Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.2269 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.2269 | 0.1996 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.2269 | 0.1996 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.2269 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.1333 | 0.1333 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.2269 | 0.1996 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 1 | 0.5 | |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.2269 | 0.108 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.2269 | 0.108 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.2269 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0342 | 0.0342 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0028 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 1 | 0.5 | |
Schistosoma mansoni | lamin | 0.0028 | 1 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0.2269 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.9658 | 0.9658 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.2269 | 0.1996 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0028 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.2269 | 0.2269 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0028 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0.2269 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 1 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.2269 | 0.5 |
Echinococcus multilocularis | musashi | 0.0028 | 1 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0.2269 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.2269 | 0.1996 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.2269 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.2269 | 0.1996 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0.2269 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.2269 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.