.394 0.5534
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Trypanosoma cruzi hypothetical protein, conserved 0.0471 0.5991 1
Mycobacterium ulcerans lipase LipD 0.0041 0.0303 0.0279
Brugia malayi AF-10 protein 0.0021 0.0035 0.0081
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0161 0.0321
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0052 0.0074
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0052 0.0103
Entamoeba histolytica serine/threonine protein kinase, putative 0.0209 0.2524 0.3011
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0226 0.02
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0052 0.0074
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0218 0.2643 0.2625
Echinococcus granulosus pyruvate kinase 0.0036 0.0226 0.045
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1126 0.1326
Entamoeba histolytica hypothetical protein 0.0025 0.0085 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0052 0.0074
Loa Loa (eye worm) hypothetical protein 0.0075 0.0754 0.1079
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0556 0.7112 1
Echinococcus multilocularis chromobox protein 1 0.0074 0.0739 0.1471
Leishmania major phosphomannose isomerase 0.0112 0.1233 0.1943
Brugia malayi PHD-finger family protein 0.0065 0.061 0.1426
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0035 0.0087
Schistosoma mansoni glutaminase 0.0314 0.391 0.9684
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0423 0.0605
Schistosoma mansoni chromobox protein 0.0074 0.0739 0.183
Plasmodium vivax JmjC domain containing protein 0.0056 0.0491 0.3859
Schistosoma mansoni regulator of G protein signaling 0.002 0.0026 0.0064
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0097 0.1038 0.122
Echinococcus granulosus chromobox protein 1 0.0074 0.0739 0.1471
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0026 0.0052
Loa Loa (eye worm) hypothetical protein 0.0089 0.0929 0.133
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0401 0.0937
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0035
Trypanosoma brucei trypanothione reductase 0.005 0.0423 0.0652
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0026 0.0064
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0112 0.1233 0.1765
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0052 0.0128
Mycobacterium ulcerans aldehyde dehydrogenase 0.0134 0.1535 0.1514
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0026 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0052 0.0121
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0054 0.0473 0.045
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0303 0.0309
Schistosoma mansoni rab6-interacting 0.0044 0.0333 0.0826
Loa Loa (eye worm) glutaminase 0.0314 0.391 0.5596
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0056 0.0491 0.1216
Echinococcus granulosus axis inhibition protein axin 0.002 0.0026 0.0052
Loa Loa (eye worm) hypothetical protein 0.005 0.0417 0.0598
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0134 0.1535 0.2455
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0052 0.0121
Mycobacterium leprae Probable lipase LipE 0.0041 0.0303 0.0309
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0303 0.0707
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0052 0.0121
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0116 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0052 0.0121
Trypanosoma brucei hypothetical protein, conserved 0.0471 0.5991 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0056 0.0491 0.0977
Loa Loa (eye worm) bromodomain containing protein 0.0027 0.0109 0.0156
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0052 0.0128
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0089 0.0929 0.2301
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0443 0.0634
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0085 0.0106
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0052 0.0128
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0303 0.0333
Loa Loa (eye worm) hypothetical protein 0.0036 0.0226 0.0324
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0054 0.0473 0.0539
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0146 0.0144
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0026 0.0052
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0423 0.0341
Echinococcus granulosus chromobox protein 1 0.0074 0.0739 0.1471
Mycobacterium ulcerans hypothetical protein 0.0054 0.0473 0.045
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0052 0.0103
Brugia malayi Cytochrome P450 family protein 0.0052 0.0443 0.1035
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0097 0.1038 0.1444
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0026 0.0052
Schistosoma mansoni lipoxygenase 0.0194 0.2327 0.5764
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0134 0.1535 0.2148
Loa Loa (eye worm) hypothetical protein 0.0041 0.0303 0.0433
Leishmania major hypothetical protein, conserved 0.0471 0.5991 1
Leishmania major pyruvate kinase 0.0036 0.0226 0.0238
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0349 0.0389
Mycobacterium tuberculosis Conserved protein 0.0054 0.0473 0.0653
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Brugia malayi Pre-SET motif family protein 0.0222 0.2693 0.6295
Loa Loa (eye worm) hypothetical protein 0.0041 0.0303 0.0433
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0647 0.8323 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0052 0.0128
Mycobacterium ulcerans hypothetical protein 0.0027 0.0116 0.0091
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0026 0.0052
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0401 0.0798
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0116 0.0091
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.005 0.0124
Onchocerca volvulus Serine\/threonine kinase homolog 0.0209 0.2524 0.8114
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0052 0.0121
Trichomonas vaginalis set domain proteins, putative 0.0253 0.3099 0.3704
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0226 0.0324
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0303 0.0749
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0074 0.0182
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0026 0.0052
Entamoeba histolytica phosphomannose isomerase, putative 0.0112 0.1233 0.1455
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0116 0.0051
Plasmodium vivax glutathione reductase, putative 0.005 0.0423 0.3296
Trypanosoma cruzi phosphomannose isomerase, putative 0.0112 0.1233 0.1746
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0134 0.1535 0.3056
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0226 0.0322
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0051 0.0432 0.0489
Trichomonas vaginalis CAMK family protein kinase 0.0209 0.2524 0.3011
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0052 0.0103
Loa Loa (eye worm) hypothetical protein 0.0027 0.0116 0.0166
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0303 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0146 0.0144
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0116 0.0051
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.1278 0.1697
Schistosoma mansoni pyruvate kinase 0.0036 0.0226 0.056
Echinococcus multilocularis expressed protein 0.0398 0.5024 1
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0739 0.0859
Chlamydia trachomatis pyruvate kinase 0.0036 0.0226 0.0202
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0303 0.0132
Schistosoma mansoni rab6-interacting 0.0044 0.0333 0.0826
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0177 0.0438
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0401 0.0798
Brugia malayi Pre-SET motif family protein 0.0032 0.0177 0.0413
Brugia malayi jmjC domain containing protein 0.0056 0.0491 0.1147
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0316 0.394 0.3926
Brugia malayi steroid hormone receptor 0.0022 0.0052 0.0121
Trypanosoma brucei phosphomannose isomerase 0.0112 0.1233 0.2012
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0303 0.0412
Echinococcus granulosus zinc finger protein 0.0029 0.0136 0.027
Schistosoma mansoni serine/threonine protein kinase 0.0209 0.2524 0.6252
Schistosoma mansoni bromodomain containing protein 0.0075 0.0753 0.1864
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Plasmodium falciparum LCCL domain-containing protein 0.0044 0.0333 0.2555
Loa Loa (eye worm) hypothetical protein 0.0546 0.6986 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.061 0.0873
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0423 0.0842
Loa Loa (eye worm) hypothetical protein 0.004 0.0284 0.0406
Loa Loa (eye worm) doublecortin family protein 0.0044 0.0333 0.0477
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0226 0.0202
Brugia malayi Bromodomain containing protein 0.0049 0.04 0.0935
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0035 0.0087
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0116 0.0091
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0647 0.8323 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0035
Giardia lamblia Fructose-bisphosphate aldolase 0.0647 0.8323 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0263 0.0523
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0085 0.0061
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0303 0.23
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0226 0.0322
Brugia malayi MH2 domain containing protein 0.0127 0.1441 0.3367
Plasmodium vivax multidomain scavenger receptor, putative 0.0044 0.0333 0.2555
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0026 0.0052
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.1278 0.1785
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0052 0.0128
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0556 0.7112 1
Schistosoma mansoni regulator of G protein signaling 0.002 0.0026 0.0064
Echinococcus multilocularis Polycystic kidney disease protein 0.0044 0.0333 0.0663
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0085 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0307 0.0338
Brugia malayi jmjC domain containing protein 0.0056 0.0491 0.1147
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0209 0.2524 0.5024
Loa Loa (eye worm) hypothetical protein 0.0041 0.0297 0.0425
Toxoplasma gondii ABC1 family protein 0.0041 0.0303 0.0385
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0226 0.0573
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0052 0.0074
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0333 0.0663
Echinococcus granulosus PHD finger protein rhinoceros 0.0065 0.061 0.1214
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0333 0.0663
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0052 0.0074
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0026 0.0052
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0303 0.0279
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0284 0.0664
Onchocerca volvulus 0.0044 0.0333 0.0924
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0112 0.1233 0.2882
Brugia malayi Doublecortin family protein 0.0044 0.0333 0.0779
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0052 0.0121
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0035
Mycobacterium tuberculosis Conserved protein 0.0041 0.0303 0.0412
Schistosoma mansoni aldehyde dehydrogenase 0.0134 0.1535 0.3803
Loa Loa (eye worm) hypothetical protein 0.0033 0.0188 0.0268
Toxoplasma gondii aldehyde dehydrogenase 0.0134 0.1535 0.2159
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0047 0.0067
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0226 0.0324
Echinococcus multilocularis peregrin 0.0075 0.0747 0.1488
Echinococcus multilocularis jumonji domain containing protein 0.009 0.0945 0.188
Onchocerca volvulus Alhambra homolog 0.0065 0.061 0.1832
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.1278 0.1785
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0417 0.1034
Toxoplasma gondii PHD-finger domain-containing protein 0.0065 0.061 0.0828
Loa Loa (eye worm) hypothetical protein 0.0041 0.0303 0.0433
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0226 0.0529
Trypanosoma cruzi polo-like protein kinase, putative 0.0209 0.2524 0.3986
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.006 0.0556 0.077
Loa Loa (eye worm) hypothetical protein 0.0051 0.0434 0.0622
Brugia malayi ecdysteroid receptor 0.0022 0.0052 0.0121
Echinococcus granulosus L aminoadipate semialdehyde 0.0089 0.0929 0.1849
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0035
Onchocerca volvulus 0.0027 0.0116 0.021
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0074
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0058 0.0518 0.1031
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0323 0.4037 0.8036
Brugia malayi hypothetical protein 0.002 0.0026 0.0061
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0074 0.0146
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0035 0.005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0529 0.1235
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.1441 0.2062
Loa Loa (eye worm) hypothetical protein 0.0044 0.0333 0.0477
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0303 0.0412
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0052 0.0074
Mycobacterium ulcerans aldehyde dehydrogenase 0.0134 0.1535 0.1514
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0774 1 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0116 0.0043
Onchocerca volvulus 0.0033 0.0188 0.0446
Toxoplasma gondii hypothetical protein 0.0546 0.6986 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0226 0.0305
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0303 0.0333
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0401 0.0798
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0303 0.0333
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0052 0.0121
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0052 0.0121
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0303 0.0433

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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