Detailed information for compound 56088

Basic information

Technical information
  • TDR Targets ID: 56088
  • Name: N-(5-phenoxy-2-prop-2-enoxyphenyl)acetamide
  • MW: 283.322 | Formula: C17H17NO3
  • H donors: 1 H acceptors: 1 LogP: 3.24 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCOc1ccc(cc1NC(=O)C)Oc1ccccc1
  • InChi: 1S/C17H17NO3/c1-3-11-20-17-10-9-15(12-16(17)18-13(2)19)21-14-7-5-4-6-8-14/h3-10,12H,1,11H2,2H3,(H,18,19)
  • InChiKey: WEYPIIGEJMFBEX-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-allyloxy-5-phenoxy-phenyl)acetamide
  • N-(2-allyloxy-5-phenoxyphenyl)acetamide
  • N-(5-phenoxy-2-prop-2-enoxy-phenyl)ethanamide
  • N-[5-(phenoxy)-2-prop-2-enoxyphenyl]acetamide
  • N-[2-allyloxy-5-(phenoxy)phenyl]acetamide
  • N-[5-(phenoxy)-2-prop-2-enoxy-phenyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei trypanothione reductase 0.01 0.045 0.8705
Brugia malayi nuclear receptor RXR 0.0011 0.0008 0.0038
Schistosoma mansoni hypothetical protein 0.0032 0.0113 0.044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0055 0.0243
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0032 0.0617
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0004 0.0094
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0032 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0236 0.4558
Plasmodium falciparum thioredoxin reductase 0.0035 0.0126 0.2803
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0048 0.0927
Schistosoma mansoni DNA polymerase IV / kappa 0.0019 0.0048 0.0187
Trypanosoma cruzi DNA polymerase eta, putative 0.0113 0.0517 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0126 0.244
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Schistosoma mansoni DNA helicase recq1 0.002 0.0056 0.0219
Trichomonas vaginalis C-MYB, putative 0.003 0.0102 0.4
Loa Loa (eye worm) PDE1B protein 0.0057 0.0236 0.1041
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.008 0.0311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0055 0.0243
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0048 0.0927
Trichomonas vaginalis MYB72, putative 0.003 0.0102 0.4
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0002 0.0007
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.9215
Schistosoma mansoni thyroid hormone receptor 0.002 0.0055 0.0215
Loa Loa (eye worm) RNA binding protein 0.0065 0.0279 0.1233
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0057 0.0236 0.092
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0057 0.0236 0.092
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0256 0.4946
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0055 0.0277
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0233 0.0837
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0104
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0409 0.1983 1
Schistosoma mansoni hypothetical protein 0.0422 0.2051 0.8009
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0113 0.0568
Schistosoma mansoni hypothetical protein 0.0032 0.0113 0.044
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0056 0.1084
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0126 0.244
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0055 0.0215
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0256 0.4946
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0056 0.1084
Trichomonas vaginalis MYB, putative 0.003 0.0103 0.4028
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0126 0.0126
Schistosoma mansoni nuclear hormone receptor 0.001 0.0002 0.0007
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0032 0.0125
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.9215
Schistosoma mansoni DNA polymerase eta 0.0113 0.0517 0.2018
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.001 0.0046
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0126 0.244
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0236 0.0845
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0102 0.4
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0248
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0055 0.541
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0003 0.001
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0256 0.4946
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0055 0.0215
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0055 0.541
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0003 0.0052
Schistosoma mansoni smad 0.0011 0.001 0.004
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0057 0.0236 0.092
Entamoeba histolytica recQ family DNA helicase 0.001 0.0006 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0055 0.0277
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0055 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0055 0.0277
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0003 0.006
Loa Loa (eye worm) Smad1 0.0025 0.008 0.0351
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0102 0.0449
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0056 0.0219
Loa Loa (eye worm) hypothetical protein 0.0057 0.0236 0.1041
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0057 0.0236 0.4558
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.9215
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Mycobacterium tuberculosis Probable oxidoreductase 0.0253 0.1211 0.1689
Schistosoma mansoni hypothetical protein 0.0032 0.0113 0.044
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0003 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0927
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.008 0.0311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0055 0.0243
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0126 0.0126
Brugia malayi polk-prov protein 0.0019 0.0048 0.0242
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0057 0.0236 0.4558
Schistosoma mansoni Smad4 0.0025 0.008 0.0311
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0003 0.0106
Echinococcus granulosus bloom syndrome protein 0.002 0.0056 0.0219
Schistosoma mansoni topbp1 0.001 0.0003 0.0011
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0126 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0055 0.0277
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0057 0.0236 0.1188
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2024 1 1
Schistosoma mansoni coup transcription factor 0.002 0.0055 0.0215
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0243
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0228 0.1085 0.1513
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0162 0.3137
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0126 0.2803
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0243
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0126 0.4934
Giardia lamblia DNA damage repair protein 0.0019 0.0048 0.0212
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.0256 0.0256
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0927
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0032 0.0161
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0055 0.0277
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0055 0.0215
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0003 0.0052
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0057 0.0236 0.092
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0002 0.0183
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0113 0.0498
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0256 0.4946
Schistosoma mansoni smad1 5 8 and 0.0025 0.008 0.0311
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0253 0.1211 0.1689
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0236 0.9215
Brugia malayi nuclear receptor RXR 0.001 0.0002 0.0009
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0055 0.0215
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0126 0.2803
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0256 0.4946
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0003 0.0003
Onchocerca volvulus 0.003 0.0102 1
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0056 0.2192
Brugia malayi nuclear hormone receptor 0.002 0.0055 0.0277
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0113 0.0517 0.2283
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0071 0.0309 0.1109
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0012
Toxoplasma gondii thioredoxin reductase 0.01 0.045 0.1615
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0279 0.109
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.001 0.0041
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0279 0.109
Echinococcus granulosus dna polymerase kappa 0.0061 0.0256 0.0998
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0236 0.0845
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0003 0.0011
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0002 0.0007
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0048 0.0172
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0279 0.109
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0465 0.2264 0.8125
Plasmodium vivax thioredoxin reductase, putative 0.01 0.045 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0003 0.0106
Echinococcus granulosus dnaJ subfamily B 0.0422 0.2051 0.8009
Schistosoma mansoni Smad4 0.0011 0.001 0.004
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0126 0.244
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0055 0.0215
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0002 0.0007
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0006 0.012
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0102 0.3243
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0032 0.0709
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0126 0.0126
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0571 0.2786 0.2786
Brugia malayi tailless protein 0.001 0.0002 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0256 0.4946
Loa Loa (eye worm) hypothetical protein 0.0057 0.0236 0.1041
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0113 0.044
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0256 0.4946
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.9215
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0055 0.0215
Brugia malayi hypothetical protein 0.0025 0.0078 0.0394
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0056 0.0247
Brugia malayi hypothetical protein 0.0011 0.0008 0.0038
Echinococcus multilocularis GPCR, family 2 0.0032 0.0113 0.044
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0078 0.151
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0236 0.0845
Onchocerca volvulus 0.001 0.0002 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0055 0.0277
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0055 0.0215
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0003 0.0003
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0236 0.0845
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Leishmania major DNA damage repair protein, putative 0.0019 0.0048 0.0927
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.4558
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0179 0.0698
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0126 0.244
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0002 0.0009
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0102 0.4
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0002 0.0007
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0057 0.0236 0.1188
Echinococcus granulosus dna polymerase eta 0.0113 0.0517 0.2018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0055 0.0243
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0454 0.2007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0256 0.4946
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0003 0.0106
Onchocerca volvulus 0.001 0.0003 0.0266
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0243
Brugia malayi ImpB/MucB/SamB family protein 0.0113 0.0517 0.2606
Schistosoma mansoni hypothetical protein 0.0011 0.001 0.0039
Echinococcus multilocularis dnaJ subfamily B 0.0422 0.2051 0.8009
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0078 0.1734
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0003 0.0106
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0102 0.3243
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0078 0.028
Brugia malayi ecdysone receptor 0.001 0.0002 0.0009
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0056 0.2192
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0048 0.0927
Schistosoma mansoni hypothetical protein 0.0525 0.2561 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0126 0.244
Trichomonas vaginalis DNA polymerase eta, putative 0.0061 0.0256 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Brugia malayi ImpB/MucB/SamB family protein 0.0061 0.0256 0.1289
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0228 0.1085 0.1513
Echinococcus multilocularis Smad4 0.0025 0.008 0.0311
Brugia malayi hypothetical protein 0.0073 0.0315 0.159
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0032 0.0125
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0454 0.2292
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0113 0.044
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0057 0.0236 0.092
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0256 0.4946
Brugia malayi MH2 domain containing protein 0.0025 0.008 0.0401
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0055 0.0277
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0243
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0055 0.0243
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0253 0.1211 0.1689
Entamoeba histolytica deoxycytidyl transferase, putative 0.0061 0.0256 0.8107
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0002 0.0007
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0126 0.244
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0179 0.079
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0465 0.2264 0.8841
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0465 0.2264 0.8841
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0236 0.0845
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0055 0.0215
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0055 0.0215
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0296 0.1494
Plasmodium falciparum DNA repair protein REV1, putative 0.0019 0.0048 0.1065
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0008 0.003
Echinococcus multilocularis dna polymerase kappa 0.0061 0.0256 0.0998
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0465 0.2264 0.8841
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0236 0.4558
Leishmania major trypanothione reductase 0.01 0.045 0.8705
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0236 0.0845
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0126 0.244
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0057 0.0236 0.4558
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0055 0.0277
Leishmania major hypothetical protein, conserved 0.0057 0.0236 0.4558
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0002 0.0007
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0056 0.0283
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.9215
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0057 0.0236 0.4558
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0006 0.0024
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0048 0.0172
Brugia malayi hypothetical protein 0.0016 0.0034 0.0173
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.001 0.0041
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0057 0.0236 0.4558
Brugia malayi conserved hypotetical protein 0.001 0.0002 0.0009
Brugia malayi MH1 domain containing protein 0.0014 0.0024 0.0119
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0057 0.0236 0.9215
Loa Loa (eye worm) hypothetical protein 0.0465 0.2264 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0055 0.0215
Schistosoma mansoni nuclear receptor 0.001 0.0002 0.0007
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.9215
Plasmodium vivax glutathione reductase, putative 0.01 0.045 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0046
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0032 0.0114
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0057 0.0236 0.092
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0048 0.0927
Trichomonas vaginalis pc-MYB2, putative 0.003 0.0102 0.4
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0057 0.0236 0.1188
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0126 0.2803
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Brugia malayi MH1 domain containing protein 0.0025 0.008 0.0401
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0571 0.2786 0.2786
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0055 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0256 0.4946
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.5236
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0032 0.0617
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0033
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0057 0.0236 0.4558
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0057 0.0236 0.092
Plasmodium vivax phosphodiesterase gamma, putative 0.0057 0.0236 0.5236
Trypanosoma brucei chrX additional, unordered contigs 0.0019 0.0048 0.0927
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0236 0.0845
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0061 0.0256 0.0998
Trypanosoma brucei unspecified product 0.0042 0.0162 0.3137
Entamoeba histolytica hypothetical protein 0.0073 0.0315 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0126 0.0636
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0126 0.244
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0253 0.1211 0.1689
Brugia malayi mothers against decapentaplegic homolog 3 0.0011 0.001 0.0052
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.0256 0.0256
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0032 0.0125
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0002 0.0008
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.9215
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.008 0.0351
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0081 0.0406
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0256 0.4946
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0126 0.244
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.9215
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0012
Entamoeba histolytica hypothetical protein 0.0073 0.0315 1
Echinococcus granulosus GPCR family 2 0.0032 0.0113 0.044
Giardia lamblia DINP protein human, muc B family 0.0061 0.0256 0.1129
Schistosoma mansoni hypothetical protein 0.0032 0.0113 0.044
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0048 0.0927
Brugia malayi Nuclear hormone receptor E75 0.001 0.0002 0.0009
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0102 0.4
Brugia malayi RNA binding protein 0.0065 0.0279 0.1408
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0126 0.4934
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0179 0.0698
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0113 0.044
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0102 0.3243
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0055 0.0215
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0055 0.0215
Leishmania major DNA polymerase kappa, putative 0.0019 0.0048 0.0927
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0315 0.1231
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.01 0.045 0.0628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0055 0.0243
Brugia malayi MH2 domain containing protein 0.037 0.1791 0.9031
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0078 0.1734
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0103 0.4028
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0032 0.0141
Echinococcus multilocularis thioredoxin glutathione reductase 0.01 0.045 0.1757
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0056 0.0201
Schistosoma mansoni hypothetical protein 0.0525 0.2561 1
Echinococcus multilocularis dna polymerase eta 0.0113 0.0517 0.2018
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Schistosoma mansoni cpg binding protein 0.003 0.0102 0.0397
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0056 0.0201
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0102 0.4
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.9215
Loa Loa (eye worm) RecQ helicase 0.002 0.0056 0.0248
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1453 0.7168 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0236 0.0845
Loa Loa (eye worm) hypothetical protein 0.0032 0.0113 0.0498
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0179 0.0698
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0256 0.4946
Trichomonas vaginalis MYB3r3, putative 0.003 0.0102 0.4
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0032 0.0125
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0056 0.0283
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0236 0.0845
Loa Loa (eye worm) glutathione reductase 0.01 0.045 0.1987
Echinococcus multilocularis cpg binding protein 0.0031 0.011 0.043
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0055 0.541
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0057 0.0236 0.4558
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0057 0.0236 0.092
Leishmania major DNA polymerase eta, putative 0.0071 0.0309 0.5981
Mycobacterium ulcerans hypothetical protein 0.0019 0.0048 0.0048
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0035 0.0126 0.0176
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0057 0.0236 0.1041
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0061 0.0256 0.1129
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0126 0.244
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0057 0.0236 0.092
Onchocerca volvulus 0.002 0.0055 0.541
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0032 0.0617
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0055 0.0215
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0008 0.003
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.001 0.0039
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0078 0.151
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.5236
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0032 0.0125
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0028
Brugia malayi glutathione reductase 0.01 0.045 0.2269
Brugia malayi CXXC zinc finger family protein 0.003 0.0102 0.0513
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0003 0.0014
Echinococcus multilocularis bloom syndrome protein 0.002 0.0056 0.0219
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0103 0.4028
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0228 0.1085 0.1513
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0179 0.0698
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0126 0.0492
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0003 0.0014
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0126 0.0453
Leishmania major DNA polymerase kappa, putative 0.0061 0.0256 0.4946
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0126 0.244
Mycobacterium tuberculosis Conserved hypothetical protein 0.0061 0.0256 0.0357
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0465 0.2264 1
Echinococcus granulosus geminin 0.0525 0.2561 1
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0003 0.0004
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0057 0.0236 0.1188
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0057 0.0236 0.092
Plasmodium falciparum glutathione reductase 0.0035 0.0126 0.2803
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0057 0.0236 0.092
Echinococcus granulosus replication factor c subunit 1 0.001 0.0003 0.0011
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0056 0.0219
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0126 0.0493
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0126 0.0557
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.9215
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0012
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0236 0.0845
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0102 0.3243
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0236 0.0845
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0002 0.0009
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0003 0.006
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0055 0.0277
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0279 0.1408
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0057 0.0236 0.4558
Mycobacterium tuberculosis Probable dehydrogenase 0.0228 0.1085 0.1513
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.001 0.0041
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0032 0.0617
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0057 0.0236 0.1188
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0236 0.9215
Leishmania major cAMP-specific phosphodiesterase, putative 0.0057 0.0236 0.4558
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0236 0.0845
Giardia lamblia Replication factor C, subunit 1 0.001 0.0003 0.0012
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0113 0.0568
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0056 0.0219
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0243
Brugia malayi DKFZp564C0469 protein 0.001 0.0003 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0055 0.0243
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.008 0.0351
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0081 0.0406
Brugia malayi topoisomerase 0.001 0.0003 0.0014
Brugia malayi nuclear receptor NHR-88 0.002 0.0055 0.0277
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0162 0.3137
Brugia malayi hypothetical protein 0.001 0.0003 0.0014
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0465 0.2264 0.8841
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0279 0.109
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0279 0.109
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.9215
Trypanosoma brucei unspecified product 0.0042 0.0162 0.3137
Loa Loa (eye worm) hypothetical protein 0.0101 0.0454 0.2007
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0057 0.0236 0.1188
Trichomonas vaginalis C-MYB, putative 0.003 0.0102 0.4
Entamoeba histolytica hypothetical protein 0.0073 0.0315 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0057 0.0236 0.4558
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0126 0.0453
Echinococcus granulosus nibrin 0.001 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0033
Echinococcus granulosus FTZ F1 alpha 0.002 0.0055 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0055 0.0277
Treponema pallidum DNA ligase (lig) 0.001 0.0003 0.0003
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0056 0.2192
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0055 0.0277
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0056 0.0283
Brugia malayi isocitrate dehydrogenase 0.0016 0.0032 0.0161
Chlamydia trachomatis DNA ligase 0.001 0.0003 0.0003
Schistosoma mansoni DNA helicase recq5 0.002 0.0056 0.0219
Loa Loa (eye worm) hypothetical protein 0.0069 0.0296 0.1309
Giardia lamblia Myb 1-like protein 0.003 0.0103 0.0455
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2024 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0055 0.0215
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0056 0.1245
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0003 0.001
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0002 0.0007
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0465 0.2264 0.8841
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0057 0.0236 0.5236
Schistosoma mansoni terminal deoxycytidyl transferase 0.0061 0.0256 0.0998
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0008 0.0029
Trypanosoma brucei unspecified product 0.0061 0.0256 0.4946
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.008 0.0311
Schistosoma mansoni DNA ligase IV 0.001 0.0003 0.0011
Schistosoma mansoni smad 0.0025 0.008 0.0311
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0236 0.4558
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Loa Loa (eye worm) thioredoxin reductase 0.01 0.045 0.1987
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0006 0.0022
Plasmodium falciparum thioredoxin reductase 0.01 0.045 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0057 0.0236 0.092
Treponema pallidum NADH oxidase 0.0035 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0012
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0113 0.044
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0056 0.1245
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0055 0.0215
Mycobacterium tuberculosis Probable reductase 0.0228 0.1085 0.1513
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0243
Brugia malayi nuclear receptor NHR-88 0.001 0.0002 0.0009
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1453 0.7168 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0315 0.1231
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0256 0.4946
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0002 0.0007
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0056 0.0248
Plasmodium vivax DNA repair protein REV1, putative 0.0019 0.0048 0.1065
Brugia malayi hypothetical protein 0.001 0.0002 0.0009
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0032 0.0617
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0006 0.0138
Plasmodium falciparum phosphodiesterase gamma, putative 0.0057 0.0236 0.5236
Loa Loa (eye worm) hypothetical protein 0.0025 0.0078 0.0345
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0179 0.0698
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.001 0.0041
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0057 0.0236 0.092
Brugia malayi Thioredoxin reductase 0.01 0.045 0.2269
Entamoeba histolytica hypothetical protein 0.001 0.0003 0.0086
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0008 0.0033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0126 0.244
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0003 0.0011
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0102 0.4
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0162 0.3137
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0055 0.0215
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.008 0.0311
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0003 0.0106
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0267 0.1041
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0236 0.4558
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0409 0.1983 0.8758
Trypanosoma cruzi trypanothione reductase, putative 0.01 0.045 0.8705
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0212
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0126 0.244
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0126 0.244
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.9215
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0006 0.012
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0012
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0057 0.0236 0.092
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0057 0.0236 0.4558
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0256 0.4946
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0179 0.0698
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0055 0.0277
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0256 0.4946
Schistosoma mansoni nuclear hormone receptor 0.001 0.0002 0.0007
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0056 0.0219
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2024 1 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0102 0.4
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0179 0.0698
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0078 0.151
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0256 0.4946
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0236 0.9215
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0008 0.0038
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0057 0.0236 0.4558
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0057 0.0236 0.092
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.001 0.0046
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0055 0.0215
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.9215
Schistosoma mansoni hypothetical protein 0.0069 0.0296 0.1157
Schistosoma mansoni thyroid hormone receptor 0.002 0.0055 0.0215
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0003 0.0106
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0033
Leishmania major DNA polymerase eta, putative 0.0113 0.0517 1
Brugia malayi nuclear receptor NHR-67 0.001 0.0002 0.0009
Loa Loa (eye worm) DR-78 0.001 0.0002 0.0008
Schistosoma mansoni hypothetical protein 0.0073 0.0315 0.1231
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0057 0.0236 0.092
Schistosoma mansoni smad1 5 8 and 0.0025 0.008 0.0311
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0048 0.0927
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0057 0.0236 0.4558
Brugia malayi Nuclear hormone receptor E75 0.001 0.0002 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0055 0.0277
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0236 0.0845
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0057 0.0236 0.9215
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0409 0.1983 0.7743
Trichomonas vaginalis pc-MYB2, putative 0.003 0.0102 0.4
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0279 0.1233
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0057 0.0236 0.092
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0454 0.2292
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0002 0.0007
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0055 0.0277
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0061 0.0256 0.0998
Brugia malayi MH1 domain containing protein 0.0014 0.0024 0.0119
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0236 0.0845
Entamoeba histolytica recQ family helicase, putative 0.001 0.0004 0.0134
Brugia malayi TAR-binding protein 0.0065 0.0279 0.1408
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0126 0.244
Brugia malayi steroid hormone receptor 0.002 0.0055 0.0277
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0061 0.0256 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0057 0.0236 0.092
Brugia malayi hypothetical protein 0.001 0.0003 0.0014
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0126 0.2803
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0057 0.0236 0.092
Loa Loa (eye worm) hypothetical protein 0.0057 0.0236 0.1041
Plasmodium falciparum glutathione reductase 0.01 0.045 1
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0055 0.0215
Leishmania major hypothetical protein, conserved 0.0057 0.0236 0.4558
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Brugia malayi hypothetical protein 0.001 0.0002 0.0009
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.008 0.0311
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0032 0.0125
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0002 0.0009
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0055 0.0215
Schistosoma mansoni cpg binding protein 0.0031 0.011 0.043
Trypanosoma cruzi DNA polymerase eta, putative 0.0071 0.0309 0.5981
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0102 0.3243
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0315 0.1231
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0126 0.0126
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0002 0.0007
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0055 0.0243
Brugia malayi ecdysteroid receptor 0.002 0.0055 0.0277
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0061 0.0256 0.4946
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0236 0.0845
Echinococcus granulosus Smad4 0.0025 0.008 0.0311
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0571 0.2786 0.3887
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0003 0.0052
Schistosoma mansoni nuclear receptor 0.001 0.0002 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0236 0.4558
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0236 0.0845
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0055 0.0215
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0256 0.4946
Entamoeba histolytica recQ family helicase, putative 0.002 0.0056 0.1777
Schistosoma mansoni cpg binding protein 0.0031 0.011 0.043
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0057 0.0236 0.092
Giardia lamblia hypothetical protein 0.0057 0.0236 0.104
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0236 0.0845
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0004 0.0015
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0061 0.0256 0.0998
Echinococcus multilocularis geminin 0.0525 0.2561 1
Brugia malayi MH1 domain containing protein 0.0025 0.008 0.0401
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0003 0.0106
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.003 0.0103 0.0369
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0409 0.1983 0.7743
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0078 0.1734
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0055 0.0215
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0003 0.0106
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0055 0.0215
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0011 0.001 0.1018
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0003 0.0052
Trypanosoma brucei DNA polymerase eta, putative 0.0113 0.0517 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0008 0.0038
Schistosoma mansoni topbp1 0.001 0.0003 0.0011
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.9215
Echinococcus multilocularis nibrin 0.001 0.0003 0.0011
Brugia malayi MH2 domain containing protein 0.0011 0.001 0.0052
Schistosoma mansoni zinc finger protein 0.001 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0243
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0032 0.0709
Schistosoma mansoni Smad4 0.0011 0.001 0.004
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.5236
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0055 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0003 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0055 0.0277
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.001 0.0039
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0002 0.0007
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0048 0.0927
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0061 0.0256 0.0357
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.4558
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0032 0.0125
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0003 0.0086
Giardia lamblia Hypothetical protein 0.0057 0.0236 0.104
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0236 0.9215
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0057 0.0236 0.9215
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0057 0.0236 0.4558
Brugia malayi nuclear hormone receptor 0.001 0.0002 0.0009
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0228 0.1085 0.1513
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0028
Leishmania major hypothetical protein, conserved 0.0025 0.0078 0.151
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0033
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0032 0.0114
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0056 0.1084
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0055 0.0277
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0002 0.0008
Plasmodium falciparum phosphodiesterase delta, putative 0.0057 0.0236 0.5236
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0126 0.244
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0057 0.0236 0.092
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0236 0.4558
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0048 0.0927
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0003 0.0052
Loa Loa (eye worm) nuclear factor I 0.0014 0.0024 0.0104
Onchocerca volvulus 0.001 0.0002 0.0183
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0002 0.0007
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0279 0.1233
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0571 0.2786 1
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0002 0.0007
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0057 0.0236 0.092
Schistosoma mansoni nuclear hormone receptor 0.002 0.0055 0.0215
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0126 0.0493
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0179 0.0901
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0243
Echinococcus granulosus tar DNA binding protein 0.0065 0.0279 0.109
Schistosoma mansoni smad1 5 8 and 0.0025 0.008 0.0311
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0006 0.0006
Brugia malayi MH2 domain containing protein 0.0025 0.008 0.0401
Loa Loa (eye worm) MH2 domain-containing protein 0.037 0.1791 0.791
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0057 0.0236 0.5236
Echinococcus multilocularis smad 0.0025 0.008 0.0311
Echinococcus granulosus cpg binding protein 0.0031 0.011 0.043
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0228 0.1085 0.1513
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.5236
Echinococcus granulosus smad 0.0025 0.008 0.0311
Trypanosoma brucei hypothetical protein, conserved 0.0057 0.0236 0.4558
Entamoeba histolytica hypothetical protein 0.0073 0.0315 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0279 0.109
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0002 0.0183
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0002 0.0008
Brugia malayi hypothetical protein 0.0011 0.0008 0.0038
Loa Loa (eye worm) transcription factor SMAD2 0.037 0.1791 0.791
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0236 0.5236
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0055 0.0215
Brugia malayi Smad1 0.0025 0.008 0.0401
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0008 0.0029
Echinococcus granulosus thioredoxin glutathione reductase 0.01 0.045 0.1757

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 97 uM Concentration required to inhibit proliferation of the epimastigote form of T. cruzi ChEMBL. 9554887
IC50 (functional) = 97 uM Concentration required to inhibit proliferation of the epimastigote form of T. cruzi ChEMBL. 9554887

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.