Detailed information for compound 560882

Basic information

Technical information
  • TDR Targets ID: 560882
  • Name: 3-(1-naphthyloxy)propane-1,2-diol
  • MW: 218.248 | Formula: C13H14O3
  • H donors: 2 H acceptors: 2 LogP: 1.84 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(COc1cccc2c1cccc2)O
  • InChi: 1S/C13H14O3/c14-8-11(15)9-16-13-7-3-5-10-4-1-2-6-12(10)13/h1-7,11,14-15H,8-9H2
  • InChiKey: BYNNMWGWFIGTIC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(1-naphthalenyloxy)propane-1,2-diol
  • 3-naphthalen-1-yloxypropane-1,2-diol
  • 3-(1-naphthoxy)propane-1,2-diol
  • propranolol glycol
  • 36112-95-5
  • 1,2-PROPANEDIOL, 3-(1-NAPHTHYLOXY)-
  • 1-(2,3-Dihydroxypropoxy)naphthalene
  • 3-(alpha-Naphthoxy)-1,2-propanediol
  • Naphthalene, 1-(2,3-dihydroxypropoxy)-
  • Propanolol glycol
  • Oprea1_270821
  • NCGC00024825-02
  • 1,2-Propanediol, 3-(1-naphthalenyloxy)-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens regulator of G-protein signaling 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Echinococcus multilocularis expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.023 0.27 0.27
Brugia malayi RNA, U transporter 1 0.0164 0.1873 0.6937
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0387 1
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0087 0.0087
Echinococcus multilocularis importin subunit beta 1 0.0058 0.0525 0.0525
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0087 0.0114
Echinococcus granulosus FTZ F1 alpha 0.00140813 0.5 0.5
Schistosoma mansoni ran 0.0021 0.0054 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.023 0.27 0.3554
Brugia malayi beta-lactamase family protein 0.0035 0.0241 0.0893
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0087 0.0087
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0087 0.0114
Loa Loa (eye worm) hypothetical protein 0.00140813 0.5 0.5
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0241 0.5
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0087 0.0322
Brugia malayi ecdysteroid receptor 0.00140813 0.5 0.5
Brugia malayi Muscleblind-like protein 0.0148 0.1665 0.6166
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0087 0.0087
Plasmodium falciparum importin beta, putative 0.0058 0.0525 1
Brugia malayi hypothetical protein 0.0023 0.0087 0.0322
Echinococcus granulosus retinoic acid receptor rxr beta a 0.00140813 0.5 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.00140813 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.0448 0.059
Schistosoma mansoni Tr4/Tr2 (homologue) 0.00140813 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0087 0.0993
Loa Loa (eye worm) hypothetical protein 0.0035 0.0241 0.0317
Loa Loa (eye worm) hypothetical protein 0.00140813 0.5 0.5
Echinococcus granulosus GPCR family 2 0.0016 0.0001 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.023 0.27 0.3554
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0241 0.5624
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0387 1
Schistosoma mansoni thyroid hormone receptor 0.00140813 0.5 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.00140813 0.5 0.5
Brugia malayi beta-lactamase 0.0035 0.0241 0.0893
Loa Loa (eye worm) hypothetical protein 0.0035 0.0241 0.0317
Schistosoma mansoni importin beta-1 0.0058 0.0525 0.0691
Loa Loa (eye worm) hypothetical protein 0.0035 0.0241 0.0318
Brugia malayi Nuclear hormone receptor family member nhr-14 0.00140813 0.5 0.5
Echinococcus multilocularis snurportin 1 0.0617 0.7597 0.7597
Echinococcus multilocularis FTZ F1 alpha 0.00140813 0.5 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0241 0.0894
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.00140813 0.5 0.5
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0525 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1276 0.168
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.0087 0.0993
Brugia malayi nuclear hormone receptor 0.00140813 0.5 0.5
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0087 0.0114
Loa Loa (eye worm) hypothetical protein 0.0035 0.0241 0.0317
Leishmania major GTP-binding protein, putative 0.0021 0.0054 0.1389
Mycobacterium ulcerans hypothetical protein 0.0035 0.0241 0.5
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0054 0.1023
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0087 0.0114
Echinococcus granulosus ecdysone induced protein 78C 0.00140813 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0241 0.6232
Schistosoma mansoni steroid hormone receptor ad4bp 0.00140813 0.5 0.5
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0566 0.0745
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.0087 0.0114
Brugia malayi jmjC domain containing protein 0.0061 0.0566 0.2096
Loa Loa (eye worm) hypothetical protein 0.00140813 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.00140813 0.5 0.5
Schistosoma mansoni coup transcription factor 0.00140813 0.5 0.5
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0087 0.0114
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0241 0.0317
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0194 0.0255
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0241 0.5624
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0002
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0087 0.0114
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.023 0.27 0.3554
Brugia malayi MH2 domain containing protein 0.0117 0.1276 0.4726
Brugia malayi PXA domain containing protein 0.0023 0.0087 0.0322
Onchocerca volvulus 0.00140813 0.5 0.5
Echinococcus granulosus muscleblind protein 0.0148 0.1665 0.2191
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0087 0.0114
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0002
Echinococcus multilocularis expressed protein 0.0451 0.5492 0.5492
Trichomonas vaginalis esterase, putative 0.0035 0.0241 0.5624
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.00140813 0.5 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.00140813 0.5 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0448 0.166
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.023 0.27 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0001 0.0004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0241 0.0317
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.0087 0.0322
Toxoplasma gondii ABC1 family protein 0.0035 0.0241 0.4592
Brugia malayi Nuclear hormone receptor family member nhr-25 0.00140813 0.5 0.5
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0087 0.0087
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0087 0.0087
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0241 0.5624
Brugia malayi jmjC domain containing protein 0.0061 0.0566 0.2096
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0087 0.0993
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0566 0.0566
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.00140813 0.5 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.00140813 0.5 0.5
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0087 0.0114
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1276 0.168
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0087 0.0322
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.0087 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0087 0.0993
Loa Loa (eye worm) hypothetical protein 0.0035 0.0241 0.0317
Loa Loa (eye worm) hypothetical protein 0.0035 0.0241 0.0317
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0241 0.0317
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0054 0.1023
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.0087 0.0114
Schistosoma mansoni ran 0.0021 0.0054 0.0071
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0002
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0054 0.1389
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0054 0.5
Onchocerca volvulus 0.0035 0.0241 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0087 0.0993
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0054 0.0199
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0617 0.7597 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0241 0.6232
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0054 0.0071
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0001 0.0002
Echinococcus multilocularis muscleblind protein 1 0.0148 0.1665 0.1665
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.00140813 0.5 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.00140813 0.5 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.00140813 0.5 0.5
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0054 0.0054
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0566 0.0745
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0087 0.0114
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0054 0.1023
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0087 0.0114
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.00140813 0.5 0.5
Onchocerca volvulus 0.0035 0.0241 0.5
Mycobacterium ulcerans lipase LipD 0.0035 0.0241 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0087 0.0993
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0001 0.0001
Echinococcus multilocularis geminin 0.0164 0.1866 0.1866
Loa Loa (eye worm) hypothetical protein 0.0023 0.0087 0.0114
Loa Loa (eye worm) hypothetical protein 0.0023 0.0087 0.0114
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0566 0.0745
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.0087 0.0114
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.00140813 0.5 0.5
Brugia malayi steroid hormone receptor 0.00140813 0.5 0.5
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0087 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-19 0.00140813 0.5 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0001 0.0002
Loa Loa (eye worm) RGS-3 protein 0.0023 0.0087 0.0114
Loa Loa (eye worm) hypothetical protein 0.0023 0.0087 0.0114
Schistosoma mansoni hypothetical protein 0.0164 0.1866 0.2457
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.00140813 0.5 0.5
Echinococcus granulosus snurportin 1 0.0617 0.7597 1
Entamoeba histolytica hypothetical protein 0.0023 0.0087 0.0993
Loa Loa (eye worm) hypothetical protein 0.00140813 0.5 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.00140813 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.00140813 0.5 0.5
Brugia malayi beta-lactamase family protein 0.0035 0.0241 0.0893
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.00140813 0.5 0.5
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0387 1
Schistosoma mansoni hypothetical protein 0.0617 0.7597 1
Schistosoma mansoni thyroid hormone receptor 0.00140813 0.5 0.5
Onchocerca volvulus 0.0035 0.0241 0.5
Brugia malayi Importin beta-1 subunit 0.0058 0.0525 0.1945
Echinococcus granulosus nuclear receptor 2DBD gamma 0.00140813 0.5 0.5
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.0087 0.0087
Echinococcus multilocularis GPCR, family 2 0.0016 0.0001 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0241 0.5624
Loa Loa (eye worm) steroid hormone receptor 0.00140813 0.5 0.5
Echinococcus granulosus geminin 0.0164 0.1866 0.2457
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.00140813 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0148 0.1665 0.2191
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.00140813 0.5 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.00140813 0.5 0.5
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0087 0.0114
Schistosoma mansoni nuclear hormone receptor 0.00140813 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0087 0.0114
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.00140813 0.5 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.023 0.27 0.3554
Brugia malayi PXA domain containing protein 0.0023 0.0087 0.0322
Loa Loa (eye worm) hypothetical protein 0.0148 0.1665 0.2191
Entamoeba histolytica hypothetical protein 0.0023 0.0087 0.0993
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0566 0.0745
Schistosoma mansoni hypothetical protein 0.0035 0.0241 0.0318
Brugia malayi Nuclear hormone receptor-like 1 0.00140813 0.5 0.5
Brugia malayi Nuclear hormone receptor family member nhr-40 0.00140813 0.5 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0241 0.5624
Leishmania major hypothetical protein, conserved 0.0035 0.0241 0.6232
Echinococcus granulosus importin subunit beta 1 0.0058 0.0525 0.0691
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0241 0.0317
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.00140813 0.5 0.5
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0525 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.023 0.27 0.3554
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.00140813 0.5 0.5
Echinococcus multilocularis ecdysone induced protein 78C 0.00140813 0.5 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.023 0.27 0.3554
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0241 0.0893
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.0087 0.0087
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0087 0.0114
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0087 0.0114
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0002
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0087 0.0114
Schistosoma mansoni retinoic acid receptor RXR 0.00140813 0.5 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0241 0.4592
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0087 0.0322
Brugia malayi Cytochrome P450 family protein 0.0032 0.0194 0.0717
Echinococcus multilocularis thyroid hormone receptor alpha 0.00140813 0.5 0.5
Loa Loa (eye worm) beta-lactamase 0.0035 0.0241 0.0317
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0087 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-3 0.00140813 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0087 0.0993
Loa Loa (eye worm) hypothetical protein 0.0035 0.0241 0.0317
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0448 0.059
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0054 0.0071
Entamoeba histolytica hypothetical protein 0.0047 0.0387 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.00140813 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0023 0.0087 0.0993
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.00140813 0.5 0.5
Echinococcus multilocularis muscleblind protein 0.0148 0.1665 0.1665
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0241 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.00140813 0.5 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0448 0.166
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.00140813 0.5 0.5
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0087 0.0114
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0087 0.0087
Brugia malayi nuclear receptor NHR-88 0.00140813 0.5 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.00140813 0.5 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.00140813 0.5 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0566 0.0745
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0001 0.0002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0001 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.00140813 0.5 0.5
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.0087 0.0322
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.023 0.27 0.27
Plasmodium vivax importin-beta 2, putative 0.0058 0.0525 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.00140813 0.5 0.5
Schistosoma mansoni hypothetical protein 0.0164 0.1866 0.2457
Echinococcus granulosus expressed protein 0.0451 0.5492 0.7229
Onchocerca volvulus Bile acid receptor homolog 0.00140813 0.5 0.5
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0023 0.0087 0.0114
Loa Loa (eye worm) hypothetical protein 0.00140813 0.5 0.5
Leishmania major importin beta-1 subunit, putative 0.0047 0.0387 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0054 0.1389
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2649 1
Toxoplasma gondii HEAT repeat-containing protein 0.0058 0.0525 1
Loa Loa (eye worm) hypothetical protein 0.00140813 0.5 0.5
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0087 0.0114
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0241 0.0241
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0387 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0087 0.0114
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.00140813 0.5 0.5
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0241 0.4592
Mycobacterium leprae Probable lipase LipE 0.0035 0.0241 0.5
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0241 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0001 0.0004
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.0087 0.0087
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0087 0.0114
Echinococcus granulosus nuclear receptor 2DBD gamma 0.00140813 0.5 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.00140813 0.5 0.5
Mycobacterium ulcerans beta-lactamase 0.0035 0.0241 0.5
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0087 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-1 0.00140813 0.5 0.5
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.0087 0.0114
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.00140813 0.5 0.5
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0054 0.1023
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0566 0.0566
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0087 0.0114
Brugia malayi hypothetical protein 0.0023 0.0087 0.0322
Brugia malayi Nuclear hormone receptor family member nhr-49 0.00140813 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.0525 0.0691
Loa Loa (eye worm) hypothetical protein 0.0023 0.0087 0.0114
Brugia malayi Steroid receptor seven-up type 2 0.00140813 0.5 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0566 0.0745
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.0087 0.0114

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 11.22 uM Huh7 cytotoxicity for Pf inhibitors Novartis-GNF Malaria Box. No reference
CC50 > 11.22 uM NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) ChEMBL. 18579783
EC50 (functional) < 0.02967 uM W2 Pf proliferation inhibition Novartis-GNF Malaria Box. No reference
EC50 (functional) < 0.02967 uM NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (functional) > 1.046 uM PF proliferation inhibition 3D7 Novartis-GNF Malaria Box. No reference
EC50 (functional) > 1.046 uM NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
IFI promiscuity index = 0.00775 IFI promiscuity index Novartis-GNF Malaria Box. No reference
Potency (functional) 0.1192 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 18579783

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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