Detailed information for compound 560798

Basic information

Technical information
  • TDR Targets ID: 560798
  • Name: 6,9,11-trihydroxy-9-(1-hydroxyethyl)-4-methox y-8,10-dihydro-7H-tetracene-5,12-dione
  • MW: 384.379 | Formula: C21H20O7
  • H donors: 4 H acceptors: 6 LogP: 2.83 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc2c1C(=O)c1c(O)c3CCC(Cc3c(c1C2=O)O)(O)C(O)C
  • InChi: 1S/C21H20O7/c1-9(22)21(27)7-6-10-12(8-21)19(25)15-16(17(10)23)20(26)14-11(18(15)24)4-3-5-13(14)28-2/h3-5,9,22-23,25,27H,6-8H2,1-2H3
  • InChiKey: FCGIQQFXNIJXMK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6,9,11-trihydroxy-9-(1-hydroxyethyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-quinone
  • 7-deoxy-13-dihydrodaunorubicinone
  • 35994-55-9
  • 7-Deoxydaunorubicinol aglycone
  • NSC 258819
  • DAUNORUBICINOL, 7-DEOXY- AGLYCONE
  • NSC283832
  • NSC258819
  • 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(1-hydroxyethyl)-1-methoxy-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0116 0.0266
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.1459 0.1452
Echinococcus multilocularis acetylcholinesterase 0.0271 0.3607 0.8859
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0235 0.0559
Loa Loa (eye worm) hypothetical protein 0.0046 0.0366 0.0358
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0733 0.1783
Brugia malayi Carboxylesterase family protein 0.0046 0.0366 0.0366
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0131 0.0321
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0271 0.3607 0.8862
Schistosoma mansoni BC026374 protein (S09 family) 0.0046 0.0366 0.09
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0046 0.0366 0.0882
Plasmodium falciparum phd finger protein, putative 0.0059 0.0555 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.2944 0.2939
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1018 0.2501
Loa Loa (eye worm) hypothetical protein 0.0046 0.0366 0.0358
Loa Loa (eye worm) hypothetical protein 0.0029 0.0131 0.0122
Echinococcus granulosus snurportin 1 0.0303 0.407 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0733 0.18
Brugia malayi Pre-SET motif family protein 0.0205 0.2657 0.2657
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0555 1
Entamoeba histolytica hypothetical protein 0.0037 0.0235 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.2481 0.6089
Onchocerca volvulus 0.0046 0.0366 0.0804
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0008 0.0008
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0116 0.1975
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.407 0.4065
Loa Loa (eye worm) carboxylesterase 0.0046 0.0366 0.0358
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.1018 0.101
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0235 0.0559
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1018 0.2501
Echinococcus granulosus BC026374 protein S09 family 0.0046 0.0366 0.0882
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0131 0.0321
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1018 0.2501
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0046 0.0366 0.1172
Plasmodium falciparum importin beta, putative 0.0028 0.0116 0.1975
Mycobacterium ulcerans carboxylesterase, LipT 0.0046 0.0366 0.5
Brugia malayi PHD-finger family protein 0.0059 0.0555 0.0555
Schistosoma mansoni neuroligin 3 (S09 family) 0.0046 0.0366 0.09
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0733 0.0725
Onchocerca volvulus 0.0233 0.3064 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0046 0.0366 0.0882
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0039 0.01
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0555 0.1362
Brugia malayi hypothetical protein 0.0046 0.0366 0.0366
Brugia malayi hypothetical protein 0.0037 0.0235 0.0235
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2657 0.2651
Schistosoma mansoni acetylcholinesterase 0.0046 0.0366 0.09
Brugia malayi Carboxylesterase family protein 0.0046 0.0366 0.0366
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0131 0.0321
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0235 0.0578
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0366 0.5
Echinococcus granulosus jumonji domain containing protein 0.0082 0.0886 0.2161
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1018 0.2485
Brugia malayi Carboxylesterase family protein 0.0271 0.3607 0.3607
Plasmodium vivax importin-beta 2, putative 0.0028 0.0116 0.1975
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0115 0.0263
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0733 0.1783
Loa Loa (eye worm) hypothetical protein 0.0046 0.0366 0.0358
Schistosoma mansoni hypothetical protein 0.0033 0.0184 0.0452
Trichomonas vaginalis set domain proteins, putative 0.0233 0.3064 1
Schistosoma mansoni jumonji domain containing protein 0.0153 0.1911 0.4696
Loa Loa (eye worm) hypothetical protein 0.0048 0.0404 0.0396
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0101 0.116 0.1152
Entamoeba histolytica hypothetical protein 0.0023 0.0039 0.1348
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0039 0.01
Schistosoma mansoni hypothetical protein 0.0303 0.407 1
Schistosoma mansoni ran 0.0021 0.0008 0.0021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0404 0.0396
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0404 0.0404
Leishmania major C-8 sterol isomerase-like protein 0.0714 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1018 0.2485
Onchocerca volvulus Alhambra homolog 0.0059 0.0555 0.1445
Brugia malayi RNA, U transporter 1 0.0081 0.087 0.087
Echinococcus multilocularis peregrin 0.0059 0.0555 0.1345
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0555 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0116 0.0108
Loa Loa (eye worm) hypothetical protein 0.0028 0.0116 0.0108
Echinococcus granulosus acetylcholinesterase 0.0271 0.3607 0.8859
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.1456 0.1449
Schistosoma mansoni gliotactin 0.0046 0.0366 0.09
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0131 0.0301
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.2481 0.6089
Brugia malayi follicle stimulating hormone receptor 0.0225 0.2944 0.2944
Leishmania major importin beta-1 subunit, putative 0.0023 0.0039 0.0031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1018 0.2485
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0366 0.09
Brugia malayi Carboxylesterase family protein 0.0271 0.3607 0.3607
Echinococcus granulosus importin subunit beta 1 0.0028 0.0116 0.0266
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0555 0.0547
Echinococcus multilocularis neuroligin 0.0046 0.0366 0.0882
Plasmodium vivax SET domain protein, putative 0.0029 0.0131 0.2239
Loa Loa (eye worm) hypothetical protein 0.0271 0.3607 0.3601
Brugia malayi Importin beta-1 subunit 0.0028 0.0116 0.0116
Echinococcus multilocularis BC026374 protein (S09 family) 0.0046 0.0366 0.0882
Onchocerca volvulus 0.0046 0.0366 0.0804
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0116 0.0108
Loa Loa (eye worm) carboxylesterase 0.0271 0.3607 0.3601
Loa Loa (eye worm) hypothetical protein 0.0046 0.0366 0.0358
Echinococcus granulosus neuroligin 0.0046 0.0366 0.0882
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0555 0.1345
Loa Loa (eye worm) hypothetical protein 0.0714 1 1
Brugia malayi jmjC domain containing protein 0.0071 0.0733 0.0733
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0714 1 1
Schistosoma mansoni hypothetical protein 0.0037 0.0235 0.0578
Echinococcus multilocularis para nitrobenzyl esterase 0.0046 0.0366 0.0882
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0184 0.0184
Brugia malayi Pre-SET motif family protein 0.0029 0.0131 0.0131
Trypanosoma brucei C-8 sterol isomerase, putative 0.0714 1 1
Trichomonas vaginalis spcc417.12 protein, putative 0.0046 0.0366 0.1172
Entamoeba histolytica hypothetical protein 0.0037 0.0235 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0366 0.09
Echinococcus granulosus acetylcholinesterase 0.0271 0.3607 0.8859
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0131 0.0301
Schistosoma mansoni importin beta-1 0.0028 0.0116 0.0286
Echinococcus granulosus peregrin 0.0059 0.0555 0.1345
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0131 0.0301
Onchocerca volvulus 0.0046 0.0366 0.0804
Loa Loa (eye worm) hypothetical protein 0.0059 0.0555 0.0547
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1018 0.2485
Loa Loa (eye worm) hypothetical protein 0.0046 0.0366 0.0358
Echinococcus multilocularis snurportin 1 0.0303 0.407 1
Echinococcus multilocularis carboxylesterase 5A 0.0271 0.3607 0.8859
Entamoeba histolytica hypothetical protein 0.0037 0.0235 1
Entamoeba histolytica hypothetical protein 0.0037 0.0235 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.1018 0.1018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0733 0.18
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0366 0.5
Echinococcus multilocularis acetylcholinesterase 0.0271 0.3607 0.8859
Onchocerca volvulus 0.0046 0.0366 0.0804
Loa Loa (eye worm) hypothetical protein 0.0365 0.4968 0.4964
Brugia malayi Carboxylesterase family protein 0.0046 0.0366 0.0366
Schistosoma mansoni ran 0.0021 0.0008 0.0021
Brugia malayi jmjC domain containing protein 0.0192 0.2481 0.2481
Onchocerca volvulus 0.0046 0.0366 0.0804
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0131 0.2239
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0555 0.1345
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.1459 0.1452
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0039 0.01
Brugia malayi Carboxylesterase family protein 0.0046 0.0366 0.0366
Echinococcus granulosus para nitrobenzyl esterase 0.0046 0.0366 0.0882
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0366 0.09
Loa Loa (eye worm) carboxylesterase 0.0046 0.0366 0.0358
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0131 0.0321
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0039 0.0031
Echinococcus granulosus carboxylesterase 5A 0.0271 0.3607 0.8859
Loa Loa (eye worm) hypothetical protein 0.0046 0.0366 0.0358
Giardia lamblia PHD finger protein 15 0.0059 0.0555 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0271 0.3607 0.3601
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0555 1
Loa Loa (eye worm) hypothetical protein 0.0271 0.3607 0.3601
Loa Loa (eye worm) hypothetical protein 0.0033 0.0184 0.0176
Echinococcus multilocularis jumonji domain containing protein 0.0082 0.0886 0.2161
Brugia malayi Bromodomain containing protein 0.0059 0.0555 0.0555
Mycobacterium tuberculosis Carboxylesterase LipT 0.0046 0.0366 0.5
Schistosoma mansoni hypothetical protein 0.0059 0.0555 0.1362
Loa Loa (eye worm) hypothetical protein 0.0046 0.0366 0.0358
Brugia malayi MH2 domain containing protein 0.0122 0.1459 0.1459

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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